Negative / Null Result ReportOpen accessImmunology and Microbiology
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →Negative / Null Result ReportOpen accessSocial Sciences
John M. Carey, Brian J. Fogarty, Marília Gehrke et al. · 2025 · Science Advances
We investigate how to counter misinformation about voter and election fraud using data from the US and Brazil. Our study first compares two types of messages countering claims of widespread fraud: (i) retrospective corrections from…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Davide Faccialà, M. Bonanomi, Bruno Nunes Cabral Tenorio et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide We report a study of the electronic and nuclear relaxation dynamics of the photoexcited RNA base uracil in the gas phase using time-resolved core-level photoelectron spectroscopy together with high-level calculations. The dynamics was investigated by trajectory surface hopping calculations, and the core ionization energies were calculated for geometries sampled from these. The molecule was excited by a UV laser and dynamics probed on the oxygen, nitrogen, and carbon sites by core electron spectroscopy. We find that the main de-excitation chann
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Jonas Schmidinger, Viacheslav Barkov, Sebastian Vogel et al. · 2025 · Computers and Electronics in Agriculture
Machine learning and geostatistics are two fundamentally different frameworks for the prediction and spatial mapping of soil properties. Geostatistics leverages the spatial structure of soil properties, whereas machine learning models capture the relationship between available environmental features and soil properties. We propose a hybrid framework that augments machine learning with spatial context through the engineering of ‘spatial lag’ features derived from ordinary kriging. We call this approach ‘kriging prior regression’ (KpR), as it reverses the logic of regression kriging by incorpera
View details →Negative / Null Result ReportOpen accessMedicine
Приходько Вероника Александровна, Sergey V. Okovityi · 2026 · Biomedicines
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an exceptionally high global prevalence that is projected to continue rising in the near future. MASLD is strongly associated with a spectrum of cardiometabolic risk factors, and may itself, in turn, contribute to cardiovascular morbidity and mortality. This interconnection warrants the development of integrated treatment strategies targeting shared pathophysiological processes and addressing both hepatic, metabolic, and cardiovascular outcomes. In this work, we review the modern MASLD clinical development pip
View details →Negative / Null Result ReportOpen accessNeuroscience
Sabine Willems, Vasily Morozov, Julian A. Marschner et al. · 2025 · Journal of Medicinal Chemistry
The ligand-activated transcription factors of the NR4A family are implicated as promising drug targets with neuroprotective and anticancer potential and attract strong attention in drug discovery. Several NR4A modulators have been…
View details →Negative / Null Result ReportOpen accessMedicine
Sabrina Gloria Giulia Testoni, Guglielmo Albertini Petroni, Maria Laura Annunziata et al. · 2025 · Diagnostics
Inflammatory bowel diseases (IBDs), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated inflammatory diseases of the gastrointestinal (GI) tract with still-elusive etiopathogeneses and an increasing prevalence worldwide. Despite the growing availability of more advanced therapies in the last two decades, there are still a number of unmet needs. For example, the achievement of mucosal healing has been widely demonstrated as a prognostic marker for better outcomes and a reduced risk of dysplasia and cancer; however, the accuracy of endoscopy is crucial for bo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lidia Bakota, Kerli Tulva, Nataliya I. Trushina et al. · 2026 · Translational Psychiatry
The neuronal microtubule-associated protein tau is involved in several neurodegenerative diseases, collectively referred to as tauopathies. In these diseases, it aggregates and plays a central role in triggering cell death. Tau was…
View details →Negative / Null Result ReportOpen accessPsychology
Pim Cuijpers, Mathias Harrer, Clara Miguel et al. · 2026 · Journal of Affective Disorders
It is not yet clear whether baseline severity is associated with the effects of psychotherapies. We examined baseline severity at the study level in a large sample of randomized controlled trials comparing psychotherapies against a control condition for the treatment of depression. We used an existing large database of randomized trials comparing psychotherapies for depression with control groups ( www.metapsy.org ). We converted baseline severity scores across different depression measures into a common metric. We ran bivariable and multivariable meta-regression analyses to examine the associ
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fulai Zhou, Guangmao Mu, Honglei Bi et al. · 2025 · Cancers
Background. The dense hyaluronan (HA)-rich stroma in solid tumors can prevent effective tumor growth inhibition by hindering drug delivery and immune cell infiltration. However, the degradation of HA alone by systemic delivery of hyaluronidase has not shown significant improvement of tumor growth inhibition. Objectives/Methods. In this study, we targeted hyaluronan degradation by using antibody–enzyme (AbEn) molecules by fusing antibodies to a recombinant human hyaluronidase (HYAL). Results. The AbEn molecules were stable, retained both antigen-binding and enzymatic activities, and demonstrate
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Muhammad Murad, Muhammad Ahmed, Nizam ul din et al. · 2026 · AgriEngineering
Artificial intelligence (AI) shows great promise for transforming the agriculture sector and can enable the development of many modern farming practices over conventional methods. Nowadays, AI agents and agentic AI have attained popularity due to their autonomous structure and working mechanism. This research work proposes an agentic AI framework that integrates multiple agents developed for farming land to promote climate-smart agriculture and support United Nations (UN) sustainable development goals (SDGs). The developed structure has four agents: Agent A for monitoring soil properties, Agen
View details →Negative / Null Result ReportOpen accessMedicine
Elliott J. Jenkins, Joseph A. Killick, Owain Zerilli et al. · 2025 · The Journal of Physiology
Abstract Long‐term heat acclimation has been shown to elevate haemoglobin mass (Hb mass ) and enhance maximal oxygen consumption (). To date, however, all evidence derives from exercise‐induced heat stress, making it unclear whether passive strategies, which allow athletes to maintain training intensities, can produce similar adaptations. Moreover, while heat‐induced increases in are often attributed to haematological changes, adaptation of other convective components of oxygen transport may underpin these improvements. To investigate whether 5 weeks of hot‐water immersion (HWI) would enhance
View details →Negative / Null Result ReportOpen accessEngineering
Hanxu Ma, Shunda Qiao, Ying He et al. · 2026 · Reports on Progress in Physics
Abstract This paper proposed an optical detection mechanism that utilized orthogonal phase modulation (OPM) and Lissajous mode decoupling within a light-induced thermoelastic spectroscopy (LITES) sensor for the first time, enabling…
View details →Negative / Null Result ReportOpen accessPsychology
Lujain Ibrahim, Franziska Sofia Hafner, Luc Rocher · 2026 · Nature
. Here we show how this can create a significant trade-off: optimizing language models for warmth can undermine their performance, especially when users express vulnerability. We conducted controlled experiments on five different language models, training them to produce warmer responses, then evaluating them on consequential tasks. Warm models showed substantially higher error rates (+10 to +30 percentage points) than their original counterparts, promoting conspiracy theories, providing inaccurate factual information and offering incorrect medical advice. They were also significantly more lik
View details →Negative / Null Result ReportOpen accessEngineering
Mohamed Abdellatief, Mohamed Mortagi · 2026 · Scientific Reports
Accurate prediction of the unconfined compressive strength (UCS) of geopolymer-stabilized clayey soil is critical for geotechnical engineering. Conventional regression algorithms and even advanced machine learning approaches such as artificial neural networks often struggle to fully capture the highly non-linear interactions among soil properties and geopolymer mix parameters while maintaining computational efficiency and interpretability on limited datasets. To address these challenges, this investigation proposes a novel hybrid predictive framework based on a sector fruit fly optimization al
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Remonda Raafat Ragheb, Rodayana Atef, Kareem Abdou et al. · 2026 · AAPS PharmSciTech
Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhenghao Sun, Qian Gong, Zi-lai Wang et al. · 2026 · International Journal of Biological Sciences
The gut microbiota, as a source of profound genetic and metabolic capacity, affects every aspect of human biology including health, development and aging, as well as disease. Studies have demonstrated the crosstalk between the gut…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaohua Xiao, Xueqin Yan, Chunhua Liang et al. · 2026 · Frontiers in Neurology
Alzheimer's disease (AD) is a gradual and irreversible decline in the brain's ability to function which is not only signified by amyloid-beta plaques and neurofibrillary tangles but also by and metabolic and mitochondrial changes that have a negative impact on the classical neuropathological hallmarks. It is becoming increasingly clear that the central roles in the process of synaptic dysfunction, neuronal death and cognitive decline are played by the brain's impaired glucose utilization, insulin resistance, lipid metabolism alterations, and energy homeostasis disruption. Mitochondrial dysfunc
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lucia Chico, Erika Schirinzi, Linda Balestrini et al. · 2026 · International Journal of Molecular Sciences
Neurodegenerative diseases (NDs) are among the leading causes of disability and mortality worldwide and are characterized by multifactorial pathogenesis involving interconnected mechanisms, such as oxidative stress, protein misfolding and aggregation, neuroinflammation, and mitochondrial dysfunction. Dysregulation of transcription factors, governing cellular defense responses, particularly nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of antioxidant and proteostatic pathways, plays a critical role in neurodegenerative processes. Currently, available pharmacological treatm
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Moritz Mager, Lukas Zeilerbauer, Alexander Felgel-Farnholz et al. · 2026 · Waste Management
European legislation, particularly the Packaging and Packaging Waste Regulation (PPWR), is rapidly increasing the demand for high-quality recycled polypropylene (PP) in packaging applications. Achieving such qualities through mechanical recycling remains challenging due to the heterogeneity of post-consumer waste, while the role of intensified washing in the overall decontamination remains debated. This study evaluates the influence of additional sorting and washing intensity on material properties, product performance, and environmental impacts in mechanical recycling of Dutch post-consumer r
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
L E Mayorga, Arnau Noguera Segura, Laura Campderros et al. · 2026 · Gut
BACKGROUND: Inflammatory bowel disease (IBD) arises from complex interactions among diet, host and gut microbiome. Although diet influences intestinal inflammation, the microbial and metabolic pathways involved, and their differences…
View details →Negative / Null Result ReportOpen accessMedicine
Shangkai Gao, Léa Décarie-Spain, Cindy Gu et al. · 2026 · Comprehensive physiology
Glucagon-like peptide-1 (GLP-1) is a nutrient-responsive hormone classically associated with glucose homeostasis and food intake control, yet its receptor is broadly expressed throughout the central nervous system (CNS) in circuits governing complex cognitive processes. Here, we synthesize emerging evidence from preclinical models and human studies demonstrating that GLP-1 receptor (GLP-1R) signaling modulates multiple cognitive domains, including reward and motivational processes relevant to obesity and substance use disorder, affective-related behaviors, and learning and memory. We propose a
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tomasz Kulik, Paulina Staniszewska, Patryk Wiśniewski et al. · 2025 · Frontiers in Microbiology
Products derived from Trichoderma fungi, primarily marketed as biofungicides and biofertilizers, are widely utilized to promote sustainable and regenerative farming practices. In this study, we characterized Trichoderma -based products currently available in both international and local (the Polish) markets. We estimated the number of viable cells in these products, which is a key factor boosting their efficacy. We found substantial differences in the number of colony-forming units (CFUs) among various products, with all products exhibiting fewer CFUs than claimed. The degree of this inconsist
View details →Negative / Null Result ReportOpen accessMedicine
Claudiu Stoicescu, Cristina Văcărescu, Dragoș Cozma · 2025 · Journal of Clinical Medicine
High-density lipoprotein (HDL) and small dense low-density lipoprotein (sdLDL) represent two critical yet contrasting components in lipid metabolism and cardiovascular risk modulation. While HDL has traditionally been viewed as cardioprotective due to its role in reverse cholesterol transport and anti-inflammatory effects, emerging evidence emphasizes that HDL functionality-rather than concentration alone-is pivotal in atheroprotection. Conversely, sdLDL particles are increasingly recognized as highly atherogenic due to their enhanced arterial penetration, oxidative susceptibility, and prolong
View details →Negative / Null Result ReportOpen accessMaterials Science
Emrah Yıldırım, J. Naish, J. Trueba et al. · 2026 · Nuclear Fusion
Abstract An integrated tritium fuel-cycle architecture has been developed for ST-E1, a low-aspect-ratio, high-power fusion power plant. The approach couples a helium-cooled liquid-lithium breeder blanket with a dedicated circulation loop providing tritium extraction, heat removal, and inventory control within a unified system boundary. Downstream of the blanket, the tritium processing system comprises of extraction, purification, isotope separation, and storage subsystems sized to accommodate the plant’s dynamic tritium production and consumption rates. Inventory modelling is used to assess ca
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Byong Duk Ye, Hyo Jong Kim, Dongil Park et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: The incidence of ulcerative colitis (UC) has been increasing in Asia. Comprehensive data on the long-term course of moderate-to-severe UC remain scarce. This study investigated the clinical outcomes and factors…
View details →Negative / Null Result ReportOpen accessNeuroscience
Elena Krugliakova, Friederike Breuer, Nico Adelhöfer et al. · 2025 · Physiological Reviews
Sleep is essentially contributing to human health and well-being through multiple biological functions, including restoration and biosynthesis, brain clearance, energy metabolism, immunological and endocrine processing, synaptic…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Kamel Mouloudj, Tiziana Amoriello, Eeman Almokdad et al. · 2026 · Sustainability
Product waste in grocery supply chains remains a major concern for multiple stakeholders, particularly retailers, due to the direct financial losses it generates and the potential risks it poses to customer health and safety. In this context, digital technologies—especially artificial intelligence (AI)—offer promising opportunities to improve retail performance and reduce waste. Accordingly, this study aims to investigate the factors influencing retailers’ intentions to adopt AI-based solutions for product waste reduction. To achieve this objective, the Technology Acceptance Model (TAM) was ex
View details →Negative / Null Result ReportOpen accessEngineering
Justyna Kujawska, Wojciech Cel, B. Charmas et al. · 2026 · Energies
Biochar obtained from digestate is a promising material in the context of digestate management. However, it is important to note that the properties of the resulting material are largely dependent on the parameters of the pyrolysis process, with temperature being a particularly significant factor. The objective of this study was to evaluate the impacts of the digestate pyrolysis temperature on the chemical structure, thermal stability, and thermal decomposition characteristics of biochar produced at temperatures of 400, 500, 600, and 800 °C in an inert nitrogen atmosphere. Material characteriz
View details →Negative / Null Result ReportOpen accessSocial Sciences
Mohammad Hadra, Karleen Cambridge, Mostefa Mesbah · 2026 · International Journal for Educational Integrity
The rapid adoption of generative AI (GenAI) in higher education has intensified concerns about academic integrity, particularly for institutions serving English as a Foreign Language (EFL) learners. AI content detectors such as Turnitin…
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