Negative / Null Result ReportOpen accessEngineering
Yu‐Hui Zhang, Lu-Qiang Wei, Chen-Shuang Liu et al. · 2025 · ACS Omega
High Resolution Image Download MS PowerPoint Slide Pesticides are of great significance in ensuring food yield. However, the extensive use of pesticides has led to severe environmental pollution and significant economic losses.…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Paul Behrens, Catherine M. Champagne, Jason C. G. Halford et al. · 2025 · Frontiers in Science
The global obesity crisis involves an unprecedented and rapid change to the human phenotype. Conferring vast levels of avoidable morbidity and mortality at enormous cost, it has proved refractory to previous policy-led action. This article reviews recent developments in our understanding of obesity and its links to the climate co-crisis, aiming to inform evidence-based, societal-level actions to address both. Recent therapeutic developments now offer transformative interventions for millions of people living with obesity. However, treating all affected adults and children with major bariatric
View details →Negative / Null Result ReportOpen accessPsychology
Chantal A. Miller, Keshun Zhang, Ronald Hübner · 2025 · Humanities and Social Sciences Communications
Abstract Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices. People have the ability to infer the aesthetic preferences of others within their own culture through their Theory of Aesthetic Preferences , which is a subcategory of the Theory of Mind. An important question is whether people can also infer aesthetic preferences across different cultures. This study aimed to investigate aesthetic preference and aesthetic inference, as well as the underlying m
View details →Negative / Null Result ReportOpen accessMedicine
Fedir Hladkykh, Tetiana Liadova, Mariia Matvieienko et al. · 2026 · Journal of Pain Research
Introduction: Central sensitization explains the mismatch between structural damage or inflammation and pain intensity in chronic musculoskeletal diseases. It defines the phenotype of fibromyalgia and contributes to persistent pain in…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Yashvee Dunneram, Jia Yi Lee, Cody Z. Watling et al. · 2026 · British Journal of Cancer
BACKGROUND: Vegetarian diets might influence cancer risk. METHODS: We studied 1,645,555 meat eaters, 57,016 poultry eaters, 42,910 pescatarians, 63,147 vegetarians and 8849 vegans in 9 cohorts (UK, US, Taiwan, India). After a median 16 years follow-up, incident cancers were: 4504 mouth and pharynx, 1308 oesophagus (squamous cell), 2105 oesophagus (adenocarcinoma), 3578 stomach, 30,528 colorectum, 2970 liver, 8030 pancreas, 3077 lung (never smokers), 61,368 breast, 11,220 endometrium, 8076 ovary, 45,946 prostate, 7193 kidney, 6869 bladder, 11,651 non-Hodgkin lymphoma, 4658 multiple myeloma and
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Migliore, Elisabetta Fenocchio, Silvia Giordano et al. · 2025 · Cancer Treatment Reviews
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and is associated with a very poor prognosis, largely due to its aggressive nature and, typically, late-stage diagnosis. Molecular classifications proposed one decade ago have provided valuable insights into the disease's heterogeneity and paved the way for clinical trials of tailored treatments. However, most of these trials have failed, often due to inadequate patient selection, lack of reliable biomarkers of response/resistance, or for the high level of inter- and intra-tumor heterogeneity characterizing t
View details →Negative / Null Result ReportOpen accessMedicine
Steffen Tiedt, Alejandro Bustamante, Alan Cameron et al. · 2026 · The Lancet Neurology
The complexity and incomplete understanding of the pathophysiology of stroke poses substantial challenges to personalised medicine and the development of novel therapies, as reflected in the neutral results of many randomised trials. Current clinical algorithms lack the precision to diagnose stroke before hospital admission, predict disease progression and recovery, or assess recurrence risk. Biomarkers are urgently needed, yet the absence of a robust evidence base hinders their clinical translation. To lay the groundwork for addressing this knowledge gap, an international multidisciplinary pa
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mohammad Fayyad‐Kazan, Sarah Ayad Al-Tameemi, Allal Ouhtit · 2026 · Cells
Cancer immunotherapy has transformed modern oncology, yet durable responses remain limited for many patients due to immune exclusion, adaptive resistance, and tumor heterogeneity. Oncolytic viruses (OVs) have emerged as a novel class of immunotherapeutics that unify direct tumor cytolysis with stimulation of antitumor immunity. By inducing immunogenic cell death (ICD) and releasing tumor-associated antigens (TAAs), OVs remodel the tumor microenvironment (TME) into an inflamed and immune-permissive niche capable of enabling systemic immune activation. Rapid advances in viral engineering have st
View details →Negative / Null Result ReportOpen accessMedicine
T. Nguyen, Tam Dao, Ha Thu Nguyen et al. · 2026 · Endocrinology and Metabolism
Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its…
View details →Negative / Null Result ReportOpen accessMedicine
Eleanor Quek, Neve Horn, Salman Siddiqui · 2025 · ImmunoTargets and Therapy
Asthma represents a profoundly heterogeneous syndrome underpinned by multiple, distinct and overlapping immunopathological mechanisms. Nevertheless, prevailing management algorithms continue to adopt a largely uniform, stepwise approach in…
View details →Negative / Null Result ReportOpen accessMedicine
Dinh Van Trung, Bui Thi Huong Giang, Đang Quoc Tuan et al. · 2025 · Scientific Reports
Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP…
View details →Negative / Null Result ReportOpen accessComputer Science
Mohammadreza Kamsari, Soroush Sadeghi, Gabriel Gomes de Oliveira et al. · 2025 · Scientific Reports
This study conducts a comprehensive analysis of various configurations of the UNet + ConvNeXt Tiny architecture for breast tumor segmentation. We assess the influence of data augmentation, skip connections, attention mechanisms, and…
View details →Negative / Null Result ReportOpen accessMedicine
Mathilde Duchon, Raj Naik, Fabrice R Lecuru et al. · 2025 · Cancers
Background: The surgical and medical management of recurrent ovarian cancer is complex and requires a personalized approach based on several factors, including the timing of recurrence, the patient’s performance status, previous treatment regimens, and the tumor’s histology and molecular characteristics. Objectives: Five randomized trials—GOG-0213, DESKTOP III, SOC 1, HORSE, and CHIPOR—have been conducted and shed light on our practice. Results: Both the DESKTOP III and the SOC 1 trials support the benefit of secondary surgery. The GOG-0213 trial, however, did not show an overall survival bene
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Fereshteh Bakhshalipoor, Marzieh Bolandi, Fariborz Nahidi et al. · 2026 · Scientific Reports
This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
A. M. Farah, A. Vijaykumar, M. Fishbach · 2026 · The Astrophysical Journal Letters
Abstract There is growing evidence from gravitational-wave (GW) observations that some merging black holes (BHs) are created from previous mergers. Using the prediction that these hierarchically merged BHs have dimensionless spin magnitudes of χ ≈ 0.69, we identify a subpopulation in the GW data consistent with a hierarchical-merger origin in dense star clusters. This subpopulation’s primary mass distribution peaks at 17 . 0 − 4.4 + 18.3 M ⊙ , which is approximately twice as large as its secondary mass distribution’s mode ( 10 . 5 − 4.7 + 29.7 M ⊙ ), and its spin tilt distribution is consisten
View details →Negative / Null Result ReportOpen accessMedicine
Nina Boskovic, Marilin Ivask, Gamze Yazgeldi Gunaydin et al. · 2025 · Scientific Reports
Abstract Mammalian preimplantation embryo development is a complex sequence of events. This period of development is sensitive to oxygen (O 2 ) levels that can affect various cellular processes. We compared the influence of O 2 tension by culturing embryos either in normoxic (20% O 2 ) or physiological hypoxic (6% O 2 ) conditions, or sequential low O 2 concentration starting with 6% O 2 until 16-cell stage and then switching to ultrahypoxic conditions (2% O 2 ). Due to ethical concerns, we used bovine as an animal model with a good similarity of embryogenesis to human. We found that the cleav
View details →Negative / Null Result ReportOpen accessMedicine
Shanshan Zhang, Tingyu Wang, Ye Peng et al. · 2026 · Molecular Biomedicine
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairments such as bradykinesia, tremor, and rigidity. Its neuropathological hallmarks include the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the aggregation of α-synuclein (α-syn) into Lewy bodies (LBs), which gradually spread to other central nervous system regions and peripheral tissues. The etiology of PD is multifactorial, involving a complex interplay of genetic predisposition, aging, environmental exposures, and lifestyle factors. Disease pathogenesis
View details →Negative / Null Result ReportMedicine
Jean-Pierre Frat, J. Quenot, Christophe Guitton et al. · 2026 · New England Journal of Medicine
BACKGROUND: Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. METHODS: In this…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Yunpeng Qiu, Yunfeng Zhao, Bianbian Wang et al. · 2026 · Nature Communications
Plant roots and arbuscular mycorrhizal fungi (AMF) form a ubiquitous symbiosis in terrestrial ecosystems and critically affect soil organic carbon (SOC) dynamics. However, how roots and AMF mediate the impact of reactive nitrogen (Nr) and…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ninggui Duan, Lina Li, Guangbo Lin et al. · 2026 · Scientific Reports
The rapid advancement of artificial intelligence (AI) has reshaped the employment market, triggering widespread anxiety among college students about their future careers and posing a potential threat to their career decisions. Grounded in…
View details →Negative / Null Result ReportOpen accessMedicine
Pia De Stefano, Sira M. Baumann, Urs Fisch et al. · 2026 · Neurology
BACKGROUND AND OBJECTIVES: Although etiology is considered central to outcomes in status epilepticus (SE), previous studies often lacked standardized classification and adjustment for confounders, particularly withdrawal of life-sustaining treatment (WLST). This study examined the association between SE etiology, mortality, and neurologic recovery using the International League Against Epilepsy (ILAE) classification while accounting for confounders and WLST. METHODS: This 2-center observational study included adults (≥18 years) with SE treated at the University Hospitals of Basel and Geneva fr
View details →Negative / Null Result ReportOpen accessMedicine
Corey A. Lester, Brigid Rowell, Yifan Zheng et al. · 2025 · JMIR Medical Informatics
Background: Artificial intelligence (AI)-based clinical decision support systems are increasingly used in health care. Uncertainty-aware AI presents the model's confidence in its decision alongside its prediction, whereas black-box AI only provides a prediction. Little is known about how this type of AI affects health care providers' work performance and reaction time. Objective: This study aimed to determine the effects of black-box and uncertainty-aware AI advice on pharmacist decision-making and reaction time. Methods: Recruitment emails were sent to pharmacists through professional listser
View details →Negative / Null Result ReportOpen accessChemistry
Josep Esteve Guasch, Debasis Pal, Marcos G. Suero · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide Herein, we disclose the first catalytic generation of alkyl–I (III) Rh (II) -carbynoids via oxidative ligand transfer between alkyl iodides and aryl–I (III) Rh (II) -carbynoids. When homoallylic iodides were used, alkyl–I (III) Rh (II) -carbynoids evolved through a diastereoselective cyclopropanation that led to highly electrophilic bicyclic alkyl–I (III) species. We observed that the latter species reacted with a plethora of nucleophiles, enabling access to a valuable class of cyclopropanes that were converted to housanes.
View details →Negative / Null Result ReportOpen accessComputer Science
M. Said Doğru, Emily Faulconer · 2025 · Research in Science Education
Abstract The emergence of ChatGPT brings an opportunity to lighten the workload of in-person teaching assistance in science laboratory courses. We investigated the use of the language model developed by OpenAI as a virtual teaching assistant for an introductory undergraduate biology laboratory course. Student-generated questions related to a laboratory exercise on enzyme activity were separately provided to ChatGPT and a cohort of graduate teaching assistants (TAs). Responses were evaluated for content accuracy and teaching effectiveness. Results revealed that human TAs were more accurate in t
View details →Negative / Null Result ReportOpen accessMedicine
Mateja Napravnik, Franko Hržić, Martin Urschler et al. · 2025 · Scientific Reports
Deep learning models require large amounts of annotated data, which are hard to obtain in the medical field, as the annotation process is laborious and depends on expert knowledge. This data scarcity hinders a model's ability to generalise…
View details →Negative / Null Result ReportOpen accessPsychology
Joaquin A. Anguera, Aleem Choudhry, Michael Seaman et al. · 2025 · JMIR Formative Research
Background There is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. While the engagement of executive functions is suggested to be part of high-level sporting activities, it is unclear whether such training approaches could directly benefit athletic performance. Objective The objective of this study was to evaluate the impact of a combined virtual reality (VR)– and tablet-based cognitive training intervention on
View details →Negative / Null Result ReportOpen accessComputer Science
Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports
Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Stella Koch Ocker, J. M. Cordes · 2026 · The Astrophysical Journal
Abstract Free electrons in the Galactic interstellar medium (ISM) disperse and scatter coherent radio waves, by amounts that depend on the distance to the radio source. Models of the Galactic electron density are thus widely used to predict distances and scattering of compact radio sources (including pulsars, fast radio bursts, and long-period transients), in addition to mitigating ISM foregrounds in Galactic and extragalactic studies. We use a sample of 171 precise pulsar distances, based entirely on parallaxes and globular cluster associations, as well as scattering measurements of 568 pulsa
View details →Negative / Null Result ReportOpen accessPsychology
Elena Hayoung Lee, Yidan Yin, Nan Jia et al. · 2026 · Scientific Reports
Artificial intelligence (AI) promises major productivity gains, but it also raises fundamental questions about how technology can reshape people's relationship to their work. Historical debates over industrialization warned that…
View details →Negative / Null Result ReportOpen accessEngineering
Yasin Onuralp Özkılıç, Mohamed Abdikarin Mohamud, Fatih Yılmaz et al. · 2026 · Scientific Reports
This study investigates the mechanical performance of geopolymer concrete cured under various oven temperatures and ambient conditions, focusing on the interactions among curing regimes, alkaline activator molarities, and ground granulated…
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