Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Jessica Coria, Jūratė Jaraitė · 2025 · Research Policy
This paper examines whether the EU Emissions Trading Scheme (EU ETS) and innovation subsidies interact to enhance green innovation at the firm level. Using staggered difference-in-differences and matched samples, we find no evidence of synergetic effects: firms subject to both the EU ETS and innovation subsidies do not outperform those subject only to subsidies in terms of green patenting outcomes. By contrast, subsidies alone have a clear positive impact on green innovation. Firms receiving subsidies generate more green patents, receive more citations, and develop technologies with greater te
View details →Negative / Null Result ReportOpen accessDecision Sciences
Giuseppe Russo, Manoel Horta Ribeiro, Tim R. Davidson et al. · 2025 · Proceedings of the ACM on Human-Computer Interaction
Journals and conferences worry that peer reviews assisted by artificial intelligence (AI), in particular, large language models (LLMs), may negatively influence the validity and fairness of the peer-review system, a cornerstone of modern…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lei Li, Hongchao Huang, Yin He et al. · 2025 · Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high. Emerging evidence indicates that cell-free DNA (cfDNA), as a novel biomarker and molecular therapeutic target, holds promise for improving the clinical management of sepsis. cfDNA refers to DNA fragments present in body fluids, including naked DNA, membrane-coated DNA, nucleosomes, and neutrophil extracellular traps (NETs). cfDNA is released from host cells o
View details →Negative / Null Result ReportOpen accessComputer Science
Ali Raza, Fareeha Hanif, Heba Abdelgader Mohammed · 2026 · Scientific Reports
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and accurate early diagnosis plays a critical role in improving patient survival. In this study, a comparative analysis of multiple lightweight Convolutional Neural Network (CNN) variants is presented for multi-class lung cancer classification using histopathological images. Four CNN architectures were designed to systematically explore the trade-off between model complexity and classification performance. Each variant was trained and evaluated within a unified experimental framework incorporating data augment
View details →Negative / Null Result ReportOpen accessMedicine
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
View details →Negative / Null Result ReportOpen accessEngineering
Teevrat Garg, Ryan Hanna, Jeff Myers et al. · 2026 · Journal of Environmental Economics and Management
Aligning electric vehicle (EV) charging with periods of abundant clean energy is essential for decarbonizing transportation. In solar-dominated grids, this requires shifting charging to midday hours – when vehicles are typically parked at workplaces. Yet workplace charging networks operate under institutional constraints such as shared infrastructure, bundled parking and charging services, and limited willingness to require drivers to move vehicles, making time-of-day pricing and active management difficult to implement. In a natural field experiment (n = 629 drivers) across a large workplace
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Richard E. Pratley, Douglas Scott Denham, Rupal Trivedi et al. · 2026 · Nature Medicine
Abstract Loss of lean mass in proportion to total weight loss is observed with incretin mimetic therapies such as tirzepatide and has the potential to adversely affect health and function. Apitegromab is an investigational, fully human monoclonal antibody that selectively inhibits myostatin activation and is, thereby, capable of increasing muscle mass. In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg −1 ) or tirzepatide plus placebo. At week 24, apitegrom
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Koen H.M. Prange, Gemma Bel-Bordes, MAC Depuydt et al. · 2026 · European Heart Journal
BACKGROUND AND AIMS: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage data. Moreover, to date no direct link has been established between cellular content of atherosclerotic lesions and secondary clinical outcome. This study is aimed at characterization of atherosclerot
View details →Negative / Null Result ReportOpen accessMedicine
Jean‐Christophe Marine, Osnat Bartok, Shira Sagie et al. · 2026 · Cell
Intratumor heterogeneity (ITH) encompasses genetic, epigenetic, transcriptional, proteomic, and immunopeptidomic diversity. Beyond genetic heterogeneity, it is increasingly clear that non-mutational heterogeneity and plasticity generate…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chengjiao Yang, Ruici Yang, Binbin Zheng et al. · 2026 · Cell Death and Disease
Protein lactylation emerges as a pivotal metabolic rheostat, translating microenvironmental lactate flux into stable programs that orchestrate cancer treatment resistance. This review synthesizes recent advances under the framework of "Lactylation Switch in Cancer Vulnerabilities." We dissect the dominant enzymatic pathways (AARS1/2, KATs, HDACs) and non-enzymatic mechanisms (MGO/LGSH), alongside their critical structural underpinnings. Furthermore, we delineate how lactylation signals are interpreted by specific readers (e.g., TRIM33), directly reprogram non-histone protein function through s
View details →Negative / Null Result ReportOpen accessPsychology
Matthew Bourke, Claudia I. Maddren, Franziska Sippel et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Understanding the within-person association between daily screen use and sleep can help clarify whether this association reflects potentially causal effects or confounding factors. Objective: To synthesize evidence on the…
View details →Negative / Null Result ReportOpen accessMedicine
Lyduine Eisa Collij, Gemma Salvadó, Kanta Horie et al. · 2026 · Nature Communications
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease duration was estimated using Aβ-PET and tau-PET with the SILA algorithm. Bootstrapped LOESS models showed that %p-tau217 changes earliest, increasing just before Aβ-PET positivity. Other p-tau species
View details →Negative / Null Result ReportOpen accessMaterials Science
Ran Dong, Yingao Ru, Xi Zhang et al. · 2026 · ACS Omega
Abstract Batch nanofabrication of complex nanostructures remains a critical challenge, restricting their translation from laboratory design to industrial application. To address this, we report a conceptual and methodological advance by…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Gongwei Guo, Zhihui Tang, Honggang Liu · 2026 · European Journal of Education
ABSTRACT Although the proliferation of artificial intelligence (AI) and digital tools has facilitated AI‐enhanced and informal digital learning of English, traditional classroom ecology remains a central context for adolescent English‐as‐a‐foreign‐language (EFL) learners' language learning and development. Additionally, while the importance of achievement emotions among tertiary‐level EFL learners has been well established, research on retrospective outcome emotions (e.g., pride and shame) among non‐tertiary EFL learners remains scarce. As such, the study investigated whether and how language
View details →Negative / Null Result ReportOpen accessMathematics
Michelle Pistner Nixon, Kyle C. McGovern, Maxwell A. Konnaris et al. · 2026 · The Annals of Applied Statistics
Many scientific fields, including human gut microbiome science, collect multivariate count data where the sum of the counts is unrelated to the scale of the underlying system being measured (e.g., total microbial load in a subject’s…
View details →Negative / Null Result ReportOpen accessEngineering
Lorenzo Tamboia, Giorgio Montinaro, Elisa Ravesio et al. · 2026 · Journal of Cleaner Production
The growing demand for sustainable energy solutions has highlighted the crucial role of lithium-ion batteries (LIBs) in the global energy transition. However, the conventional use of polyvinylidene fluoride (PVDF) binders combined with…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ingvild Almås, Alexander W. Cappelen, Erik Ø. Sørensen et al. · 2026 · The Quarterly Journal of Economics
Abstract This article provides the first comprehensive global evidence on people’s fairness and efficiency preferences, beliefs about the sources of inequality and the efficiency cost of redistribution, and policy attitudes toward redistribution. Using a globally harmonized consequential experiment with more than 65,000 individuals across 60 countries, we show that the source of inequality plays a substantially larger role for inequality acceptance than the efficiency cost of redistribution. At the global level, implemented inequality increases by 85% when inequality is caused by merit rather
View details →Negative / Null Result ReportOpen accessMedicine
Marta Młodawska, Anna Zmelonek-Znamirowska, Grzegorz Świercz et al. · 2026 · Journal of Clinical Medicine
Background and Objectives: Placenta accreta spectrum (PAS) complicating placenta praevia is associated with increased maternal morbidity; however, neonatal respiratory burden may be underappreciated. We compared neonatal outcomes between pregnancies complicated by placenta praevia with and without histopathologically confirmed PAS, with additional adjustment of respiratory outcomes for gestational age at delivery. Materials and Methods: We conducted a retrospective single-centre cohort study (n = 82). Based on placental histopathology, women were classified as PAS (n = 37; accreta/increta/perc
View details →Negative / Null Result ReportOpen accessDecision Sciences
Yuan Tao, Yu Z, Tianxue Chen et al. · 2026 · iScience
Phytomedicine extraction-process optimization often relies on regression or machine learning models, but model choice is commonly judged by goodness of fit alone. Here, we assembled 1,148 structurally eligible extraction datasets from…
View details →Negative / Null Result ReportOpen accessArts and Humanities
Yongliang Wang, Han Shi · 2026 · Discover Computing
Abstract The role of generative artificial intelligence (GenAI) affordance in specific task teaching, particularly the continuation writing task, remains insufficiently theorized and empirically underexplored. To bridge this research gap, a repeated-measures intervention study was conducted within the framework of Dynamic Systems Theory (DST) to investigate the implementation of GenAI-assisted continuation task instruction and its associations with the development of English as a Foreign Language (EFL) students’ writing performance. Twenty-five Chinese EFL high school students participated in
View details →Negative / Null Result ReportOpen accessMedicine
Ashley I. Martinez, Sarah C. MacDonald, Sruthi Adimadhyam et al. · 2026 · JAMA Network Open
Importance: Respiratory syncytial virus (RSV) is a leading cause of infant hospitalizations. In August 2023, the US Food and Drug Administration approved a bivalent RSV prefusion F subunit-based vaccine (RSVpreF) for maternal immunization…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Saimum Hossain, Faruque Ahmed · 2026 · Dhaka University Journal of Business Studies
The study investigates the relationship between bank profitability and a comprehensive list of bank-specific, industry-specific and macroeconomic variables using unique panel data from 23 Bangladeshi banks with large market shares from…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucy R. Ivey, J. Scholtz, A. Lola Danhaive et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT A majority of JWST/NIRSpec integral field unit (IFU) studies at high redshifts to date have focused on UV-bright or massive objects, while our understanding of low-mass galaxies at early cosmic times remains limited. In this work, we present NIRSpec/IFU high-resolution observations of two low-mass ($M_*< 10^9 \ \mathrm{ M}_\odot$), low-metallicity ($[12+\log (\mathrm{O/H})]< 8$) galaxies at $z\sim 7.66$, one of which we identify as hosting a Type-II active galactic nucleus (AGN). We measure flat strong-line metallicity gradients, suggestive of interstellar medium redistribution by out
View details →Negative / Null Result ReportOpen accessNeuroscience
Eva Sclabassi, Sophie Peret, Chunqi Qian et al. · 2025 · Biomedicines
Background and Objectives: Autism spectrum disorder (ASD) is a heterogeneous neuro-developmental condition characterized by social communication deficits, restricted interests, and repetitive behaviors. Pharmacological management is challenging given the complex neurobiology and frequent comorbidities. This review summarizes the current evidence for pharmacological treatments in ASD, highlighting efficacy, mechanisms, limitations, and emerging therapeutic targets. Methods: A comprehensive literature review was conducted across PubMed, Cochrane Library, and Embase to identify clinical trials, s
View details →Negative / Null Result ReportOpen accessMedicine
Grzegorz K. Jakubiak, Natalia Pawlas, Monika Starzak et al. · 2026 · Vascular Health and Risk Management
Purpose: The purpose of this study was to analyze the relationship between resting high-sensitive serum cardiac troponin T concentration (hs-cTnT), D-dimer, and N-terminal pro–B-type natriuretic peptide (NT-proBNP), measured outside the…
View details →Negative / Null Result ReportOpen accessMedicine
Suli Yu, Zhen Pang, Hong Fang et al. · 2026 · Molecular Biomedicine
Ferroptosis, a regulated cell death modality driven by iron accumulation and lipid peroxidation, has emerged as a pivotal pathophysiological mechanism across a broad spectrum of cardiovascular diseases (CVDs), which remain the leading cause of global mortality. Although robust preclinical evidence indicates that modulation of ferroptosis attenuates myocardial and vascular injury, clinical translation is constrained by incomplete understanding of context-specific roles, the paucity of validated biomarkers, and the absence of targeted therapeutics with acceptable safety profiles. In this Review,
View details →Negative / Null Result ReportOpen accessMedicine
Jiahui Xiang, Jiayi Li, Zizhao Guo et al. · 2026 · Biomarker Research
Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a paradigm-shifting therapeutic strategy in oncology, demonstrating significant synthetic lethality in tumors characterized by homologous recombination deficiency. Due to their…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Liangzhan sun, Xiaojing Chu, Tingting Kong et al. · 2026 · Immunity
Tumor-associated macrophages (TAMs) can suppress antitumor immunity and reduce responses to immune checkpoint blockade (ICB). Here, we asked how TAM programs contribute to ICB non-response. Integration of public single-cell RNA sequencing (scRNA-seq) datasets across 12 cancer types identified SPP1 + TAMs as a tumor-enriched macrophage subset with immunosuppressive features. TAMs from ICB non-responders across multiple tumor types exhibited higher SPP1 expression. In murine models, macrophage Spp1 deletion suppressed tumor growth and prolonged survival and was associated with a remodeled tumor
View details →Negative / Null Result ReportOpen accessMedicine
Joe M. Butler, Hessel Peters Sengers, Tom D. Y. Reijnders et al. · 2025 · EBioMedicine
BACKGROUND: Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI). METHODS: RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-
View details →Negative / Null Result ReportOpen accessPsychology
Federica Pallavicini, Eleonora Francesca Orena, Lisa Arnoldi et al. · 2024 · JMIR Serious Games
BACKGROUND: Virtual reality (VR) is helpful for the management of stress and anxiety. However, current interventions have limitations related to location (ie, therapist's office or hospitals) and content (ie, virtual experiences only for relaxation). OBJECTIVE: This randomized pilot trial aims to investigate the efficacy and acceptability of a brief remote VR-based training for supporting stress and anxiety management in a sample of Italian health care workers. METHODS: A total of 29 doctors and nurses (n=21; 72% female; mean age 35.6, SD 10.3 years) were recruited and randomized to a VR inter
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