Negative / Null Result ReportOpen accessEngineering
M. A. Huque, Leon M. Tolbert, Benjamin J. Blalock et al. · 2026 · IMAPSource Proceedings
High-temperature power conversion modules (DC-DC converters, inverters, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. Power-to-volume and…
View details →Negative / Null Result ReportOpen accessNursing
Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer et al. · 2025 · Pharmaceutics
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have dem
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →Negative / Null Result ReportOpen accessEngineering
Rafael Cabral, Ricardo Santos, José A.F.O. Correia et al. · 2025 · Sensors
The automated inspection of civil infrastructure with Unmanned Aerial Vehicles (UAVs) is hampered by the challenge of accurately segmenting multi-damage in high-resolution imagery. While foundational models like the Segment Anything Model (SAM) offer data-efficient segmentation, their effectiveness is constrained by prompting strategies, especially for geometrically complex defects. This paper presents a comprehensive comparative analysis of deep learning strategies to identify an optimal deep learning pipeline for segmenting cracks, efflorescences, and exposed rebars. It systematically evalua
View details →Negative / Null Result ReportOpen accessComputer Science
Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports
Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Korenjak, Nuri A. Temiz, Stéphane Keïta et al. · 2026 · Genome Medicine
BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in…
View details →Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →Negative / Null Result ReportOpen accessEngineering
Lina Maria Ellegård, Gustav Kjellsson, Linn Mattisson · 2026 · The Economic Journal
Abstract The emergence of markets for on-demand online physician consultations —direct-to-consumer telemedicine (DCT) — is currently transforming many healthcare settings. DCT may be a cost-effective substitute for in-person consultations, but the convenience of seeking DCT may increase the demand for the service and consequently also the costs for health insurers. To causally assess the degree to which DCT consultations substitute for in-person primary care consultations, we exploit exogenous changes in patient fees in a fuzzy difference-in-discontinuities analysis of young adults in Sweden.
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
A. J. Nayana, R. Margutti, Eli Wiston et al. · 2025 · The Astrophysical Journal Letters
Abstract We present X-ray (0.3–79 keV) and radio (0.25–203 GHz) observations of the most luminous fast blue optical transient (LFBOT) AT 2024wpp at z = 0.0868, spanning 2–280 days after first light. AT 2024wpp shows luminous ( L X ≈ 1.5 × 10 43 erg s −1 ), variable X-ray emission with a Compton hump peaking at δt ≈ 50 days. The X-ray spectrum evolves from a soft ( F ν ∝ ν −0.6 ) to an extremely hard state ( F ν ∝ ν 1.26 ) accompanied by a rebrightening at δt ≈ 50 days. The X-ray emission properties favor an embedded high-energy source shining through asymmetric expanding ejecta. We detect radi
View details →Negative / Null Result ReportOpen accessMedicine
Joanna M Porter, Cici Jin, Michael Churchman et al. · 2025 · European Journal of Cancer
BACKGROUND: Antibody-drug conjugates (ADCs) are emerging anti-cancer agents. The folate receptor alpha (FOLRα)-directed ADC mirvetuximab soravtansine recently demonstrated clinical activity in platinum-resistant ovarian cancer, with other ADCs currently in development. The relative expression of FOLRα and other ADC targets is largely unknown across ovarian cancer histotypes. METHODS: Expression levels of the ADC targets FOLRα, TROP2 and B7-H4 were assessed by immunohistochemistry in patient cohorts using tumour tissue microarrays of the major ovarian cancer histotypes: high grade serous (HGSOC
View details →Negative / Null Result ReportOpen accessHealth Professions
Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
View details →Negative / Null Result ReportOpen accessPsychology
E. G. J. M. Arts, Bram Orobio de Castro, Ellen Luteijn et al. · 2024 · Social Development
Abstract This study investigated whether interactive virtual reality (VR) training of social and emotional abilities (InterAction) improves socio‐emotional functioning of youth with developmental language disorders (DLD). To this end we conducted a multiple baseline intervention study, comparing participants’ social abilities during a baseline phase with their changes in abilities during the intervention and posttest phase. The training group consisted of 29 adolescents ( 20 boys, 9 girls ) with DLD from the Netherlands. The training consisted of nine, weekly (45–50 min) individual sessions wi
View details →Negative / Null Result ReportOpen accessMedicine
Dayoung Seo, Yangsean Choi, Eunseon Jeong et al. · 2025 · Nature Communications
Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain unclear. We analyzed blood proteins and brain MRI from individuals approximately one…
View details →Negative / Null Result ReportOpen accessMedicine
Gustavo Jimenez‐Maggiora, Arndt‐Peter Schulz, Michael Donohue et al. · 2024 · The Journal of Prevention of Alzheimer s Disease
BACKGROUND: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) studies were conducted between 2014 and 2023, with enrollment completed in 2017 and final study results reported in 2023. The study screening process involved the collection of initial clinical, cognitive, neuroimaging, and genetic measures to determine eligibility. Once randomized, enrolled participants were assessed every four weeks over a 4.5-year follow-up period during which longitudinal clinical, cognitive, and neuroimaging measures wer
View details →Negative / Null Result ReportOpen accessMedicine
Qun Xiao, WeiCheng Huang, Yuheng Zhuang et al. · 2025 · Aging Clinical and Experimental Research
BACKGROUND: Stroke is a significant public health issue, with its risk influenced by various metabolic factors. The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index has been identified as a valid stroke predictor. However, the…
View details →Negative / Null Result ReportOpen accessEngineering
Fhysmélia Firmino de Albuquerque, Rodrigo M. Iost, Frank N. Crespilho · 2025 · ACS Measurement Science Au
The development of enzyme-based bioelectronic devices, including biosensors and biomimetic systems, has significantly advanced with the introduction of innovative materials such as hydrogels, deep eutectic solvents (DES), and ionic liquids (ILs). These materials offer unique advantages in enhancing biodevice performance, particularly in enzyme stabilization, biocompatibility, and electrochemical sensitivity. Hydrogels, known for their high water content and flexibility, provide an ideal matrix for enzyme immobilization in biological applications but are limited by low ionic conductivity. DES,
View details →Negative / Null Result ReportOpen accessMedicine
Patrick Highton, Mark P. Funnell, Pankaj Gupta et al. · 2025 · Diabetologia
Abstract Medication adherence is critical for optimal glycaemic management and the prevention of complications in type 2 diabetes mellitus. Despite its importance, non-adherence remains a prevalent issue, with global estimates suggesting that approximately 38% of people with type 2 diabetes do not take their medications as prescribed, although estimates vary widely due to a range of patient-related, socioeconomic, condition-related (e.g. chronicity, severity of comorbidities) and healthcare system factors. This review synthesises the current evidence on the prevalence of non-adherence in type
View details →Negative / Null Result ReportMedicine
Manav Raj, Justin M. Berg, Rob Seamans · 2026 · Journal of Experimental Psychology General
= 27,491), we examine how evaluations of creative writing are affected by whether participants believe the content is produced with an AI model. We find consistent evidence of an AI disclosure penalty: Participant evaluations of creative…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Bálint Soczó, Ildikó Pethes · 2025 · Journal of Molecular Liquids
Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations . Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction potential model for water. In various studies, the models have been evaluated based on their ability to reproduce different properties of water. This work focuses on the atomic-scale structure in the liquid phase of water. Forty-four classical water potential models are compared to identify those that can accurately describe the structure in alignment with experim
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Chunmei Cai, Guohua Ni, Lei Chen et al. · 2026 · Signal Transduction and Targeted Therapy
At high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which leads to decreased oxygen availability and a cascade of physiological responses. However, inadequate or excessive responses can lead to malacclimatization, resulting in hypoxemia and various high-altitude illnesses, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and high-altitude pulmonary hy
View details →Negative / Null Result ReportOpen accessSocial Sciences
Matěj Opatrný, Tomáš Havránek, Zuzana Iršová et al. · 2025 · Journal of Labor Economics
Class size reduction mandates are frequent and invariably justified by studies reporting positive effects on student achievement. Yet other studies report no effects, and the literature as a whole awaits correction for potential…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Paul Behrens, Catherine M. Champagne, Jason C. G. Halford et al. · 2025 · Frontiers in Science
The global obesity crisis involves an unprecedented and rapid change to the human phenotype. Conferring vast levels of avoidable morbidity and mortality at enormous cost, it has proved refractory to previous policy-led action. This article reviews recent developments in our understanding of obesity and its links to the climate co-crisis, aiming to inform evidence-based, societal-level actions to address both. Recent therapeutic developments now offer transformative interventions for millions of people living with obesity. However, treating all affected adults and children with major bariatric
View details →Negative / Null Result ReportOpen accessMedicine
Qi Sun, Yanping Zhao, Simiao Qiao et al. · 2026 · Nature Communications
Radiotherapy can both activate and suppress immunity, making it difficult to predict or modulate these opposing effects for better cancer treatment. Boron neutron capture therapy (BNCT), a cellular-level radiotherapy, has demonstrated…
View details →Negative / Null Result ReportOpen accessEngineering
Bin Liu, Changfeng Yan, Ming Lv et al. · 2026 · Computers in Industry
Domain adaptation-based methods are extensively applied to predict the Remaining Useful Life (RUL) of rolling bearings under complex operating conditions. However, the nonlinear degradation process of bearings gives rise to markedly…
View details →Negative / Null Result ReportOpen accessPsychology
Marielle Demarais, Melissa Fisher, Anne Williams-Wengerd et al. · 2024 · BMC Psychiatry
BACKGROUND: Coordinated specialty care (CSC) programs for first episodes of psychosis are increasingly offered in the United States. A component of CSC programs is active family engagement in treatment, though research on the impact of…
View details →Negative / Null Result ReportOpen accessNursing
Lea Klein, Claudia Lenz, Karsten Krüger et al. · 2025 · Lipids in Health and Disease
BACKGROUND: Different dietary choices can influence blood fatty acid profiles, which are crucial for maintaining physiological health and reducing disease risk. In particular, the exclusion of animal foods in vegetarian diets is associated with a higher risk of undersupply of long-chain omega (n)-3 fatty acids, which could, potentially, have a negative effect on inflammation. This study aimed to examine differences in plasma and erythrocyte fatty acid profiles as well as inflammation-related biomarkers between various plant-based diets and a regular omnivores diet. METHODS: The Nutritional Eva
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Orkhan Ibrahimov, László Vancsura, Anett Parádi-Dolgos · 2025 · Economies
Measuring financial performance is pivotal not only for assessing a firm’s current health but also for informing strategic decisions that shape its long-term trajectory. This study investigates how macroeconomic volatility affects the firm profitability across five major sectors in Türkiye—industrial manufacturing, food, beverage and tobacco, chemicals and plastics, technology, and energy—during the turbulent period from 2016 to 2023. Using return on assets (ROA) and return on equity (ROE) as performance indicators, we apply panel data regression to test the impact of inflation, interest rates
View details →Negative / Null Result ReportOpen accessMedicine
Sathish Babu Vasamsetti, Samreen Sadaf, Mohammad A. Uddin et al. · 2026 · Nature Communications
How cellular metabolism facilitates tissue-resident macrophage maintenance remains elusive. Here we show that visceral adipose tissue (VAT)-resident macrophages, unlike monocyte-derived macrophages, are enriched with mitochondrial-specific antioxidant enzymes restraining inflammation and promoting VAT homeostasis and insulin sensitivity. Additionally, VAT resident macrophages express high levels of plasminogen activator inhibitor type 2, encoded by SerpinB2, which is involved in the blood coagulation cascade. SerpinB2 promotes adipose resident macrophage survival by regulating mitochondrial ox
View details →Negative / Null Result ReportOpen accessEngineering
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
View details →Negative / Null Result ReportMedicine
Maximilian Stahl, Amer M. Zeidan · 2025 · Blood
ABSTRACT: Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
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