Negative / Null Result ReportOpen accessPhysics and Astronomy
P. Abratenko, D. Andrade Aldana, Luciano Arellano et al. · 2025 · Nature
Abstract The existence of three distinct neutrino flavours, ν e , ν μ and ν τ , is a central tenet of the Standard Model of particle physics 1,2 . Quantum-mechanical interference can allow a neutrino of one initial flavour to be detected sometime later as a different flavour, a process called neutrino oscillation. Several anomalous observations inconsistent with this three-flavour picture have motivated the hypothesis that an additional neutrino state exists, which does not interact directly with matter, termed as ‘sterile’ neutrino, ν s (refs. 3–9 ). This includes anomalous observations from
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Alexandra Moroianu, Shivani Bhandari, Maria R. Drout et al. · 2025 · The Astrophysical Journal Letters
Abstract We report the milliarcsecond localization of a high (∼1379 pc cm −3 ) dispersion measure (DM) repeating fast radio burst (FRB), FRB 20190417A. Combining European VLBI Network detections of five repeat bursts, we confirm the FRB’s host to be a low-metallicity, star-forming dwarf galaxy at z = 0.12817, similar to the hosts of FRB 20121102A, FRB 20190520B, and FRB 20240114A. We also confirm that it is associated with a previously reported persistent radio source (PRS), which is compact on milliarcsecond scales. Visibility-domain model fitting constrains the transverse physical size of th
View details →Negative / Null Result ReportOpen accessMedicine
Francesco Nonino, Silvia Minozzi, L. Sambati et al. · 2026 · Cochrane Database of Systematic Reviews
RATIONALE: Alzheimer's disease is a neurodegenerative disorder and the most common cause of dementia. Aggregated amyloid-beta protein deposits are implicated in its pathogenesis. Amyloid-beta-targeting monoclonal antibodies (sometimes represented as Aβ-mAbs) are potentially disease-modifying for Alzheimer's disease: through the clearance of amyloid in the brain, they may slow cognitive and functional decline. OBJECTIVES: To assess the clinical benefits and harms of amyloid-beta-targeting monoclonal antibodies aducanumab, bapineuzumab, crenezumab, donanemab, gantenerumab, lecanemab, ponezumab,
View details →Negative / Null Result ReportOpen accessMedicine
Youying Mao, Weidong Shen, Jiayao Shen et al. · 2025 · Kidney International Reports
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease and approximately 40% of patients with SLE progress to lupus nephritis (LN). The treatment of refractory SLE and LN remains challenging. This clinical study aimed to…
View details →Negative / Null Result ReportOpen accessMedicine
Florian Kahles, Andreas L. Birkenfeld, Nikolaus Marx · 2026 · Journal of Clinical Investigation
The incretin hormone glucagon-like peptide-1 (GLP-1) exerts potent effects on glucose metabolism, prompting the development of therapeutic strategies that enhance activity of the GLP-1 receptor (GLP-1R) pathway. Inhibitors of dipeptidyl peptidase 4 (DPP-4) prolong the half-life of endogenous GLP-1 and typically achieve reductions in HbA1c of 0.5%-0.8%. However, large-scale cardiovascular (CV) outcomes trials (CVOTs) with DPP-4 inhibitors demonstrated CV safety but did not show a reduction in CV events. A second incretin-based therapeutic approach was the development of GLP-1R agonists (GLP-1RA
View details →Negative / Null Result ReportOpen accessMedicine
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa et al. · 2026 · Pain
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Alfonz Kedves, Máté Balogh, Zoltán Kónya · 2026 · ACS ES&T Water
High Resolution Image Download MS PowerPoint Slide The increasing discharge of emerging contaminants (ECs) such as zinc oxide nanoparticles (ZnO NPs) and degradable microplastics (DMPs) into aquatic environments poses a growing challenge for next-generation wastewater treatment technologies. This study investigates the individual and combined effects of ZnO NPs, polylactic acid (PLA), and polycaprolactone (PCL) microplastics on microalgal-bacterial granular sludge (MBGS), a promising low-energy biotechnological system. Using photosequencing batch reactors, changes in extracellular polymeric su
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Mohamed T. El‐Saadony, Ahmed Mohamed Saad, Mahmoud Zaki Sitohy et al. · 2026 · Frontiers in Immunology
Probiotics, defined as living microorganisms, are widely recognized for their ability to positively influence the gut microbiota, an effect increasingly linked to a wide array of health benefits. They are claimed to treat or prevent conditions ranging from infant colic to cardiovascular disease, respiratory infections, and certain cancers. Since the beginning of the 21st century, consumer demand for probiotic-enriched foods has risen significantly, propelled by these health assertions. The consumption of such products has been associated with the alleviation of disorders, including irritable b
View details →Negative / Null Result ReportOpen accessEngineering
Jun Tao, Zhihan Wang, Jianqiu Wu et al. · 2026 · Remote Sensing
Early detection of agricultural fires with Unmanned Aerial Vehicles (UAVs) is important for environmental safety, yet it remains difficult because ignition cues are extremely small, smoke patterns vary widely, and farmland scenes often contain strong background interference such as specular reflections. Model development is further constrained by the scarcity of data from the early ignition stage. To address these challenges, we propose a joint data and model optimization framework. We first build a hybrid dataset through an ROI-guided synthesis pipeline, in which latent diffusion models are u
View details →Negative / Null Result ReportOpen accessSocial Sciences
Sofience · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This record provides SΔϕ-65 — Slop as Externalized Restabilization Cost: AI Slop, Human Slop, Authority Pollution, and the Cost of Re-entry (v1.0). SΔϕ-65 defines Slop not by whether it is produced by AI or humans, but by whether low execution or production cost externalizes high verification, rebuttal, correction, interpretation, cleanup, and restabilization cost onto others. The central proposition of this document is: Slop is not defined by the producer. Slop is defined by a cost asymmetry: low execution TCC on the producer side, high restabilization TCC on the receiver, platform, expert, p
View details →Negative / Null Result ReportOpen accessMedicine
L. Liang, Weidong Wang · 2026 · Frontiers in Immunology
Mutant p53(Mtp53) not only loses its canonical tumor-suppressive functions but also acquires oncogenic gain-of-function properties, positioning it as a central orchestrator in reshaping the tumor immune microenvironment. This review systematically delineates how Mtp53 actively establishes and sustains an immunosuppressive niche through multiple interconnected mechanisms, including chronic inflammation, immune cell dysfunction, reprogramming of cancer-associated fibroblasts, metabolic dysregulation, epigenetic hijacking, and potentially aberrant liquid–liquid phase separation, thereby promoting
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Iveny Makore, Chisinga Ngonidzashe Chikutuma · 2025 · Journal of risk and financial management
Zimbabwe’s economy has experienced extreme exchange rate fluctuations over the past decades, driven by persistent macroeconomic instability and episodes of hyperinflation. The instability in exchange rates can significantly impact trade balances, inflation rates, and overall economic resilience. Understanding the impact of exchange rate volatility (ERV) on international trade is crucial in such a context. This study investigates the impact of exchange rate volatility (ERV) on international trade in Zimbabwe, addressing a literature gap related to its unique economic challenges and hyperinflati
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Cătălin Gheorghe, Oana Panazan, Hind Alnafisah et al. · 2025 · Risks
This study investigates the asymmetric responses of AI and ESG Exchange Traded Funds (ETFs) to geopolitical and financial uncertainty, with a focus on resilience across market regimes. The NASDAQ-100 and MSCI ESG Leaders indices are used as proxies for thematic ETFs, and their dynamic interlinkages are examined in relation to volatility indicators (VIX, GPR), alternative assets (Bitcoin, Ethereum, gold, oil, natural gas), and safe-haven currencies (CHF, JPY). A daily dataset spanning the 2016–2025 period is analyzed using Quantile-on-Quantile Regression (QQR) and Wavelet Coherence (WCO), enabl
View details →Negative / Null Result ReportOpen accessDecision Sciences
Milivoje Davidović, Jacqueline McCleary · 2025 · Journal of risk and financial management
The study relies on an extensive dataset (≈1.86 million news headlines) to investigate the heterogeneity and predictive power of explicit sentiment signals (TextBlob, VADER, and FinBERT) and implied sentiment (VIX) for stock market trends. We find that news content predominantly consists of objective or neutral information, with only a small portion carrying subjective or emotive weight. There is a structural market bias toward upswings (bullish market states). Market behavior appears anticipatory rather than reactive: forward-looking implied sentiment captures a substantial share (≈45–50%) of
View details →Negative / Null Result ReportOpen accessPsychology
Isaac Davor, Francis Ohene Boateng, Franco Osei-Wusu et al. · 2026 · Cogent Education
This study examines the mediating and moderating role of metacognitive awareness in the relationship between self-regulated learning and mathematics achievement of university students in Ghana. Although self-regulated learning has attracted attention as a predictor of academic performance, few studies have examined how metacognitive awareness interacts with self-regulated learning to influence mathematics achievement in the Ghanaian context. A quantitative cross-sectional design was employed. Data were collected from 315 university students, representing a population of 3,240, using a structur
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ashley Rich, Ziqi Li, Alessandro De Simone et al. · 2026 · Nature Physics
Amputated salamander limbs or fish fins precisely regenerate to their pre-injury size, providing a paradigm for positional memory. Although this phenomenon has been appreciated for centuries, how position-dependent cues control tissue…
View details →Negative / Null Result ReportOpen accessEngineering
Teevrat Garg, Ryan Hanna, Jeff Myers et al. · 2026 · Journal of Environmental Economics and Management
Aligning electric vehicle (EV) charging with periods of abundant clean energy is essential for decarbonizing transportation. In solar-dominated grids, this requires shifting charging to midday hours – when vehicles are typically parked at workplaces. Yet workplace charging networks operate under institutional constraints such as shared infrastructure, bundled parking and charging services, and limited willingness to require drivers to move vehicles, making time-of-day pricing and active management difficult to implement. In a natural field experiment (n = 629 drivers) across a large workplace
View details →Negative / Null Result ReportOpen accessMedicine
Y. Kanemitsu, Yasuhiro Shimizu, Junki Mizusawa et al. · 2026 · Journal of Clinical Oncology
JCOG0603 demonstrated improved disease-free survival (DFS) with adjuvant mFOLFOX6 after hepatectomy compared with hepatectomy alone in colorectal liver-only metastasis (CRLM), but the overall survival (OS) data were immature. Here, we…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Sieun Kim · 2025 · Scientific Reports
This study investigated the neurophysiological and affective responses elicited by nature-inspired indoor design elements, including curvilinear forms (CL), nature views (N), and wooden interiors (W), in a virtual environment, and their…
View details →Negative / Null Result ReportOpen accessComputer Science
Ali Raza, Fareeha Hanif, Heba Abdelgader Mohammed · 2026 · Scientific Reports
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and accurate early diagnosis plays a critical role in improving patient survival. In this study, a comparative analysis of multiple lightweight Convolutional Neural Network (CNN) variants is presented for multi-class lung cancer classification using histopathological images. Four CNN architectures were designed to systematically explore the trade-off between model complexity and classification performance. Each variant was trained and evaluated within a unified experimental framework incorporating data augment
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthias Klein, J. J. Mohr, C. T. Davies · 2024 · Astronomy and Astrophysics
Galaxy clusters are useful cosmological probes and interesting astrophysical laboratories. As the cluster samples continue to grow in size, a deeper understanding of the sample characteristics and improved control of systematics becomes more crucial. For this analysis we created a new and larger ACT-DR5-based thermal Sunyaev–Zel’dovich Effect- (tSZE-) selected galaxy cluster catalog with improved control over sample purity and completeness. We employed the red sequence based cluster redshift and confirmation tool MCMF together with optical imaging data from the Legacy Survey DR-10 and infrared
View details →Negative / Null Result ReportOpen accessPsychology
Muhammad Kamal Uddin, Md Tarikul Islam, Muhammad Asaduzzaman · 2026 · Zenodo (CERN European Organization for Nuclear Research)
A large body of research has documented that smoking behavior is associated with a number of psychological variables. Weiss, Mouttapa, Cen, Johnson, and Unger (2011) studied a culturally diverse sample of 1,771 adolescents who reported that the risk of smoking initiation was significantly higher among students who scored higher on hostility and depressive symptoms, and were bully-victims. Mykletun, Overland, Aaro, Liabo, and Stewart (2008) carried out a population-based health survey on 60,814 adults aged between 20 to 89 years and reported that anxiety and depression were the most common in c
View details →Negative / Null Result ReportOpen accessMedicine
I Gede Nyoman Mindra Jaya, Yudhie Andriyana, Bertho Tantular et al. · 2025 · Sustainability
Accurate dengue forecasting is essential for sustainable public health planning, especially in tropical regions where the disease remains a persistent threat. This study evaluates the predictive performance of seven modeling approaches—Seasonal Autoregressive Integrated Moving Average (SARIMA), Extreme Gradient Boosting (XGBoost), Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), Bidirectional LSTM (BiLSTM), Convolutional LSTM (CNN–LSTM), and a Bayesian spatiotemporal model—using monthly dengue incidence data from 2009 to 2023 in Bandung City, Indonesia. Model performance was asse
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tahrim Ramzan, Muhammad Shahbaz, Farooq Ahmad et al. · 2026 · New Zealand Journal of Crop and Horticultural Science
Salinity stress is a major abiotic factor that inhibits plant growth and yield. This study's objective was to evaluate how foliar applications of melatonin and ascorbic acid affected canola varieties under salt stress. The treatments of…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Muhammad Asif, Long Yun-rong, Muhammad Azam Zia et al. · 2025 · Energy & Environment
Climate change, caused by the burning of fossil fuels, has emerged as an acute world problem, especially in the Group of Twenty (G20), where CO 2 emissions and other greenhouse gases are accumulating. This research examines how energy…
View details →Negative / Null Result ReportOpen accessPsychology
Anatolia Batruch, Nicolas Sommet, Frédérique Autin · 2025 · Nature Human Behaviour
Abstract Theoretical models have been developed to understand how social class influences individual thoughts, feelings and behaviours. However, the validity of these models is threatened by the prevailing use of small, non-diverse samples and flexible measurement practices. We preregistered replications of 35 key hypotheses from 17 correlational and 5 experimental studies, and collected large, quota-based or probability samples from the USA, France, Switzerland and India ( N total = 33,536). Our analysis yielded three central findings: (1) ~50% of the effects were successfully replicated; (2)
View details →Negative / Null Result ReportOpen accessDentistry
Guowu Gan, Ruonan Chen, Peining Zheng et al. · 2026 · Frontiers in Cellular and Infection Microbiology
The oral-gut axis represents a critical bidirectional pathway linking oral microbiota to systemic health. Dysbiosis of the oral microbiome, driven by pathogens like Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus species, and Helicobacter pylori, disrupts gut ecology via direct translocation, metabolite signaling (e.g., TMAO, SCFAs), and immune crosstalk (e.g., Th17). This leads to gut barrier dysfunction, systemic inflammation, and metabolic disturbances, contributing to diverse diseases beyond the oral cavity. Evidence supports causal links with conditions including rheumato
View details →Negative / Null Result ReportOpen accessNeuroscience
Eldad Keha, Hadar Naftalovich, Ariel Shahaf et al. · 2024 · Cognition & Emotion
The current investigation examined the bidirectional effects of cognitive control and emotional control and the overlap between these two systems in regulating emotions. Based on recent neural and cognitive findings, we hypothesised that…
View details →Negative / Null Result ReportOpen accessNursing
Hengying Chen, Jue Wang, Baohua Zheng et al. · 2024 · Lipids in Health and Disease
BACKGROUND: Exposure to different concentration levels of fatty acids (FAs) may have an impact on depression. However, previous studies using individual FAs may not reflect the performance of mixtures of various FAs, and the associations of FA patterns with depression remain unclear. METHODS: We conducted the cross-sectional analysis in 792 adults aged 18 and older with available serum FAs and depression screening data in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The serum concentrations of thirty FAs were measured using gas chromatography-mass spectrometry and t
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lei Li, Hongchao Huang, Yin He et al. · 2025 · Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high. Emerging evidence indicates that cell-free DNA (cfDNA), as a novel biomarker and molecular therapeutic target, holds promise for improving the clinical management of sepsis. cfDNA refers to DNA fragments present in body fluids, including naked DNA, membrane-coated DNA, nucleosomes, and neutrophil extracellular traps (NETs). cfDNA is released from host cells o
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