Negative / Null Result ReportOpen accessEnvironmental Science
Yuchen Suo, Tong Li, Christian von Sperber et al. · 2025 · Biogeochemistry
Abstract The stability of carbon (C) stocks in peatlands is intricately linked to phosphorus (P) bioavailability. Given that organic P compounds (P o ) can make up to 89% of total soil P in these ecosystems, it is vital to understand their role in regulating plant productivity and organic matter decomposition. Despite this significance, the mechanisms controlling P bioavailability remain poorly understood. Plants and soil microorganisms primarily regulate the release of soil P via low-molecular-weight organic acids (LMWOAs) and modulate the hydrolysis of P o through phosphatase enzymes, partic
View details →Negative / Null Result ReportOpen accessEngineering
Yiyin Nie, Shujie Jiao, Xing Yang et al. · 2026 · Light Science & Applications
Abstract The rapid advancement of artificial intelligence has propelled the development of β-Ga 2 O 3 photo-synapses for solar-blind ultraviolet neuromorphic machine vision systems. However, existing β-Ga 2 O 3 photo-synapses not only exhibit reduced stability but also display high weight update nonlinearity. Herein, we propose a novel strategy to construct β-Ga 2 O 3 photo-synapses with low weight update nonlinearity based on self-trapped holes, aiming to achieve multi-level in-sensor computing tasks. Theoretical and experimental investigations revealed that the interaction between the larger
View details →Negative / Null Result ReportOpen accessMedicine
André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Francelle Bouwer, Marius Brits, Joe M. Viljoen · 2025 · Pharmaceutics
Dermal drug delivery is a promising alternate route of drug administration, offering localized therapeutic effects, reduced systemic effects, and improved patient compliance. However, the skin’s intricate configuration, especially the stratum corneum (SC), presents formidable barriers, restricting drug permeation. This review summarizes biological, synthetic, and methodological models employed to study dermal absorption and permeability. Ex vivo human skin is a reference point, but limited availability and ethical constraints necessitate reliance on animal models, including porcine, rodent, ra
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Stevo Pavićević, Thomas Keil · 2024 · Strategic Management Journal
Abstract Research Summary Why do some boards of directors dismiss the CEO when a firm performs poorly, while others do not? We argue that military directors—outside directors with military backgrounds—on the board increase the likelihood…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dingya Sun, Jialu Wang, Xin Li et al. · 2026 · Antioxidants
Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely low systemic bioavailability, curcumin demonstrates significant bioactivity in vivo, a phenomenon likely attributable to its accumulation in the intestines and subsequent modulation of systemic oxidative stress and inflammation. This article systematically reviews the comprehensive regulatory effects of curcumin on systemic metabolic networks-including glucose metabolism, amino acid metab
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Timothy S. Collett, Scott Marsteller, Ray M. Boswell et al. · 2026 · Energy & Fuels
Abstract The “Collaborative Gas Hydrate R&D Project in Alaska,” led by the Japan Organization for Metals and Energy Security (JOGMEC), the U.S. Department of Energy (DOE), and the U.S. Geological Survey, aims to examine and assess gas…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Buhari Doğan, Mohammad Razib Hossain, Rabeh Khalfaoui et al. · 2026 · Financial Innovation
Abstract Drawing from the recent COP28, which espouses a boom in clean energy transition through technological forwardness, and the framework of the SDG, we address critical questions related to green investment, energy investment, and environmental sustainability. We scrutinize whether green technology genuinely leads to green investment and energy investment in China and whether the causal nexus between these variables holds amid an EKC postulation. We use Chinese provincial data from 1998 to 2020 and deploy the quantile moment-based non-parametric regression technique and the newly develope
View details →Negative / Null Result ReportOpen accessNeuroscience
Ola Ozernov‐Palchik, Amanda O’Brien, Elizabeth Jiachen Lee et al. · 2026 · Nature Communications
In adults, left hemisphere (LH) damage often leads to aphasia, but many cases of early damage leave linguistic processing intact, with a functional language system developing in the right hemisphere. To explain this early apparent equipotentiality of the two hemispheres for language, some have proposed that the language system is more bilateral during early development and becomes increasingly left-lateralized with age. We examined language lateralization using fMRI in two large developmental cohorts (total n=273 children aged 4-16 years; n=107 adults). Strong, adult-like LH lateralization (in
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Andrei Teodor Matei, Anita Ioana Vișan · 2025 · Antibiotics
The growing ineffectiveness of common antibiotics against multidrug-resistant pathogens has made antimicrobial resistance (AMR) a serious global health concern. This review emphasizes that natural antibiotics from animals, bacteria, fungi, and plants are worthy alternatives for combating this crisis. Evolutionary pressure has shaped these molecules, leading to antibiotic-resistant bacteria that can withstand single-target synthetic drugs but are vulnerable to multiple attack pathways (e.g., cell wall disruption, protein synthesis inhibition, biofilm interference) from natural compounds. Natura
View details →Negative / Null Result ReportOpen accessMedicine
Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hubert Krukowski, Sophie Valkenburg, A. Vich Vila et al. · 2026 · Nature Microbiology
Despite recent progress, microbial associations reported in chronic kidney disease (CKD) remain inconsistent. Here we combined quantitative faecal metagenomics (n = 130) and cross-study biomarker comparisons (ntotal = 4,420) to study…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Karin Hrovatin, Amir Ali Moinfar, Luke Zappia et al. · 2025 · BMC Genomics
Integration of single-cell RNA-sequencing (scRNA-seq) datasets is standard in scRNA-seq analysis. Nevertheless, current computational methods struggle to harmonize datasets across systems such as species, organoids and primary tissue, or different scRNA-seq protocols, including single-cell and single-nuclei. Conditional variational autoencoders (cVAE) are a popular integration method, however, existing strategies for stronger batch correction have limitations. Increasing the Kullback-Leibler divergence regularization does not improve integration and adversarial learning removes biological sign
View details →Negative / Null Result ReportOpen accessPsychology
Sarah Shi Hui Wong, Sophia Xuefei Qiu · 2026 · Educational Psychology Review
Abstract Generative artificial intelligence (AI) tools such as ChatGPT can boost creative performance, but do these boosts translate into learning gains? This study examined whether the benefits of ChatGPT for creativity persist even when its assistance is removed, and how people can effectively use ChatGPT to enhance their learning and independent creativity. University students ( N = 196) solved a creative product improvement task either independently (human-only group) or using ChatGPT freely (general-AI group) or using ChatGPT in a guided way (regulated-AI group). Specifically, the regulat
View details →Negative / Null Result ReportOpen accessMedicine
Faith Hartley, Martin A. Ebert, Alistair Cook · 2025 · Clinical & Translational Immunology
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warranting research into combined treatment strategies for improving outcomes. The use of radiotherapy for this purpose has garnered much interest. Preclinical study has established that radiotherapy activates various immune mechanisms to improve T-cell activation, localisation and function within tumors, which improves response to immune checkpoint inhibitors.
View details →Negative / Null Result ReportOpen accessMedicine
Indira Paz‐Graniel, Junko Kose, Pauline Duquenne et al. · 2025 · American Journal of Preventive Medicine
INTRODUCTION: Smoking has been independently related to an increased risk of Type 2 diabetes, whereas the role of alcohol remains controversial. The joint impact of tobacco and alcohol use on Type 2 diabetes risk is understudied. This…
View details →Negative / Null Result ReportOpen accessMedicine
Simon Istenič, Anže Jerman, Luka Pušnik et al. · 2025 · Regional Anesthesia & Pain Medicine
BACKGROUND: There are conflicting data on the efficacy of transnasal topical anesthetic approaches intended to achieve a pterygopalatine ganglion block, specifically regarding the extent to which local anesthetics reach the pterygopalatine…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Bile Abdisalan Nor, Yusniliyana Yusof · 2025 · Discover Sustainability
Abstract Somalia’s economy has faced persistent instability due to shocks from COVID-19, climate-related disasters, and conflict, resulting in stagnant GDP growth (averaging 2% from 2019 to 2023) and declining real GDP per capita (− 0.8% annually). Despite government expenditure rising to 9% of GDP in 2021, its efficiency in driving growth remains uncertain, raising critical questions about fiscal policy effectiveness in fragile states. We aim to investigate the relationship between government expenditure and GDP growth in Somalia from 1991 to 2021 using the ARDL estimation technique. The resu
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nannan Li, Guoliang Li, Xiaofang Huang et al. · 2026 · Nature Plants
The rhizosphere microbiome plays a crucial role in determining plant performance and fitness. Nevertheless, regulatory mechanisms linking host genetic variation, root gene regulation and microbiome assembly-and their collective influence on plant nutritional traits-remain poorly understood. Here we generated and integrated 1,341 paired datasets, including root transcriptomes, rhizosphere bacterial 16S rRNA profiles and root ionomes, across 175 resequenced Brassica napus ecotypes grown at two contrasting field sites. We identified 203 highly heritable bacterial amplicon sequence variants (ASVs)
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Hanjie Tan, Xiaoran Yan, Jian‐Yang Li · 2026 · The Astrophysical Journal Letters
Abstract 3I/ATLAS is an interstellar object whose activity provides critical insights into its composition and origin. However, due to its orbital geometry, the object is too close to the Sun near perihelion to be observed from the ground, and space-based measurements are therefore required. Here we characterize the water production rate of 3I/ATLAS using Solar and Heliospheric Observatory/SWAN Ly α observations from 2025 November to December (heliocentric distances 1.4–2.2 au) with 3D Monte Carlo modeling. We report a peak postperihelion water production rate of Q H 2 O ≈ 4 × 1 0 28 molecules
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Gabriele Cristelli, Francesco Lissoni · 2026 · Journal of the European Economic Association
Abstract We study the innovation effects of the Agreement on the Free Movement of Persons, signed by Switzerland and the European Union in 1999. We exploit a quasi-experimental setting created by Switzerland’s implementation of the treaty, which initially eased entry restrictions only for commuters from neighboring countries, thereby inducing a large inflow of “cross-border inventors” in regions close to the border. We find that the treaty increased patenting in such regions relative to comparable ones farther away from the border. We find no evidence indicating the displacement of native inve
View details →Negative / Null Result ReportOpen accessMedicine
Olena Garmish, Svitlana Smiyan, Fedir Hladkykh et al. · 2025 · Vascular Health and Risk Management
Patients with inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have an elevated risk of cardiovascular complications due to systemic inflammation, immune-mediated endothelial…
View details →Negative / Null Result ReportOpen accessNeuroscience
Evgeny A. Ermakov, Irina A. Mednova, Anastasiia S. Boiko et al. · 2025 · Journal of Integrative Neuroscience
Neuroinflammation, meaning an inflammatory process primarily occurring within the central nervous system (CNS), is thought to be associated with the pathogenesis of psychiatric disorders including schizophrenia (SC), although existing evidence is sometimes contradictory. This review critically summarizes the existing data on neuroinflammation and possible neuroinflammatory mechanisms in the pathogenesis of SC. Despite heterogeneity and inconsistency, the existing evidence indicates dysregulation of inflammatory genes and infiltration of the CNS parenchyma by immune cells, disturbances in the b
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Tianyang Zhao, Noemí Echegaray, José M. Lorenzo et al. · 2025 · Food Control
Food safety and environmental concerns are global challenges that require innovative solutions, and alternative protein sources like insect proteins, plant-based meat analogs (PBMAs), and single-cell proteins represent promising pathways toward sustainable nutrition. These proteins are produced through different techniques including extrusion, fermentation, and cell cultivation, with emerging technologies like 3D printing and shear cell structuring enhancing their texture and nutritional quality. Beyond their technological advantages, these alternatives provide significant environmental benefi
View details →Negative / Null Result ReportEngineering
Tianxin Hou, S X Liu, Weiyu Mao et al. · 2026 · International Journal of Pavement Engineering
The dynamic response analysis of aircraft and rigid pavement is critical for runway design and roughness evaluation. Existing methods typically assume fixed aircraft parameters, but actual variations in aircraft weight, landing gear, and…
View details →Negative / Null Result ReportOpen accessMedicine
Nemanja Maletin · 2026 · Frontiers in Immunology
The tumor microenvironment (TME) is increasingly recognized as a dynamic regulator of cancer progression and therapeutic resistance. Far from being a passive scaffold, the TME comprises diverse immune and stromal components, including cancer-associated fibroblasts, myeloid-derived suppressor cells, tumor-associated macrophages, dysfunctional vasculature, and metabolic stressors, that collectively shape tumor evolution and modulate treatment response. In this review, we explore how spatial immune exclusion, immune cell dysfunction, hypoxia, and metabolic reprogramming create barriers to effecti
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Luca Henkel, Christian Zimpelmann · 2026 · Review of Financial Studies
Abstract This paper introduces a key factor influencing households’ decision to invest in the stock market: how people view stockholders. Using surveys we conducted with nearly 8,500 individuals from 11 countries, we document that a large majority hold negative views of stockholders based on identity-relevant characteristics. Linking survey and administrative data, we find that negative perceptions strongly predict households’ stock market participation. We show that negative perceptions causally influence household decision-making and provide evidence supporting identity concerns as the under
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lorenzo Fant, Iuri Macocco, Jacopo Grilli · 2026 · PLoS Computational Biology
Microbial communities are taxonomically diverse and variable: species presence and abundances widely fluctuate over time, space, and even across biological replicates under controlled experimental conditions. However, environmental conditions exert strong selection on the traits of community members and their functions. Similar environmental conditions are expected to produce functionally similar communities. This environmental selection, combined with taxonomic variability, leads to the influential concept of functional redundancy - the idea that many species can perform the same function, al
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Hui-Yu Huang, Shu‐Ping Tsao, Tu‐Hsueh Yeh · 2025 · International Journal of Molecular Sciences
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra, resulting in motor symptoms such as bradykinesia, tremor, rigidity, and postural instability, as well as a wide variety of non-motor manifestations. Branched-chain amino acids (BCAAs)-leucine, isoleucine, and valine-are essential nutrients involved in neurotransmitter synthesis, energy metabolism, and cellular signaling. Emerging evidence suggests that BCAA metabolism is intricately linked to the pathophysiology of PD. Dysregulation of BCAA l
View details →Negative / Null Result ReportOpen accessMedicine
Edward Tyrrell, Suniljeet Sandhu, Kathryn Berry et al. · 2025 · JMIR Formative Research
Background: There is a need to increase health care professional training capacity to meet global needs by 2030. Effective communication is essential for delivering safe and effective patient care. Artificial intelligence (AI) technologies may provide a solution. However, evidence for high-fidelity virtual patient simulators using unrestricted 2-way verbal conversation for communication skills training is lacking. Objective: This study aims to compare a fully automated AI-driven voice recognition-based virtual patient simulator with traditional actor-based consultation skills simulated trainin
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