Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Gabriele Meyer, Jeffrey R. Leipprandt, Jianwei Xie et al. · 2012 · Endocrinology
Mammary organoids from adult mice produce tubules, analogous to mammary ducts in vivo, in response to hepatocyte growth factor (HGF) when cultured in collagen gels. The combination of HGF plus progestin (R5020) causes reduced tubule number…
View details →Negative / Null Result ReportOpen accessNeuroscience
Nicholas Murphy, Alison Killen, Rajnish Kumar Gupta et al. · 2021 · Frontiers in Neurology
Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear although visual evoked potential (VEP) differences have been associated with VH at an earlier stage of PD. Here we compared the amplitude and latency pattern reversal VEPs in healthy controls ( n = 21) and PDD patients ( n = 34) w
View details →Negative / Null Result ReportOpen accessMedicine
Marie Lefebvre, Michael P. Hengartner, Enrico Tronci et al. · 2022 · Physiology & Behavior
BACKGROUND: As eating behavior changes in relation to the menstrual cycle and weight changes with menopausal transition, ovarian hormones appear to be involved in regulating eating behavior. However, observations are contradictory and are difficult to compare, due to methodological problems related to nutritional epidemiology. To better understand the relationship between ovarian steroid hormones and eating behavior, our study evaluates women's responses to visual food cues at different points in the menstrual cycle with their specific serum estrogen/progesterone levels and women's responses i
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Kateryn Rochon, Rodney B. Baker, Glen W. Almond et al. · 2015 · Journal of Medical Entomology
We investigated the acquisition of porcine reproductive and respiratory syndrome (PRRS) virus by the stable fly (Diptera: Muscidae; Stomoxys calcitrans (L.)) through a bloodmeal, and virus persistence in the digestive organs of the fly…
View details →Negative / Null Result ReportMedicine
Maha N. Mian, Brianna R. Altman, Luna F. Ueno et al. · 2020 · Journal of Psychoactive Drugs
Savoring has covaried inversely with cannabis problems and moderated the association between cannabis use and negative consequences related to use. Research has not yet addressed the acceptability of savoring interventions for cannabis…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ivana Vranješ, Tinne Vander Elst, Yannick Griep et al. · 2022 · Group & Organization Management
In this study, we investigated whether and how perpetrators of bullying become targets themselves. Building on the notion of bullying as an escalation process and the Conservation of Resources Theory, we hypothesized that following enactment of bullying, people would experience increased relationship conflicts with colleagues, diminishing their sense of control and making them more likely to become exposed to bullying themselves. We tested this idea using longitudinal sequential mediated Structural Equation Modelling in a sample of 1420 Belgian workers. Our results confirmed that enactment of
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jessica A. Blayney, Matthew D. Scalco, Sharon Radomski et al. · 2019 · Psychology of Addictive Behaviors
= 480; 61% female) reported on their alcohol and drug use behaviors across 5 time points spanning 1 calendar year. For many, this year included the transition out of college. Latent growth curve analysis was used to determine whether…
View details →Negative / Null Result ReportMedicine
James Foulds, Kim N. T. Ton, Martin A. Kennedy et al. · 2015 · Pharmacogenetics and Genomics
A functional polymorphism rs1799971 (A118G) in the μ-opioid receptor gene (OPRM1) produces an amino acid substitution Asn40Asp, which is believed to influence naltrexone response in nondepressed alcohol-dependent patients. In this study,…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Feride Acar · 2015 · Procedia - Social and Behavioral Sciences
Extant research shows that female managers face significant hurdles in the attainment of top level positions in IT organizations. Recently there have been some examples to women breaking through the glass ceiling to reach to higher…
View details →Negative / Null Result ReportSocial Sciences
Guy Assaker, Vincenzo Esposito Vinzi, Peter O’Connor · 2011 · Tourism and Hospitality Research
This study provides insights into a powerful statistical technique to test model invariance across multiple groups. In doing so, it provides insights for policymakers and contributes to the literature on tourism demand forecasting by…
View details →Negative / Null Result ReportOpen accessPsychology
Irene Trilla, Hanna Drimalla, Malek Bajbouj et al. · 2020 · Frontiers in Behavioral Neuroscience
Recent findings suggest a role of oxytocin on the tendency to spontaneously mimic the emotional facial expressions of others. Oxytocin-related increases of facial mimicry, however, seem to be dependent on contextual factors. Given previous literature showing that people preferentially mimic emotional expressions of individuals associated with high (vs. low) rewards, we examined whether the reward value of the mimicked agent is one factor influencing the oxytocin effects on facial mimicry. To test this hypothesis, 60 male adults received 24 IU of either intranasal oxytocin or placebo in a doubl
View details →Negative / Null Result ReportNeuroscience
Stefania Piscopo, Euan R. Brown · 2018 · Small
Abstract Membrane–nanoparticle interactions are important in determining the effects of manufactured nanomaterials on cell physiology and pathology. Here, silica, titanium, zinc, and magnesium oxide nanoparticles are screened against human…
View details →Negative / Null Result ReportOpen accessMedicine
Chang Yu, Ning Zhang, Weikang Zhu et al. · 2019 · Evidence-based Complementary and Alternative Medicine
Objectives . To evaluate the safety of moxa smoke, especially to provide quantitative information and details for the occupational prevention of acupuncturists. Methods . We combined the questionnaire-based cross-sectional survey and lung function testing-based historical retrospective cohort research to investigate the safety of moxa smoke exposure (MSE) among acupuncturists. A mathematical regression model was established to quantitatively evaluate the relationship between moxa smoke exposure and the respiratory health of the acupuncturist. The smoke exposure time of the acupuncturist and th
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jennifer Zou, Jinjing Zhou, Sarah Faller et al. · 2022 · G3 Genes Genomes Genetics
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in genome-wide association studies has been well-studied in the context of Winner's Curse, which is the inflation of effect size estimates for significant variants due to statistical chance. However, Winner's Curse is often not sufficient to explain lack of replication. Another reason why studies fail to replicate is that there are fundamental difference
View details →Negative / Null Result ReportNeuroscience
Linda Liu, Zachary Burchill, Michael K. Tanenhaus et al. · 2017 · eScholarship (California Digital Library)
Sentence understanding is affected by recent experience. Animportant open question is whether this reflects adaptationto the statistics of the input. Support for this hypothesiscomes from the recent finding that listeners can…
View details →Negative / Null Result ReportOpen accessMedicine
Zofia Strojny, Rafał Rutkowski, Alina Kanikowska et al. · 2021 · Nutrients
Background: Chronotype is the pattern of the circadian rhythm that allows an individual to optimize times of sleep and activity. It has been observed that chronotypes may associate with some conditions and diseases, including obesity. It is not known, however, whether chronotypes determine the effectiveness of weight loss regimens. Therefore, in the present study, we compared the outcomes of a 3-week moderate calorie restriction undertaken by individuals with obesity under the same controlled hospital conditions. Methods: A total of 131 participants with obesity (median BMI 40.0) were studied.
View details →Negative / Null Result ReportOpen accessEngineering
Wan Azani Mustafa, Haniza Yazid, Hiam Alquran et al. · 2024 · PLoS ONE
Weld defect inspection is an essential aspect of testing in industries field. From a human viewpoint, a manual inspection can make appropriate justification more difficult and lead to incorrect identification during weld defect detection. Weld defect inspection uses X-radiography testing, which is now mostly outdated. Recently, numerous researchers have utilized X-radiography digital images to inspect the defect. As a result, for error-free inspection, an autonomous weld detection and classification system are required. One of the most difficult issues in the field of image processing, particu
View details →Negative / Null Result ReportMaterials Science
Shanshan Jiang, Jaka Sunarso, Wei Zhou et al. · 2013 · Journal of Materials Chemistry A
Layered oxides of Sr4Fe4Co2O13 (SFC2) which contains alternating perovskite oxide octahedral and polyhedral oxide double layers are attractive for their mixed ionic and electronic conducting and oxygen reduction reaction properties. In…
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Loet Leydesdorff, Caroline S. Wagner, Lin Zhang · 2021 · Journal of Data and Information Science
Abstract Purpose Building on Leydesdorff, Bornmann, and Mingers (2019), we elaborate the differences between Tsinghua and Zhejiang University as an empirical example. We address the question of whether differences are statistically…
View details →Negative / Null Result ReportDecision Sciences
Dapeng Liu, Heinz Roland Weistroffer · 2020 · Journal of Computer Information Systems
Trust, such as trust in a technology or believing that a technology has trustworthy utility, manifests its importance by affecting user behaviors toward information systems (IS). There is no dearth of evidence showing that the effect of…
View details →Negative / Null Result ReportOpen accessMedicine
Michael Benatar, Christopher McDermott, Martin R. Turner et al. · 2024 · Brain
There is a long history in amyotrophic lateral sclerosis (ALS) of promoting therapies based on phase 2 data, which then fail in phase 3 trials. Experience suggests that studies of 6 months in duration are too short, especially with…
View details →Negative / Null Result ReportOpen accessPsychology
Kaylin Ratner, Anthony L. Burrow, Felix Thoemmes · 2016 · Royal Society Open Science
Having a sense of meaning in life (MIL) has been acknowledged as a catalyst to psychological flourishing. As such, understanding ways to promote MIL represents a worthy goal for those interested in bolstering positive outcomes. This study sought to replicate the findings of Heintzelman, Trent & King (2013 Psychol. Sci. 24 , 991–998 ( doi:10.1177/0956797612465878 )), who found that MIL could be influenced by external stimulation. Their findings suggest that exposure to coherent stimuli produces significantly higher MIL scores than exposure to incoherent stimuli. Using materials and methodol
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Faisal AlReshaid, Alper Ertürk, Razan Alkhayyat et al. · 2025 · Frontiers in Psychology
Introduction: Leaders' self-awareness is essential to leadership effectiveness. Cognitive styles-how individuals perceive and process information-are key factors in fostering self-awareness. Drawing on Social Identity Theory (SIT), this study explores whether cognitive style congruence between supervisors and subordinates enhances supervisors' self-awareness, and whether Leader-Member Exchange (LMX) mediates this relationship. Methods: We used a time-lagged dyadic design and multilevel polynomial regression to analyze data from 189 subordinates and 36 supervisors. Cognitive styles were measure
View details →Negative / Null Result ReportOpen accessMedicine
Malte L Schmieding, Marvin Kopka, Myrto Bolanaki et al. · 2025 · Journal of Medical Internet Research
BACKGROUND: Symptom checker apps (SCAs) are layperson-facing tools that advise on whether and where to seek care, or possible diagnoses. Previous research has primarily focused on evaluating the accuracy, safety, and usability of their recommendations. However, studies examining SCAs' impact on clinical care, including the patient-physician interaction and satisfaction with care, remain scarce. OBJECTIVE: This study aims to evaluate the effects of an SCA on satisfaction with the patient-physician interaction in acute care settings. Additionally, we examined its influence on patients' anxiety a
View details →Negative / Null Result ReportOpen accessMedicine
Steven D. Nathan, Victoria Lacasse, Heidi Bell et al. · 2024 · Pulmonary Circulation
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative…
View details →Negative / Null Result ReportOpen accessMedicine
Athina Trachalaki, Anna Lindahl, Simone Petrarulo et al. · 2025 · Breathe
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with limited treatment options. Despite the approval of pirfenidone and nintedanib that slow disease progression, IPF remains a disease with poor survival. Promising therapeutic…
View details →Negative / Null Result ReportOpen accessMedicine
Jason E. Pope, Ajay Antony, Erika Petersen et al. · 2024 · Pain and Therapy
INTRODUCTION: Drawbacks of fixed-output spinal cord stimulation (SCS) screening trials may lead to compromised trial outcomes and poor predictability of long-term success. Evoked compound action potential (ECAP) dose-controlled closed-loop…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Chitra Priyadarshani, Ranjan Laik, Sumit Sow et al. · 2025 · Archives of Agronomy and Soil Science
Integrated crop residue management with micronutrient application can effectively addresses dual challenges of maintaining productivity while enhancing grain nutritional quality of rice in calcareous soils. This study evaluated the role of different soil properties for enhancing yield and grain quality of rice under 29 years of long-term effects of crop residue incorporation and zinc (Zn) fertilization in calcareous Typic Haplaquepts soils. Results showed 100% crop residue incorporation significantly enhanced soil organic carbon (SOC), available nitrogen, available Zn, soil respiration, and we
View details →Negative / Null Result ReportOpen accessNeuroscience
Chao Jiang, Yingying Dai, Yunheng Ding et al. · 2024 · Brain Sciences
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain-computer interfaces. In this paper, we propose TSANN-TG (temporal-spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal-spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal sca
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Giacomo Mutti, Eduard Ocaña‐Pallarès, Toni Gabaldón · 2025 · Molecular Biology and Evolution
Recent developments in protein structure prediction have allowed the use of this previously limited source of information at genome-wide scales. It has been proposed that the use of structural information may offer advantages over…
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