Negative / Null Result ReportOpen accessSocial Sciences
Suzanne M. Skevington, Kara Schick‐Makaroff, Christine Rowland et al. · 2024 · PLoS ONE
Gender inequalities in health-related quality of life (QoL) are generally few and small, even in large surveys. Many generic measures limit assessment to QoL overall and its physical and psychological dimensions, while overlooking internationally important environmental, social, and spiritual QoL domains. Unique cross-cultural legacy data was collected using four WHOQOL-100 surveys of adults living in 43 cultures world-wide (17,608 adults; ages 15-101). It was first used to examined gender profiles of its five QoL international domains, and their component facets. Few significant gender differ
View details →Negative / Null Result ReportOpen accessNeuroscience
Meenakshi Khosla, Leila Wehbe · 2026 · Nature Communications
Neuroscientific studies rely heavily on a-priori hypotheses, which can bias results toward existing theories. Here, we use a hypothesis-neutral approach to study category selectivity in higher visual cortex. Using only stimulus images and their associated fMRI activity, we constrain randomly initialized neural networks to predict voxel activity. Despite no category-level supervision, units in the trained networks act as detectors for semantic concepts like 'faces' or 'words', providing solid empirical support for categorical selectivity. Importantly, this selectivity is mostly maintained when
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mathieu Quinodoz, Kim Rodenburg, Zuzana Cvačková et al. · 2026 · Nature Genetics
Small nuclear RNAs (snRNAs) combine with specific proteins to generate small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. U4 snRNA forms a duplex with U6 and, together with U5, contributes to the tri-snRNP…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Shanwen Gu, Adil Javed · 2025 · Sustainability
The E-7 nations face significant challenges in harmonizing artificial intelligence (AI) adoption with sustainable economic and environmental goals. While AI holds transformative potential to revolutionize energy structures, modernize infrastructure, broaden financial inclusion, and reduce carbon emissions, its effective integration is frequently hindered by policy inertia, economic limitations, and long-standing institutional barriers. Using the multi-level perspective (MLP), this study employs the method of moments quantile regression (MMQREG) on panel data from 2004 to 2024 to investigate th
View details →Negative / Null Result ReportOpen accessMedicine
Atul Malhotra, R GRUNSTEIN, Ali Azarbarzin et al. · 2026 · Nature Medicine
Obstructive sleep apnea (OSA) is associated with obesity and cardiovascular risk. The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated…
View details →Negative / Null Result ReportOpen accessNeuroscience
Olivier Senn, Florian Hoesl, Toni Bechtold et al. · 2024 · PLoS ONE
There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dingya Sun, Jialu Wang, Xin Li et al. · 2026 · Antioxidants
Curcumin, a natural polyphenol derived from turmeric, functions as a potent exogenous antioxidant and exhibits a range of benefits in the prevention and management of metabolic diseases. Despite its extremely low systemic bioavailability, curcumin demonstrates significant bioactivity in vivo, a phenomenon likely attributable to its accumulation in the intestines and subsequent modulation of systemic oxidative stress and inflammation. This article systematically reviews the comprehensive regulatory effects of curcumin on systemic metabolic networks-including glucose metabolism, amino acid metab
View details →Negative / Null Result ReportOpen accessMedicine
Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Stevo Pavićević, Thomas Keil · 2024 · Strategic Management Journal
Abstract Research Summary Why do some boards of directors dismiss the CEO when a firm performs poorly, while others do not? We argue that military directors—outside directors with military backgrounds—on the board increase the likelihood…
View details →Negative / Null Result ReportOpen accessMedicine
Faith Hartley, Martin A. Ebert, Alistair Cook · 2025 · Clinical & Translational Immunology
The most successful immunotherapies for solid malignancies to date, immune checkpoint inhibitors, target the essential role of T cells in antitumor immunity. However, T-cell dysfunction presents a major hindrance to treatment efficacy, warranting research into combined treatment strategies for improving outcomes. The use of radiotherapy for this purpose has garnered much interest. Preclinical study has established that radiotherapy activates various immune mechanisms to improve T-cell activation, localisation and function within tumors, which improves response to immune checkpoint inhibitors.
View details →Negative / Null Result ReportOpen accessMedicine
Edward Tyrrell, Suniljeet Sandhu, Kathryn Berry et al. · 2025 · JMIR Formative Research
Background: There is a need to increase health care professional training capacity to meet global needs by 2030. Effective communication is essential for delivering safe and effective patient care. Artificial intelligence (AI) technologies may provide a solution. However, evidence for high-fidelity virtual patient simulators using unrestricted 2-way verbal conversation for communication skills training is lacking. Objective: This study aims to compare a fully automated AI-driven voice recognition-based virtual patient simulator with traditional actor-based consultation skills simulated trainin
View details →Negative / Null Result ReportOpen accessNeuroscience
Ola Ozernov‐Palchik, Amanda O’Brien, Elizabeth Jiachen Lee et al. · 2026 · Nature Communications
In adults, left hemisphere (LH) damage often leads to aphasia, but many cases of early damage leave linguistic processing intact, with a functional language system developing in the right hemisphere. To explain this early apparent equipotentiality of the two hemispheres for language, some have proposed that the language system is more bilateral during early development and becomes increasingly left-lateralized with age. We examined language lateralization using fMRI in two large developmental cohorts (total n=273 children aged 4-16 years; n=107 adults). Strong, adult-like LH lateralization (in
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Andrei Teodor Matei, Anita Ioana Vișan · 2025 · Antibiotics
The growing ineffectiveness of common antibiotics against multidrug-resistant pathogens has made antimicrobial resistance (AMR) a serious global health concern. This review emphasizes that natural antibiotics from animals, bacteria, fungi, and plants are worthy alternatives for combating this crisis. Evolutionary pressure has shaped these molecules, leading to antibiotic-resistant bacteria that can withstand single-target synthetic drugs but are vulnerable to multiple attack pathways (e.g., cell wall disruption, protein synthesis inhibition, biofilm interference) from natural compounds. Natura
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhuoxu Gu, Zhonghao Wang, Xianquan Zhang et al. · 2025 · Frontiers in Pharmacology
As a modern dosage form of traditional Chinese medicine, Traditional Chinese Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as a critical material basis for elucidating its multi-target regulatory mechanisms. Recent studies have highlighted the significant potential of TCMFG in treating complex diseases, such as inflammation, tumors, metabolic disorders, fibrosis, and orthopedic conditions like osteoarthritis and osteoporosis, by modulati
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Andrei Kudriashov, Xiong Zhou, Razmik A. Hovhannisyan et al. · 2025 · Science Advances
Josephson junctions (JJs) are key to superconducting quantum technologies and the search for self-conjugate quasiparticles potentially useful for fault-tolerant quantum computing. In topological insulator (TI)–based JJs, measuring the current-phase relation (CPR) can reveal unconventional effects such as Majorana bound states (MBS) and nonreciprocal transport. However, reconstructing CPR as a function of magnetic field has not been attempted. Here, we present a platform for field-dependent CPR measurements in planar JJs made of NbSe 2 and few-layer Bi 2 Se 3 . When a flux quantum Φ 0 thr
View details →Negative / Null Result ReportOpen accessMedicine
Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital
View details →Negative / Null Result ReportOpen accessMaterials Science
Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović et al. · 2025 · npj Biomedical Innovations.
3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lorenzo Fant, Iuri Macocco, Jacopo Grilli · 2026 · PLoS Computational Biology
Microbial communities are taxonomically diverse and variable: species presence and abundances widely fluctuate over time, space, and even across biological replicates under controlled experimental conditions. However, environmental conditions exert strong selection on the traits of community members and their functions. Similar environmental conditions are expected to produce functionally similar communities. This environmental selection, combined with taxonomic variability, leads to the influential concept of functional redundancy - the idea that many species can perform the same function, al
View details →Negative / Null Result ReportOpen accessMathematics
Yong Li, Henry Sun, Zuoli Zhang · 2025 · Pharmaceutics
Background: Physiologically based pharmacokinetic (PBPK) modeling is a mathematical approach that integrates human physiological parameters with drug-specific characteristics (including both active pharmaceutical ingredients and excipients), and it has emerged as one of the core technologies for optimizing the efficiency and reliability of drug development. Methods: This study synthesizes applications of PBPK models in FDA-approved drugs (2020–2024), systematically analyzing model utilization frequency, indication distribution, application domains and choice of modeling platforms, to reveal th
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luyuan Chang, Yang Liu, Haipeng Li et al. · 2025 · Frontiers in Cellular and Infection Microbiology
Cirrhosis remains a significant global health burden, causing approximately 1.4-1.5 million deaths each year and contributing to nearly 46 million disability-adjusted life years (DALYs) worldwide. Increasing evidence identifies the gut-liver axis as a central driver of disease progression, wherein intestinal dysbiosis, barrier disruption, and microbe-derived metabolites collectively exacerbate inflammation, fibrogenesis, and related complications. Across more than 40 recent studies, gut microbial α-diversity declined by 30-60%, and over 80% reported a marked depletion of short-chain fatty acid
View details →Negative / Null Result ReportOpen accessSocial Sciences
Roddy Theobald, Zeyu Xu, Allison F. Gilmour et al. · 2025 · Educational Evaluation and Policy Analysis
We study the impact of a bonus policy in Hawai‘i Public Schools that raised the salaries of all special education teachers by $10,000. We estimate that this policy reduced the proportion of vacant special education teaching positions…
View details →Negative / Null Result ReportOpen accessMedicine
Xuefeng Jin, Zhaojie Su, Jian-Fa Zhong et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic disorders, and cardiovascular disease is the leading cause of death among affected individuals. Identifying simple biomarkers…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theresa Abdo, Ahmad Alhalabi, Sacha Yaghi et al. · 2026 · Cancer
Minimal residual disease (MRD) refers to the presence of residual cancer cells or tumor-derived fragments that persist after treatment and remain undetectable by conventional imaging or protein-based assays. Circulating tumor DNA (ctDNA)…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Gabriele Cristelli, Francesco Lissoni · 2026 · Journal of the European Economic Association
Abstract We study the innovation effects of the Agreement on the Free Movement of Persons, signed by Switzerland and the European Union in 1999. We exploit a quasi-experimental setting created by Switzerland’s implementation of the treaty, which initially eased entry restrictions only for commuters from neighboring countries, thereby inducing a large inflow of “cross-border inventors” in regions close to the border. We find that the treaty increased patenting in such regions relative to comparable ones farther away from the border. We find no evidence indicating the displacement of native inve
View details →Negative / Null Result ReportOpen accessMedicine
Alexandra Irma Gabriela Bauşic, Francesca Scurtu, Andrei Manu et al. · 2025 · International Journal of Molecular Sciences
Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using
View details →Negative / Null Result ReportOpen accessMedicine
André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nannan Li, Guoliang Li, Xiaofang Huang et al. · 2026 · Nature Plants
The rhizosphere microbiome plays a crucial role in determining plant performance and fitness. Nevertheless, regulatory mechanisms linking host genetic variation, root gene regulation and microbiome assembly-and their collective influence on plant nutritional traits-remain poorly understood. Here we generated and integrated 1,341 paired datasets, including root transcriptomes, rhizosphere bacterial 16S rRNA profiles and root ionomes, across 175 resequenced Brassica napus ecotypes grown at two contrasting field sites. We identified 203 highly heritable bacterial amplicon sequence variants (ASVs)
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
He Chen, Shaochen Yu, Mengjie Zhang et al. · 2026 · Frontiers in Immunology
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder resulting from a combination of genetic susceptibility, environmental factors, and an abnormal immune response of the intestinal immune system to commensal microorganisms. The gut microbiota and its metabolites play a pivotal role in maintaining intestinal immune homeostasis. Recent advances indicate that dysbiosis of the microbiota is accompanied by alterations in its metabolic functions. Abnormal levels of key metabolites, particularly short-chain fatty acids (SCFAs), tryptophan derivatives, and secondary bile acids, are clo
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Wagner Augusto Müller, Sandro Binsfeld Ferreira, Suse Botelho da Silva · 2026 · Journal of Food Science
Effective cold chain management is crucial for ensuring food safety, but traditional monitoring approaches remain reactive and fragmented. Industry 4.0 technologies, such as the Internet of Things (IoT) and artificial intelligence (AI), offer transformative potential for real-time tracking, automation, and predictive analytics. Many studies have explored the application of IoT and AI in the cold chain, but the existing literature focuses on isolated technologies. This review presents an integrated perspective, examining the synergistic potential of IoT-enabled data acquisition and AI-driven pr
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sumon Islam, Md. Hassan Bin Nabi, Iftekhar Ahmad et al. · 2026 · International Journal of Food Science
Encapsulation is an essential technology for the stabilization and controlled delivery of bioactive compounds in contemporary foods, but studies are mostly technique-based and seem not to be associated with the actual performance in the world. This review considers micro- and nanoencapsulation based on real-world performance bioavailability, food-matrix compatibility, industrial scalability, and regulatory feasibility, as well as long-term environmental sustainability as opposed to encapsulation efficiencies in the laboratory. We demonstrate that high encapsulation efficacy is not necessarily
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