Negative / Null Result ReportOpen accessNeuroscience
Clara E. James · 2012 · Frontiers in Psychology
A commentary on Musical expertise and statistical learning of musical and linguistic structures by Schön, D., and François, C. (2011). Front. Psychology 2:167. doi: 10.3389/ fpsyg.2011.00167 Both language and music consist of discrete elements organized in embedded hierarchical structures. Schön and François nicely expose in this review that musical expertise facilitates learning of both linguistic and musical structures. At the behavioral level, the musicians did not outperform the nonmusicians. However, ERP analyses showed that acquisition of boundary perception (segmentation) between units
View details →Negative / Null Result ReportOpen accessSocial Sciences
Untung Rahardja · 2025 · Journal of Digital Market and Digital Currency.
This study investigates the effectiveness of various digital marketing campaign types—Awareness, Conversion, and Retention—on conversion rates and engagement levels. Using a dataset of 8,000 records, we conducted a comprehensive analysis through ANOVA, Chi-Square tests, and OLS regression to understand the impact of these campaign types. The ANOVA results indicated no significant differences in conversion rates across the campaign types, with an F-statistic of 0.4752 and a p-value of 0.6218. Similarly, the analysis for engagement levels, measured by website visits, yielded an F-statistic of 0.
View details →Negative / Null Result ReportMedicine
Mélissa De Regge, Koenraad G. Monsieurs, K. Vandewoude et al. · 2012 · PubMed
Automated external defibrillators (AEDs) have shown to improve survival after cardiopulmonary arrest (CPA) in many, but not all clinical settings. A recent study reported that the use of AEDs in-hospital did not improve survival. The…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Roddy Theobald, Zeyu Xu, Allison F. Gilmour et al. · 2025 · Educational Evaluation and Policy Analysis
We study the impact of a bonus policy in Hawai‘i Public Schools that raised the salaries of all special education teachers by $10,000. We estimate that this policy reduced the proportion of vacant special education teaching positions…
View details →Negative / Null Result ReportMedicine
Han Sang Kim, Jung Yong Hong, Jaekyung Cheon et al. · 2020 · Journal of Clinical Oncology
4584 Background: Previously, two phase III clinical trials of immune checkpoint inhibitors (ICI) failed to meet their primary endpoints, leading to doubts regarding the clinical activity of ICI monotherapy in patients with aHCC. Here, we…
View details →Negative / Null Result ReportOpen accessNeuroscience
Olivier Senn, Florian Hoesl, Toni Bechtold et al. · 2024 · PLoS ONE
There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Marcello Candelli, Marta Sacco Fernandez, Gloria Rozzi et al. · 2025 · Diagnostics
Background and Objectives: Despite major advances in medical science and critical care, sepsis remains a leading cause of morbidity and mortality worldwide: it arises from dysregulated host response to infections and may culminate in organ dysfunction. A hallmark of its pathogenesis is the cytokine storm, in which interleukins (ILs) serve as central mediators of both protective and deleterious immune responses. This review summarizes the current knowledge on the role of ILs in sepsis, emphasizing their potential as biomarkers and therapeutic targets. Material and Methods: We analyzed recent cl
View details →Negative / Null Result ReportOpen accessSocial Sciences
Junhua Dang, Zeynep E. Ekim, Sarah Ohlsson et al. · 2020 · BMC Psychology
BACKGROUND: Previous studies showed that anger, rather than sadness, created automatic intergroup bias in a minimal group context. METHODS: The current research reports a single study (N = 99) aiming to replicate this finding and further to test whether the intergroup bias manifests as ingroup favoritism, outgroup derogation, or both. RESULTS: Our results failed to replicate the effect of anger on automatic bias. Intriguingly, participants across all emotion conditions exhibited high level of ingroup favoritism, but there was little evidence of outgroup derogation. CONCLUSION: These results su
View details →Negative / Null Result ReportOpen accessSocial Sciences
Amy Nivette, Christof Nägel, Emily Gilbert · 2023 · Police Practice and Research
High-profile incidents of police misconduct can have serious consequences for public trust in the police. A recent study in the British Journal of Political Science found that Eric Garner’s death in NYC lead to more negative attitudes towards the police in London among Black residents compared to White and Asian residents. The current study aimed to replicate this transnational effect by assessing the impact of George Floyd’s death on Londoners’ perceptions of police. Using the same data and methodological approach, we did not replicate the immediate effect on Black Londoners’ attitudes. We di
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Y C Shih · 2026 · Frontiers in Environmental Science
To assess the systematic integration of Marine Spatial Planning (MSP) and Other Effective Area-Based Conservation Measures (OECMs) into Taiwan’s coastal and marine governance frameworks to balance marine conservation and coastal development. The study adopts a comparative mixed-methods design that combines quantitative statistical analysis of spatial and ecological-economic data with qualitative policy analysis of the two selected governance frameworks. The comparative aspect of the research design explores the performance of multiple hub cases across temporal, spatial and multimodal aspects,
View details →Negative / Null Result ReportOpen accessMedicine
Xinyi Chen, Mu Yang, Yongbiao Huang et al. · 2025 · Therapeutic Advances in Medical Oncology
Abscopal immunity—the regression of distant, non-irradiated lesions after localized radiotherapy (RT)—signals conversion of focal DNA damage into systemic antitumor immunity. This review advances a unifying three-stage…
View details →Negative / Null Result ReportOpen accessNeuroscience
James Downar, James Downar, Julie Lapenskie et al. · 2024 · Palliative Medicine
Background: Psychological and existential suffering affects many people with advanced illness, and current therapeutic options have limited effectiveness. Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective therapy…
View details →Negative / Null Result ReportOpen accessNeuroscience
Eric A. Finkel, Yi-Ting Chang, Rajan Dasgupta et al. · 2024 · Cell Reports
The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
R. J. Stewart, George Younes, A. K. Harding et al. · 2025 · The Astrophysical Journal Letters
Abstract We report on IXPE and NuSTAR observations beginning 40 days after the 2024 outburst onset of magnetar 1E 1841−045, marking the first IXPE observation of a magnetar in an enhanced state. Our spectropolarimetric analysis indicates that both a blackbody (BB) plus double power-law (PL) and a double blackbody plus power-law spectral model fit the phase-averaged intensity data well, with a hard PL tail (Γ = 1.19 and 1.35, respectively) dominating above ≈5 keV. For the former model, we find the soft PL (the dominant component at soft energies) exhibits a polarization degree (PD) of ≈30% whil
View details →Negative / Null Result ReportOpen accessNeuroscience
Astrid Feiten, Kilian Dahm, Kai Schlepckow et al. · 2026 · Nature Communications
Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer's disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse. In APP transgenic animals, bulk RNA-sequencing of isolated microglia sorted based on reporter expression highlighted TREM2 level-related changes in major immunometabolic pathways, and enrichment of genes in oxidative phosphorylation and cholesterol met
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fanzhuo Xu, Yu Xie, Weiwei Yu et al. · 2026 · Frontiers in Microbiology
Multidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration, serving as the core mechanism of resistance. This paper systematically analyses antimicrobial strategies targeting the outer membrane of Gram-negative bacteria, mainly including: (1) directly disrupting the outer membrane structure and enhancing drug permeability; (2) inhibiting the biosynthesis or transport pathways of key outer membrane com
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Andrei Kudriashov, Xiong Zhou, Razmik A. Hovhannisyan et al. · 2025 · Science Advances
Josephson junctions (JJs) are key to superconducting quantum technologies and the search for self-conjugate quasiparticles potentially useful for fault-tolerant quantum computing. In topological insulator (TI)–based JJs, measuring the current-phase relation (CPR) can reveal unconventional effects such as Majorana bound states (MBS) and nonreciprocal transport. However, reconstructing CPR as a function of magnetic field has not been attempted. Here, we present a platform for field-dependent CPR measurements in planar JJs made of NbSe 2 and few-layer Bi 2 Se 3 . When a flux quantum Φ 0 thr
View details →Negative / Null Result ReportOpen accessMedicine
Alexandra Irma Gabriela Bauşic, Francesca Scurtu, Andrei Manu et al. · 2025 · International Journal of Molecular Sciences
Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using
View details →Negative / Null Result ReportOpen accessMedicine
Fiona McPhee, Joseph Ueland, Vincent Vellucci et al. · 2019 · Antimicrobial Agents and Chemotherapy
[tested DAAs] of >5,000 nM) and were detected in evaluated GT-6b and -6f sequences. NS5A-L28A-R30A, observed in GT-6r, did not replicate. In conclusion, HCV GT-6b, GT-6f, and GT-6r sequences harbored highly resistant RASs to all evaluated…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nannan Li, Guoliang Li, Xiaofang Huang et al. · 2026 · Nature Plants
The rhizosphere microbiome plays a crucial role in determining plant performance and fitness. Nevertheless, regulatory mechanisms linking host genetic variation, root gene regulation and microbiome assembly-and their collective influence on plant nutritional traits-remain poorly understood. Here we generated and integrated 1,341 paired datasets, including root transcriptomes, rhizosphere bacterial 16S rRNA profiles and root ionomes, across 175 resequenced Brassica napus ecotypes grown at two contrasting field sites. We identified 203 highly heritable bacterial amplicon sequence variants (ASVs)
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Martin Olsson, Joacim Tå̊g · 2025 · The Journal of Finance
ABSTRACT Privatization of state‐owned enterprises is on the agenda across the globe. Using Swedish data covering two decades, we show that productivity gains and headcount reductions are associated with economic costs for incumbent…
View details →Negative / Null Result ReportOpen accessMedicine
Martin G Schultz, Petr Otahal, Philip Roberts-Thomson et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: A hypertensive response to exercise is independently associated with cardiovascular disease (CVD), but clinical interpretation may be confounded by aerobic capacity (fitness). The aim of this study was to determine the relationship between exercise blood pressure (BP) relative to fitness and CVD events. METHODS: Clinical exercise test records were analysed from 12 743 people (aged 53 ± 13 years, 60% male) who completed a standard exercise stress test (Bruce treadmill protocol, stages 1-4) at six Australian hospitals. Records were linked to administrative datasets (hospital
View details →Negative / Null Result ReportOpen accessMedicine
Arthur R. H. van Zanten, Y. G. Van Der Meer, Willem A. Venhuizen et al. · 2015 · Journal of Parenteral and Enteral Nutrition
Neurologic adverse reactions, including extrapyramidal disorders, dyskinesia, dystonia, convulsions, hypertonia, and tremors.4 The reported occurrence of tardive dyskinesia ranges from <0.01%–23%.5 High occurrence is attributed to chronic…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Vasilios Liapis, Aneta Zysk, Mark DeNichilo et al. · 2017 · Cancer Medicine
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors. Evofosfamide is a hypoxia-activated prodrug that is created by linking the hypoxia-seeking 2-nitroimidazole moiety to the cytotoxic bromo-isophosphoramide mustard (Br-IPM). When evofosfamide is delivered to hypoxic regions of tumors, the DNA cross-linking toxin, Br-IPM, is released leading to cell death. This study assessed the anticancer efficacy of evofosfamide in
View details →Negative / Null Result ReportMedicine
Xu Yang, Lina Zhao, Anhui Shi et al. · 2023 · The American Journal of Gastroenterology
INTRODUCTION: Adjuvant radiotherapy is recommended for pT1b esophageal squamous cell cancer (ESCC) after endoscopic submucosal dissection (ESD). However, it is unclear whether additional radiotherapy can improve patient survival. This…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hiroki Isono, Taiju Miyagami, Kohta Katayama et al. · 2016 · Internal Medicine
Tetanus is a potentially fatal infection. Approximately 100 cases are reported in Japan each year; however, little is known about its clinical course and outcomes in the current era of treatment. We herein report three cases of tetanus in…
View details →Negative / Null Result ReportOpen accessMedicine
Timothy S. Pardee, Bayard L. Powell, Richard A. Larson et al. · 2024 · Blood Neoplasia
Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism.…
View details →Negative / Null Result ReportOpen accessMedicine
Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas
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Luís Alberto de Pádua Covas Lage, Rita Novello de Vita, Lucas Bassolli de Oliveira Alves et al. · 2024 · Cancers
Background: Diffuse large B-cell lymphoma (DLBCL) especially affects the older population. Old (≥60 years) and very old age (≥80 years) DLBCL patients often present high-risk molecular alterations, lower tolerability to conventional immunochemotherapy, and poor clinical outcomes. In this scenario, attenuated therapeutic strategies, such as the R-MiniCHOP and R-MiniCHOP of the elderly regimens, have emerged for this particularly fragile population. However, the responses, clinical outcomes, and toxicities of these regimens currently remain poorly understood, mainly because these individuals are
View details →Negative / Null Result ReportOpen accessMedicine
Masatoshi Uchida, Toshikazu Abe, Kazuyuki Ono et al. · 2017 · Acute Medicine & Surgery
Aim Our aim was to evaluate the effect of ulinastatin on 28‐day mortality in patients who developed multiple organ failure ( MOF ) related to their acute illness and were admitted to the intensive care unit ( ICU ). Methods We carried out a retrospective observational study of MOF patients in a general ICU of a tertiary care hospital in Japan from January 2009 to December 2012. The primary outcome was 28‐day all‐cause mortality. Secondary outcomes were ventilator‐free days, ICU ‐free days, and vasopressor‐free days at day 28. We investigated the association between ulinastatin treatment and ou
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