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750 real negative results, null findings, and replication failures · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Seeing color following gene augmentation therapy in achromatopsia.

McKyton A, Marks Ohana D, Nahmany E et al. · 2023 · Current biology : CB

How will people who spent their visual lives with only rods respond to cone function restoration? Will they be able suddenly see the colors of the rainbow? CNGA3-achromatopsia is a congenital hereditary disease in which cone dysfunction…

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Failed Experiment ReportOpen accessMedicine

Evidence for a reactionary account of retrieval state initiation.

Han S, Long NM · 2025 · Imaging neuroscience (Cambridge, Mass.)

Engagement of the retrieval state (or mode) is theorized to be a precursor to successful retrieval, but precisely when the retrieval state is engaged is unclear. Our aim in the present study is to determine the time course of retrieval…

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Failed Experiment ReportOpen accessMedicine

Profile of immune response during nasal challenge with dermatophagoides pteronyssinus in subjects with allergic airway diseases.

Tamasauskiene L, Gradauskiene B · 2024 · Journal of inflammation (London, England)

Background T lymphocyte helper (Th) 2 plays the main role in pathogenesis of allergic airway diseases (AAD). Recent studies showed that interleukin (IL) 33, Th17 and Th22 also may be involved in allergic inflammation. The aim is to…

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Failed Experiment ReportMedicine

Impact of ETI therapy on bone health, body composition and cardiopulmonary fitness in children with CF.

Holden A, Burns P, Devenny A et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Background Improved survival in cystic fibrosis (CF) has shifted clinical focus toward late complications, including altered body composition, bone health and cardiopulmonary fitness. The effects of Elexacaftor/Tezacaftor/Ivacaftor (ETI)…

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Failed Experiment Report

Engineering Alignment has Mixed Effects on hiPSC-CM Maturation

Kalkunte NG, Delabmbre TE, Sohn S et al. · 2022 · Preprint

The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) is greatly limited by their functional immaturity. Strong relationships exist between CM structure and function, leading many in the field to…

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Failed Experiment Report

HighAltitude ballooning

Seojoon Park, Paul Adams, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day

Every person would have thought of this idea of launching aballoon high up in the sky in their youth, and that is exactlywhat we did. We filled a large elastic balloon filled withhelium and flew it high up into the sky until it popped…

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Failed Experiment Report

The cytoplasmic C-terminal domain of the MmpL11 lipid transporter is required for interaction with its co-cistronic partner MSMEG_0240 in Mycobacterium smegmatis

Lecher S, Jaisinghani N, Previti M et al. · 2026 · Preprint

MmpL proteins play an important role in the various mechanisms associated with mycobacterial virulence. Identification of interacting protein partners required for a detailed understanding of their role remains hampered because of their…

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Failed Experiment ReportMedicine

YTHDF proteins differentially regulate a subset of m6A-modified transcripts to restrain endothelial inflammation during homeostasis.

Shyam Kumar R, Chakraborty S, Jayakumar H et al. · 2026 · Molecular biology reports

Background N6-methyladenosine (m6A) modification of mRNAs through METTL3 maintains homeostasis in many cell types. The mechanism by which METTL3 complexes together with reader proteins, especially the YTH domain-containing protein, governs…

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