Negative / Null Result ReportOpen accessPsychology
Kata Gellén, David Buttelmann · 2017 · Child Development Research
Rather than reenacting every action they observe, preverbal infants adapt their imitative behavior. Although previous studies have revealed the capability of preverbal infants to imitate selectively, the question about the adaptability of this behavior on an individual level did not attract considerable scientific attention until now. In the current study, we investigated whether 14-month-old infants flexibly alternate their imitative response in accordance with a model’s changing physical constraints in a body-part imitation paradigm. Participants were presented with two novel actions whereby
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Amélie Cabirol, Andrew Quinn, Julie Schafer et al. · 2026 · Proceedings of the National Academy of Sciences
Abstract The composition of the gut microbiota has recently been identified as a cause of cognitive variability in humans and animals. Germ-free individuals and individuals exposed to an antibiotic treatment show severe alteration of their learning and memory performance measured in various cognitive tasks. While different species of bacteria are known to interact in the gut, their cumulative or synergistic effects on cognitive performance remain elusive. Here we established a defined bacterial community - composed of core members of the corbiculate bee microbiota - which enhances honey bees’
View details →Negative / Null Result ReportOpen accessMedicine
Soichiro Sasaki, Takayuki Matsuura, Rei Takahashi et al. · 2026 · PubMed
Regular exercise has recognized health benefits, partly because it reportedly lowers the levels of the oxidation products of proteins and DNA at rest, in contrast with the effect of acute exercise. However, when we compared oxidative…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roohi Chaudhary, Ralf Weiskirchen, Marcelo Ehrlich et al. · 2025 · Frontiers in Pharmacology
The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs). These cytokines play critical roles in liver function and disease progression. Here, we discuss Smad-dependent (canonical) and non-Smad pathways activated by these cytokines in a hepatocellular context. We highlight the connection between the deregulation of these pathways or the balance between them and key hepatocellular processes (e.g., proliferation, apoptosis, and epithelial-mesenchym
View details →Negative / Null Result ReportOpen accessMedicine
Yu Zhang, Yuxi Liu, Yanping Li et al. · 2026 · JAMA
Importance: Evidence linking coffee and tea to cognitive health remains inconclusive, and most studies fail to differentiate caffeinated from decaffeinated coffee. Objective: To investigate associations of coffee and tea intake with…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid, Nesrine Gafsi · 2025 · International Journal of Energy Economics and Policy
The purpose of this research paper is to examine the long-term dynamics between economic growth, technological integration, and environmental sustainability in Saudi Arabia from 1995 to 2023. It aims to identify the impact of key economic, technological, and environmental indicators, including GDP, ICT sector performance, foreign direct investment (FDI), trade, and ecological footprint, on the country’s development trajectory. The research employs a quantitative approach, using VAR-VECM models to analyze time-series data. The study applies Granger causality tests and impulse response functions
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Clare Balboni, Robin Burgess, Benjamin Olken · 2025 · The Review of Economic Studies
Abstract Environmental externalities—uncompensated damages imposed on others—lie at the root of climate change, pollution, deforestation and biodiversity loss. Empirical evidence is limited, however, as to how externalities drive private decision making. We study one such behaviour, illegal tropical forest fires, using 15 years of daily satellite data covering over 107,000 fires across Indonesia. Weather-induced variation in fire spread risk and variation in who owns surrounding land allow us to identify how far externalities influence the decision to use fire. Relative to when all spread risk
View details →Negative / Null Result ReportOpen accessEngineering
Takahiro Ezaki, Kazumichi Ohtsuka, Mohcine Chraibi et al. · 2026 · Qucosa (Saxon State and University Library Dresden)
To better design safe and comfortable urban spaces, understanding the nature of human crowd movement is important. However, precise interactions among pedestrians are difficult to measure in the presence of their complex decision-making processes and many related factors. While extensive studies on pedestrian flow through bottlenecks and corridors have been conducted, the dominant mode of interaction in these scenarios may not be relevant in different scenarios. Here, we attempt to decipher the factors that affect human reactions to other individuals from a different perspective. We conducted
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Kevin J. Mitchell, Darren Dahly, Dorothy Bishop · 2025 · Neuron
The idea that the gut microbiome causally contributes to autism has gained currency in the scientific literature and popular press. Support for this hypothesis comes from three lines of evidence: human observational studies, preclinical experiments in mice, and human clinical trials. We critically assessed this literature and found that it is beset by conceptual and methodological flaws and limitations that undermine claims that the gut microbiome is causally involved in the etiology or pathophysiology of autism.
View details →Negative / Null Result ReportOpen accessEngineering
Shujun Hu, Xiaopeng Yin, Wen Liu et al. · 2025 · Structures
In prefabricated concrete structures, interfacial slip induced by shear at connection zones can critically undermine structural integrity, particularly when load transfer relies on reinforcing bar lap splices. To address this issue, this…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Luísa Sório Flor, Cory N Spencer, Jack Cagney et al. · 2025 · The Lancet
BACKGROUND: Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both nat
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roberta Ottria, Susan Mirmajidi, Pierangela Ciuffreda · 2026 · International Journal of Molecular Sciences
This review delves into the complex relationship between short-chain fatty acids (SCFAs) produced by the gut microbiota and inflammatory bowel disease (IBD). IBD, which includes Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal disorders with an increasing global incidence. Despite extensive research, the exact etiopathogenesis remains elusive, although a complex interplay involving genetic predisposition, environmental influences, and abnormal immune responses against commensal gut microbes is widely recognized. SCFAs, primarily acetate and butyrate, emerge as key
View details →Negative / Null Result ReportOpen accessMedicine
Anna Kankaanpää, Asko Tolvanen, Laura Joensuu et al. · 2025 · European Journal of Epidemiology
OBJECTIVES: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association. METHODS: Study participants were twins from the older Finnish Twin Cohort (n = 22,750; 18-50 years at baseline). LTPA was assessed using questionnaires in 1975, 1981 and 1990. The mortality follow-up lasted until 2020 and biol
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Sanaa R. Elsegeny, Fatima S. Radwan, Yomna M. Elshamy et al. · 2025 · Annals of Microbiology
Abstract Background Aquaculture is an essential sector for global food security, providing protein-rich food, reducing pressure on wild stocks, creating jobs, and contributing to national economies. However, it faces major sustainability challenges, including disease outbreaks, inefficient feed utilization, and environmental impact. Main body The significance of probiotics in mitigating these issues is highlighted in this review. The current review underscores and highlights important considerations while developing or using probiotics in the aquaculture field: how strains are selected as cand
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhiyu Yang, Fanny‐Dhelia Pajuste, Kristina Zguro et al. · 2025 · Nature Genetics
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Aris Katzourakis, Stéphane Hué, Paul Kellam et al. · 2011 · Journal of Virology
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) has been amplified from human prostate cancer and chronic fatigue syndrome (CFS) patient samples. Other studies failed to replicate these findings and suggested PCR contamination…
View details →Negative / Null Result ReportOpen accessChemistry
Andrew T. Rajczewski, J. Alfredo Blakeley‐Ruiz, Annaliese Meyer et al. · 2025 · PROTEOMICS
Mass spectrometry (MS)-based metaproteomics is used to identify and quantify proteins in microbiome samples, with the frequently used methodology being data-dependent acquisition mass spectrometry (DDA-MS). However, DDA-MS is limited in…
View details →Negative / Null Result ReportOpen accessMedicine
Jiacheng Ma, Shengrui Liu, Yuting Pei · 2025 · Scientific Reports
Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability. Using the Kaggle "University Football Injury Prediction Dataset"…
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Claudia Monaco, Coleen A. McNamara, Bram Slütter et al. · 2025 · Physiological Reviews
Cardiovascular disease is the global number one cause of mortality and morbidity. The majority of cardiovascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Aliasghar Azma, Yakun Liu, Eden Tatek Alemu · 2026 · Scientific Reports
The aim of this study was to evaluate groundwater quality the Marvdasht aquifer using the Groundwater Quality Index (GWQI), which was determined using a conventional method and also predicted using three machine learning algorithms:…
View details →Negative / Null Result ReportOpen accessEnergy
Yuqi Ren, Miao Cheng, Hongbin He et al. · 2025 · Nature Communications
CO2-to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O2 partial pressures and sluggish C2-product formation. Herein, Ru0.6Cu1(Cu0–Cu1+)/CeO2 catalysts with adaptive O2 tolerance are…
View details →Negative / Null Result ReportPsychology
Kay Brauer, René T. Proyer · 2020 · Journal of Personality Assessment
Personality assessment typically relies on self-report questionnaires utilizing Likert-type scales. Recently, the Expanded format has been proposed as alternative, but research on the consequences of adapting Likert-like responses to…
View details →Negative / Null Result ReportSocial Sciences
Ashley I. Naimi · 2016 · Epidemiology
The less a science is advanced, the more its terminology rests on an uncritical assumption of mutual understanding. —Quine1 Complex systems science is a new field that continues to garner prominence. Arguments for a more widespread…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Miloš Krist, Pavel Munclinger · 2011 · Molecular Ecology
Extra-pair copulations (EPC) are the rule rather than an exception in socially monogamous birds, but despite widespread occurrences, the benefits of female infidelity remain elusive. Most attention has been paid to the possibility that…
View details →Negative / Null Result ReportOpen accessPsychology
Chengxi Zang, Yu Hou, Daoming Lyu et al. · 2024 · Translational Psychiatry
Machine Learning models trained from real-world data have demonstrated promise in predicting suicide attempts in adolescents. However, their transportability, namely the performance of a model trained on one dataset and applied to…
View details →Negative / Null Result Report
Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology
Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…
View details →Negative / Null Result Report
Mark Cornelis van der Plas, Krista Ingeborg Janssen, Nikolaos Pandis et al. · 2017 · The Angle Orthodontist
ABSTRACT Objective: To investigate the effect of acrylic capping, treatment duration, overjet, and lower incisor inclination on the posttreatment tooth position in patients treated with 2 Twin Block (TB) appliance versions. Materials and…
View details →Negative / Null Result Report
Shan Ren, Wenjing Wang, Junfeng Lu et al. · 2022 · Frontiers in Immunology
Objective In clinical practice, a substantial proportion of chronic hepatitis B virus (HBV) infections that do not fit into any of the usual immune states are considered to be in the “grey zone (GZ)”. This study aimed to investigate the…
View details →Negative / Null Result Report
A.R.J.V. Vossen, H.H. van der Zee, N. Davelaar et al. · 2018 · Journal of the European Academy of Dermatology and Venereology
Abstract Background Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa ( HS ). Objective To evaluate the change in expression of inflammatory markers in lesional skin…
View details →Negative / Null Result Report
Winston A. Haynes, Kathy Kamath, Rebecca Waitz et al. · 2021 · Frontiers in Immunology
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader identification of…
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