Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen et al. · 2022 · Epigenetics
Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP
View details →Negative / Null Result ReportMedicine
S.J.H. Bredie, Miek C. Jong · 2011 · Journal of Cardiovascular Pharmacology
BACKGROUND: Medicinal treatment of vasospastic Raynaud phenomenon is limited to primarily vasodilator medicines. OBJECTIVE: To explore the possible beneficial effects and tolerability of 120 mg two times a day of Ginkgo Biloba special…
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Guangsheng Song, Zhihui Qian, Xiangyu Liu et al. · 2023 · Advanced Functional Materials
Abstract Degenerative disc disease (DDD) has become a significant public health issue worldwide. This can result in loss of spinal function affecting patient health and quality of life. Artificial total disc replacement (A‐TDR) is an…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Damian J. Ruck, R. Alexander Bentley, Alberto Acerbi et al. · 2017 · Advances in Complex Systems
Here, we test Neutral models against the evolution of English word frequency and vocabulary at the corpus scale, as recorded in annual word frequencies from three centuries of English language books. Against these data, we test both static…
View details →Negative / Null Result ReportOpen accessMathematics
Esra Yiğit, Fikri Gökpınar · 2010 · Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics
The classical F-test to compare several population means depends on the assumption of homogeneity of variance of the population and the normality. When these assumptions especially the equality of variance is dropped, the classical F-test fails to reject the null hypothesis even if the data actually provide strong evidence for it. This can be considered a serious problem in some applications, especially when the sample size is not large. To deal with this problem, a number of tests are available in the literature. In this study, the Brown-Forsythe, Weerahandiís Generalized F, Parametric Bootst
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Saurav Mallik, Zhongming Zhao · 2017 · Quantitative Biology
Background Marker detection is an important task in complex disease studies. Here we provide an association rule mining (ARM) based approach for identifying integrated markers through mutual information (MI) based statistically significant…
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N. C. Hunt, K. M. Ghosh, A. P. Blain et al. · 2015 · The Bone & Joint Journal
The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in…
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Nawhath Thanvisitthpon · 2021 · Sustainability
This research proposes an updated version of homestay indicators for 10 existing component-level homestay requirements. The updated indicators were aimed to replace the decade-old original indicators for Thai homestay businesses. Besides,…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Zouhaier Aloui, Mekki Hamdaoui, Samir Maktouf · 2024 · Transnational Corporation Review
This paper examines the moderating role of governance in the effect of Foreign Direct Investment (FDI) on poverty using simultaneous equations models for sub-Saharan African, Asian, Latin American and Eastern European countries over the…
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Gabriel P. Langlois, Donald M. Arnold, Jayson Potts et al. · 2018 · Clinical Case Reports
Key Clinical Message Cyclic thrombocytopenia is often misdiagnosed as immune thrombocytopenia due to similar clinical features, a fact of significance because cyclic thrombocytopenia generally responds poorly to treatments used…
View details →Negative / Null Result ReportAgricultural and Biological Sciences
Miloš Krist, Pavel Munclinger · 2011 · Molecular Ecology
Extra-pair copulations (EPC) are the rule rather than an exception in socially monogamous birds, but despite widespread occurrences, the benefits of female infidelity remain elusive. Most attention has been paid to the possibility that…
View details →Negative / Null Result ReportOpen accessPsychology
Chengxi Zang, Yu Hou, Daoming Lyu et al. · 2024 · Translational Psychiatry
Machine Learning models trained from real-world data have demonstrated promise in predicting suicide attempts in adolescents. However, their transportability, namely the performance of a model trained on one dataset and applied to…
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Matia Vannoni · 2018 · Policy Studies Journal
Public policy scholars argue that in highly tangible policies, such as tobacco control, the public learns from the direct experience of the beneficial effects of the policy. Empirical evidence supports this argument, suggesting that in the…
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Arnaud Norena · 2024 · Frontiers in Psychology
Misophonia is a disorder of decreased tolerance to specific sounds, often produced by humans but not always, which can trigger intense emotional reactions (anger, disgust etc.). This relatively prevalent disorder can cause a reduction in…
View details →Negative / Null Result ReportOpen accessMedicine
Yi Cao, Qing‐wei Guo, Ye‐da Wan · 2020 · Orthopaedic Surgery
Objective The T2 value of lumbar cartilage endplates was measured using the T2 mapping imaging technique, aiming to explore the correlation between the T2 value and Pfirrmann grading of intervertebral discs. Methods A total of 130 patients with lumbar spine MR examination due to persistent low back pain were enrolled, including 71 men and 59 women (age: 21–63 years). Lumbar Modic changes and Schmorl nodules were recognized by conventional T1WI and T2WI images in 49 patients, and these patients were excluded from the study. A total of 81 patients were enrolled in this study, including 45 men (4
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Kumju Hwang, Jinsook Choi · 2021 · International Journal of Environmental Research and Public Health
Entrepreneurial failure is prevalent, and particularly when the COVID−19 crisis exacerbates the economic recession, it becomes even more prevalent. Entrepreneurs experience an intensive emotional crisis when their ventures fail, and this…
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Jingran Zhang, Wukui Wang, Lei Gao et al. · 2022 · Atmosphere
Air pollution caused by coal burning not only increases the cost of environmental pollution but also harms human health. It is urgent for China to change the practice of coal-fired central heating. Therefore, the effectiveness and…
View details →Negative / Null Result ReportMedicine
Han‐Joo Lee, Amy R. Goetz, Jennifer E. Turkel et al. · 2014 · Anxiety Stress & Coping
BACKGROUND AND OBJECTIVES: Current cognitive-behavioral theorists conceptualize hypochondriasis as excessive health anxiety (HA). Growing evidence suggests that elevated HA is associated with attentional bias (AB) toward potential…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Fernanda Marcondes de Rezende, M. Haile‐Mariam, J.E. Pryce et al. · 2020 · Journal of Dairy Science
The use of information across populations is an attractive approach to increase the accuracy of genomic predictions for numerically small breeds and traits that are time-consuming and difficult to measure, such as male fertility in cattle.…
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Mark Cornelis van der Plas, Krista Ingeborg Janssen, Nikolaos Pandis et al. · 2017 · The Angle Orthodontist
ABSTRACT Objective: To investigate the effect of acrylic capping, treatment duration, overjet, and lower incisor inclination on the posttreatment tooth position in patients treated with 2 Twin Block (TB) appliance versions. Materials and…
View details →Negative / Null Result ReportEngineering
Donna Kotsopoulos, Samantha Makosz, Joanna Zambrzycka et al. · 2019 · Early Child Development and Care
An enduring challenge in visual-spatial research has been to identify the factors contributing to individual differences in ability. This research investigated the overall, verbal, and nonverbal visual-spatial ability of 61 (34 boys)…
View details →Negative / Null Result ReportPsychology
Kay Brauer, René T. Proyer · 2020 · Journal of Personality Assessment
Personality assessment typically relies on self-report questionnaires utilizing Likert-type scales. Recently, the Expanded format has been proposed as alternative, but research on the consequences of adapting Likert-like responses to…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Isaac Shiri, Sebastian Balzer, Giovanni Baj et al. · 2024 · European Journal of Nuclear Medicine and Molecular Imaging
PURPOSE: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a frequent concomitant condition in patients with severe aortic stenosis (AS), yet it often remains undetected. This study aims to comprehensively evaluate artificial intelligence-based models developed based on preprocedural and routinely collected data to detect ATTR-CM in patients with severe AS planned for transcatheter aortic valve implantation (TAVI). METHODS: Tc]-DPD) for the presence of ATTR-CM. Clinical, laboratory, electrocardiogram, echocardiography, invasive measurements, 4-dimensional cardiac CT (4D-CCT) strain data, and C
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Hsien-Wu Kuo, Chung‐Yu Huang, Chun‐Kai Fu et al. · 2014 · PubMed
BACKGROUND AND AIM: Gastric cancer is one of the most common malignant tumors worldwide. Due to the complex initiation and intricate progression mechanisms, early detection and effective treatment of gastric cancer are both difficult to…
View details →Negative / Null Result ReportSocial Sciences
Ashley I. Naimi · 2016 · Epidemiology
The less a science is advanced, the more its terminology rests on an uncritical assumption of mutual understanding. —Quine1 Complex systems science is a new field that continues to garner prominence. Arguments for a more widespread…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mireia M. Ginesta, Zamira V. Díaz‐Riascos, Juli Busquets et al. · 2016 · Oncology Letters
Early detection of pancreatic and periampullary neoplasms is critical to improve their clinical outcome. The present authors previously demonstrated that DNA hypermethylation of adenomatous polyposis coli (APC), histamine receptor H2…
View details →Negative / Null Result ReportOpen accessMedicine
Barbora Weinbergerová, Tomáš Kabut, Iva Kocmanová et al. · 2020 · Scientific Reports
Invasive fungal disease (IFD) early diagnosis improves hematological patient survival. Non-culture-based methods may reduce diagnostic time to identify IFD. As complex data on the value of 1,3-β-D-glucan (BDG) from bronchoalveolar lavage fluid (BALF) compared to serum for the most frequent invasive pulmonary aspergillosis (IPA) diagnosis are scarce, particularly including evaluation of potential factors adversely affecting BDG assay, we provided prospective single-center analysis evaluating 172 episodes of pulmonary infiltrates with BDG detection in BALF and serum samples collected in parallel
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Nalinie Joharatnam‐Hogan, William Wilson, Kai Keen Shiu et al. · 2020 · Cancers
Background: Despite notable advances in the management of metastatic colorectal cancer (mCRC) over the last two decades, treatment intent in the vast majority of patients remains palliative due to technically unresectable disease, extensive disease, or co-morbidities precluding major surgery. Up to 30% of individuals with mCRC are considered potentially suitable for primary or metastasis-directed multimodal therapy, including surgical resection, ablative techniques, or stereotactic radiotherapy (RT), with the aim of improving survival outcomes. We reviewed the potential benefits of multimodal
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Kaneen Gomez-Hixson, Ericka Biagioni, Melissa Brown · 2020 · Journal of American College Health
Objective: This study evaluated dietary intake patterns of NCAA Division III soccer players compared to recommended levels. Participants: NCAA Division III soccer players (n = 75). Methods: Actual dietary intake was determined by the…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
IREC, CSIC–UCLM–JCCM, Ciudad Real, Spain, Ainhoa Mateo-Moriones, Rafael Villafuerte et al. · 2012 · Animal Biodiversity and Conservation
This work evaluates the effectiveness of fox control as a method to improve the survival of red–legged partridge (Alectoris rufa). We radio–tracked 89 adult partridges and their chicks (62 few days old chicks and 46 over one–month–old chicks) and monitored their nests (N = 45) on two hunting estates in northern Spain over two years. Generalist predators (red fox, Vulpes vulpes, and magpie, Pica pica) were selectively controlled on one half of each estate during the first year, and on the other half in the second year. We estimated the effect of predator control on survival rates. Predator cont
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