e-ISSN: Pending

Browse the failure-mode index

19,808 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries

Olayemi O. Adeoye, Vincent Bouthors, Margaret C. Hubbell et al. · 2014 · Journal of Applied Physiology

Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth muscle, although hypoxia produces only transient increases in VEGF that return to normoxic levels despite sustained changes in arterial structure and…

View details →
Negative / Null Result ReportOpen accessMedicine

Comparison of the Physical Demands of Friendly Matches and Different Types On-Field Integrated Training Sessions in Professional Soccer Players

Jesús Giménez, Julen Castellano, Patrycja Lipińska et al. · 2020 · International Journal of Environmental Research and Public Health

The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS1,2,3) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS1), SSG+CT+LSG (TS2) and MG+CT+LSG (TS3). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.7 years, height = 178 ± 6 cm, body mass = 73.2 ± 6.9 kg, mean and SD, respectively) using 10-Hz global positioning system devices, and pla

View details →
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Replication of plasmids derived from Shiga toxin-converting bacteriophages in starved Escherichia coli

Bożena Nejman-Faleńczyk, Beata Nadratowska-Wesołowska, Agnieszka Szalewska-Pałasz et al. · 2010 · Microbiology

The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that…

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-wide association study of treatment-related toxicity two years following radiotherapy for breast cancer

Harkeran K. Jandu, Colin Veal, Laura Fachal et al. · 2023 · Radiotherapy and Oncology

Background and purpose Up to a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity. If patients at high risk of adverse effects could be identified at diagnosis, their treatment could be tailored accordingly. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity two years following whole breast radiotherapy. Materials and Methods A genome-wide association study (GWAS) was performed in 1,640 breast cancer patients with complete SNP, clinical, treatment and toxicity data, recruited a

View details →
Negative / Null Result ReportOpen accessNeuroscience

Amygdala and nucleus accumbens involvement in appetitive extinction

Onno Kruse, S. Klein, Isabell Tapia León et al. · 2020 · Human Brain Mapping

Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural…

View details →
Negative / Null Result ReportNeuroscience

Does contextual diversity affect serial recall?

Dominic Guitard, Leonie M. Miller, Ian Neath et al. · 2019 · Journal of Cognitive Psychology

People are better at recalling lists of high- than low-frequency words but as Parmentier, Comesãna, and Soares [(2017). Disentangling the effects of word frequency and contextual diversity on serial recall performance. Quarterly Journal of…

View details →
Negative / Null Result ReportOpen accessNeuroscience

Vulnerability to Distraction in Schizophrenia

Chieffi S Iavarone A · 2015 · African Journal of Psychiatry

Attentional processes enhancing relevant information and attenuating competing irrelevant information are required for coherent and effective action. One of deficits that may characterize schizophrenia is the impairment of the ability in focusing on relevant information while inhibiting the irrelevant. The intrusion of irrelevant stimuli during information processing may impair cognitive and behavioral functioning. In this paper we review studies that investigated the vulnerability to distracting stimuli in schizophrenia by using visual interference paradigms, namely flanker, Stroop, and negat

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design

Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen et al. · 2022 · Epigenetics

Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP

View details →
Negative / Null Result ReportOpen accessMedicine

Bioinspired Intervertebral Disc with Multidirectional Stiffness Prepared via Multimaterial Additive Manufacturing

Guangsheng Song, Zhihui Qian, Xiangyu Liu et al. · 2023 · Advanced Functional Materials

Abstract Degenerative disc disease (DDD) has become a significant public health issue worldwide. This can result in loss of spinal function affecting patient health and quality of life. Artificial total disc replacement (A‐TDR) is an…

View details →
Negative / Null Result ReportOpen accessMathematics

A SIMULATION STUDY ON TESTS FOR ONE-WAY ANOVA UNDER THE UNEQUAL VARIANCE ASSUMPTION

Esra Yiğit, Fikri Gökpınar · 2010 · Communications Faculty Of Science University of Ankara Series A1Mathematics and Statistics

The classical F-test to compare several population means depends on the assumption of homogeneity of variance of the population and the normality. When these assumptions especially the equality of variance is dropped, the classical F-test fails to reject the null hypothesis even if the data actually provide strong evidence for it. This can be considered a serious problem in some applications, especially when the sample size is not large. To deal with this problem, a number of tests are available in the literature. In this study, the Brown-Forsythe, Weerahandiís Generalized F, Parametric Bootst

View details →
Negative / Null Result Report

Towards integrated oncogenic marker recognition through mutual information‐based statistically significant feature extraction: an association rule mining based study on cancer expression and methylation profiles

Saurav Mallik, Zhongming Zhao · 2017 · Quantitative Biology

Background Marker detection is an important task in complex disease studies. Here we provide an association rule mining (ARM) based approach for identifying integrated markers through mutual information (MI) based statistically significant…

View details →
Negative / Null Result Report

No statistically significant kinematic difference found between a cruciate-retaining and posterior-stabilised Triathlon knee arthroplasty

N. C. Hunt, K. M. Ghosh, A. P. Blain et al. · 2015 · The Bone & Joint Journal

The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in…

View details →
Negative / Null Result ReportOpen accessSocial Sciences

Does governance matter to ensure significant effect of foreign direct investment on poverty reduction? Evidence from developing and emerging countries

Zouhaier Aloui, Mekki Hamdaoui, Samir Maktouf · 2024 · Transnational Corporation Review

This paper examines the moderating role of governance in the effect of Foreign Direct Investment (FDI) on poverty using simultaneous equations models for sub-Saharan African, Asian, Latin American and Eastern European countries over the…

View details →
Negative / Null Result Report

Did Kant suffer from misophonia?

Arnaud Norena · 2024 · Frontiers in Psychology

Misophonia is a disorder of decreased tolerance to specific sounds, often produced by humans but not always, which can trigger intense emotional reactions (anger, disgust etc.). This relatively prevalent disorder can cause a reduction in…

View details →
Negative / Null Result ReportOpen accessMedicine

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Yi Cao, Qing‐wei Guo, Ye‐da Wan · 2020 · Orthopaedic Surgery

Objective The T2 value of lumbar cartilage endplates was measured using the T2 mapping imaging technique, aiming to explore the correlation between the T2 value and Pfirrmann grading of intervertebral discs. Methods A total of 130 patients with lumbar spine MR examination due to persistent low back pain were enrolled, including 71 men and 59 women (age: 21–63 years). Lumbar Modic changes and Schmorl nodules were recognized by conventional T1WI and T2WI images in 49 patients, and these patients were excluded from the study. A total of 81 patients were enrolled in this study, including 45 men (4

View details →
Negative / Null Result Report

How Do Failed Entrepreneurs Cope with Their Prior Failure When They Seek Subsequent Re-Entry into Serial Entrepreneurship? Failed Entrepreneurs’ Optimism and Defensive Pessimism and Coping Humor as a Moderator

Kumju Hwang, Jinsook Choi · 2021 · International Journal of Environmental Research and Public Health

Entrepreneurial failure is prevalent, and particularly when the COVID−19 crisis exacerbates the economic recession, it becomes even more prevalent. Entrepreneurs experience an intensive emotional crisis when their ventures fail, and this…

View details →
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Across-country genomic prediction of bull fertility in Jersey dairy cattle

Fernanda Marcondes de Rezende, M. Haile‐Mariam, J.E. Pryce et al. · 2020 · Journal of Dairy Science

The use of information across populations is an attractive approach to increase the accuracy of genomic predictions for numerically small breeds and traits that are time-consuming and difficult to measure, such as male fertility in cattle.…

View details →
Negative / Null Result Report

Twin Block appliance with acrylic capping does not have a significant inhibitory effect on lower incisor proclination

Mark Cornelis van der Plas, Krista Ingeborg Janssen, Nikolaos Pandis et al. · 2017 · The Angle Orthodontist

ABSTRACT Objective: To investigate the effect of acrylic capping, treatment duration, overjet, and lower incisor inclination on the posttreatment tooth position in patients treated with 2 Twin Block (TB) appliance versions. Materials and…

View details →
Negative / Null Result ReportEngineering

Individual differences in young children’s visual-spatial abilities

Donna Kotsopoulos, Samantha Makosz, Joanna Zambrzycka et al. · 2019 · Early Child Development and Care

An enduring challenge in visual-spatial research has been to identify the factors contributing to individual differences in ability. This research investigated the overall, verbal, and nonverbal visual-spatial ability of 61 (34 boys)…

View details →