Negative / Null Result ReportOpen accessMedicine
Robert Stuver, Steven M. Horwitz, Ranjana H. Advani et al. · 2023 · British Journal of Haematology
There remains no one standard induction for nodal-based peripheral T-cell lymphoma (PTCL). We conducted a phase II study of lenalidomide plus CHOEP as a novel induction strategy. Patients received CHOEP at standard doses in combination…
View details →Negative / Null Result ReportOpen accessMedicine
Sarah S. Mougalian, Ronda Copher, Jonathan Kish et al. · 2018 · Cancer Medicine
INTRODUCTION: Real-world data are critical to demonstrate the consistency of evidence and external generalizability of randomized controlled trials (RCTs). This study examined characteristics and outcomes of metastatic triple-negative breast cancer (mTNBC) patients treated with eribulin mesylate at community oncology practices in the United States. METHODS: Physicians identified mTNBC patients initiating eribulin between 1 January 2011 and 1 January 2014 and abstracted data into an electronic case report form (eCRF). Eribulin treatment in the metastatic setting was categorized as early use (EU
View details →Negative / Null Result ReportOpen accessMedicine
Jianli Lv, Bo Han, Cuiyan Wang et al. · 2019 · Frontiers in Pediatrics
Objective To investigate the clinical features and the diagnostic and follow-up value of acute fulminant myocarditis (AFM) in children. Methods 20 children diagnosed with AFM admitted to our department were reviewed, and the clinical manifestations; pathogenic examination results; myocardial injury biomarkers; and electrocardiography, echocardiogram and cardiovascular magnetic resonance (CMR) results were analyzed. Results The initial symptoms were abdominal pain, vomiting, fatigue, syncope, and convulsions. All children had significantly increased hs-cTnT and NT-pro BNP. In addition to nonspe
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Elisa Molinari, Shalabh Srivastava, Rebecca M. Dewhurst et al. · 2020 · BMC Nephrology
Abstract Background PKHD1 is the main genetic cause of autosomal recessive polycystic kidney disease (ARPKD), a hereditary hepato-renal fibrocystic disorder which is the most important cause of end-stage renal disease during early…
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Christoph Alexander Rüst, Romuald Lepers, Thomas Rosemann et al. · 2014 · SpringerPlus
Abstract This study investigated the change in sex differences across years in ultra-distance swimming performances at the 36-km ‘Maratona del Golfo Capri-Napoli’ race held from 1954 to 2013. Changes in swimming performance of 662 men and…
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Jacques Demongeot, Hervé Seligmann · 2020 · Scientific Reports
Abstract Ribosomal RNAs are complex structures that presumably evolved by tRNA accretions. Statistical properties of tRNA secondary structures correlate with genetic code integration orders of their cognate amino acids. Ribosomal RNA…
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
Joop Schaye, Evgenii Chaikin, Matthieu Schaller et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We present the COLIBRE galaxy formation model and the COLIBRE suite of cosmological hydrodynamical simulations. COLIBRE includes new models for radiative cooling, dust grains, star formation, stellar mass loss, turbulent diffusion, pre-supernova stellar feedback, supernova feedback, supermassive black holes, and active galactic nucleus (AGN) feedback. The multiphase interstellar medium is explicitly modelled without a pressure floor. Hydrogen and helium are tracked in non-equilibrium, with their contributions to the free electron density included in metal-line cooling calculations. Th
View details →Negative / Null Result ReportOpen accessPsychology
Joyce S. Pang, Hiram Ring, Kate Y Huang et al. · 2026 · Journal of Personality Assessment
Implicit motives have a clear relation to observed behavior but are time-consuming to measure. Automating the content coding of implicit motives has been a pursuit since the 1960s, but has not been widely adopted due to limitations with…
View details →Negative / Null Result ReportOpen accessMedicine
Ömer Aydın, Enis Karaarslan, Fatih Safa Erenay et al. · 2026 · Turkish Journal of Engineering
DeepSeek v3, developed in China, was released in December 2024, followed by Alibaba’s Qwen 2.5 Max in January 2025 and Qwen3 235B in April 2025. These free and open-source models offer significant potential for academic writing and content…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ihsen Abid · 2025 · Engineering Technology & Applied Science Research
Saudi Arabia, as one of the world’s leading oil producers, faces critical challenges in transitioning to sustainable economic growth. The heavy reliance on oil exports, coupled with rapid urbanization and environmental degradation, underscores the urgent need for green growth strategies tailored to the Kingdom’s unique socioeconomic and environmental context. This study aims to investigate the factors influencing the Green Growth Index (GGI), which measures sustainable economic growth, and analyze the short-term and long-term relationships between key variables such as environmental technology
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luiz Carlos Vieira, Morgan L. Handojo, Claus O. Wilke · 2025 · Scientific Reports
Protein language models (pLMs) can offer deep insights into evolutionary and structural properties of proteins. While larger models, such as the 15 billion parameter model ESM-2, promise to capture more complex patterns in sequence space, they also present practical challenges due to their high dimensionality and high computational cost. We systematically evaluated the performance of various ESM-style models across multiple biological datasets to assess the impact of model size on transfer learning via feature extraction. Surprisingly, we found that larger models do not necessarily outperform
View details →Negative / Null Result ReportOpen accessNeuroscience
Hye-Won Yang, Danyeong Kim, YoungSoon Yang et al. · 2025 · International Journal of Molecular Sciences
TREM2 (triggering receptor expressed on myeloid cells 2) is a membrane-bound receptor primarily expressed on microglia in the central nervous system (CNS). TREM2 plays a crucial role in regulating immune responses, phagocytosis, lipid metabolism, and inflammation. Mutations in the TREM2 gene have been linked to various neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and Nasu–Hakola disease (NHD). These mutations are suggested to impair microglial activation and reduce the ability to clear amyloid aggregates, leading to ex
View details →Negative / Null Result ReportOpen accessPsychology
Joon Soo Lim, Nalae Hong, Erika J. Schneider · 2025 · Computers in Human Behavior
As generative artificial intelligence (GenAI) becomes more integrated into corporate communication, its role in crisis messaging raises critical questions about audience perception and trust. Drawing on theories of machine heuristics, this…
View details →Negative / Null Result ReportOpen accessMedicine
Akshay Khunte, Veer Sangha, Evangelos K. Oikonomou et al. · 2026 · European Heart Journal - Digital Health
ABSTRACT Background Timely and accurate assessment of electrocardiograms (ECGs) is crucial for diagnosing, triaging, and clinically managing patients. Current workflows rely on computerized ECG interpretation tools built into ECG signal…
View details →Negative / Null Result ReportOpen accessMedicine
Marta Arroyo‐Izaga, Concepción Martínez de la Pera, Laura Ansotegui et al. · 2026 · Archivos Latinoamericanos de Nutrición
The objective of this study was to determine whether a short training program, using real foods, would decreased their portion-size estimation errors after training. 90 student volunteers (20.18+/-0.44 y old) of the University of the…
View details →Negative / Null Result ReportOpen accessComputer Science
Thomas A. Buckley, James A. Diao, Cam N. Srivastava et al. · 2026 · Nature Communications
Multimodal foundation models have shown compelling but conflicting performance in medical image interpretation. However, the ways in which these models integrate and prioritize different data modalities, including images and text, remain…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Josef Biber, Catharina Gandor, Elvir Bećirović et al. · 2025 · Pharmacology & Therapeutics
Gene therapy is an innovative medical approach that offers new treatment options for congenital and acquired diseases by transferring, correcting, inactivating or regulating genes to supplement, replace or modify a gene function. The approval of voretigene neparvovec (Luxturna), a gene therapy for RPE65-associated retinopathy, has marked a milestone for the field of retinal gene therapy, but has also helped to accelerate the development of gene therapies for genetic diseases affecting other organs. Voretigene neparvovec is a vector based on adeno-associated virus (AAV) that delivers a function
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Qiyao Zhang, Zhen Cao, Shangcheng Yan et al. · 2025 · Journal of Translational Medicine
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is notorious for its aggressive nature and dismal prognosis, ranking as a leading cause of cancer-related mortality worldwide. Despite advancements in surgical…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mboneye Anselme, Huafeng He, Chengyang Lai et al. · 2025 · Journal of Translational Medicine
In the realm of cellular biochemistry, mitochondria have been increasingly recognized for their critical role in both cellular metabolism and the etiology of various diseases. Mitochondrial transporters (MTs) are essential for maintaining…
View details →Negative / Null Result ReportOpen accessNeuroscience
Patrick Vermersch, Laura Airas, Thomas Berger et al. · 2025 · Frontiers in Immunology
Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, the primary resident immune cells of the CNS. This review discusses the role of microglia in neuroinflammation, tissue repair, and neural homeostasis, as well as their involvement in MS and explores potential therapeutic strategies targeting microglial function. Methods: A literature search conducted in August 202
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Margarida Arrobas, João V. Decker, Bruna L. Feix et al. · 2021 · Soil Use and Management
Abstract Soil conditioners, such as biochar and zeolites, may play an important role in agriculture if they increase nutrient use efficiency, in particular, that of phosphorus (P), due to the depletion of phosphate rocks from which…
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Chris M. Smith-Martin, Steven Jansen, Timothy J. Brodribb et al. · 2022 · Frontiers in Forests and Global Change
One of the most prominent changes in neotropical forests has been the increase in abundance and size of lianas. Studies suggest that lianas have more acquisitive strategies than trees, which could allow them to take advantage of water more…
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Lina Caballero-Villalobos, Francisco Fajardo-Gutiérrez, Mariasole Calbi et al. · 2021 · Frontiers in Ecology and Evolution
It is predicted that climate change will strongly affect plant distributions in high elevation “sky islands” of tropical Andes. Polylepis forests are a dominant element of the treeline throughout the Andes Cordillera in South America.…
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Aidan E. Gilchrist, Brendan A. C. Harley · 2022 · Advanced Healthcare Materials
Abstract Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design of ex vivo systems that…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Tracy Leskey, Heather Andrews, Angelika Bády et al. · 2021 · Journal of Economic Entomology
Brown marmorated stink bug, Halyomorpha halys, is native to Asia and has invaded North America and Europe inflicting serious agricultural damage to specialty and row crops. Tools to monitor the spread of H. halys include traps baited with…
View details →Negative / Null Result ReportOpen accessMedicine
Paul Sondo, Biébo Bihoun, Marc Christian Tahita et al. · 2021 · Malaria Journal
BACKGROUND: Multi-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants. The influence of genetic multiplicity and whether some specific genetic variants are more or less likely to invest into gametocyte production is not clearly understood. This study explored host and parasite-related risk factors for gametocyte carriage, and the extent to which some specific P. falciparum genetic variants are associated with gametocyte carriage. METHODS: Gametocytes and asexual forms were detected by light microscopy
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Rachel Charlton, Christine Damase‐Michel, Caroline Hurault‐Delarue et al. · 2019 · Pharmacoepidemiology and Drug Safety
Abstract Objectives In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant, or in…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Da‐Tian Bau · 2011 · The Chinese Journal of Physiology
Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…
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Xiangxu Zou, Hui Zhang, Jie Zuo et al. · 2016 · Scientific Reports
Abstract To identify the facilitation effect of a cool-season aquatic macrophyte (FE am ) for use in effluent purification via constructed floating wetlands (CFWs) and to determine the possible pathways used during a winter period with an…
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Aimée C. Colbath, Steven W. Dow, Leone S. Hopkins et al. · 2020 · Equine Veterinary Journal
Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and…
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