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19,803 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Low-phytate wholegrain bread instead of high-phytate wholegrain bread in a total diet context did not improve iron status of healthy Swedish females: a 12-week, randomized, parallel-design intervention study

Michael Hoppe, Alastair B. Ross, Cecilia Svelander et al. · 2018 · European Journal of Nutrition

Abstract Purpose To investigate the effects of eating wholegrain rye bread with high or low amounts of phytate on iron status in women under free-living conditions. Methods In this 12-week, randomized, parallel-design intervention study,…

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Negative / Null Result Report

Effect of significant data loss on identifying electric signals that precede rupture estimated by detrended fluctuation analysis in natural time

E. S. Skordas, N. V. Sarlis, P. A. Varotsos · 2010 · Chaos: An Interdisciplinary Journal of Nonlinear Science

Electric field variations that appear before rupture have been recently studied by employing the detrended fluctuation analysis (DFA) to quantify their long-range temporal correlations. These studies revealed that seismic electric signal…

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Negative / Null Result ReportOpen accessMedicine

Performance of arthroscopic irrigation systems assessed with automatic blood detection

Gabriëlle J. M. Tuijthof, M. M. de Vaal, I. N. Sierevelt et al. · 2011 · Knee Surgery Sports Traumatology Arthroscopy

PURPOSE: During arthroscopies, bleeding episodes occur as a result of tissue damage. Irrigation systems assist in minimizing these disturbances. The performance of three arthroscopic irrigation systems in clearing bleeding episodes was…

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Negative / Null Result ReportOpen accessNeuroscience

Propensity or diversity? Investigating how mind wandering influences the incubation effect of creativity

Shan-Chuan Teng, Yunn-Wen Lien · 2022 · PLoS ONE

Mind wandering has been argued to be beneficial for breaking through mental impasses, which leads to better creative performance upon a second attempt (i.e., the incubation effect). However, the evidence is inconsistent. Different from the propensity for mind wandering that has been the focus of past studies, in this study we further examined the role of diversity (i.e., non-repetitiveness of mind wandering respective to its content) and types of mind wandering along the dimensions of intentionality and awareness during incubation when engaging in a 0-back task (a mind wandering-prone conditio

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Negative / Null Result ReportOpen accessMedicine

Predicting vaginal birth after previous cesarean: Using machine‐learning models and a population‐based cohort in Sweden

Charlotte Lindblad Wollmann, Kyle D. Hart, Can Liu et al. · 2020 · Acta Obstetricia Et Gynecologica Scandinavica

INTRODUCTION: Predicting a woman's probability of vaginal birth after cesarean could facilitate the antenatal decision-making process. Having a previous vaginal birth strongly predicts vaginal birth after cesarean. Delivery outcome in…

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Negative / Null Result Report

Less risk of conversion to total knee arthroplasty without significant clinical and survivorship difference for opening‐wedge high tibial osteotomies in varus knee deformities at 10‐year minimum follow‐up compared to closing‐wedge high tibial osteotomies

A. Cazor, A. Schmidt, J. Shatrov et al. · 2022 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose The purpose of this study was to evaluate the clinical outcomes and survivorship at minimum 10‐year follow‐up of patients undergoing primary valgisation high tibial osteotomy (HTO) for medial osteoarthritis (OA), treated…

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Negative / Null Result ReportOpen accessComputer Science

Evaluating clinical AI summaries with large language models as judges

Emma Croxford, Yanjun Gao, Elliot First et al. · 2025 · npj Digital Medicine

Electronic Health Records (EHRs) contain vast clinical data that are difficult for providers to synthesize. Generative AI with Large Language Models (LLMs) can summarize records to reduce cognitive burden, but ensuring accuracy requires…

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Negative / Null Result ReportOpen accessMedicine

Effect of Lactobacillus plantarum supplementation on trimethylamine-N-oxide levels in 30 patients with atherosclerotic cardiovascular disease: A double-blind randomized controlled trial

Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica

Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Fundamental Analysis VS Technical analysis: The Comparison of Two Analysis in Malaysia Stock Market

Shaharudin Jakpar, Michael Tinggi, Akmal Hisham Tak et al. · 2018 · UNIMAS Review of Accounting and Finance

This study is conducted to analyse the credibility of the fundamental analysis and technical analysis on predicting the stock return and compare both models to determine which model is more credible to be used as a good trading strategy by…

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Negative / Null Result ReportOpen accessMedicine

Significant Association of Serum Adiponectin and Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction

Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda et al. · 2017 · Journal of Atherosclerosis and Thrombosis

AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact…

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Negative / Null Result Report

Small Social Incentives Did Not Improve the Survey Response Rate of Patients Who Underwent Orthopaedic Surgery: A Randomized Trial

Hunter Warwick, Carolyn Hutyra, Cary Politzer et al. · 2019 · Clinical Orthopaedics & Related Research

Abstract Background The generalizability of data derived from patient-reported outcome measures (PROMs) depends largely on the proportion of the relevant population that completes PROM surveys. However, PROM survey responses remain low,…

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Negative / Null Result ReportOpen accessMedicine

Estimated GFR and Mortality in Older Men: Are All eGFR Formulae Equal?

Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology

<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…

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Negative / Null Result Report

A weakened AMOC may prolong greenhouse gas–induced Mediterranean drying even with significant and rapid climate change mitigation

Thomas L. Delworth, William F. Cooke, Vaishali Naik et al. · 2022 · Proceedings of the National Academy of Sciences

The Mediterranean region has been identified as a climate hot spot, with models projecting a robust warming and rainfall decline in response to increasing greenhouse gases. The projected rainfall decline would have impacts on agriculture…

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Negative / Null Result ReportPsychology

Structured assessment of suicide risk in a psychiatric emergency service: Psychometric evaluation of the Nurses’ Global Assessment of Suicide Risk scale (NGASR)

Mark van Veen, Inge van Weeghel, Bauke Koekkoek et al. · 2014 · International Journal of Social Psychiatry

BACKGROUND: Risk of suicide is notoriously difficult to assess, and no gold standard is available, in terms of an instrument of first choice. Many different instruments are in use, among which are some that are not properly…

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Negative / Null Result ReportOpen accessMedicine

Cystatin C– and Creatinine-Based Estimates of Renal Function and Their Value for Risk Prediction in Patients with Acute Coronary Syndrome: Results from the PLATelet Inhibition and Patient Outcomes (PLATO) Study

Axel Åkerblom, Lars Wallentin, Anders Larsson et al. · 2013 · Clinical Chemistry

BACKGROUND: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular death or myocardial infarction (MI) and can be estimated by creatinine and cystatin C concentrations. We evaluated 2 different cystatin C…

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Negative / Null Result ReportOpen accessMedicine

The American Association for the Surgery of Trauma renal injury grading scale: Implications of the 2018 revisions for injury reclassification and predicting bleeding interventions

Sorena Keihani, Douglas Rogers, Bryn Putbrese et al. · 2019 · The Journal of Trauma: Injury, Infection, and Critical Care

BACKGROUND: In 2018, the American Association for the Surgery of Trauma (AAST) published revisions to the renal injury grading system to reflect the increased reliance on computed tomography scans and non-operative management of high-grade…

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Negative / Null Result Report

Anomalous metals: From “failed superconductor” to “failed insulator”

Xinyang Zhang, Alexander Palevski, Aharon Kapitulnik · 2022 · Proceedings of the National Academy of Sciences

Resistivity saturation is found on both superconducting and insulating sides of an “avoided” magnetic-field-tuned superconductor-to-insulator transition (H-SIT) in a two-dimensional In/InO x composite, where the anomalous metallic behavior…

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Negative / Null Result ReportSocial Sciences

Do minority-language and majority-language students benefit from pedagogical translanguaging in early foreign language development?

Holger Hopp, Teresa Kieseier, Jenny Jakisch et al. · 2021 · Multilingua

Abstract This paper reports findings of a project on pedagogical translanguaging (PTL) among 128 fourth-grade students learning English as a foreign language (EFL) in German primary schools. Over a period of six months, 20% of lesson time…

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Negative / Null Result ReportOpen accessMedicine

GLP-1 and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential

Osama Sobhi Moaket, Sarah Eyad Obaid, Fawaz Eyad Obaid et al. · 2025 · International Journal of Molecular Sciences

Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive neuronal dysfunction and loss, yet current treatments remain largely symptomatic with limited disease-modifying efficacy. Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. Its receptor, GLP-1R, is expressed in key brain regions implicated in cognition, emotion, and motor control, including the hippocampus, frontal cortex, and substantia nigra. GLP-1R a

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Negative / Null Result ReportOpen accessMedicine

Overcoming resistance to PD-1 and CTLA-4 blockade mechanisms and therapeutic strategies

Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology

Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen

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Negative / Null Result ReportOpen accessSocial Sciences

The Effects of Board Diversity on Korean Companies’ ESG Performance

Ahmet Jeyhunov, Jong Dae Kim, Seong Mi Bae · 2025 · Sustainability

This paper explores the effect of board diversity on environmental, social, and governance (ESG) performance in Korean-listed firms using regression analysis. Our findings reveal that an increased board size significantly correlates with higher ESG scores when combined with other board diversity dimensions. The presence of female directors on boards was found to have a significant effect on environmental and social components of ESG performance. Age diversity exhibits a negative association with ESG scores, emphasizing potential disruptions from intergenerational differences. Foreign directors

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Negative / Null Result ReportOpen accessNeuroscience

V01.05 — Mirror Mathematics II: Minimal Observer Thresholds

Lloyd Christopher Smith · 2026 · Zenodo (CERN European Organization for Nuclear Research)

This paper forms part of Mirror Programme, Volume I: Observerhood. Mirror Mathematics II develops the formal threshold layer of the Mirror Mathematics arc. Building on Mirror Mathematics I, it asks when a self-model becomes observer-relevant rather than merely predictive, self-referential or descriptive. The paper introduces a minimal Mirror observer predicate grounded in self-model reliability, action-guidance, cost-sensitive repair and positive viability coupling under perturbation. The central condition is expressed through a salience functional measuring whether the expected viability bene

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Negative / Null Result ReportOpen accessEngineering

Tailoring nanoscale interfaces for perovskite–perovskite–silicon triple-junction solar cells

Jianghui Zheng, Guoliang Wang, Leiping Duan et al. · 2025 · Nature Nanotechnology

Abstract Triple‐junction solar cells theoretically outperform their double-junction and single‐junction counterparts in power conversion efficiency, yet practical perovskite–perovskite–silicon devices have fallen short of both theoretical limits and commercial targets. To address surface defects in the top perovskite junction, we introduce a piperazine-1,4-diium chloride treatment, which replaces less stable lithium fluoride. For interfacing the top and middle perovskite junctions, we optimize the size of gold nanoparticles deposited on atomic layer-deposited tin oxide for best ohmic contactin

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