Negative / Null Result ReportOpen accessPhysiology
Lin Chang, Silin Fu, Jianghua Li et al. · 2022 · Frontiers in Physiology
Background: Knee injury is common in half-marathon runners, however, the effect of compression running pants on fatigue and knee proprioception remains unclear.Objectives: The study aims to investigate whether wearing compression running pants (CRP) and treadmill running stages affect knee proprioception and fatigue-related physiological responses during half-marathon running.Methods: Eighteen half-marathon runners completed two self-paced 21 km treadmill running trials, once wearing CRP and once wearing loose running shorts (LRS). For each 21 km run, RPE, heart rate, blood lactic acid, and kn
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Yu. A. Dyleva, O. V. Gruzdeva, E. V. Belik et al. · 2023 · Ожирение и метаболизм
BACKGROUND: The information available to date on the effect of metformin on the transcriptome and secretory capacity of adipocytes in human adipose tissue (AT) is scarce and contradictory. The study analyzed whether metformin in vitro modulates gene expression and secretion of adiponectin and leptin in the AT of subcutaneous (SAT), epicardial (EAT) and perivascular (PVAT) localization of patients with ischemic artery disease (IHD).AIM: To assess the effect of metformin at various concentrations (1 and 10 mmol / L) on the level of expression of adiponectin and leptin genes and their content in
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Mahmoud A. Mohammad, Inka C. Didelija, Barbara Stoll et al. · 2020 · Physiological Reports
Abstract Background Age‐dependent changes in the intestinal gene expression of enzymes involved in the metabolism of citrulline and arginine are well characterized. Enteroids, a novel ex‐vivo model that recreates the three‐dimensional structure of the intestinal crypt‐villus unit, have shown to replicate molecular and physiological profiles of the intestinal segment from where they originated (“location memory”). Objective The present study tested the hypothesis that enteroids recapitulate the developmental changes observed in vivo regarding citrulline production in pigs (“developmental memory
View details →Negative / Null Result ReportOpen accessPhysiology
Chunwei Ma, Chunwei Ma, Yongcai Zhao et al. · 2022 · Frontiers in Physiology
Hypoxic training improves the microcirculation function of human skeletal muscle, but its mechanism is still unclear. Silent information regulator 2 homolog 3 (Sirt3) can improve mitochondrial function and oxidative status. We aimed to examine the role of Sirt3 in the process of hypoxic training, which affects skeletal muscle microcirculation. C57BL/6 mice were assigned to control (C), hypoxic training (HT), Sirt3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP), and 3-TYP + hypoxic training (3-TYP + HT) groups (n = 6/group). Sirt3 inhibition was induced by intraperitoneal injection of Sir
View details →Negative / Null Result ReportOpen accessPhysiology
Ryan M. Corrick, Huiyin Tu, Dongze Zhang et al. · 2018 · Frontiers in Physiology
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexameth
View details →Negative / Null Result ReportOpen accessPhysiology
Mazen Samie Hassn · 2018 · مجلة الرافدين للعلوم الرياضية
The subject of the research focuses on identifying the differences between the three attempts to test the viability of VC and the contribution of age ratios, and some anthropometric measurements in the best bioenergy test. It also aims to adjust a regression model to predict the biological capacitance in relation to age and some anthropometric variables. The researcher hypothesizes that there are no significant differences between the three tests of the vital capacity, and that the coefficients of the regression model for linear regression equation in the biomass test are not different from ze
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