Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Jakub Droś, Katarzyna Kowalska, Paulina Pasińska et al. · 2023 · BMC Neurology
Abstract Background Cognitive impairment is a common complication of the acute phase of stroke, which can be transient and resolve while still in the hospital. This study evaluated the prevalence and risk factors for transient cognitive impairment and their impact on long-term prognosis in a population of acute-phase stroke patients. Methods Consecutive patients admitted to a stroke unit with acute stroke or transient ischemic attack were screened twice for cognitive impairment using the parallel version of Montreal Cognitive Assessment: the first time between the first and third day and the s
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Minghui Lu, Jiajun Wei, Qiang Cai · 2026 · Frontiers in Neurology
BackgroundThe optimal timing for tracheostomy in patients with intracerebral hemorrhage extending into the ventricles who require mechanical ventilation remains controversial, and there is a paucity of evidence to guide clinical practice. This study aimed to elucidate the impact of early vs. late tracheostomy on clinical outcomes and complications in this population, utilizing multivariable models to identify risk factors and define the potential beneficiary population.MethodsThis single-center retrospective cohort study consecutively enrolled 157 patients with severe spontaneous intracerebral
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Aleš Kopal, Eva Mejzlíková, Jana Lízrová Preiningerová et al. · 2015 · Parkinson's Disease
Parkinson’s disease (PD) is characterized by motor and nonmotor symptoms. Nonmotor symptoms include primarily visual hallucinations (VH). The aim of our study was to establish whether patients with PD and visual hallucinations (PDH+) have structural changes of retina detected by an optical coherence tomography (OCT) in comparison with PD patients without visual hallucinations (PDH−). We examined 52 PD patients (18 with VH, 34 without VH) and 15 age and sex matched healthy controls. Retinal nerve fiber layer (RNFL) thickness and macular thickness and volume were assessed by OCT. Functional impa
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Anqi Wang, Anqi Wang, Xuan Meng et al. · 2024 · Frontiers in Neurology
ObjectiveTo determine the efficacy of mechanical thrombectomy combined with prolonged mild hypothermia compared with conventional treatment in managing acute middle cerebral artery occlusion, and to explore whether extending the duration of hypothermia can improve neurological function.MethodFrom 2018 to June 2023, a retrospective analysis was conducted on 45 patients with acute middle cerebral artery occlusion treated at the NICU of Suzhou Kowloon Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. After thrombectomy, patients were admitted to the neurological intensiv
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Mengyun Li, Qing Zhang, Xu Wang et al. · 2024 · Frontiers in Neurology
ObjectiveThis study aimed to analyze the clinical characteristics and prognosis of patients with autoimmune encephalitis (PWAE) who experienced seizures during the acute phase.MethodsClinical data were collected from 84 patients diagnosed with AE at the General Hospital of Ningxia Medical University between January 2015 and January 2023. Patients were divided into seizure and non-seizure groups. Clinical characteristics of both groups were compared, including differences between anti-NMDAR and anti-LGI1 encephalitis within the seizure group. Due to the limited sample size and to avoid overfitt
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Eva B. Aamodt, Martin Røvang, Mona K. Beyer et al. · 2026 · Frontiers in Neurology
BackgroundMeasures of white matter hyperintensities (WMHs) represent a crucial part of post-stroke outcome prediction. Automatic WMH segmentation has proven particularly challenging in stroke cases. Using an improved method for WMH segmentation that incorporates stroke lesions, we set out to explore factors associated with higher WMH burden, as well as the association between WMH burden and post-stroke dependency across two different countries that may demonstrate significant variation in radiological presentation.MethodsA total of 384 acute ischemic stroke (AIS) survivors from the Norwegian C
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Akçay ÖVÜNÇ ÖZÖN, Erhan BİLİR · 2015 · Archives of Epilepsy
Objectives:Epileptic seizures diagnosed wth clinical and electroencephalographic (EEG) signs were classified according to ILAE 1981, Lüders, and ILAE 2001 systems in the present study, the aim of which was to compare classification systems by means of preictal and postictal consistency, and to determine deficiencies of the classification systems.Methods:In the present study, 50 patients who had epileptic seizures during monitorization were evaluated by a single observer at the Gazi University Medical Faculty Long-Term Video-EEG Monitorization Unit between March 2003 and September 2004. Seizure
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Arima Kunimasa, Hori Hiroaki, Shizuno Tomoko et al. · 2006 · Behavioral and Brain Functions
Abstract Background Vesicular monoamine transporters (VMATs) mediate accumulation of monoamines such as serotonin, dopamine, adrenaline, and noradrenaline from the cytoplasm into storage organelles. The VMAT1 (alternatively solute carrier family 18: SLC18A1) regulates such biogenic amines in neuroendocrine systems. The VMAT1 gene maps to chromosome 8p21.3, a locus with strong evidence of linkage with schizophrenia. A recent study reported that a non-synonymous single nucleotide polymorphism (SNP) of the gene (Pro4Thr) was associated with schizophrenia. Methods We attempted to replicate this fi
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Seiichi Watanabe, Takamichi Taniguchi, Motoko Sugihara · 2021 · Schizophrenia Research: Cognition
This study investigated the effects of the bias known as jumping to conclusions (JTC) on objective functional outcomes as well as subjective assessments of quality of life (QoL) and personal recovery among a sample of patients diagnosed with schizophrenia. Specifically, this study assessed the variables of JTC, psychiatric symptoms, neurocognitive functioning, objective interpersonal and daily activities, vocational domains, subjective QoL, and personal recovery among 94 participants. Results showed that those in the JTC group had significantly lower neurocognitive and functional outcomes (mod
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Michael Christian Leitner, Michael Christian Leitner, Michael Christian Leitner et al. · 2023 · Frontiers in Neurology
IntroductionA significant number of Restitution Training (RT) paradigms claim to ameliorate visual field loss after stroke by re-activating neuronal connections in the residual visual cortex due to repeated bright light-stimulation at the border of the blind and intact fields. However, the effectiveness of RT has been considered controversial both in science and clinical practice for years. The main points of the controversy are (1) the reliability of perimetric results which may be affected by compensatory eye movements and (2) heterogeneous samples consisting of patients with visual field de
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Cecilia Higgs, James E. Hilbert, Libby Wood et al. · 2019 · Frontiers in Neurology
Introduction: Recent evidence demonstrates that women with myotonic dystrophy type 1 are at increased risk of reproductive organ tumors. However, studies of reproductive cancer risk factors in those patients are lacking.Methods: Using questionnaires, we collected and analyzed personal history information related to cancer risk factors from women enrolled in a UK and US registry for myotonic dystrophy (dystrophia myotonica; DM) patients.Results: The survey was completed by 242 DM type 1 (DM1) and 44 DM type 2 (DM2) women enrolled in the UK Registry (N = 124) and the US National Registry (N = 16
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Grisel J. Lopez, Jens Lichtenberg, Nahid Tayebi et al. · 2022 · Frontiers in Neurology
ObjectiveBiallelic mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase, cause the lysosomal storage disorder Gaucher disease (GD). In addition, mutations in GBA1 are the most common genetic risk factor for future development of Parkinson's disease (PD). However, most mutation carriers will never develop parkinsonism. Olfactory dysfunction is often a prodromal symptom in patients with PD, appearing many years prior to motor dysfunction. The purpose of this study was to assess olfactory function longitudinally in individuals with and without parkinsonism who carry at least o
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Katrin Abram, Silvia Bohne, Peter Bublak et al. · 2016 · Dementia and Geriatric Cognitive Disorders Extra
Background/Aims: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. Methods: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test. Results: The gait score showed a significant improvement 24 h after spinal tap test in al
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Megan Kristy Herbert, Marjolein B Aerts, Marijke eBeenes et al. · 2015 · Frontiers in Neurology
The differentiation between multiple system atrophy (MSA) and Parkinson’s disease (PD) is difficult, particularly in early disease stages. Therefore, we aimed to evaluate the diagnostic value of neurofilament light chain (NFL), fms-like tyrosine kinase ligand (FLT3L) and total tau protein (t-tau) in cerebrospinal fluid (CSF) as biomarkers to discriminate MSA from PD. Using commercially available enzyme-linked immunoassays (ELISAs), we measured CSF levels of NFL, FLT3L and t-tau in a discovery cohort of 36 PD patients, 27 MSA patients and 57 non-neurological controls and in a validation cohort
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Michał Sobstyl, Nina Kożuch, Magdalena Iwaniuk-Gugała et al. · 2023 · Epilepsy & Behavior Reports
Progressive myoclonic epilepsy (PME) is characterized by prominent myoclonus, generalized tonic-clonic seizures, and less often focal, tonic, or absence seizures. The KCNC1 mutation is responsible for specific clinical phenotype of PME which has been defined as myoclonic epilepsy and ataxia due to potassium channel mutation (MEAK). We present a case of a 44 years-old male patient with genetically proven MEAK who underwent subthalamic nucleus/substantia nigra (STN/SNr) deep brain stimulation (DBS) for his pharmacological-refractory myoclonus and drug-resistant epilepsy (DRE). Since the age of 4
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Sylvain Rheims, Vania Herbillon, Ségolène Gaillard et al. · 2024 · Epilepsia Open
Abstract Background Attention‐deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n‐3 Fatty Acid (PUFA) has been proposed as an alternative therapeutic approach in ADHD without epilepsy but has never been evaluated in epilepsy‐associated ADHD. Methods A multicenter double blind randomized placebo‐controlled trial evaluating supplementation with PUFA, in eicosapentaenoic‐ and docosahexaenoic‐acid form, conjugated to a phospholipi
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Qin Zhang, Qin Zhang, Qin Zhang et al. · 2022 · Frontiers in Neurology
ObjectiveVertigo is very common in children, but the specific diagnosis and characteristics are not clear. The main objective of this study was to analyze the characteristics of caloric test (CT) and video head impulse test (vHIT) in vestibular migraine of childhood (VMC), probable vestibular migraine of childhood (PVMC), and recurrent vertigo of childhood (RVC), which can provide a reference value for their clinical diagnosis.MethodsWe selected VMC, PVMC and RVC patients under 18 years of age from the outpatient Department of Otolaryngology–Head and Neck Surgery between May 2021 and August 20
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Shoji Kawashima, RCIP-Nagoya Study Group, Noriyuki Matsukawa · 2022 · BMC Neurology
Abstract Background Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition. The visuospatial n-back test is useful for assessing both domains. The 0-back test reflects visuospatial recognition, while the 1-back and 2-back tests reflect working memory. Cholinesterase inhibitors are effective in the treatment of PD-MCI and dementia in PD (PDD). Although some studies have reported the efficacy of memantine for PDD, the therapeutic efficacy of mema
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yangyang Guo, Bingyang Zhang, Lianmei Zhong et al. · 2026 · Frontiers in Neurology
BackgroundIntracranial and/or extracranial atherosclerotic stenosis is a common etiology of acute ischemic stroke (AIS). This study aimed to evaluate the impact of intracranial or extracranial atherosclerotic stenosis on early neurological deterioration (END), hemorrhagic transformation (HT) and 90-day clinical outcomes in patients receiving intravenous thrombolysis.MethodsWe retrospectively enrolled patients with AIS who received intravenous alteplase (0.9 mg/kg) at the First Affiliated Hospital of Kunming Medical University between February 2019 and August 2022. Data on demographics, stroke
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Xing Zhang, Xiao-He Hou, Ya-Hui Ma et al. · 2020 · BMC Neurology
Abstract Background Inflammation plays an important role in atherosclerosis but the contribution of neutrophils to this process is unclear. We sought to assess whether neutrophil count is associated with intracranial atherosclerotic stenosis (ICAS). Methods A total of 2847 individuals were included in our study, including 1363 with acute ischemic stroke and 1484 normal controls without stroke. The presence of ICAS was confirmed by magnetic resonance angiography. The association between neutrophil count and ICAS was evaluated by multivariable logistic regression analysis. Results Among 2847 ind
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yiyi Chen, Yiyi Chen, Yiyi Chen et al. · 2021 · Frontiers in Neurology
Background: High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds.Methods: We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. The data were collected from 30 hospitals in China and included 1,098 patients w
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Naoya Hasegawa, Masafumi Fukuda · 2020 · Epilepsy & Behavior Reports
We investigated the efficacy of lacosamide (LCM) polytherapy in improving seizure outcomes and psychiatric symptoms in patients with epilepsy with psychiatric comorbidities. We retrospectively collected data from medical records of outpatients of the Department of Psychiatry of Nishiniigata Chuo Hospital Epilepsy Center in Japan. We extracted data from all patients with epilepsy and psychiatric comorbidities who had been treated with LCM. We evaluated seizure prognosis and changes in psychiatric symptoms after LCM polytherapy. After LCM administration, 19 (47.5%) patients had improvements in s
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Kollipara Sumanth, Uma Sinharoy, Anindita Joardar et al. · 2026 · Annals of Indian Academy of Neurology
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Josef Pannee, Leslie M. Shaw, Magdalena Korecka et al. · 2021 · Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Abstract Introduction Blood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)–based assays currently used in clinical settings. In this study, we examined different blood‐based assays to measure Aβ and how they compare among centers and assays. Methods Aliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass‐spectrometric methods were used to measure plasma Aβ concentrations. Results Correlations were weak for Aβ42 while Aβ40 correlations were stronger. The rati
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Bilge Kocer, Hayat Guven, Isik Conkbayir et al. · 2016 · Parkinson's Disease
Factors related with hyperhomocysteinemia (HHcy) and the impact of HHcy in Parkinson’s disease (PD) are not well understood. We investigated the factors associated with increased levels of homocysteine (Hcy) and the relationship between HHcy and motor symptoms, cognitive status, and vascular risk in patients with Parkinson’s disease. Among 60 patients (29 males, 48.3%) with PD, the stage of the disease, the severity of clinical symptoms, and the patients’ cognitive status were measured using a modified Hoehn and Yahr Staging Scale (mHY), Unified Parkinson’s Disease Rating Scale (UPDRS) II and
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Jian Sun, Zhiyong Shi, Lebao Yu et al. · 2022 · BMC Neurology
Abstract Objective To explore potential risk factors of preoperative cognitive dysfunction in adult patients with moyamoya disease (MMD) and discuss significance of moyamoya vessels. Methods The author reviewed adult MMD patients harboring no parenchymal infarction or hemorrhage underwent a standardized neuropsychological assessment test battery from December 2018 to May 2019. The authors defined patients with cognitive dysfunction as cognitive impairment shown on 3 or more neuropsychological tests. According to the presence of cerebral angiography, arterial stenosis, moyamoya vessels, and com
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Ganeshgouda Majigoudra, Ashish K Duggal, Debashish Chowdhury et al. · 2023 · Annals of Indian Academy of Neurology
Background: Myasthenia Gravis (MG) is a chronic fluctuating illness, due to the dysfunction of neuromuscular junction which is autoimmune in nature. The disease severely affects the Quality Of Life (QOL). Objective: The primary objective of our study was to assess the QOL in patients with MG using Short Form 36 (SF 36) and MGQOL 15 R (Hindi translated).The secondary objective was to assess the correlation of age, sex, illness duration, clinical characteristics, severity, and treatment with the QOL in MG patients. Methodology: A cross sectional study of 55 MG patients was done to analyse and ev
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki et al. · 2002 · BMC Neurology
Abstract Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. Methods Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Filippo Mandelli, Filippo Mandelli, Filippo Mandelli et al. · 2021 · Frontiers in Neurology
Objective: Fatty infiltration of paraspinal muscle is associated with spinal disorders. It can be assessed qualitatively (i.e., Goutallier classification) and quantitatively using image processing software. The aims of this study were to compare paraspinal muscle fatty infiltration as assessed using the Goutallier classification vs. quantitative magnetic resonance images (MRI) measurements and to investigate the association between anthropometric parameters and paraspinal muscle morphology and fatty infiltration in patients with symptomatic lumbar spinal stenosis (LSS).Methods: Patients affect
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
杨江胜，朱祖福，高志强，陆强彬，周国庆，方琪 · 2018 · Zhongguo cuzhong zazhi
目的 探讨高龄轻型缺血性卒中3 h内行阿替普酶静脉溶栓治疗的疗效及安全性。 方法 将我院2015年10月-2017年10月连续收治入院的发病3 h内48例高龄急性轻型缺血性卒中患者 随机分为阿替普酶静脉溶栓组24例和未溶栓组24例。比较两组患者入院时的一般情况，基线美国 国立卫生研究院卒中量表（National Institutes of Health Stroke Scale，NHISS）评分，治疗24 h后颅内出 血转化率，治疗后90 d改良Rankin量表（modified Rankin Scale，mRS）评分及90 d病死率。 结果 阿替普酶静脉溶栓组和未溶栓组患者一般临床资料、基线NIHSS评分比较，差异无统计学意 义。阿替普酶静脉溶栓组和未溶栓组治疗24 h后颅内出血转化率分别为4.17%和0（P =1.000），两组 90 d病死率均为4.17%（P =1.000），阿替普酶静脉溶栓组及未溶栓组90 d mRS评分为0～2分的比率 分别为83.33%和54.17%（P =0.029）。 结论 早期阿替普酶静脉溶栓治疗高龄急性轻型缺血性卒中不增加急性期颅内出血转化的风险， 可以改善高龄轻型缺血性卒中患者预后，不增加病死率。 Abstract: Objective To investigate the efficacy and safety of alteplase i
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