83 real negative results, null findings, and replication failures in Medicine · Methods Dead-End. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Janne Estill, Matthias Egger, Nello Blaser et al. · 2013 · AIDS
BACKGROUND: Monitoring of HIV viral load in patients on combination antiretroviral therapy (ART) is not generally available in resource-limited settings. We examined the cost-effectiveness of qualitative point-of-care viral load tests…
View details →Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore et al. · 2023 · Journal of Clinical Medicine
Insufficiently treated shoulder pain may cause mental disturbances, including depression and anxiety. The Hospital Anxiety and Depression Scale (HADS) is a patient-reported outcome measure (PROM) that aims to identify depression and anxiety in patients in nonpsychiatric wards. The aim of this study was to identify the minimum clinically important difference (MCID) and patient acceptable symptom state (PASS) scores for the HADS in a cohort of individuals with rotator cuff disease. Using the HADS, participants' degrees of anxiety and depression were assessed at inception and at their final asses
View details →Koretz RL · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review To assess the quality of recently published (18 months from date of article request) randomized trials/systematic reviews of such trials that addressed the use of nutritional support in critically ill patients. Recent…
View details →Dirican EK · 2026 · Journal of assisted reproduction and genetics
Background Operator-dependent laboratory tasks-embryo selection, vitrification and warming, and intracytoplasmic sperm injection (ICSI)-have been the principal targets of IVF laboratory automation, and a fourth strand of work, integrated…
View details →Wierzbicki AS · 2025 · Expert opinion on pharmacotherapy
Introduction Lipid-lowering therapies are well established for the treatment of cardiovascular disease (CVD). Historically monotherapy studies have been performed, but the introduction of statins has led to these drugs being recognized as…
View details →Aslam A, Kamran M, Siddiqui S · 2026 · Frontiers in public health
Introduction One of the most widely studied topic in the educational research is teacher's wellbeing and rightly so, as resilient and well-supported teacher serves as an essential pillar for creating an effective and durable educational…
View details →Batista DJ, da Conceição AS · 2026 · Journal of voice : official journal of the Voice Foundation
Objectives This study aims to explore the convergence between objective acoustic measures and qualitative spectrographic analysis in the evaluation of the effects of an expressiveness-oriented training program in journalism students.…
View details →Barzaghi L, Paoletti M, Monforte M et al. · 2024 · Muscle & nerve
Introduction/aims Muscle diffusion tensor imaging has not yet been explored in facioscapulohumeral muscular dystrophy (FSHD). We assessed diffusivity parameters in FSHD subjects compared with healthy controls (HCs), with regard to their…
View details →Peters D, Crome M, Vach K et al. · 2026 · GMS journal for medical education
Objective With the regulation for the reorganization of dental education, the legislature restructured dental studies and among other things, called for a strenghtening of interdisciplinary training. This requirement was the basis for the…
View details →Sabucedo-Suárez A, Muñoz F, Permuy M et al. · 2026 · Frontiers in veterinary science
Osteoarthritis is a chronic degenerative joint disease that affects cartilage and subchondral bone, and there is growing interest in nutraceuticals such as avocado-soybean unsaponifiables as potential disease-modifying agents and possible…
View details →Sun X, Yan T, Li Z et al. · 2023 · Nutrients
(1) Background: We investigated the effects of a 12-week exercise intervention with or without vitamin D supplementation on insulin resistance and the plasma lipidome of participants with type 2 diabetes. We further explored whether the…
View details →Zadrożniak M, Biskupski M, Szymański M et al. · 2025 · Antioxidants (Basel, Switzerland)
(1) Aminoglycosides remain indispensable in modern medicine but share a serious dose-limiting adverse effect: irreversible cochleovestibular ototoxicity. (2) This scoping review systematically maps experimental and clinical strategies…
View details →Hatch-McChesney A, Whitney CC, Richardson M et al. · 2024 · Appetite
Consuming enough energy to meet high energy demands can be challenging for military personnel wherein logistical constraints limit food availability. Increasing dietary energy density (ED) and/or volume density (VD) of rations may be…
View details →Dugan L, Rei KM, Ueno A et al. · 2025 · The Permanente journal
Introduction Simulation labs provide trainees the opportunity to practice procedures in a safe, controlled, nonjudgmental environment. It is unclear which teaching method leads to the highest levels of trainee skill competency when…
View details →Dexter F, Rolfzen ML, Hoffman J et al. · 2025 · Anesthesia and analgesia
Background Earlier studies have not examined the extent to which reducing postoperative opioid use after patient discharge would improve the quality of life of opioid naïve patients, knowledge needed for economic evaluations of drugs and…
View details →Dogruoz F, Askin A, Ergun A et al. · 2026 · Journal of clinical medicine
Background/Objectives: The extent to which patient-reported outcome measures (PROMs) reflect objective functional recovery after surgical repair of acute Achilles tendon rupture remains unclear. This study aimed to evaluate the…
View details →Deng D, Shiotani H, Kawakami Y · 2025 · Journal of anatomy
Quantifying strain in the free Achilles tendon (AT F ) is essential for understanding its mechanical function, yet existing in vivo studies report inconsistent strain values, even under comparable loading. These discrepancies are partly…
View details →Psaltis PJ, Nguyen MT, Singh K et al. · 2025 · Cardiovascular research
Aims Low-dose colchicine reduces the risk of cardiovascular events after myocardial infarction (MI). The purpose of this study was to assess the effect of colchicine post-MI on coronary plaque morphology in non-culprit segments by optical…
View details →Kardjadj M, Chang TW, Chavez R et al. · 2025 · Microorganisms
Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. This multicenter, randomized,…
View details →Adhikari S, Eldfors S, Pitkänen E et al. · 2025 · Computational and structural biotechnology journal
Background Acute myeloid leukemia (AML) progresses by the accumulation of somatic mutations and clonal expansion of pre-leukemic cells. Patients may respond to initial therapy, but often relapse, underscoring an evolving disease. Next…
View details →Grant RC, He JC, Liu N et al. · 2025 · JAMA oncology
Importance Cisplatin is a widely used treatment for cancer that can permanently damage the kidneys. Treatment modifications and other strategies may prevent chronic kidney disease (CKD) in patients at risk; however, the incidence and…
View details →Artal JM, Randall L, Rubeck S et al. · 2025 · American journal of medical genetics. Part A
Parents of children with Down syndrome have historically reported poor experiences receiving a prenatal diagnosis. In a 2003 survey, mothers reported that their physicians pitied them, emphasized negative aspects of Down syndrome, and…
View details →Elizabeth R Sharp, Christian B Willberg, Peter J Kuebler et al. · 2011 · PLoS ONE
HIV-1 vertically infected children in the USA are living into adolescence and beyond with the widespread use of antiretroviral drugs. These patients exhibit striking differences in the rate of HIV-1 disease progression which could provide insights into mechanisms of control. We hypothesized that differences in the pattern of immunodomination including breadth, magnitude and polyfunctionality of HIV-1 specific CD8+ T cell response could partially explain differences in progression rate.In this study, we mapped, quantified, and assessed the functionality of these responses against individual HIV
View details →Lambert SJ, Lunde B, Porsch L et al. · 2024 · Contraception
Objectives This study aimed to compare effectiveness and safety of cervical preparation with osmotic dilators plus same-day misoprostol or overnight mifepristone prior to dilation and evacuation (D&E). Study design We conducted a…
View details →Li Y, Yan X, Li J et al. · 2026 · Ultrasound in medicine & biology
Objectives This study aimed to establish a machine-learning model that integrates contrast-enhanced ultrasound (CEUS) radiomics, conventional ultrasound (US) radiomics and clinical features for distinguishing mummified thyroid nodules…
View details →Potkrajcic V, Wahl D, Frantz S et al. · 2026 · Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
Background Postoperative radiotherapy following surgical stabilization in patients with bone metastases is commonly recommended. The aim of the study was to validate existing prognostic scores and parameters for local control and survival…
View details →Gulamani A, Shamim F, Khan S et al. · 2026 · International journal of oral and maxillofacial surgery
The Clinical Assessment Scoring System for Tracheostomy (CASST) was developed to predict the need for elective tracheostomy in head and neck cancer surgery, but evidence on its external performance remains limited. This prospective study…
View details →Saluja A, Eschert J, Ren R et al. · 2026 · The Journal of arthroplasty
Background Total hip arthroplasty (THA) is commonly performed for Crowe I developmental dysplasia of the hip (DDH) and primary osteoarthritis (OA), but comparative survivorship and patient-reported outcome measure (PROM) data remain…
View details →Fan L, Li Z, Chang L et al. · 2026 · Scientific reports
Traditional thermal comfort models often fail to capture the dynamic neurophysiological complexity of outdoor human perception. This study introduces a neurophysiological approach to investigate how Sky View Factor (SVF) modulates human…
View details →Rukhsana Tumrani, S. Sabahat Haider, Mehvish Sana · 2024 · Pakistan Journal of Medical Research
Background: Serum electrolytes are one of the most frequently requested tests in patients from critical care settings. Methodsfor estimation of serum electrolytes include direct and indirect ion selective electrode (ISE). In case of indirect ISE, the pre-analytical dilution step can result in pseudonormonatremia or pseudohypernatremia in setting of hypoalbuminemia. Discrepancy in sodium results can lead to the misdiagnosis and mismanagement of critically ill patients. Objective: To evaluate the difference of mean serum sodium level measured by direct and indirect ISE in critically ill patients
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