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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Real-World Outcomes of Upadacitinib Versus Risankizumab Among Anti-TNF Exposed Patients with Crohn's Disease.

McShane, Olivera, Candido et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

The optimal sequencing of therapy following anti-tumor necrosis factor (TNF) inhibitor failure in Crohn's disease (CD) remains uncertain. We compared the effectiveness of upadacitinib (UPA) versus risankizumab (RSZ) in patients with active…

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Negative / Null Result ReportMedicine

Exploratory Evaluation of Photon-Counting CT for Bone Marrow Edema Detection Across Multiple Joints: A Pilot Study.

Shahzadi, Reimann, Schneider et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

To retrospectively evaluate the diagnostic performance and confidence of photon-counting computed tomography (PCCT) for detecting bone marrow edema (BME) in trauma patients, using magnetic resonance imaging (MRI) as the reference standard.…

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Negative / Null Result ReportMedicine

The TargetEd MAnageMent Intervention for Reducing Stroke Risk in Black Men: A 6-Month Prospective Randomized Controlled Trial.

Sajatovic, Still, Burant et al. · 2026 · International journal of aging & human development

This 6-month randomized controlled trial compared TEAM, a group intervention to reduce stroke risk versus a 6-month wait-list control in Black men with stroke or transient ischemic attack. The primary outcome was the change from baseline…

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Negative / Null Result ReportMedicine

Impact of Diabetes on the Efficacy of Low-Voltage Area Ablation for Persistent Atrial Fibrillation: A Subanalysis of the SUPPRESS-AF Trial.

Ozaki, Inoue, Mishima et al. · 2026 · Journal of the American Heart Association

The potential value of low-voltage area (LVA) ablation for persistent atrial fibrillation (AF) has been suggested. However, its efficacy determinants remain unclear. We investigated the impact of diabetes on the outcomes of LVA ablation in…

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Negative / Null Result ReportMedicine

Morphometric Analysis of Lateral Nasal Wall and Pterygomaxillary Junction in Class II and III Skeletal Malocclusions: Implications for Orthognathic Surgical Strategy.

Pergel, Akkoyun · 2026 · The Journal of craniofacial surgery

In Le Fort I osteotomy, precise anatomic knowledge is essential to minimize intraoperative bleeding, particularly during lateral nasal wall osteotomy (LNO) and pterygomaxillary junction (PMJ) separation. This study aimed to evaluate the…

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Negative / Null Result ReportMedicine

Predictive Value of Neutrophils, Lymphocytes, Platelets, Neutrophil-Lymphocyte Ratio (NLR), and Platelets-Lymphocyte Ratio (PLR) in Preterm Labor: Single and Combined Indices.

Elmaradny, Aman, Alaskar et al. · 2026 · Obstetrics and gynecology international

Maternal neutrophils (N), lymphocyte, platelets (PLTs), neutrophil-lymphocyte ratio (NLR), and platelets-lymphocyte ratio (PLR) have been used to predict preterm birth. We studied changes in these markers in preterm labor (PTL) and whether…

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Negative / Null Result ReportMedicine

Prospective MRI-Based Comparison of Graft Maturation After ACL Reconstruction Using Quadriceps Versus Hamstring Tendon Autograft.

Erden, Ağır, Kayaalp et al. · 2026 · Orthopaedic journal of sports medicine

Biological graft maturation after anterior cruciate ligament (ACL) reconstruction is a prolonged and heterogeneous process that may not directly correlate with clinical recovery. Magnetic resonance imaging (MRI)-based signal intensity…

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Negative / Null Result ReportMedicine

Mortality Outcome Post-MI after PCI and CABG Interventions.

Al-Naqdi, Alkhammasi, Al-Naqdi · 2026 · Global heart

Worldwide, heart-related conditions, including myocardial infarction (MI), persist as the leading cause of morbidity and mortality. The aim is to compare three-year mortality outcomes and identify causes of death among post-MI patients who…

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Negative / Null Result ReportMedicine

The effect of velocity-based strength training on lower limb maximal strength, power, and muscle thickness: a comparative study of sex-specific adaptations.

Guo, Suo, Xue et al. · 2026 · Frontiers in physiology

This study aims to explore the effects of Velocity-Based Strength Training (VBT) on lower-limb strength, power, and muscle thickness in athletes of different sexes. It aims to identify sex-specific differences in training adaptations and…

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Negative / Null Result ReportMedicine

Impact of chronic kidney disease on clinical outcomes among patients with atrial fibrillation following percutaneous left atrial appendage occlusion: a multicentre cohort study.

Amin, Awashra, Khan et al. · 2026 · European heart journal open

Atrial fibrillation (AF) and chronic kidney disease (CKD) often coexist, and both increase the risk of thromboembolism and bleeding. We aim to investigate the impact of CKD in patients with AF undergoing left atrial appendage occlusion…

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Negative / Null Result ReportMedicine

Effect of Implant Design on Fracture Resistance, Mode, and Crystal Structure of One- and Two-Piece Zirconia Implants With Ceramic or Titanium Abutment Screws: An In Vitro Study.

Gul, Papia, Eqtesadi et al. · 2026 · Clinical oral implants research

To evaluate the fracture resistance, fracture modes, and crystalline phase changes of zirconia one-piece implants (OPI) and bone-level (BLTPI) or tissue-level, two-piece implants (TLTPI), with ceramic (C) or titanium (T) abutment screws…

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Negative / Null Result ReportMedicine

Effect of Visceral Manipulation Versus Integrated Neuromuscular Inhibition Technique in Shoulder Impingement Syndrome.

Elserty, Shokry, Altoury et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Shoulder pain during daily activities is a common musculoskeletal complaint affecting individuals across all age groups. Among its causes, Shoulder Impingement Syndrome (SIS) is one of the most prevalent. This study aimed to compare the…

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Negative / Null Result ReportMedicine

Outcome-driven dosimetry optimization for [ 177 Lu]Lu-PSMA-617 radiopharmaceutical therapy: proof of concept on single time point dosimetry optimization.

Hu, Seifert, Gomes et al. · 2026 · European journal of nuclear medicine and molecular imaging

Internal dosimetry in radiopharmaceutical therapy (RPT) traditionally prioritizes methodological optimization driven by physical dose accuracy. However, even recommended multiple-time-point (MTP) dosimetry remains subject to uncertainties…

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Negative / Null Result ReportMedicine

Non-tobacco nicotine use and complications in single-level posterior lumbar and transforaminal lumbar interbody fusion.

Nguyen, Hall, Lebens et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Over 300,000 lumbar fusion surgeries are performed annually for various indications. Tobacco use has previously been demonstrated to increase rates of nonunion and mechanical complications, but the impact of non-tobacco nicotine (NTN)…

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Negative / Null Result ReportMedicine

Effects of Oxidative Stress and Antioxidant Activity in Uterine Flush Fluid During Early Postpartum on Reproductive Performance of Lactating Holstein-Friesian Dairy Cows.

Hagita, Miura, Shirasuna et al. · 2026 · Animal science journal = Nihon chikusan Gakkaiho

This study examined the impact of early postpartum uterine oxidative stress and antioxidant activity on subsequent reproductive performance in lactating Holstein-Friesian dairy cows. Uterine flush fluid samples were collected at…

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Negative / Null Result ReportMedicine

Inhaled corticosteroids monotherapy in childhood asthma: Any differential response rate between activated and prodrugs?

Majumder, Smyrnova, Ducharme · 2026 · The Journal of asthma : official journal of the Association for the Care of Asthma

The efficacy of inhaled corticosteroids (ICS) as prodrugs (inactive at delivery) has been compared to activated ICS, in mean changes in lung function and symptoms, with limited evidence on achieving control. We aimed to compare the…

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