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Browse the failure-mode index

11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Is There Postoperative Fluid Accumulation After the Unilateral Biportal Endoscopic Technique as Minimally Invasive Spine Surgery: In Vivo Study.

Omer Bozduman, Kadri Yıldız, Bilal Aykaç et al. · 2025 · Turkish Neurosurgery

AIM To establish the presence and amount of fluid accumulation in UBE procedure, and the relationship of fluid management with other variables. MATERIAL AND METHODS All patients underwent UBE spinal surgery with one level between September…

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Negative / Null Result ReportOpen accessMedicine

The effectiveness of generic emails versus a remote knowledge broker to integrate mood management into a smoking cessation programme in team-based primary care: a cluster randomised trial

N. Minian, Sheleza Ahad, Anna Ivanova et al. · 2021 · Implementation Science

Background Knowledge brokering is a knowledge translation approach that has been gaining popularity in Canada although the effectiveness is unknown. This study evaluated the effectiveness of generalised, exclusively email-based prompts…

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Negative / Null Result ReportOpen accessMedicine

Effect of isolated and combined ingestion of caffeine and citrulline malate on resistance exercise and jumping performance: a randomized double-blind placebo-controlled crossover study

M. Haugen, F. T. Vårvik, J. Grgic et al. · 2023 · European Journal of Nutrition

The aim of this study was to explore the isolated and combined effects of caffeine and citrulline malate (CitMal) on jumping performance, muscular strength, muscular endurance, and pain perception in resistance-trained participants. Using…

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Negative / Null Result ReportMedicine

The influence of lesion type and lesion location on the prediction of language laterality in patients with cerebral vascular malformations using functional MRI.

Rossmann J, Hense K, Knott M et al. · 2026 · Journal of neurosurgery

Objective Predicting language lateralization using functional MRI (fMRI) in patients with cerebral vascular malformations close to language areas is essential for treatment decision-making and patient outcomes. Functional MRI-based…

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Negative / Null Result ReportOpen accessMedicine

Comparable improvements in selective, but not sustained, attention in response to a multi-ingredient nootropic formulation when compared with caffeine.

Hearris MA, Langan-Evans C, Foo WL et al. · 2026 · European journal of nutrition

PURPOSE: The ergogenic effects of caffeine on cognitive performance are largely restricted to improved alertness and enhanced attention and do not typically extend to other cognitive domains. In contrast, plant extracts and phytochemicals…

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Negative / Null Result ReportMedicine

Retrospective Analysis of Dronedarone Versus Amiodarone on Outcomes Following Radiofrequency Ablation for Atrial Fibrillation.

Shi Y, Shi X, Li H et al. · 2026 · British journal of hospital medicine (London, England : 2005)

Aims/background Pharmacological therapy can enhance the therapeutic efficacy of radiofrequency ablation (RFA) for atrial fibrillation (AF) and reduce the risk of recurrence. Dronedarone and amiodarone are two commonly prescribed adjuvant…

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Negative / Null Result ReportMedicine

Similar water uptake depths in lianas and trees, but divergent functional trait coordination across organs in a seasonally dry tropical forest in Cambodia.

Hiiragi K, Sopheak T, Sophors C et al. · 2026 · Tree physiology

Although previous studies have suggested that lianas exhibit superior growth compared with trees during dry seasons, their strategies for acquiring water remain poorly understood. This study investigated the water uptake depth and…

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Negative / Null Result ReportOpen accessMedicine

Impact of Junior Physicians' Resignation on Palliative Sedation Practices: A Retrospective Single-Center Study in South Korea.

Hong M, Lee SW, Jung M · 2026 · Journal of hospice and palliative care

Purpose This study aimed to evaluate changes in the proportion of patients receiving palliative sedation (PS) before and after the mass resignation of junior physicians in South Korea. Methods This single-center retrospective chart review…

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Negative / Null Result ReportOpen accessMedicine

Can Lactate Values Predict Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery? A Prospective Observational Study.

Temiztürk Z, Beyazal OF, Topçu AC et al. · 2026 · Brazilian journal of cardiovascular surgery

Introduction The aim of our study is to investigate the relationship and predictive significance of routinely measured serum lactate values with postoperative atrial fibrillation (POAF) in patients following isolated coronary artery bypass…

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Negative / Null Result ReportMedicine

Computed tomography based distal femoral morphology and comparative multi-implant total knee replacement fit analysis in a South East London population.

Eveson TE, Davis TP, Tindall AJ · 2026 · Journal of orthopaedics

Background Accurate medio-lateral sizing of the distal femur during total knee replacement (TKR) is essential to optimise implant fit and avoid over- or under-hang, which have been associated with suboptimal outcomes. National guidance…

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Negative / Null Result ReportOpen accessMedicine

Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.

Hu Z, Ma R, Wen Y et al. · 2026 · Cancer medicine

Background The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0…

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Negative / Null Result ReportOpen accessMedicine

Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial.

Kassem BA, Osman SM, El-Mahallawy Y · 2026 · Clinical oral investigations

INTRODUCTION: The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence. AIM: To evaluate the effect of low-level diode laser as a…

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Negative / Null Result ReportOpen accessMedicine

Clinical characteristics and prognostic differences between elderly-onset and adult-onset ulcerative colitis: a two-center retrospective cohort study.

Li H, Ding S, Li J et al. · 2026 · Frontiers in medicine

Background The incidence of elderly-onset ulcerative colitis (EO-UC) has been gradually increasing. The unique characteristics of clinical manifestations, therapeutic strategies, and prognosis in EO-UC patients compared with adult-onset…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.

Pusdekar VP, Dare G, Bhojwani P et al. · 2026 · Turkish journal of surgery

Objective Surgical site infections (SSIs) are among the most common postoperative complications, contributing to morbidity, prolonged hospital stays, and healthcare costs. Prophylactic antibiotics are widely used, but the optimal regimen…

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