11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Siqueira RC, Pinho TS, Brandao CC · 2026 · Cureus
Objective The objective of this study was to evaluate the short-term ocular safety, feasibility, and exploratory functional signals associated with intravitreal adalimumab (ADA) in patients with retinitis pigmentosa (RP). Methods This…
View details →Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science
Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…
View details →van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology
Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…
View details →Akay T, Arslan RS · 2026 · Scientific reports
Patients with deep perianal abscess (DPA) and transsphincteric fistula typically require incision and drainage as emergency treatment. However, recurrent abscesses and fistulas are common. This study aimed to evaluate the impact of…
View details →Verhulst E, Ten Broek R, Bislenghi G et al. · 2026 · Techniques in coloproctology
Postoperative intraabdominal adhesions remain one of the most common and clinically significant complications following abdominal and pelvic surgery. Adhesions contribute to adhesive small bowel obstruction (aSBO), chronic abdominal pain,…
View details →Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…
View details →Somerville E, Bollinger RM, Haxton M et al. · 2026 · OTJR : occupation, participation and health
Interventions to address polypharmacy and improve adherence are insufficient for community-dwelling older adults. To examine the feasibility, acceptability, and preliminary efficacy of a tailored medication management intervention (TIMM)…
View details →Ladriñán-Maestro A, Sánchez-Sierra A, Elfoukahi O et al. · 2026 · PloS one
The aim of this study was to evaluate the acute effects of a single session of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic regulation, blood pressure, and arterial oxygen saturation in sedentary older adults. A…
View details →Ekinci MS, Karci B, Secilmis A · 2026 · The Journal of prosthetic dentistry
Statement of problem The effects of acid exposure on interim crown materials have not been fully elucidated, and comparative data regarding different production methods are limited. Purpose This study investigated the effects of simulated…
View details →Mastrantonio R, Romantini A, Lombardo C et al. · 2026 · Infection control and hospital epidemiology
Objective Environmental contamination is a significant factor in the transmission of healthcare-associated infections. This study evaluated the effectiveness of gaseous ozone in reducing microbial contamination within hospital settings,…
View details →Moutsoglou D, Staley C, Kabage AJ et al. · 2026 · Inflammatory bowel diseases
Background The intestinal microbiota play a key role in Crohn's disease (CD) and postoperative recurrence following ileocecal resection. Microbiota transplant therapy (MTT) could impact postoperative CD recurrence. This study aimed to…
View details →Uzun E, Ozen S, Senel S et al. · 2026 · BMC urology
Purpose To investigate the factors associated with variant histology (VH) and prognostic significance of VH in urothelial carcinoma (UC) among patients undergoing radical cystectomy (RC) with ileal conduit urinary diversion. Methods A…
View details →Toor S, Francis JE · 2026 · The British and Irish orthoptic journal
Introduction Accommodation is most commonly assessed using the RAF Rule. However, this subjective test has multiple sources of error, and an objective measurement of accommodation using Nott dynamic retinoscopy may be a more appropriate…
View details →El Asfahani IA, Khalifa A, Tawfik D et al. · 2026 · International journal of implant dentistry
Purpose This pilot randomized clinical trial compared peri-implant tissue health around milled cobalt-chromium (CoCr) versus polyether ether ketone (PEEK) secondary telescopic crowns in implant-retained mandibular overdentures over 12…
View details →Sorkun M, Samancı MY, Peker S et al. · 2026 · Neuroradiology
Background Early assessment of treatment response following radiosurgery in intracranial meningiomas is critical for guiding patient management. Conventional evaluation based on tumor volume may not reliably reflect early treatment…
View details →Harrington NE, Allen F, Garcia Maset R et al. · 2026 · Microbiology (Reading, England)
The opportunistic pathogen Pseudomonas aeruginosa forms biofilm infections in the lungs of people with the genetic condition cystic fibrosis (CF) that can persist for decades. There are numerous P. aeruginosa lifestyle changes associated…
View details →Khwanes SA, Mohamed RA, Abd El-Rahman HA et al. · 2026 · Scientific reports
Imidacloprid (IM), a systemic neonicotinoid pesticide, is widely used globally due to its high effectiveness against a broad range of insects at minimal application rates. The current study aimed to examine how this insecticide can induce…
View details →Okuda DT, Stanley TA, McCreary MC et al. · 2026 · AJNR. American journal of neuroradiology
Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is a chronic condition driven by selective injury to aquaporin 4 (AQP4) channels. Accurate diagnosis and effective disease surveillance are critical to preventing…
View details →Siggard LD, Rytter D, Lildholdt T · 2026 · Acta oto-laryngologica
Tongue-tie may interfere with infant feeding, but diagnosis remains challenging due to lack of objective criteria. To evaluate the clinical utility of the electronic baby bottle (EBB), a novel device recording intraoral forces during…
View details →Abdalqadir M, Raouf L, Mohammed K et al. · 2026 · Polymers
This study aimed to investigate the effect of time and different disinfecting agents on nanocomposite filler composed of natural clay nanoparticles (modified and non-modified) added to maxillofacial silicone elastomers and readymade…
View details →Gulec A, Eravsar E, Ciftci S et al. · 2026 · Journal of clinical medicine
Background : UBE has gained popularity as a minimally invasive alternative to open spinal procedures. However, it raises concerns about potential ocular complications. Despite these concerns, there is a lack of studies evaluating UBE's…
View details →Nicola-Ducey L, Ward L, Holland A et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Prior to delivery, there are postpartum pelvic floor recovery topics to provide education on; however, because of a variety of factors, the majority of these are commonly unaddressed, leaving a patient unknowledgeable and…
View details →Ying Z, Kondo A, De D et al. · 2026 · Journal of transcultural nursing : official journal of the Transcultural Nursing Society
Introduction We evaluated a Collaborative Online International Learning (COIL) programme in enhancing nursing students' intercultural sensitivity and understanding of cultural safety. Methods From April to May 2024, nursing students in…
View details →Dutta P, Verma S, Patni P et al. · 2026 · The British journal of ophthalmology
Automated pupillometry (AP) has been studied in established optic neuropathies. This prospective, sequential AP evaluation of 62 newly diagnosed adult patients with pulmonary/extra-pulmonary tuberculosis, showed a statistically significant…
View details →Zhang H, Zhao Y · 2026 · Pakistan journal of pharmaceutical sciences
Background Narlumosbart is a key agent for modulating bone cell function. Given the potential of curcumin nanoparticles to inhibit cell growth when applied alone. Objectives This study aims to investigate the role of their combination with…
View details →Shaju A, Mishra BR, Mohapatra D et al. · 2026 · Journal of psychopharmacology (Oxford, England)
BackgroundRecent evidence increasingly links schizophrenia to mitochondrial dysfunction, implicating altered mitochondrial respiratory and metabolic processes in its pathophysiology. Preclinical data suggest that atypical antipsychotics…
View details →Le Basle Y, Sautou V, Sarraute S et al. · 2026 · Biomedical materials (Bristol, England)
The study of extractable chemicals is used to evaluate whether a medical device contains harmful substances susceptible to migrate and contaminate the patients they are used in. The analysis of the biomaterial itself after extraction is…
View details →Yılmaz T, Özdemir S · 2026 · Heart & lung : the journal of critical care
Background Norepinephrine is widely used as a first-line vasopressor in acute hypotension and septic shock. Its acute effects on electrocardiographic (ECG) parameters, particularly the frontal QRS-T angle, remain unclear. Objectives To…
View details →Wentink N, van Gent M, Borns C · 2026 · The British journal of radiology
Objectives To quantify the reduction in effective dose achieved through organ dose modulation (ODM) on a General Electric Revolution Apex CT scanner, while preserving image quality. Methods First, the noise index (NI) corresponding to…
View details →Abid R, Murphy RF, Hogue GD et al. · 2026 · Journal of pediatric orthopedics
Background Treatment options for early-onset scoliosis (EOS) are confounded by the risks associated with intervention at a younger age. Spinal instrumentation must be considered carefully due to potentially adverse effects to the spine,…
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