490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Looman MI, Klau MM, Schoenmakers TM et al. · 2026 · Journal of sleep research
While time in bed restriction is a core treatment mechanism of Sleep Restriction Therapy (SRT), empirical research has not yielded a relationship between insomnia improvement and adherence to the prescribed time in bed. We coin this…
View details →Martin E, Conway CJ · 2026 · Ecology and evolution
Aggregation is common across taxa and typically confers clear benefits to group members (e.g., allo-parenting, group defense, thermoregulation, access to resources). But aggregation can also be costly. The mechanisms that underpin…
View details →Del Rivero J, Donahue RN, Marte JL et al. · 2025 · The oncologist
Background It has been hypothesized that sequencing antigen-directed immunotherapy with immune checkpoint inhibitors could prime a tumor for immune response to immune checkpoint inhibitors. Methods This study (NCT03072160) was designed to…
View details →Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of dairy science
Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…
View details →Martinez G, Tolentino K, Sukheja P et al. · 2025 · Bioorganic & medicinal chemistry letters
Screening of the ChemDiv molecular library in cholesterol media against Mycobacterium tuberculosis (Mtb) H37Rv strain identified a novel isoxazole thiophene hit as a putative Rv1625c/Cya activator with a promising in vitro activity and…
View details →Coello K, Stanislaus S, Forman JL et al. · 2025 · Free radical biology & medicine
Aims Increased oxidative stress-generated tissue damage seems to play a pivotal role in the pathophysiology and progression of bipolar disorder (BD). Malondialdehyde (MDA), a product of lipid oxidation, may represent a trait marker in BD…
View details →Strandberg E, Vikmoen O, Svindland KV et al. · 2026 · European journal of sport science
To evaluate whether strength training during chemotherapy alters (1) serum cytokines and (2) skeletal muscle autophagy- and heat-shock-related proteins in women with breast cancer. Exploratory analyses assessed associations between changes…
View details →García-Mendoza A, González-Hernández M, Vega-Manriquez DX et al. · 2026 · Veterinary sciences
This study investigated the associations among dam lactation number, passive immunity transfer, internal parasite burden, and weaning performance in female calves. Early consumption of high-quality colostrum is critical for effective…
View details →Reis-Silva LL, Tomeo RA, Barreto-de-Souza L et al. · 2026 · Autonomic neuroscience : basic & clinical
The present study investigated the contribution of corticotropin-releasing factor (CRF) neurotransmission acting through local CRF₁ receptors in the anterior (aIC), rostral-posterior (rpIC), and caudal-posterior (cpIC) subregions of the…
View details →Katanec T, Šimunović L, Likić R et al. · 2026 · Acta stomatologica Croatica
Objective Statins exhibit pleiotropic effects on bone metabolism, including osteogenic and angiogenic activity. The aim of this pilot study was to evaluate whether local application of simvastatin combined with a bovine-derived xenogeneic…
View details →Toshida K, Sugitani Y, Itoh S et al. · 2026 · Surgery today
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. Machine learning (ML) may enable the noninvasive prediction of histopathological features using clinical and imaging data. This study evaluated the utility of…
View details →Song S, Wang B, Kong X et al. · 2025 · Journal of cannabis research
Granulocyte colony-stimulating factor (G-CSF) has the capacity to enhance brain repair following various injuries to brain. G-CSF treatment after TBI in rodents has been reported to promote brain repair, hippocampal neurogenesis, and…
View details →Souleyrette CER, West PC, Kirkpatrick SS et al. · 2026 · Biomedicines
Background/Objectives : RNA interference (RNAi) is a promising strategy for mitigating diseases at the molecular level. However, RNAi is limited by its instability in biological fluids and impermeability to cellular membranes. In response,…
View details →Miraftabi H, Berjisian E, Nouri Dizicheh M et al. · 2025 · Journal of the International Society of Sports Nutrition
Background This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods…
View details →Ioannidis K, Katmerou I, Nikolaidis A et al. · 2026 · Journal of endodontics
Introduction The aim of this study was to examine, in vitro, the formation of formaldehyde with the aid of high performance liquid chromatography (HPLC), following the interaction of sodium hypochlorite (NaOCl) 2% w/v and…
View details →Coker JA, Sun R, Polzer PM et al. · 2026 · ACS chemical biology
Point mutations in the exonuclease (ExoN) site of nonstructural protein 14 (NSP14) compromise the fitness of betacoronaviruses such as SARS-CoV-2, implicating NSP14 ExoN inhibition as an antiviral strategy. However, there are no advanced…
View details →Ye S, Wu M, Yao C et al. · 2024 · eNeuro
Visual working memory (VWM) requires precise feature binding. Previous studies have revealed a close relationship between the posterior parietal cortex (PPC) and feature binding during VWM; this study further examined their causal…
View details →Yao Q, Yao Y, Liao Z et al. · 2026 · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
BackgroundSepsis and its complications pose a major global health burden. Mendelian randomization (MR) provides a genetic approach to assess causality.MethodsWe conducted a two-sample Mendelian randomization (MR) study using data from…
View details →Allard A, Clavien C · 2023 · PloS one
The recent replicability crisis in social and biomedical sciences has highlighted the need for improvement in the honest transmission of scientific content. We present the results of two studies investigating whether nudges and soft social…
View details →Zhao X, Yang Y, Wang Y · 2026 · PeerJ
Background Tennis, characterized by intermittent high-intensity bursts, demands both aerobic and anaerobic energy pathways for optimal performance. Remote ischemic preconditioning (RIPC) has emerged as a potential method to enhance…
View details →Khan S, Dobrovolny HM · 2021 · Virus research
Respiratory syncytial virus can cause severe illness and even death, particularly in infants. The increased severity of disease in young children is thought to be due to a lack of previous exposure to the virus as well as the limited…
View details →Lai X, Yu J, Zhu S et al. · 2026 · Frontiers in endocrinology
Objective To evaluate the effects of continuous glucose monitoring (CGM) compared with standard self-monitoring of blood glucose (SMBG) on neonatal perinatal outcomes among pregnant women with diabetes. Methods A systematic search of…
View details →Lohmann A · 2020 · Phonetica
The present article describes an extended replication of a reading study by Sereno and Jongman (1995) that reported acoustic differences between noun and verb pronunciations of English disyllabic, non-stress-shifting homophone pairs, for…
View details →de Mattos ESR, Guedes A, Zana Y et al. · 2025 · F1000Research
Background Sensory recovery following digital nerve neurorrhaphy is often incomplete, and strategies to enhance regeneration remain under investigation. Low-frequency transcutaneous electrical stimulation has been proposed as a potential…
View details →Hicks J, Dash C, Smith D et al. · 2025 · Contemporary clinical trials
Background Physical inactivity and obesity, which are disproportionately higher in Black women, are known risk factors of breast cancer. Novel methods to address this public health concern involve leveraging screen-viewing activities to…
View details →Gouilly D, Da-Costa A, Vrillon A et al. · 2025 · Journal of neuroinflammation
BACKGROUND: Neuro-inflammation is an early mechanistic target in Alzheimer’s disease (AD). However, the effect of anti-inflammatory drugs on biomarkers of neuro-inflammation has yet to be described. Biomarkers of neuro-inflammation showed…
View details →Millington O, Sharma A, Montanaro S et al. · 2023 · Chemical science
In molecular dimers that undergo intramolecular singlet fission (iSF), efficient iSF is typically accompanied by triplet pair annihilation at rates which prohibit effective triplet harvesting. Collisional triplet pair separation and…
View details →Mauricio AM, Cioffi CC, Sanders AM et al. · 2025 · Psychological services
This explanatory sequential mixed methods hybrid Type 1 study examined the efficacy and implementation of Connect2Test, a brief motivational enhancement intervention to increase SARS-CoV-2 testing among people experiencing houselessness…
View details →Kieras DE, Meyer DE · 2026 · Psychonomic bulletin & review
This article concerns simple visual-search tasks that require people to respond "yes" or "no" about whether a specified target object is present in stimulus displays containing relatively small numbers of typically simple objects. The…
View details →Wessels AM, Edgar CJ, Nathan PJ et al. · 2021 · Drug discovery today
Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer's disease. Recent negative trial results have been attributed to a lack of efficacy and important safety concerns. Furthermore,…
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