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Browse the failure-mode index

11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Radiofrequency Fields at 2.45 GHz Reprogram Mitochondria-Lysosome Crosstalk and Modulate the Survival/Death of Macrophages Exposed to LPS and/or the SARS-CoV-2 Spike Protein.

Sueiro-Benavides RA, Leiro-Vidal JM, Rodríguez-González JA et al. · 2026 · International journal of molecular sciences

The redox mechanisms of RAW 264.7 macrophages exposed to 2.45 GHz RF-EMF at subthermal specific absorption rates and to lipopolysaccharide (LPS) and/or the SARS-CoV-2 spike protein (CSP) were investigated. To this end, cellular responses…

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Negative / Null Result ReportOpen accessMedicine

Toxicological Relevance of Biogenic Amines in Honey: Dietary Exposure and Integrated Risk Indicators in Algerian and Moroccan Honeys.

Bruno F, Bruschetta G, Miller A et al. · 2026 · Foods (Basel, Switzerland)

Biogenic amines are nitrogenous compounds that may occur in foods through plant metabolism, bee enzymatic activity, or microbial decarboxylation. This study evaluated biogenic amines content in monofloral honeys from Algeria and Morocco,…

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Negative / Null Result ReportMedicine

[Analysis of the prevalence characteristics and trends of allergen-specific IgE levels in a children's hospital in Wuhan City from 2019 to 2024].

Liu YH, Du Q, Zhang MR et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

Objective: To investigate the changes in the positive rate of specific immunoglobulin E (sIgE) for inhalant and ingestive allergens in children at a certain children's hospital in Wuhan City from 2019 to 2024, and to analyze the…

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Negative / Null Result ReportMedicine

Local Delivery of Tranexamic Acid and Dexamethasone via Piezoelectric Irrigationin Rhinoplasty: A Prospective Double-Blind Comparative Study of Early Postoperative Morbidities.

Gunay G, Ece M, Beloglu Tonyali Y et al. · 2026 · The Journal of craniofacial surgery

This study aimed to evaluate the effects of adding tranexamic acid (TXA) and dexamethasone to the irrigation solution of a piezoelectric device during open rhinoplasty on postoperative periorbital edema, ecchymosis, and pain. In this…

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Negative / Null Result ReportOpen accessMedicine

Microscopic and computational analysis of the stomach, duodenum, and liver of rats with induced hyperprolactinemia treated with exogenous melatonin.

da Silva JV, da Silva RC, Ferreira RGDS et al. · 2026 · Frontiers in veterinary science

Introduction This study evaluated the effects of exogenous melatonin (MEL) on morphological and computational alterations in the stomach, duodenum, and liver of hyperprolactinemic rats. Methods Twenty-four animals were divided into three…

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Negative / Null Result ReportMedicine

The application of internal ring closure in laparoscopic transabdominal preperitoneal (TAPP) repair for large indirect inguinal hernias: a retrospective study of 162 cases.

Liu M, Shen X · 2026 · Langenbeck's archives of surgery

Purpose Patients with primary unilateral indirect inguinal hernias and large internal inguinal rings have a higher incidence of seroma formation following laparoscopic transabdominal preperitoneal (TAPP) hernia repair. This study aims to…

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Negative / Null Result ReportMedicine

Acetabular cup orientation differs across surgical approaches in primary total hip arthroplasty: a retrospective analysis.

Chimeno-Pigrau C, Fernández-Valencia JA, Alías A et al. · 2026 · International orthopaedics

Purpose Accurate acetabular cup positioning is crucial in primary total hip arthroplasty (THA), as malposition is associated with instability and early failure. We hypothesized that acetabular cup orientation may differ according to the…

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Negative / Null Result ReportOpen accessMedicine

Psychostimulant effects on motor and cognitive function in adults attention deficit hyperactivity disorder.

Cundari M, Kanold L, Bergwall D et al. · 2026 · The international journal of neuropsychopharmacology

Objectives This study aims to compare the performance on motor and cognitive functions of adult patients with attention deficit hyperactivity disorder (ADHD) with or without psychostimulant medication and controls. A secondary objective is…

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Negative / Null Result ReportMedicine

Obstetric and perinatal outcomes in twin pregnancies conceived through assisted reproduction: A retrospective cohort study.

Izbizky GH, Sevillano G, Abramor RM et al. · 2026 · Archivos argentinos de pediatria

Introduction. Multiple pregnancies are more frequently associated with adverse maternal and neonatal outcomes. The incidence of multiple pregnancies has increased with the use of assisted reproductive technologies (ART): they account for…

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Negative / Null Result ReportMedicine

[Experience of glutamine in parenteral nutrition in patients undergoing hematopoietic stem cell transplantation].

Alonso Domínguez MªT, Sánchez Navarro E, López López MJ et al. · 2026 · Nutricion hospitalaria

Introduction Introduction: hematopoietic stem cell transplantation (HSCT) is an aggressive and toxic procedure that can lead to malnutrition in patients. It has been proposed that these conditions may worsen under conditions of glutamine…

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Negative / Null Result ReportOpen accessMedicine

Variations in Pulse-Oxygen Saturation and Physical Development within the First 2 Hours after Birth Among Healthy Term Neonates Different Altitudes.

Du K, Yang YL, Li GY et al. · 2026 · Physiological research

This study aimed to examine early postnatal changes in pulse oxygen saturation (SpO2) and physical growth parameters during the first 2 hours following birth among healthy term neonates born at varying altitudes. A total of 963 healthy…

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Negative / Null Result ReportMedicine

Effectiveness, Sex Differences, and Patient Experience in Real-World Use of Long-Acting Cabotegravir and Rilpivirine: Results from a Prospective Study.

González-Cordón A, Calvo J, Berrocal L et al. · 2026 · Infectious diseases and therapy

Introduction Long-acting intramuscular cabotegravir plus rilpivirine (LA-CAB/RPV) administered every 2 months (Q2M) has been available in Spain since January 2023 as a switch strategy for HIV treatment. We evaluated characteristics,…

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Negative / Null Result ReportMedicine

The role of gender in patients with developmental dysplasia of the hip treated with closed reduction and spica cast immobilization: does it affect prognosis?

Kang Z, Li Y, Canavese F et al. · 2026 · Journal of pediatric orthopedics. Part B

To investigate the impact of gender on the prognosis of children with developmental dysplasia of the hip (DDH) treated with closed reduction and spica cast immobilization (CR-SCI). A retrospective analysis was conducted on 302 DDH children…

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Negative / Null Result ReportMedicine

The Effectiveness and Safety of Robotic-Assisted Bronchoscopy Across Diverse Patient Heights: A Subset Analysis of a Multicenter, Prospective, Observational Trial.

Gomes C, Gomes C, Cowan B et al. · 2026 · Journal of bronchology & interventional pulmonology

Background Outcomes of robotic-assisted bronchoscopy (RAB) in patients of small stature remain uncertain due to concerns about their potentially smaller lung volumes. We assess the effectiveness and safety of RAB across height variations.…

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Negative / Null Result ReportMedicine

Lipid profile and angiogenic markers in the detection of preeclampsia: The RECLAMA study.

Ibarretxe D, Tameish S, González-Lleó A et al. · 2026 · Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

Introduction and objectives Preeclampsia (PE) is a multisystem hypertensive disorder affecting 2-8% of pregnancies worldwide and represents a major cause of maternal and fetal morbidity and mortality. Its pathophysiology involves placental…

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Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of preimplantation genetic testing for structural rearrangements in couples with chromosomal inversions: a retrospective analysis.

Li Y, Keqie Y, Peng C et al. · 2026 · Frontiers in genetics

Chromosomal inversion is one of the common types of chromosomal structural rearrangements. For couples with chromosomal inversions, the appropriate recommendations for preimplantation genetic testing (PGT) remain a subject of ongoing…

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Negative / Null Result ReportOpen accessMedicine

Impact of different endometrial preparation protocols on pregnancy outcomes in frozen-thawed embryo transfer cycles among patients ≤35 years with a history of intrauterine adhesion separation surgery: a retrospective cohort study.

Sun H, Du M, Guo S et al. · 2026 · Frontiers in endocrinology

Objective To investigate the impact of three endometrial preparation protocols-hormone replacement therapy (HRT), natural cycle (NC), and down-regulation HRT-on pregnancy outcomes in frozen embryo transfer (FET) cycles among patients with…

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Negative / Null Result ReportOpen accessMedicine

Associations of new intracranial haemorrhage, ischaemic stroke and survival with dual antiplatelet therapy regimen or duration after endovascular treatment for ruptured cerebral aneurysm.

Perng PS, Chang Y, Chuang MT et al. · 2026 · Stroke and vascular neurology

Background Dual antiplatelet therapy (DAPT) is often necessary following endovascular treatment for ruptured cerebral aneurysms; however, the optimal drug combination and treatment duration remain uncertain. Method Patients with…

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