Negative / Null Result ReportOpen accessMedicine
Weimin Cai, Jun Xu, Xiao Wu et al. · 2023 · Cardiovascular Diabetology
Abstract Background The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG index in patients with severe stroke requiring ICU admission remains unclear. The aim of this study was to investigate the association between the TyG index and clinical prognosis of critically ill patients with ischemic stroke (IS). Methods This study identified patients with severe IS requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV)
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Gabrielle Campbell, Wayne Hall, Amy Peacock et al. · 2018 · The Lancet Public Health
BACKGROUND: Interest in the use of cannabis and cannabinoids to treat chronic non-cancer pain is increasing, because of their potential to reduce opioid dose requirements. We aimed to investigate cannabis use in people living with chronic…
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Steven Boonen, Jan Van Meirhaeghe, L. Bastian et al. · 2011 · Journal of Bone and Mineral Research
Vertebral fractures are often painful and lead to reduced quality of life and disability. We compared the efficacy and safety of balloon kyphoplasty to nonsurgical therapy over 24 months in patients with acute painful fractures. Adults…
View details →Negative / Null Result ReportOpen accessMedicine
Zoe Moodie, Leah Price, Cécile Gouttefangeas et al. · 2010 · Cancer Immunology Immunotherapy
No consensus has been reached on how to determine if an immune response has been detected based on raw data from an ELISPOT assay. The goal of this paper is to enable investigators to understand and readily implement currently available…
View details →Negative / Null Result ReportMedicine
Azucena Pérez‐Burgos, Bingxian Wang, Yukang Mao et al. · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Mounting evidence supports the influence of the gut microbiome on the local enteric nervous system and its effects on brain chemistry and relevant behavior. Vagal afferents are involved in some of these effects. We previously showed that…
View details →Negative / Null Result ReportOpen accessMedicine
Inessa Bekerman, Paul Gottlieb, Michael Vaiman · 2014 · Journal of Ophthalmology
The purpose of the current research was to reevaluate the normative data on the eyeball diameters. Methods. In a prospective cohort study, the CT data of consecutive 250 adults with healthy eyes were collected and analyzed, and sagittal, transverse, and axial diameters of both eyeballs were measured. The data obtained from the left eye and from the right eye were compared. The correlation analysis was performed with the following variables: orbit size, gender, age, and ethnic background. Results. We did not find statistically significant differences correlated with gender of the patients and t
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Masanari Kuwabara, Koichiro Niwa, Ichiro Hisatome et al. · 2017 · Hypertension
Whether asymptomatic hyperuricemia in the absence of comorbidities increases the risk for cardiometabolic disorders and chronic kidney disease remains controversial. This study was conducted to clarify the association between asymptomatic…
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Thamaraiselvan Murugan, Sugumari Elavarasu, Thangakumaran Suthanthiran et al. · 2014 · Journal of Indian Society of Periodontology
AIM: The aim of this study was to determine whether the addition of an autologous platelet rich fibrin (PRF) membrane to a coronally advanced flap (CAF) would improve the clinical outcome in terms of root coverage, in the treatment of…
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Firanescu, Jolanda De Vries, Paul Lodder et al. · 2018 · BMJ
OBJECTIVE: To assess whether percutaneous vertebroplasty results in more pain relief than a sham procedure in patients with acute osteoporotic compression fractures of the vertebral body. DESIGN: Randomised, double blind, sham controlled…
View details →Negative / Null Result ReportOpen accessMedicine
James W. Welsh, Stephen H. Settle, Arya Amini et al. · 2011 · Cancer
BACKGROUND: Local failure after definitive chemoradiation therapy for unresectable esophageal cancer remains problematic. Little is known about the failure pattern based on modern-day radiation treatment volumes. We hypothesized that most…
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Davy Vancampfort, Joseph Firth, Christoph U. Correll et al. · 2019 · World Psychiatry
We summarized and compared meta-analyses of pharmacological and non-pharmacological interventions targeting physical health outcomes among people with schizophrenia spectrum disorders. Major databases were searched until June 1, 2018. Of…
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Laura García, Brandon Birckhead, Parthasarathy Krishnamurthy et al. · 2021 · Journal of Medical Internet Research
BACKGROUND: Chronic low back pain is the most prevalent chronic pain condition worldwide and access to behavioral pain treatment is limited. Virtual reality (VR) is an immersive technology that may provide effective behavioral therapeutics for chronic pain. OBJECTIVE: We aimed to conduct a double-blind, parallel-arm, single-cohort, remote, randomized placebo-controlled trial for a self-administered behavioral skills-based VR program in community-based individuals with self-reported chronic low back pain during the COVID-19 pandemic. METHODS: A national online convenience sample of individuals
View details →Negative / Null Result ReportOpen accessMedicine
Ingrid L. Holster, Eric T.T.L. Tjwa, Adriaan Moelker et al. · 2015 · Hepatology
UNLABELLED: Gastroesophageal variceal bleeding in patients with cirrhosis is associated with significant morbidity and mortality, as well as a high rebleeding risk. Limited data are available on the role of transjugular intrahepatic…
View details →Negative / Null Result ReportOpen accessMedicine
Allison E. Aiello, Vanessa Pérez, Rebecca M. Coulborn et al. · 2012 · PLoS ONE
UNLABELLED: Limited vaccine availability and the potential for resistance to antiviral medications have led to calls for establishing the efficacy of non-pharmaceutical measures for mitigating pandemic influenza. Our objective was to examine if the use of face masks and hand hygiene reduced rates of influenza-like illness (ILI) and laboratory-confirmed influenza in the natural setting. A cluster-randomized intervention trial was designed involving 1,178 young adults living in 37 residence houses in 5 university residence halls during the 2007-2008 influenza season. Participants were assigned t
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Min Cao, Guozheng Wang, Jianfeng Xie · 2023 · Cell Death Discovery
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious hazard to human health, but it also imposes a substantial economic burden on the healthcare system. The cornerstones of current treatment for sepsis remain source control, fluid resuscitation, and rapid administration of antibiotics, etc. To date, no drugs have been approved for treating sepsis, and most clinical trials of potential therapies have failed to reduce mortality. The immune response caused by the pathogen is complex, resulting in a dysregul
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Patricia A. Ganz, Lorna Kwan, Steven A. Castellon et al. · 2013 · JNCI Journal of the National Cancer Institute
BACKGROUND: Cognitive complaints are reported frequently after breast cancer treatments. Their association with neuropsychological (NP) test performance is not well-established. METHODS: Early-stage, posttreatment breast cancer patients…
View details →Negative / Null Result ReportOpen accessMedicine
Silvia Sookoian, Gustavo Castaño, Romina Scian et al. · 2014 · Hepatology
UNLABELLED: We explored the role of transmembrane 6 superfamily member 2 (TM6SF2) rs58542926 C/T nonsynonymous (p.Glu167Lys) variant in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and disease severity. A total of 361…
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Roy N. Alcalay, Tama Dinur, Timothy J. Quinn et al. · 2014 · JAMA Neurology
IMPORTANCE: Information on age-specific risk for Parkinson disease (PD) in patients with Gaucher disease (GD) and glucocerebrosidase (GBA) heterozygotes is important for understanding the pathophysiology of the genetic association and for…
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Yoshiya Yamada, Evangelia Katsoulakis, Ilya Laufer et al. · 2017 · Neurosurgical FOCUS
OBJECTIVE An analysis of factors contributing to durable radiographic control of spinal metastases was undertaken, drawing from a large single-institution database in an attempt to elucidate indications and dose requirements for successful…
View details →Negative / Null Result ReportMedicine
Allen S. Liu, Huang‐Kai Kao, Richard G. Reish et al. · 2011 · Plastic & Reconstructive Surgery
BACKGROUND: Acellular dermal matrix has become a common adjunct in prosthesis-based breast reconstruction. The authors' aim was to determine whether acellular dermal matrix use in immediate prosthesis-based breast reconstruction is…
View details →Negative / Null Result ReportOpen accessMedicine
Carlos Celis‐Morales, Donald M. Lyall, Jana Anderson et al. · 2016 · European Heart Journal
Aims: It is unclear whether the potential benefits of physical activity differ according to level of cardiorespiratory fitness (CRF) or strength. The aim of this study was to determine whether the association between physical activity and…
View details →Negative / Null Result ReportOpen accessMedicine
Gavin Churchyard, Wendy Stevens, L D Mametja et al. · 2015 · The Lancet Global Health
BACKGROUND: In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme…
View details →Negative / Null Result ReportOpen accessMedicine
Yen‐Wei Li, Tung‐Wei Kao, Pi-Kai Chang et al. · 2021 · Scientific Reports
Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medi
View details →Negative / Null Result ReportOpen accessMedicine
Carlos Ferrando, Ricard Mellado Artigas, Alfredo Gea et al. · 2020 · Critical Care
BACKGROUND: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone. METHODS: Prospective, multicenter, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June 2020. Patients were cla
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Jimme K. Wiggers, Bas Groot Koerkamp, Kasia P. Cieslak et al. · 2016 · Journal of the American College of Surgeons
BACKGROUND: Liver surgery for perihilar cholangiocarcinoma (PHC) is associated with postoperative mortality ranging from 5% to 18%. The aim of this study was to develop a preoperative risk score for postoperative mortality after liver…
View details →Negative / Null Result ReportOpen accessMedicine
Chris Twelves, Javier Cortés, Linda T. Vahdat et al. · 2014 · Breast Cancer Research and Treatment
Data from two phase 3 studies of eribulin were pooled in analyses initially requested by the European Medicines Agency to assess whether specific patient subgroups, previously treated with an anthracycline and a taxane, benefited from…
View details →Negative / Null Result ReportOpen accessMedicine
Giuseppe Boriani, Antoine Da Costa, Aurelio Quesada et al. · 2016 · European Journal of Heart Failure
AIMS: The aim of this study was to evaluate the clinical efficacy and safety of remote monitoring in patients with heart failure implanted with a biventricular defibrillator (CRT-D) with advanced diagnostics. METHODS AND RESULTS: The…
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Marieke M. Lansbergen, Martine van Dongen‐Boomsma, Jan K. Buitelaar et al. · 2010 · Journal of Neural Transmission
Electroencephalography (EEG)-neurofeedback has been shown to offer therapeutic benefits to patients with attention-deficit/hyperactivity disorder (ADHD) in several, mostly uncontrolled studies. This pilot study is designed to test the…
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Daniel J. Owens, Richard J. Allison, Graeme L. Close · 2018 · Sports Medicine
The last decade has seen a dramatic increase in general interest in and research into vitamin D, with many athletes now taking vitamin D supplements as part of their everyday dietary regimen. The most recognized role of vitamin D is its regulation of calcium homeostasis; there is a strong relationship between vitamin D and bone health in non-athletic individuals. In contrast, data have consistently failed to demonstrate any relationship between serum 25[OH]D and bone health, which may in part be due to the osteogenic stimulus of exercise. Vitamin D may interact with extra-skeletal tissues such
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Pekka Oja, Paul Kelly, Željko Pedišić et al. · 2016 · British Journal of Sports Medicine
BACKGROUND/AIM: Evidence for the long-term health effects of specific sport disciplines is scarce. Therefore, we examined the associations of six different types of sport/exercise with all-cause and cardiovascular disease (CVD) mortality…
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