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Browse the failure-mode index

11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of Basal Septal Hypertrophy on TAVR Outcomes: Evidence From a Large Cohort Study.

Arow Z, Oliva O, Iwata J et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background Basal septal hypertrophy (BSH) is commonly encountered in elderly patients undergoing transcatheter aortic valve replacement (TAVR). However, its impact on periprocedural and procedural outcomes remains unclear. Aims The aim of…

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Negative / Null Result ReportMedicine

Improving Medication Adherence in Kidney Transplant Recipients Through Educational Intervention and Monitoring: A Randomized Clinical Trial.

Heinrich de Oliveira C, Schweig A, Gonçalves BP et al. · 2026 · Transplantation proceedings

Background Kidney graft survival after transplantation is highly dependent on continuous adherence to immunosuppressive therapy. Poor adherence is a significant cause of graft loss, and educational interventions to optimize care have been…

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Negative / Null Result ReportOpen accessMedicine

The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.

Hu L, Zhao C, Wang T et al. · 2026 · BMC oral health

BACKGROUND: Pain is the common complication after tooth extraction, while the reasons behind it still remains. Insomnia, another prevalent issue, negatively affects physical, mental health, and quality of life. The relations between…

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Negative / Null Result ReportOpen accessMedicine

Dose and clinical impact of delineation variability in brain metastases treated with stereotactic radiotherapy.

Perrot A, Dissaux B, Roux AC et al. · 2026 · Clinical and translational radiation oncology

Introduction Accurate delineation is critical for stereotactic radiotherapy (SRT) of brain metastases. We evaluated how inter-reader delineation variability affects target dose coverage and local relapse-free survival (LRFS). Methods and…

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Negative / Null Result ReportMedicine

Outcomes of a penicillin allergy de-labelling implementation intervention in a UK hospital: a prospective, single centre, type 2 hybrid effectiveness-implementation study evaluated using mixed methods.

Powell N, Hearsey D, West R et al. · 2026 · Implementation science communications

Background Non-allergy specialist healthcare workers removing low-risk penicillin allergy (penA) records, enabling patients to receive penicillin antibiotics, is safe but not common practice. We developed a behavioural change…

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Negative / Null Result ReportMedicine

Pre-processing and thermal treatment modulate structure, solubility and digestibility of faba bean protein isolates: A structure–function perspective

Sharma N, Gwala S, Owens RA et al. · 2026 · Food Hydrocolloids.

Despite growing interest in faba bean (Vicia faba L.) as a sustainable plant protein source, limited studies address process-induced structural mechanisms linking functionality with gastro-intestinal (GI) digestion. This study elucidates…

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Negative / Null Result ReportMedicine

Do steroids improve outcomes of idiopathic sixth nerve palsy in children?

Sternfeld A, Goren L, Ehrenberg M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To analyze the effect of systemic steroid treatment in children with benign acquired isolated sixth nerve palsy (BAISNP) regarding healing, recurrence risk and late sequelae. Methods A retrospective cohort design was used. The…

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Negative / Null Result ReportMedicine

Climatic impact on ram lamb reproductive development: the effect of solar radiation.

Gómez-Vargas JC, Parra-Bracamonte GM, Muñoz-García C et al. · 2026 · Animal : an international journal of animal bioscience

Climate change has a significant impact on global animal production. The objective was to evaluate the long-term effects of direct solar radiation on reproductive development in Pelibuey ram lambs under heat stress. Eighteen ram lambs (6.9…

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Negative / Null Result ReportMedicine

Interhospital transfer dynamics in foreign body aspiration: Age-stratified nationwide retrospective cohort study.

Deniz MS, Çiflik KB, Özdemir Çiflik B et al. · 2026 · Turk gogus kalp damar cerrahisi dergisi

Background Foreign body aspiration (FBA) is an acute clinical emergency that is particularly common in the pediatric population and, if not managed promptly, can lead to serious morbidity and mortality across all age groups. The need for…

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Negative / Null Result ReportMedicine

Evaluating the predictive utility of European-based and transethnic polygenic risk scores for kidney function in older Black adults: insights from the Health and Retirement Study.

Cobb RJ, Thorpe RJ Jr, Norris KC · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences

Background Black populations in the U.S. experience a disproportionately faster progression of chronic kidney disease than the general population. Polygenic risk scores (PRS) are a promising tool for risk stratification, yet their utility…

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Negative / Null Result ReportMedicine

[Exploration of the value of VAS score in the diagnosis and treatment of patients with vestibular diseases during caloric test].

Tian L, Liu X, Yu J et al. · 2026 · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery

Objective: To identify the factors influencing the visual analogue scale(VAS) scores for distress experienced by patients with vestibular diseases during caloric tests, and to explore the value of VAS scores in disease diagnosis and…

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Negative / Null Result ReportMedicine

Echolocating free-tailed bats use vision and hearing but not magnetoreception when navigating a maze.

Lemus K, Meyers R, Ellis S et al. · 2026 · Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology

Insectivorous bats navigate mainly by echolocation, but may also use visual, olfactory, and magnetic cues when travelling long distances. Parsing the relative contributions of different senses for navigation is difficult in wild bats. In…

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Negative / Null Result ReportMedicine

Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure and clinical severity in children: a prospective observational study.

Naseem M, Anand V, Das R et al. · 2026 · European journal of pediatrics

Elevated intracranial pressure (ICP) can complicate various neurological conditions in children and may result in fatal brainstem herniation. Early detection and management can prevent this fatal complication. This prospective…

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Negative / Null Result ReportMedicine

Dysregulation of HIF-1α-regulated and thromboinflammatory genes may contribute to thrombotic risk in patients with BCR::ABL1-negative myeloproliferative neoplasms.

Morath O, Wolfrum T, Crodel C et al. · 2026 · Journal of thrombosis and haemostasis : JTH

Background Hypoxia-inducible factor-1α (HIF-1α) regulates multiple pathways involved in metabolism, inflammation, and coagulation and may contribute to thrombotic complications in patients with BCR::ABL1-negative myeloproliferative…

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Negative / Null Result ReportMedicine

Persistent Chemotherapy-Induced Alopecia: Updates in Diagnosis and Treatment Persistent Chemotherapy Induced Alopecia: An Updated Approach.

Garza-Rodríguez V, Imbernon-Moya A, Hermosa-Gelbard A et al. · 2026 · Actas dermo-sifiliograficas

Chemotherapy-induced alopecia (CIA) is characterized by absent or incomplete hair regrowth after completion of chemotherapy. Alopecia that persists beyond 6 months after completing chemotherapy is defined as persistent chemotherapy-induced…

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Negative / Null Result ReportMedicine

Autopolyploidy exacerbates dominance masking under negative frequency-dependent selection: evidence from sporophytic self-incompatibility in Arabidopsis arenosa and Arabidopsis lyrata.

Vekemans X, Kolesnikova U, Vlček J et al. · 2026 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Polyploidy is widespread within flowering plants, with 35% of extant species being recent polyploids. Whether and how polyploidy modulates the action of natural selection remains debated, and the particular case of balancing selection has…

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