Evaluating the risk of methadone and QTc interval prolongation in an oncologic population.
Li DY; Kim S; Javed S; Huh B · 2026 · Regional anesthesia and pain medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Methadone is commonly used as an alternative to other opioids for managing cancer-related pain. High-dose methadone, primarily in opioid dependence treatment, has been associated with QTc prolongation and dangerous arrhythmias.…
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Metadata source: Europe PMC · DOI 10.1136/rapm-2025-107328