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Browse the failure-mode index

11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The scramblase anoctamin 9 controls the immune response in lymphocytes.

Schreiber R, Ousingsawat J, Kunzelmann K · 2026 · Cellular and molecular life sciences : CMLS

We previously reported a loss of T cell activation following knockdown of the phospholipid scramblase and ion channel ANO9 (TMEM16J) in human Jurkat lymphocytes. We have now analyzed in detail the role of ANO9 in Jurkat ANO9 knockout cells…

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Negative / Null Result ReportMedicine

Factors influencing the sensory profile in patients with autism spectrum disorder from 16 months to 14 years: results of an observational study.

Marani N, di Gennaro D, Garotti R et al. · 2026 · Frontiers in psychiatry

Introduction Sensory processing abnormalities represent a high-impact clinical feature in individuals with Autism Spectrum Disorder (ASD). Sensory alterations can be classified by modality and behavioral responses to stimuli. The…

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Negative / Null Result ReportMedicine

Spondylolisthesis Reduction and Changes in Sagittal Alignment Following Single-Position Lateral Versus Lateral-Then-Prone Oblique Lumbar Interbody Fusion With Navigation-Assisted Posterior Percutaneous Instrumentation.

Ansari D, Bethel JA, Greeneway GP et al. · 2026 · Operative neurosurgery (Hagerstown, Md.)

Background and objectives Lateral interbody fusion represents a minimally-invasive approach to achieve indirect decompression via disc height restoration and alignment correction in patients with degenerative lumbar spondylolisthesis. If…

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Negative / Null Result ReportMedicine

Tunable self-association of partially dephosphorylated beta-casein

Rasmussen PL, Rinnan Å, Nielsen SB et al. · 2026 · Food Hydrocolloids.

The utilization of bovine casein for creating casein micelles with properties resembling those in human milk presents an opportunity to bridge the nutritional gap between human milk and infant formula. However, the processing of these…

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Negative / Null Result ReportMedicine

No Significant Impact of Preoperative Electrodiagnostic Testing on Short-Term Outcomes after Carpal Tunnel Release.

Williams AJ, Pum JM, Deyoung JK et al. · 2026 · The journal of hand surgery Asian-Pacific volume

Background: The purpose of this study was to compare Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (UE) and PROMIS Pain Interference (PI) scores before and after carpal tunnel release (CTR) between…

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Negative / Null Result ReportMedicine

Mechanistic-statistical model for the expansion of ash dieback.

Fritsch C, Grosdidier M, Gégout-Petit A et al. · 2026 · Theoretical population biology

Hymenoscyphus fraxineus is an invasive forest fungal pathogen that induces severe dieback in European ash populations. The spread of the disease has been closely monitored in France by the forest health survey system which has made it…

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Negative / Null Result ReportMedicine

Evaluating the Role of the Self-Assembling Topical Haemostat PuraBond in Periorbital Ecchymosis Associated with Osteotomies in Septorhinoplasty.

Rafay A, Beegun I, Joseph J · 2026 · Facial plastic surgery : FPS

Abstract Septorhinoplasty for both functional and cosmetic purposes is a widely performed operation. As with any surgical intervention, there are inherent risks that include bleeding manifesting as periorbital ecchymosis (PE). PuraBond is…

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Negative / Null Result ReportMedicine

Assessing the Effectiveness of Multidisciplinary Interventions in Reducing Catheter-Associated Urinary Tract Infection: An Interrupted Time Series Modeling Approach.

Wills W, Rosever K, Bugajski A et al. · 2026 · Journal of nursing care quality

Background Recommendations support multi-interventional catheter-associated urinary tract infection (CAUTI) reduction programs; however, identifying specific interventions with significant impact may be beneficial in resource-limited…

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Negative / Null Result ReportMedicine

Exploring the Mediating Role of Social Media and Gaming in the Relationship between Adolescents' Feelings of Loneliness, Ostracism and Internalizing and Externalizing symptoms.

Bruneel S, Sjöblom J, Lagerström M et al. · 2026 · Child psychiatry and human development

Social outsiderhood - particularly loneliness and ostracism - has a significant impact on mental health issues such as internalizing symptoms (e.g., depression, anxiety) and externalizing symptoms (e.g., aggression, conduct problems). Yet,…

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Negative / Null Result ReportMedicine

Evaluation of rotational profile and foot loading in the uninvolved leg of children with unilateral clubfoot treated with foot abduction orthoses.

Lawing CR, Bailey CE, Garg S et al. · 2026 · Journal of pediatric orthopedics. Part B

Ponseti treatment of congenital clubfoot utilizes foot abduction bracing to prevent recurrence. In unilateral clubfoot, families have expressed concern about inducing deformity in the uninvolved leg. This study evaluated rotational…

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Negative / Null Result ReportMedicine

Impact of the COVID-19 pandemic on pediatric hemolytic uremic syndrome: Epidemiology, complications, and outcomes.

Jarosz-Wójcik E, Zajączkowski MA, Drożdż D et al. · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Hemolytic-uremic syndrome (HUS) is a thrombotic microangiopathy that is most commonly caused by infection with Shiga toxin-producing Escherichia coli (STEC-HUS). Atypical HUS (aHUS) is associated with inappropriate activation of…

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Negative / Null Result ReportMedicine

Effect of a multifaceted hospital fluid conservation approach to intravenous fluid shortages on patient outcomes.

Xu O, Graven P, Downs S et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose In September 2024, Hurricane Helene disrupted a key North Carolina facility producing 60% of medical-grade fluids in the United States, causing a nationwide intravenous fluid (IVF) shortage and prompting urgent conservation in…

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