Replication FailureMedicine
Kim JH, Hwang YH, Kang E et al. · 2026 · Kidney research and clinical practice
Background Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the…
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Gross AR, Lee H, Chacko N et al. · 2026 · The Cochrane database of systematic reviews
Rationale Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain. Objectives To assess the benefits and harms of…
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Neeser HR, Gerwinn T, Forschbach VC et al. · 2026 · Journal of pediatric surgery
Background Children still suffer from substantial pain after laparoscopic surgery. It has been hypothesized that low-pressure pneumoperitoneum reduces postoperative pain after laparoscopic surgery. However, this has not yet been studied in…
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Rice WM, Shaw AP, Britt RC et al. · 2026 · Journal of the American College of Surgeons
Background Rising patient volumes and an aging population are leading to difficulties in providing timely surgical intervention in emergency general surgery (EGS). With decreased resilience and greater comorbidity burden, we hypothesized…
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Ye J, Hoàng DĐ, Liu X et al. · 2025 · Biochemical and Biophysical Research Communications
Schisandrin B (SchB), a natural lignan with reported organ-protective effects, was hypothesized to ameliorate severe acute pancreatitis (SAP). We investigated the effects of SchB (30 and 60 mg/kg) in a caerulein-induced mouse model of SAP…
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Morgan W, Butler J · 2023 · BJPsych open
Aims Women from Black and minority ethnic backgrounds have been shown to experience an increased burden of common postnatal mental health conditions and higher rates of involuntary admissions. However, evidence demonstrates disparities in…
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Rana D, DeBaer L, Pourcyrous M · 2025 · Children (Basel, Switzerland)
Background Polysubstance use, particularly combining opioids with stimulants such as cocaine, is rising among individuals with substance use disorders. This practice aims to balance cocaine's stimulant effects with opioids' sedative…
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Whitehead NN, Kelly SA, Demes JS et al. · 2023 · Behavioural processes
Locomotor play is vigorous and seemingly purposeless behavior, commonly observed in young mammals. It can be costly in terms of energy expenditure, increased injury risk, and predator exposure. The main hypothesized benefit of locomotor…
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Grethen KJ, Gómez Y, Toscano MJ · 2025 · Applied Animal Behaviour Science
As the egg-laying industry transitions from cages to cage-free housing, laying hens are increasingly housed in large groups. Cognitive limitations may impair recognition of conspecifics in such large groups, raising questions on the hens’…
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Jedinger A, Feldhausen M · 2025 · The Journal of social psychology
The study examines the impact of hostile and benevolent sexism on attitudes toward public versus private breastfeeding. According to ambivalent sexism theory, we hypothesized that hostile sexism would result in disapproval of public…
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Takagi K, Saito G, Tanaka H et al. · 2025 · ESMO open
Background The REMORA trial demonstrated efficacy and safety of lenvatinib in patients previously treated for advanced thymic carcinoma. However, more data regarding its use in clinical practice are required. Methods This multicenter…
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Nagpal S, Nguyen KS, Bertrand S et al. · 2025 · Cancer reports (Hoboken, N.J.)
Background Brain metastases are common in patients with lung and breast cancer and are associated with poor outcomes. While there is some intracranial activity with systemic therapies, most chemotherapies are minimally effective.…
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Miller RM, Nworu C, McKee L et al. · 2020 · Applied immunohistochemistry & molecular morphology : AIMM
Ataxia-telangiectasia mutated (ATM), a key activator of DNA damage response mechanisms, represents a potential biomarker for targeted gastric carcinoma therapies. A phase II study (Study 39; NCT01063517) designed to investigate the…
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Miceli MH, Dalton LM, Pasqualotto AC et al. · 2025 · Open Forum Infectious Diseases
Background Histoplasma urine antigen detection, a valuable diagnostic tool, is often used to monitor response to antifungal therapy, but persistently positive antigen values, even when the infection has resolved, often present a clinical…
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Akowundu PK, Salako AO, Akinsete AM et al. · 2025 · BMC pediatrics
Background Sickle cell anaemia (SCA) is a lifelong, chronic haemolytic disorder with episodic vaso-occlusive crises (VOC) and chronic end-organ damage. Red cell dehydration during a VOC changes permeability with loss of potassium and…
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Blanco JR, Albendin-Iglesias H, Negredo-Puigmal E et al. · 2025 · PloS one
Introduction Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic…
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Solanki JD, Shah AP, Lalwani N et al. · 2025 · Journal of family medicine and primary care
Introduction Among type 2 diabetics (T2D), macrovascular complication lower limb Peripheral Arterial Disease (PAD) and microvascular complication Diabetic Peripheral Sensory Neuropathy (DPSN) have scarcely studied concordance and their…
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Lin X, Ou J, Wu G et al. · 2025 · Biochemistry and biophysics reports
Introduction Venous malformations are the most common congenital vascular anomaly, accounting for 65 % of all congenital vascular abnormalities. This study aims to investigate the correlation between genetic polymorphisms of MALAT1 and the…
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Velaga SB, Alagorie AR, Nittala MG et al. · 2025 · Ophthalmology science
Purpose To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design Longitudinal cohort study. Subjects The study reviewed 1332 eyes…
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Belica I, Blasko F, Sleziak I et al. · 2025 · Biological psychology
Resting heart rate variability (HRV) reflects rhythmic changes in heart rate over time associated with autonomic nervous system (ANS) activity. It has served as a predictor of health and the development of various diseases. Therefore, it…
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Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)
OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…
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Gaul C, Ferreira S, Johansen T · 2026 · Headache
Objective Evaluate the efficacy and safety of a novel partial rebreathing device for early treatment of acute attacks of migraine with aura. Background Earlier clinical studies have indicated a potential for CO 2 -enriched gas to be…
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Ha SH, Kim S, Lee S et al. · 2026 · Parkinsonism & related disorders
Introduction Approximately one-third of patients with Parkinson's disease (PD) develop dementia, and anticholinergic use has been implicated as a risk factor, particularly with prolonged exposure. This study examined whether short-term…
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Burgoyne K, Hargreaves S, Akhter N et al. · 2025 · JCPP advances
Background Parents play a key role in their child's early development but evidence that parental engagement strategies are effective is unclear. The current study evaluated a parent-delivered early language teaching programme that aimed to…
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Rymaszewska J, Szcześniak D, Maciaszek J et al. · 2026 · Journal of affective disorders
The exploration of Theta Burst Stimulation (TBS) in Obsessive-compulsive disorder (OCD) treatment is still in its nascent stages, and these initial findings underscore the need for further research to optimize stimulation parameters and…
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Bao J, Uchiyama T, Kusunoki K et al. · 2026 · Life (Basel, Switzerland)
N -hydroxypipecolic acid (NHP) is a key mobile signal in systemic acquired resistance in plants, and its glycosylation has been proposed to regulate immune signaling. Previous studies have demonstrated that the UDP-glycosyltransferase…
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Mansell J, Wang X, Jering KS et al. · 2026 · European journal of heart failure
Sex differences in transthyretin cardiac amyloidosis (ATTR-CM) are increasingly recognised; however, women are underrepresented in trials and sex-specific treatment effects remain incompletely understood. We evaluated sex differences in…
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O'Connor LM, Singh A, Luallen RJ et al. · 2026 · microPublication biology
Vertically transmitted endosymbionts are microbes that live inside host cells and are transmitted between parent and offspring. Free-living nematodes interact with a wide variety of microbes but no vertically transmitted microbes have been…
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Friedman O, Maiershon D, Paniri Y et al. · 2026 · Plastic and reconstructive surgery
Background Hematoma remains a major complication following breast surgery. While tranexamic acid (TXA) efficacy is established in reduction mammaplasty, its utility across other breast procedures remains unclear. Methods This retrospective…
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Kundu A, Khan A, Saha S et al. · 2026 · Journal of perioperative practice
Background Effective patient education materials on prehabilitation are essential for optimising patients before surgery. With the growing use of generative artificial intelligence (AI) chatbots in health care communication, it is…
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