11,310 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Caple MA, Lau JA · 2025 · Proceedings. Biological sciences
Local adaptation is widely documented, but contributing selective agents are rarely identified or disentangled. Here, we test whether plants are adapted to their local soil nitrogen conditions and whether microbes mediate plant adaptation…
View details →Muñoz-Vendrell A, Arroyo-Pereiro P, León I et al. · 2026 · Journal of neurology
Background Subcutaneous natalizumab offers greater convenience than intravenous administration, but pharmacokinetic differences have raised concerns about potential subclinical disease activity. Serum neurofilament light chain (sNfL) and…
View details →Zhao L, Zeng C, Jia X et al. · 2026 · Medicine
Breast cancer (BC) has the highest cancer incidence and mortality in women worldwide, and the relationship between serum enzymes and BC has been inconsistent in previous observational studies. In this paper, 2-sample Mendelian…
View details →Al-Mohana RAAM, Jianping H, Alhammadi MS et al. · 2026 · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
Objective To elucidate the pattern and extent of long-term condylar adaptation within the temporomandibular joint (TMJ) following mandibular setback by bilateral sagittal split osteotomy (BSSO) in patients with mandibular prognathism, with…
View details →Kubota H, Makino Y, Yoshida M et al. · 2026 · International journal of legal medicine
Background It is important to understand post-mortem changes in post-mortem computed tomography (PMCT) image interpretation. Only a few studies have focused on the eyeballs. This study aimed to clarify the changes in eyeball findings on…
View details →Lu Y, Shu L, Liu C et al. · 2026 · Frontiers in cardiovascular medicine
Background Ethanol infusion of the vein of Marshall (EIVOM) has emerged as a promising adjunct to pulmonary vein isolation (PVI) for atrial fibrillation (AF). Methods Patients undergoing catheter ablation for persistent AF (>3 months) were…
View details →Kocaman Y, Yanmaz LE · 2026 · Veterinary ophthalmology
Purpose This study aimed to evaluate the effects of ivermectin administration on aqueous tear production and ocular surface health in dogs and to investigate its potential association with quantitative keratoconjunctivitis sicca (KCS).…
View details →Lin YJ, Chen QY, Zhao SY et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose This study investigated the clinical characteristics and prognosis of rhegmatogenous retinal detachment (RRD) in patients with implantable collamer lens (ICL). Methods A retrospective review was conducted of medical records from…
View details →Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology
Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…
View details →Demirel N, Yildiz B, Demir M · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Objective To evaluate the safety and efficacy of CDK4/6 inhibitors in combination with hormone therapy, and to investigate potential predictive markers of treatment in metastatic breast cancer (MBC). Study design An observational study.…
View details →Hashemi TM, Khami MR, Razeghi S et al. · 2026 · BMC oral health
Introduction Transitioning from a treatment-oriented model to a prevention-focused approach is essential for improving oral health outcomes. This study aimed to assess the feasibility and implementation outcomes of Integrated Oral Health…
View details →Slowinski J, Lutnick E, Frappa N et al. · 2026 · Foot & ankle international
Background This study aimed to demonstrate long term clinical follow-up and implant survivorship of Salto Talaris-type primary total ankle arthroplasty (TAA) by 1 foot and ankle-trained surgeon at a single institution. Methods Patients…
View details →Ghiri AA, Cavanaugh SJ, Nuñez AA et al. · 2026 · Annals of biomedical engineering
While American football games are played across a wide range of temperatures, current helmet rating protocols assess performance primarily at room temperature. This study evaluates how temperature influences impact attenuation performance…
View details →Hyun HK, Lee OH, Roh JW et al. · 2026 · Yonsei medical journal
Purpose Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors…
View details →Li X, Liu C, Wu W et al. · 2026 · Frontiers in neuroscience
Purpose To investigate the short-term effect of a longpass filter on myopic defocus-induced changes in axial length (AL) and choroidal thickness (ChT). Methods This study included 23 young myopic adults. AL and ChT were measured in both…
View details →Lou Z, Yang H · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: The objective of this study was to evaluate the graft success rate, hearing outcomes, and complications associated with three-layer graft myringoplasty for repairing subtotal and total perforations. MATERIALS AND METHODS:…
View details →Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood
Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…
View details →Xiang Y, Li S, Wang T et al. · 2026 · Seizure
Background This study aimed to evaluate the effectiveness of the China Acute Seizure Action Plan (CASAP), a context-adapted acute seizure action plan developed for China, on caregivers' knowledge, attitudes, and practices (KAP) regarding…
View details →Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress
The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…
View details →Scott R, Sale C, James R et al. · 2026 · Bone
Exercise interventions frequently prescribe impact activities assuming that identical tasks produce similar mechanical loads, yet few studies quantify the external loads experienced during such interventions. This study examined drop-jump…
View details →Sadic AK, Susgun S, Alkhalidi D et al. · 2026 · Nutrition and health
BackgroundAspartame, a widely used artificial sweetener, is metabolized into phenylalanine, aspartic acid, and methanol. Previous studies have suggested that these metabolites may exert detrimental effects on the human body, particularly…
View details →Huang CT, Wen YT, Liu PK et al. · 2026 · QJM : monthly journal of the Association of Physicians
Background Indirect traumatic optic neuropathy (TON) is associated with severe vision loss and no proven treatment. Aim To evaluate the safety and exploratory functional outcomes of intravitreal pegfilgrastim in patients with indirect TON.…
View details →Hodgson NA, Latif S, Talwar S et al. · 2026 · Journal of the American Geriatrics Society
Background The Alzheimer's Association partnered with health systems in Illinois, Greater Missouri, and Washington to implement and evaluate the Knight Family dementia care coordination (DCC) program, a novel telephone-based care…
View details →Deniz B, Arpaci MF, Pekmez H et al. · 2026 · Journal of neuro-oncology
Purpose Brain tumors, characterized by the uncontrolled proliferation of abnormal cells within cerebral tissue, remain clinically challenging entities. Radiotherapy and chemotherapy constitute fundamental therapeutic modalities; however,…
View details →Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior
Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…
View details →Sen E, Aytekin A · 2026 · Revista da Associacao Medica Brasileira (1992)
Objective Thiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients…
View details →Sinha R, Singh R, Tripathi M et al. · 2025 · Indian journal of ophthalmology
Purpose To study the change in the vault of phakic Intraocular Lens (IOL) (pIOL) with RT view anterior segment optical coherence tomography (ASOCT) in different light conditions and define its relationship with the change in pupillary…
View details →Bachelard L, Blanc N, Michel A · 2026 · BMJ supportive & palliative care
Objective Breast cancer surgery often leads to a high burden of distressing symptoms, underscoring the need for supportive care to help patients throughout the perioperative period. This pilot study aimed to evaluate the feasibility,…
View details →Mosch B, Diers M · 2026 · Pain reports
Introduction Since the outbreak of COVID-19, many studies have investigated long-term consequences associated to the pandemic. Undoubtedly, restrictions and changes in everyday life during that time have had a broad impact on mental health…
View details →Achar A, Houser P, Cherian J et al. · 2026 · Lupus
ObjectiveTo determine the long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus (pSLE) treated with systematic administration of combination rituximab (RTX) and cyclophosphamide (CYC) at our…
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