11,309 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Rezagholizadeh, Tavassoli, Saeedi et al. · 2026 · Brain research bulletin
Traumatic Brain Injury (TBI) is an important contributing factor to cognitive impairment, frequently linked to disturbances in synaptic plasticity and metaplasticity. Astrocytes, as essential regulators of synaptic function, are crucial…
View details →Wang, Li, Zhang et al. · 2026 · Child development
This study examines how center-based parenting interventions aimed at improving early child development in rural China affect the mental health of caregivers. Data from an analytic sample of 615 caregiver-child dyads (children aged 6 to 24…
View details →Gurcay, Bilgin, Sert et al. · 2026 · Advances in skin & wound care
Frailty, resulting from physical and psychological factors, may lead to the development of care dependency in people diagnosed with diabetic foot. This study was conducted to determine frailty and care dependency in patients diagnosed with…
View details →Molnes, Vinje, Opheim et al. · 2026 · Translational animal science
In June 2023, an incident at a Norwegian feed mill caused pig feed being over-supplemented with sodium selenite (NaSe), resulting in feed selenium concentrations ranging from 2.47 to 4.70 mg Se/kg feed from sodium selenite (NaSe),…
View details →Cui, Luo, Tajika et al. · 2026 · Journal of affective disorders
This study aimed to examine the effectiveness of smartphone-delivered cognitive behavioral therapy (CBT) in participants with subthreshold depression, considering the potential influence of physical comorbidities. In this secondary…
View details →Bai, Kim, Cao et al. · 2026 · Social psychiatry and psychiatric epidemiology
Universal Credit (UC) is a major UK welfare reform that consolidates six means-tested benefits into a single monthly payment, aiming to simplify benefits delivery and incentivize labor market participation. However, concerns have emerged…
View details →Sun, Gong, Liu et al. · 2026 · Molecules (Basel, Switzerland)
A novel urea complexation technology was developed based on the agglomeration phenomenon induced by ambient-temperature agitation of a ternary system consisting of urea, water and fatty acid ethyl esters (EEs). The agglomeration phenomenon…
View details →Guleria, Horijan, Kumar et al. · 2026 · Scientific reports
The study aimed to evaluate fumigation and repellent properties of essential oils (EOs) from Juniperus macropoda leaves and cedarwood, Cedrus deodara against storage pests viz., Tribolium castaneum and Callosobruchus maculatus. Further,…
View details →Heidari, Amiri, Mobarakeh · 2026 · Journal of speech, language, and hearing research : JSLHR
Age-related hearing loss (ARHL) has been associated with cognitive decline. Although bilingualism may influence cognitive performance, its interaction with hearing loss remains unclear. This study aimed to investigate the effects of ARHL…
View details →Wang, Lv, Zeng et al. · 2026 · Neurocritical care
This study compared the effectiveness of noninvasive positive pressure ventilation (NIPPV) and high-flow nasal cannula (HFNC) in preventing reintubation among neurosurgical intensive care patients following extubation. A retrospective…
View details →Aouimeur, Sagnial, Travers et al. · 2026 · Scientific reports
Primary human corneal endothelial cell (CEC) culture is a key step toward developing cell-based therapies for corneal endothelial diseases, yet its success remains highly variable, particularly when using tissues from older donors. This…
View details →Le Jan, Gourmelon, Destrumelle et al. · 2026 · Microvascular research
Endothelial dysfunction (ED) is a hallmark of metabolic disturbances such as Metabolic Syndrome (MetS), where oxidative stress and reduced nitric oxide (NO) bioavailability play key roles. High glucose (HG), a major metabolic alteration in…
View details →Li, Megaw, Shenker et al. · 2026 · Journal of applied microbiology
Molecular methods have shown bacteriophage diversity in human milk, but this does not reflect viability, particularly within donor human milk which has been subjected to multiple freeze-thaw cycles and heat treatment. Our aim was to…
View details →Tchum, Koto, Kanyoke et al. · 2026 · medRxiv : the preprint server for health sciences
Affecting 40% of infants and young children worldwide, anaemia in sub-Saharan Africa hampers cognitive and physical development, often in ways that cannot be reversed. Iron-based micronutrient powders (MNPs) are recommended to combat…
View details →Wu, Jiang, Wei · 2026 · The New phytologist
Spring phenology is closely linked to plant growth and reproduction and is highly sensitive to environmental changes. For dioecious species, the temporal overlap between female and male flowering is critical for their successful…
View details →Wang, Chao, Chen et al. · 2026 · Scientific reports
Smart home appliances are pivotal for advancing energy efficiency and environmental sustainability; however, their widespread adoption faces complex psychological and functional barriers. This study investigates the key determinants of…
View details →Erdoğan, Ayaz-Alkaya · 2026 · Nurse education in practice
To evaluate the effect of crossword puzzle activities on nursing students' willingness to work with older adults and their competence in gerontological nursing. Although crossword puzzles are widely used learning tools, their effects in…
View details →Ramay, Bundur, Riaz et al. · 2026 · Veterinary medicine and science
Optimizing ruminant diets and mitigating methane emissions using feed additives like yeast cell wall is of growing significance in animal nutrition. The present study aimed to evaluate the effects of varying roughage-to-concentrate (R:C)…
View details →Yan, Liang, Zhou et al. · 2026 · Frontiers in aging neuroscience
The relationship between plasma chaperone-related autophagy proteins and white matter hyperintensity (WMH) in Alzheimer's disease (AD) remains unclear. We employed 4D-DIA proteomics to identify plasma protein changes, and evaluated the…
View details →Suzuki, Kandar, Ting et al. · 2026 · Cancer immunology research
Loss-of-function STK11 mutations occur in 15-20% of lung adenocarcinomas (LUAD) and correlate with immunotherapy failure and worse survival. By integrating analysis of human tumor samples, a human LUAD cell line panel, and CCLE and TCGA…
View details →Andersen, Sloth, Bøgestad et al. · 2026 · MicrobiologyOpen
IMP-1700 was developed as a compound designed to target bacterial DNA repair-associated pathways, including homologous recombination mediated by the AddAB/RecBCD system. While its antibacterial properties are well established, the…
View details →Kang, Lee, Choi et al. · 2026 · Frontiers in public health
Despite the rapid rise in adolescent poly-tobacco use, evidence on what drives quit attempts in this high-risk group remains limited compared to single-product users. This study identifies these differential predictors using a…
View details →Mohammadian, Ghiasi, Soleimani · 2025 · Galen medical journal
This study assessed the effects of 0.05% cetylpyridinium chloride (CPC) and 1% povidone iodine (PI) on flexural strength of nickel-titanium (NiTi) orthodontic wires. In this in vitro, experimental study, 27 pieces of NiTi orthodontic wires…
View details →Jia, Han, Macreadie et al. · 2026 · Global change biology
Coastal wetlands represent one of the most intensive carbon sinks, and the stability of their soil carbon reserves is critical to the global carbon balance. While existing studies have predominantly focused on the effects of changes in…
View details →Eminoğlu · 2026 · Food science & nutrition
In this study, yogurt formulations with paraprobiotic (heat inactivated Lactobacillus acidophilus ) and postbiotic (autolyzed and dried Saccharomyces cerevisiae ) additions were developed to improve the techno-functional properties of…
View details →Lim, Chin, Chee et al. · 2026 · The American journal of cardiology
Patients' length of stay (LOS) during admission for myocardial infarction (MI) represents a closely tracked outcome metric for Cardiology services, which has declined over time. Charlson Comorbidity Index (CCI) is a validated tool for…
View details →Yoshida, Fukuoka, Kawahara et al. · 2026 · Biochimica et biophysica acta. General subjects
Vasculogenic mimicry (VM) is a phenomenon in which tumor cells form capillary-like networks without endothelial cells and is associated with tumor progression and poor prognosis. Understanding mechanisms of VM and identifying its reliable…
View details →Kim, Shin, Kim et al. · 2026 · The journal of adhesive dentistry
Self-adhesive flowable giomer (SAG) has been used in dental practice recently to simplify clinical procedures and shorten chair times. However, there are only few studies evaluating its bond strength to enamel and dentin, resulting in a…
View details →Sternberg, Podolsky, Yu et al. · 2026 · The journal of prevention of Alzheimer's disease
High cholesterol contributes to the development and progression of dementia due to both Alzheimer's disease (A.D.) and vascular pathology. However, the effects of lipid-lowering regimen (LLR) on cognitive dysfunction and brain…
View details →Lau, Fok, Lee et al. · 2026 · PloS one
Ankle joint quasi-stiffness is a measure representing the control of quiet standing. Here we investigated three methods for determining parameters associated with ankle joint quasi-stiffness. Eleven healthy, young males were asked to stand…
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