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Browse the failure-mode index

11,407 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Multi-omics analysis reveals Parabacteroides distasonis and Kineothrix alysoides as potential key bacterial species associated with anemia in sows.

Sun, Chen, Yang et al. · 2026 · Journal of animal science and biotechnology

Sow anemia has been reported to be associated with reduced reproductive performance. Additionally, anemia may alter gut microbiota composition. However, the gut microbiota and metabolic signatures specifically linked to sow anemia status…

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Negative / Null Result ReportMedicine

Effect of visual disruption on the lower limb kinematic and kinetic characteristics in athletes after anterior cruciate ligament reconstruction.

Yu, Yu, Sun et al. · 2026 · Frontiers in bioengineering and biotechnology

Proprioceptive deficits following anterior cruciate ligament (ACL) injury increase reliance on visual input in athletes after ACL reconstruction (ACLR). Visual disruption may therefore alter movement patterns and increase re-injury risk.…

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Negative / Null Result ReportMedicine

Hot dogs for snakes: alternative method for feeding coral snakes (Micrurus corallinus) maintained at Butantan Institute.

Ribeiro, Stuginski, do Amaral E Luna et al. · 2026 · Toxicon : official journal of the International Society on Toxinology

Snakebites represent a significant public health concern in tropical and subtropical countries. In 2025, approximately 21,000 incidents of snakebites were reported in Brazil, with 1.7% attributed to coral snakes. Although the incidence of…

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Negative / Null Result ReportMedicine

Clinical outcome of fiber post and fiber-reinforced resin composite for the full crowns of anterior endodontically treated teeth: a 5-year randomized clinical trial.

Ferrari, Saracutu, Pontoriero et al. · 2026 · Journal of dentistry

To compare the outcome of short fiber reinforced composites, as a core material, with respect to conventional fiber post, for the reconstruction of anterior endodontically treated teeth (ETT), covered by a lithium disilicate crown.…

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Negative / Null Result ReportMedicine

Vitamin B 12 Availability and Interaction with Bacterium Mesorhizobium loti Affect Growth and Biochemical Composition of Mixotrophic Alga Euglena Gracilis.

Ghimire, Sohrabi, Zhou et al. · 2026 · Microbial ecology

Over 90% of the mixotrophic algae surveyed require vitamin B 12 (B 12 ), a micronutrient synthesized exclusively by certain prokaryotes. Bacteria-mediated B 12 supply presents an important but poorly understood control on physiology and…

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Negative / Null Result ReportMedicine

Bile duct segmental resection versus pancreaticoduodenectomy for middle-third extrahepatic cholangiocarcinoma: A propensity-matched, single-center retrospective analysis.

Park, Kim, Kim et al. · 2026 · Annals of hepato-biliary-pancreatic surgery

The optimal surgical approach for middle-third extrahepatic cholangiocarcinoma (MCC)-bile duct segmental resection (BDSR) or pancreaticoduodenectomy (PD)-remains controversial. This study aimed to compare the short- and long-term outcomes…

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Negative / Null Result ReportMedicine

[Study on the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus, and acellular pertussis combined vaccine after immunization schedule adjustment].

Shao, Feng, Yang et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

This study compared the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus and acellular pertussis combined vaccine (DTaP) after the immunization schedule adjustment in…

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Negative / Null Result ReportMedicine

Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China.

Meicen, Wei, Yanai et al. · 2026 · Frontiers in endocrinology

Thyroid hormones play critical roles in regulating bone turnover and maintaining bone mass. However, the relationship among thyroid hormones, their sensitivity indices, bone mineral density (BMD) and fracture risk remained unclear in the…

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Negative / Null Result ReportMedicine

Timing for green prescription: comparing the immediate and cumulative effects of different duration horticultural therapy programs on college students' mental health.

Liu, Chen, Sun et al. · 2026 · Frontiers in psychology

Although the mental health benefits of horticultural therapy (HT) are well-established, the influence of intervention duration and the temporal dynamics of effects remain insufficiently explored, lacking evidence for optimal protocol…

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Negative / Null Result ReportMedicine

Risk Factors and Survival Analysis of Epstein-Barr Virus Infection After Pediatric Liver Transplantation.

Li, Li, Xie et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

To explore the risk factors affecting Epstein-Barr virus (EBV) infection after pediatric liver transplantation (PLT) and analyze the survival outcomes of EBV infection in PLT. A retrospective analysis was conducted on clinical data from…

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Negative / Null Result ReportMedicine

[Targeted muscle reinnervation for treatment of painful stump neuroma].

Xiong, Shali, Kadier et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the effectiveness of incorporating small gap anastomosis (SGA) and epineurial sheath tube (EST) sleeve coaptation into conventional targeted muscle reinnervation (TMR) for the treatment of post-amputation painful stump…

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Negative / Null Result ReportMedicine

[Comparative study on effectiveness of bioinductive patch-augmented arthroscopic rotator cuff repair].

Sun, Yao, Gu et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To evaluate the effectiveness of using a bioinductive patch on tendon healing, functional recovery, and safety in arthroscopic rotator cuff repair. A non-concurrent controlled study with prospective enrollment of the intervention group and…

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Negative / Null Result ReportMedicine

[Effectiveness analysis of single-incision treatment for adjacent two-segmental lumbar disc herniation using uni-portal non-coaxial spinal endoscopic surgery].

He, Li, Xiao et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the feasibility and effectiveness of uni-portal non-coaxial spinal endoscopic surgery (UNSES) via a single incision for the treatment of adjacent two-segmental lumbar disc herniation (LDH). A retrospective analysis was…

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Negative / Null Result ReportMedicine

Effect of ammonia-free silver fluoride and silver diammine fluoride on immediate microshear bond strength of resin-modified glass ionomer to demineralised primary tooth dentine.

Abedinzade Zare, Vafadar, Behroozibakhsh et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

This study aimed to compare the effect of water-based ammonia-free silver fluoride (SF) and silver diammine fluoride (SDF) on the microshear bond strength (MSBS) of resin-modified glass ionomer (RMGIC) to artificially demineralised primary…

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Negative / Null Result ReportMedicine

Biologically enhanced anterior cruciate ligament reconstruction: Platelet-rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes-A randomized controlled trial of 175 cases with 2 years of follow-up.

Mokhtar, Gawish, Abdelgawad et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard…

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