11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Luke Macyszyn, Hamed Akbari, Jared Pisapia et al. · 2015 · Neuro-Oncology
BACKGROUND: MRI characteristics of brain gliomas have been used to predict clinical outcome and molecular tumor characteristics. However, previously reported imaging biomarkers have not been sufficiently accurate or reproducible to enter…
View details →Bjarne M. Nes, Imre Janszky, Ulrik Wisløff et al. · 2012 · Scandinavian Journal of Medicine and Science in Sports
Maximal heart rate (HRmax ) declines substantially with age, but the magnitude and possible modifying effect of gender, body composition, and physical activity are not fully established. The present study examined the relationship between…
View details →Song‐Yi Park, Neal D. Freedman, Christopher A. Haiman et al. · 2017 · Annals of Internal Medicine
BACKGROUND: Coffee consumption has been associated with reduced risk for death in prospective cohort studies; however, data in nonwhites are sparse. OBJECTIVE: To examine the association of coffee consumption with risk for total and…
View details →T.J. Bonner, William Eardley, Paul R. Patterson et al. · 2011 · Journal of Bone and Joint Surgery - British Volume
Correct positioning and alignment of components during primary total knee replacement (TKR) is widely accepted to be an important predictor of patient satisfaction and implant durability. This retrospective study reports the effect of the…
View details →Dania Abdul Razzak Kouider, Nageeb Hassan, Yaser Mohammed Al‐Worafi · 2019 · Biomedical Research
Objectives: The aim of this study was to explore the association between vitamin D deficiency and depression among university students and to identify the factors affecting this association. Methodology: A cross-sectional study was…
View details →Trevor Scobey, Boyd L. Yount, Amy Sims et al. · 2013 · Proceedings of the National Academy of Sciences
Severe acute respiratory syndrome with high mortality rates (~50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory syndrome coronavirus (MERS-CoV). We synthesized a panel of contiguous cDNAs that…
View details →Ronald B. Natale, Sumitra Thongprasert, F. Anthony Greco et al. · 2011 · Journal of Clinical Oncology
PURPOSE: Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling. This phase III study assessed the efficacy of vandetanib versus erlotinib in unselected…
View details →Andrew J. Coldman, Norm Phillips, Christine Wilson et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Screening with mammography has been shown by randomized controlled trials to reduce breast cancer mortality in women aged 40 to 74 years. Estimates from observational studies following screening implementation in different…
View details →Stephen D. Silberstein, David W. Dodick, Joel R. Saper et al. · 2012 · Cephalalgia
BACKGROUND: Chronic migraine (CM) is a debilitating neurological disorder with few treatment options. Peripheral nerve stimulation (PNS) of the occipital nerves is a potentially promising therapy for CM patients. METHODS: In this…
View details →Kathleen N. Moore, Amit M. Oza, Nicoletta Colombo et al. · 2021 · Annals of Oncology
•In platinum-resistant EOC MIRV did not significantly improve PFS over chemotherapy.•No unexpected toxicities were observed, and tolerability profiles were consistent with those observed in previous studies.•The most promising signals of…
View details →Matthew J. Reilley, Patricia McCoon, Carl Cook et al. · 2018 · Journal for ImmunoTherapy of Cancer
BACKGROUND: The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activation of immune responses. In diffuse large B-cell lymphoma (DLBCL), the transcription factor STAT3 has been associated with aggressive disease phenotype and worse overall survival. While multiple therapies inhibit upstream signaling, there has been limited success in selectively targeting STAT3 in patients. Antisense oligonucleotides (ASOs) represent a comp
View details →Navneet Singh, Stephen J. Hopkins, Sharon Hulme et al. · 2014 · Journal of Neuroinflammation
BACKGROUND: Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood-brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. METHODS: A small phase II, double-blind, randomised controlled study was carried out across two UK neurosurgical centres
View details →Maria Justine, Azliyana Azizan, Vally Hassan et al. · 2013 · Singapore Medical Journal
INTRODUCTION Although the benefits of physical activity and exercise are widely acknowledged, many middle-aged and elderly individuals remain sedentary. This cross-sectional study aimed to identify the external and internal barriers to…
View details →Gaurav Aggarwal, Giuseppe Lippi, Brandon Michael Henry · 2020 · International Journal of Stroke
INTRODUCTION: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.…
View details →Huijuan Wu, Christopher P. Larsen, Cesar F. Hernandez-Arroyo et al. · 2020 · Journal of the American Society of Nephrology
Significance Statement Kidney involvement may occur in coronavirus disease 2019 (COVID-19), and can be severe among Black individuals. In this study of collapsing glomerulopathy in six Black patients with COVID-19, the authors found that…
View details →Felipe Lobelo, Isabel Garcia de Quevedo · 2014 · American Journal of Lifestyle Medicine
Physical inactivity constitutes the fourth leading cause of death worldwide. Health care providers (HCPs) should play a key role in counseling and appropriately referring their patients to adopt physical activity (PA). Previous reports…
View details →Chris Eijsbouts, Tenghao Zheng, Nicholas A. Kennedy et al. · 2021 · Nature Genetics
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1 ,
View details →Mats Brittberg, David P. Recker, John Ilgenfritz et al. · 2018 · The American Journal of Sports Medicine
Background: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured…
View details →Mark van den Boogaard, Arjen J. C. Slooter, Roger J. M. Brüggemann et al. · 2018 · JAMA
Importance: Results of studies on use of prophylactic haloperidol in critically ill adults are inconclusive, especially in patients at high risk of delirium. Objective: To determine whether prophylactic use of haloperidol improves survival…
View details →Simon Finfer, Sharon Micallef, Naomi Hammond et al. · 2022 · New England Journal of Medicine
BACKGROUND: Whether the use of balanced multielectrolyte solution (BMES) in preference to 0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney injury or death is uncertain. METHODS: In a…
View details →Markus Gschwind, Gilles Pourtois, Sophie Schwartz et al. · 2011 · Cerebral Cortex
Face recognition is of major social importance and involves highly selective brain regions thought to be organized in a distributed functional network. However, the exact architecture of interconnections between these regions remains…
View details →Anup Katheria, Frank Reister, Jochen Essers et al. · 2019 · JAMA
Importance: Umbilical cord milking as an alternative to delayed umbilical cord clamping may provide equivalent benefits to preterm infants, but without delaying resuscitation. Objective: To determine whether the rates of death or severe…
View details →Philippe Bégin, Jeannie Callum, Erin Jamula et al. · 2021 · Nature Medicine
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml of convalescent plasma or standard of care. The composite primary outcome was intubation or death by 30 d. Exploratory analyses
View details →Cindy Van Humbeeck, Tom Cornelissen, Hilde Hofkens et al. · 2011 · Journal of Neuroscience
Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy).…
View details →James D. A. Parker, Graeme J. Taylor, Michael Bagby · 2010 · Psychotherapy and Psychosomatics
Slides of photographs depicting posed facial expressions of nine different emotions were presented to 131 females and 85 males who were asked to identify the emotion(s) being experienced by the person in each photograph. Subjects were then…
View details →Stefan Lohmander, Scarlett Hellot, Don Dreher et al. · 2014 · Arthritis & Rheumatology
OBJECTIVE: To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA). METHODS: The study was a randomized, double-blind,…
View details →Steven T. Lanier, Eric D. Wang, John J. Chen et al. · 2010 · Annals of Plastic Surgery
Tissue expander/implant breast reconstructions by 5 surgeons at a single institution from 2005 to 2008 were retrospectively identified and divided into 2 cohorts: use of acellular dermal matrix (ADM, n = 75) versus standard submuscular…
View details →Atthaphorn Trakarnsanga, Mithat Gönen, Jinru Shia et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Tumor regression grade (TRG) is a measure of histopathological response of rectal cancer to neoadjuvant chemoradiation and is associated with outcomes. Several TRG systems are used: Mandard (5,3-tier), Dowrak/Rödel (5,3-tier),…
View details →Taofeek K. Owonikoko, Keunchil Park, Ramaswamy Govindan et al. · 2021 · Journal of Clinical Oncology
PURPOSE: In extensive-disease small-cell lung cancer (ED-SCLC), response rates to first-line platinum-based chemotherapy are robust, but responses lack durability. CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus…
View details →Kaitlin B. Casaletto, Anya Umlauf, Jennifer L. Beaumont et al. · 2015 · Journal of the International Neuropsychological Society
Demographic factors impact neuropsychological test performances and accounting for them may help to better elucidate current brain functioning. The NIH Toolbox Cognition Battery (NIHTB-CB) is a novel neuropsychological tool, yet the…
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