299 real negative results, null findings, and replication failures in Medicine · Replication Failure. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Oreskovic NM, Erwin AE, Allon ZA et al. · 2026 · The American journal of managed care
Objectives Office-based care coordination programs are increasingly utilizing social work-trained care coordinators to manage high-cost, high-need (HCHN) patients with increased psychosocial risk, including patients covered by Medicaid.…
View details →Lin MC, Jiang X, Qiu ZC et al. · 2026 · Head & neck
Background Management of the clinically node-negative (cN0) neck in intermediate-grade mucoepidermoid carcinoma (MEC) of the head and neck remains controversial. Methods We retrospectively reviewed patients with cN0 intermediate-grade MEC…
View details →Takeda Y, Nakai T, Okamoto T et al. · 2026 · The Journal of arthroplasty
Background Mirogabalin, a selective α2δ-1 ligand, has been proposed to exhibit potent analgesic effects with fewer central nervous system (CNS) side effects than prior gabapentinoids. Its effectiveness for acute postoperative pain after…
View details →Meerman M, Buijser M, Neto AS et al. · 2026 · Critical care medicine
Objectives To determine whether perioperative IV magnesium sulfate infusion, targeting serum magnesium concentrations of 1.5-2.0 mmol/L, reduces the incidence of postoperative atrial fibrillation (POAF) in patients undergoing cardiac…
View details →Baxi SM, Igbinosa II, Main EK et al. · 2026 · AJOG global reports
Background Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent that has been shown to reduce hemorrhage-related mortality in trauma, is used…
View details →Wang C, Li S, Lu H et al. · 2026 · BMC gastroenterology
Background While routine use of abdominal drainage in cases of perforated appendicitis is not generally recommended, there exists a paucity of evidence regarding the detailed stratification of its necessity based on varying degrees of…
View details →Elenjickal EJ, Mavrakanas TA · 2026 · American journal of nephrology
Background Aldosterone regulates genes controlling fluid and electrolyte balance through mineralocorticoid receptor (MR) activation. Sustained MR activation promotes inflammation, fibrosis, sodium retention, and myocardial remodeling. MR…
View details →Alallah J, Mohtisham F, Ahmed A et al. · 2026 · Journal of neonatal-perinatal medicine
BackgroundThe study examined the medical impact of tahneek with dates on hypoglycemia in high-risk newborns. Tahneek, an Islamic tradition, may offer benefits such as stimulating mouth muscles and aiding in breastfeeding initiation. The…
View details →Gangeri L, Alfieri S, Anselmi V et al. · 2025 · Tumori
Background As part of the improvement plan of the Organisation of European Cancer Institutes at the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan (INT) a Committee composed of patients, caregivers, and representatives of patient…
View details →Vukšić J, Kustić D · 2026 · Rheumatology international
To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…
View details →Medeiros CNA, Azevedo IG, Gomes Fernandes SG et al. · 2026 · PeerJ
Background Urinary incontinence (UI) is a common complaint among middle-aged and older women, associated with many negative impacts in health. The aim of this study was to analyze whether an association exists between UI and sarcopenic…
View details →Awwad A, Das Adhikari U, Burdo TH et al. · 2026 · AIDS (London, England)
Objective To determine whether pitavastatin reduces enterocyte injury, assessed by intestinal fatty acid-binding protein (I-FABP), among antiretroviral therapy-treated people with HIV (PWH) enrolled in the REPRIEVE mechanistic substudy.…
View details →Tidblad L, Öberg Sysojev A, Delcoigne B et al. · 2025 · RMD open
Objective To examine whether obesity and/or overweight are independently associated with an increased risk of remission failure in patients with early rheumatoid arthritis (RA), treated with methotrexate as first disease-modifying…
View details →Küçükatalay Ö, Kantarcı S, Dağlı U et al. · 2026 · JSLS : Journal of the Society of Laparoendoscopic Surgeons
Introduction Total laparoscopic hysterectomy (TLH) is widely performed for benign gynecologic conditions; however, postoperative pain particularly shoulder pain related to residual intraperitoneal CO 2 remains a clinical concern. This…
View details →Alevi KCC, Ravazi A, de Oliveira J et al. · 2025 · Scientific reports
The diversification of Rhodnius species has been primarily attributed to vicariance events. Phylogenomic studies have proposed various evolutionary hypotheses - such as incomplete lineage sorting, hybrid speciation, and introgression - to…
View details →Magno Serrano P, Barros P, Dores M et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
Introduction Antibiotic resistance represents a major public health problem driven by inappropriate antimicrobial use. Cystoscopy is a common urological procedure associated with a low risk of urinary tract infection (UTI), and the role of…
View details →Moss AS, Nguyen QG, Iyer P · 2026 · Clinical rheumatology
Background Patient education materials are vital to health education and, according to the American Medical Association (AMA), should not be written above a 6th grade reading level (Weiss 2003). We aim to assess American College of…
View details →Mølhave M, Olsen ZL, Svanesøe S et al. · 2025 · Acta oto-laryngologica
Background Tracheostomy is widely used in critically ill patients, yet limited clinical data exist from Danish ENT departments. Aims/objectives To describe clinical outcomes and perioperative care in patients undergoing tracheostomy at a…
View details →Bhardwaj A, Jain A, Jain N et al. · 2026 · Indian pediatrics
Objective To evaluate whether epinephrine nebulization, when used in addition to standard care, reduces extubation failure (EF) in term and preterm neonates. Methods A parallel, randomized controlled superiority trial was conducted in a…
View details →Khadanga S, Yant B, Savage PD et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Despite the benefits, cardiac rehabilitation (CR) is underutilized, particularly in women. Case management (CM) has been shown to reduce the risk of cardiovascular disease and improve health outcomes. The purpose of this study was…
View details →Can V, Polat F, Kaya AF et al. · 2026 · Journal of cardiovascular pharmacology
Abstract Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This study evaluated whether mean…
View details →Liu Y, Zhong S, Zhong K et al. · 2026 · Frontiers in endocrinology
Aim To investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive disorders of pregnancy in subsequent pregnancy (s-HDP). Methods A retrospective cohort of 5, 928 women with two…
View details →Amuji DN, Iweala EEJ · 2026 · BMC cancer
BACKGROUND: Breast cancer (BC) is a major cause of cancer-related mortality among women worldwide. Genetic polymorphisms, such as those in the Mesenchymal Epithelial Transition factor (MET) proto-oncogene, may influence cancer risk and…
View details →Franco-Ortega JA, Albertos-Alpuche PJ, Mora-Medina P et al. · 2026 · Journal of fish diseases
Immersion anaesthesia is widely used in fish handling and research, yet optimization of protocols requires not only effective immobilization but also consideration of internal physiological responses. This study evaluated the effects of…
View details →Rowhani M, Hörmannstorfer-Fessl K, Kastner M et al. · 2026 · Respiratory medicine
Background Dry powder inhalers (DPIs) prescribed for respiratory diseases require patients to generate sufficient peak inspiratory flow (PIF) for optimal drug delivery to the airways. However, information is scarce regarding PIF of asthma…
View details →Ugail H, Howard N, Elmahmudi AA et al. · 2026 · Sensors (Basel, Switzerland)
Major depressive disorder remains difficult to diagnose objectively, as routine assessment is still largely dependent on clinical interview and rating scales. Resting-state electroencephalography (EEG) is an attractive complementary…
View details →Liang XQ, Han L, Yan T et al. · 2026 · Journal of anesthesia
Purpose Postoperative pulmonary complications are common and associated with worse long-term outcomes. In our previous trial, prophylactic penehyclidine inhalation reduced pulmonary complications in high-risk patients. Herein, we tested…
View details →Toft M, Hansen MS, Vestergaard JD et al. · 2026 · British journal of sports medicine
Objective To evaluate whether individualised treatment using the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) is superior to default operative or non-operative strategies. Methods We conducted a multicentre, three-arm,…
View details →Zaidi S, Zoya M, Ishrat M et al. · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
The study aimed to evaluate delays in emergency department (ED) arrival among stroke patients and to identify demographic factors that contribute to these delays. It was a cross-sectional study conducted at the Department of Neurology,…
View details →Cheng WJ, Kao CL, Hung IY · 2026 · Frontiers in nutrition
Background Hearing impairment is associated with an elevated risk of depression, yet modifiable risk factors in this population remain poorly characterized. Although vitamin D deficiency (VDD) has been linked to depression in general…
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