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286 real negative results, null findings, and replication failures in Medicine · Replication Failure. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication FailureOpen accessMedicine

Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study.

Liu Y, Zhong S, Zhong K et al. · 2026 · Frontiers in endocrinology

Aim To investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive disorders of pregnancy in subsequent pregnancy (s-HDP). Methods A retrospective cohort of 5, 928 women with two…

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Replication FailureMedicine

Peak inspiratory flow in Austrian patients with asthma and/or COPD using dry powder inhalers- a cross-sectional, observational real-world study.

Rowhani M, Hörmannstorfer-Fessl K, Kastner M et al. · 2026 · Respiratory medicine

Background Dry powder inhalers (DPIs) prescribed for respiratory diseases require patients to generate sufficient peak inspiratory flow (PIF) for optimal drug delivery to the airways. However, information is scarce regarding PIF of asthma…

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Replication FailureMedicine

A Comprehensive Assessment of Acute Stroke Care: Delays, Treatment Patterns, and Barriers to Timely Intervention.

Zaidi S, Zoya M, Ishrat M et al. · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

The study aimed to evaluate delays in emergency department (ED) arrival among stroke patients and to identify demographic factors that contribute to these delays. It was a cross-sectional study conducted at the Department of Neurology,…

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Replication FailureOpen accessMedicine

A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950).

Bhatia A, Chen Z, Zhang Y et al. · 2026 · Cancer

Background Ataxia telangiectasia Rad3-related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors…

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Replication FailureMedicine

Prospective observational comparative study on antibiotic prophylaxis in cystoscopy: towards a rational use of antimicrobials.

Magno Serrano P, Barros P, Dores M et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Introduction Antibiotic resistance represents a major public health problem driven by inappropriate antimicrobial use. Cystoscopy is a common urological procedure associated with a low risk of urinary tract infection (UTI), and the role of…

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Replication FailureMedicine

Role of Case Management for Improving Cardiac Rehabilitation Participation in Women: A RANDOMIZED CONTROLLED TRIAL.

Khadanga S, Yant B, Savage PD et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention

Purpose Despite the benefits, cardiac rehabilitation (CR) is underutilized, particularly in women. Case management (CM) has been shown to reduce the risk of cardiovascular disease and improve health outcomes. The purpose of this study was…

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Replication FailureMedicine

Facial shape and self-perceived personality traits in young adults.

Gkantidis N, Tsikouriadou E, Halazonetis D et al. · 2026 · Scientific reports

The present study investigated the association between facial shape and self-perceived personality and psychosocial traits. The study population consisted of 613 young adults (399 females and 214 males) aged 21-35 years, with similar…

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Replication FailureOpen accessMedicine

Subject-Wise Depression Screening from Eight-Channel Resting-State EEG Using Asymmetry-Aware Spectral Features and Connectivity Ablation.

Ugail H, Howard N, Elmahmudi AA et al. · 2026 · Sensors (Basel, Switzerland)

Major depressive disorder remains difficult to diagnose objectively, as routine assessment is still largely dependent on clinical interview and rating scales. Resting-state electroencephalography (EEG) is an attractive complementary…

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Replication FailureMedicine

Impact of prevention of postoperative pulmonary complications with penehyclidine inhalation on long-term outcomes in high-risk patients: follow-up of a randomized trial.

Liang XQ, Han L, Yan T et al. · 2026 · Journal of anesthesia

Purpose Postoperative pulmonary complications are common and associated with worse long-term outcomes. In our previous trial, prophylactic penehyclidine inhalation reduced pulmonary complications in high-risk patients. Herein, we tested…

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Replication FailureMedicine

Randomised three-armed trial investigation of the Copenhagen Achilles tendon Rupture Treatment Algorithm (CARTA) for individualised treatment of acute Achilles tendon rupture.

Toft M, Hansen MS, Vestergaard JD et al. · 2026 · British journal of sports medicine

Objective To evaluate whether individualised treatment using the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) is superior to default operative or non-operative strategies. Methods We conducted a multicentre, three-arm,…

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Replication FailureOpen accessMedicine

Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Small Cell Lung Cancer: A Dramatic Recovery after Chemotherapy.

Yano K, Ishida T, Yokosuka K et al. · 2026 · Internal medicine (Tokyo, Japan)

Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for…

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