11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mohamad Habes, Güray Erus, Jon B. Toledo et al. · 2016 · Brain
White matter hyperintensities are associated with increased risk of dementia and cognitive decline. The current study investigates the relationship between white matter hyperintensities burden and patterns of brain atrophy associated with…
View details →Deirdre K. Tobias, An Pan, Chandra L. Jackson et al. · 2014 · New England Journal of Medicine
BACKGROUND: The relation between body weight and mortality among persons with type 2 diabetes remains unresolved, with some studies suggesting decreased mortality among overweight or obese persons as compared with normal-weight persons (an…
View details →Daniël B.F. Saris, Andrew Price, Wojciech Widuchowski et al. · 2014 · The American Journal of Sports Medicine
BACKGROUND: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured…
View details →Mohamed L. Sorror, Rainer Storb, Brenda M. Sandmaier et al. · 2014 · Journal of Clinical Oncology
PURPOSE: Age has long been used as a major factor for assessing suitability for allogeneic hematopoietic cell transplantation (HCT). The HCT-comorbidity index (HCT-CI) was developed as a measure of health status to predict mortality risk…
View details →Michael F. Green, Carrie E. Bearden, Tyrone D. Cannon et al. · 2011 · Schizophrenia Bulletin
Social cognitive impairments are consistently reported in schizophrenia and are associated with functional outcome. We currently know very little about whether these impairments are stable over the course of illness. In the current study,…
View details →Alex R. Kemper, William T. Mahle, Gerard R. Martin et al. · 2011 · PEDIATRICS
BACKGROUND: Although newborn screening for critical congenital heart disease (CCHD) was recommended by the US Health and Human Services Secretary's Advisory Committee on Heritable Disorders in Newborns and Children to promote early…
View details →Cátia Laranjeira, Katarina Sandgren, Nicoletta Kessaris et al. · 2011 · Journal of Clinical Investigation
The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in the adult intestine using clonal cultures and in…
View details →Suetonia C. Palmer, Dimitris Mavridis, Antonio Nicolucci et al. · 2016 · JAMA
IMPORTANCE: Numerous glucose-lowering drugs are used to treat type 2 diabetes. OBJECTIVE: To estimate the relative efficacy and safety associated with glucose-lowering drugs including insulin. DATA SOURCES: Cochrane Library Central…
View details →Hanne Vanheel, María Vicario, Tim Vanuytsel et al. · 2013 · Gut
OBJECTIVE: Functional dyspepsia (FD) is an extremely common functional gastrointestinal disorder, the pathophysiology of which is poorly understood. We hypothesised that impaired intestinal barrier function is involved in the onset and…
View details →Kai Liu, Ying Chen, Duozhi Wu et al. · 2020 · Complementary Therapies in Clinical Practice
BACKGROUND: Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. Some sleep-improving drugs may inhibit the respiratory system and worsen the condition.…
View details →David R. Mandel, Katy Eichas, J Holmes · 2010 · BMC Complementary and Alternative Medicine
BACKGROUND: Lactic acid-producing bacteria (LAB) probiotics demonstrate immunomodulating and anti-inflammatory effects and the ability to lessen the symptoms of arthritis in both animals and humans. This randomized, double-blind, placebo-controlled, parallel-design, clinical pilot trial was conducted to evaluate the effects of the LAB probiotic preparation, Bacillus coagulans GBI-30, 6086, on symptoms and measures of functional capacity in patients with rheumatoid arthritis (RA) in combination with pharmacological anti-arthritic medications. METHODS: Forty-five adult men and women with symptom
View details →L. A. Smith, Natalia Price, Vanessa Simonite et al. · 2013 · BMC Pregnancy and Childbirth
BACKGROUND: Our aim was to describe the range of perineal trauma in women with a singleton vaginal birth and estimate the effect of maternal and obstetric characteristics on the incidence of perineal tears. METHODS: We conducted a prospective observational study on all women with a planned singleton vaginal delivery between May and September 2006 in one obstetric unit, three freestanding midwifery-led units and home settings in South East England. Data on maternal and obstetric characteristics were collected prospectively and analysed using univariable and multivariable logistic regression. Th
View details →Adam Brufsky, Musa Mayer, Hope S. Rugo et al. · 2011 · Clinical Cancer Research
PURPOSE: registHER is a prospective, observational study of 1,023 newly diagnosed HER2-positive metastatic breast cancer (MBC) patients. EXPERIMENTAL DESIGN: Baseline characteristics of patients with and without central nervous system…
View details →Horacio J. Asbun, John Stauffer · 2012 · Journal of the American College of Surgeons
BACKGROUND: Minimal access surgery techniques have evolved to include complex surgical procedures. Laparoscopic pancreaticoduodenectomy (LPD) is a complex operation that pancreas surgeons have been slow to adopt. This article reviews our…
View details →US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Pancreatic cancer is an uncommon cancer with an age-adjusted annual incidence of 12.9 cases per 100 000 person-years. However, the death rate is 11.0 deaths per 100 000 person-years because the prognosis of pancreatic cancer is…
View details →Ingmar Schäfer, Eike-Christin von Leitner, Gerhard Schön et al. · 2010 · PLoS ONE
OBJECTIVE: Multimorbidity is a common problem in the elderly that is significantly associated with higher mortality, increased disability and functional decline. Information about interactions of chronic diseases can help to facilitate diagnosis, amend prevention and enhance the patients' quality of life. The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity. METHODS: Multimorbidity patterns were identified by exploratory tetrachoric factor ana
View details →Gary Cook, Connie Yip, Muhammad Siddique et al. · 2012 · Journal of Nuclear Medicine
UNLABELLED: There is evidence in some solid tumors that textural features of tumoral uptake in (18)F-FDG PET images are associated with response to chemoradiotherapy and survival. We have investigated whether a similar relationship exists…
View details →Kevin C. Soares, Agnieszka A. Rucki, Annie A. Wu et al. · 2014 · Journal of Immunotherapy
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and resistance to conventional therapies. Published studies show that the PDA tumor microenvironment is predominantly infiltrated with immune suppressive…
View details →Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren et al. · 2012 · Journal of Clinical Oncology
PURPOSE: To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced…
View details →Matthew J. Ward, Stephen M. Thirdborough, Toby Mellows et al. · 2013 · British Journal of Cancer
BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared with HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Currently, there is no…
View details →Tom Jefferson, Mark Jones, Peter Doshi et al. · 2014 · Cochrane Database of Systematic Reviews
BACKGROUND: Neuraminidase inhibitors (NIs) are stockpiled and recommended by public health agencies for treating and preventing seasonal and pandemic influenza. They are used clinically worldwide. OBJECTIVES: To describe the potential…
View details →Jay H. Traverse, Timothy D. Henry, Carl J. Pepine et al. · 2012 · JAMA
CONTEXT: While the delivery of cell therapy after ST-segment elevation myocardial infarction (STEMI) has been evaluated in previous clinical trials, the influence of the timing of cell delivery on the effect on left ventricular function…
View details →A. Sun, Kyounghwa Bae, Elizabeth Gore et al. · 2010 · Journal of Clinical Oncology
PURPOSE: There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL). Radiation Therapy Oncology Group trial 0214 showed no overall survival (OS) benefit…
View details →Danny Rischin, Lester J. Peters, Brian O’Sullivan et al. · 2010 · Journal of Clinical Oncology
PURPOSE: Promising results in a randomized phase II trial with the hypoxic cytotoxin tirapazamine (TPZ) combined with cisplatin (CIS) and radiation led to this phase III trial. PATIENTS AND METHODS: Patients with previously untreated stage…
View details →Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga et al. · 2019 · Movement Disorders
BACKGROUND: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants…
View details →Ann Ganestam, Thomas Kallemose, Anders Troelsen et al. · 2015 · Knee Surgery Sports Traumatology Arthroscopy
The purpose of this study is to investigate the incidence of acute Achilles tendon rupture in Denmark from 1994 to 2013 with focus on sex, age, geographical areas, seasonal variation and choice of treatment. The National Patient Registry…
View details →Stephanie Cardarella, Atsuko Ogino, Mizuki Nishino et al. · 2013 · Clinical Cancer Research
PURPOSE: BRAF mutations are found in a subset of non-small cell lung cancers (NSCLC). We examined the clinical characteristics and treatment outcomes of patients with NSCLC harboring BRAF mutations. EXPERIMENTAL DESIGN: Using DNA…
View details →May Al-Nbaheen, Radhakrishnan Vishnubalaji, Dalia Ali et al. · 2012 · Stem Cell Reviews and Reports
Human stromal (mesenchymal) stem cells (hMSCs) are multipotent stem cells with ability to differentiate into mesoderm-type cells e.g. osteoblasts and adipocytes and thus they are being introduced into clinical trials for tissue regeneration. Traditionally, hMSCs have been isolated from bone marrow, but the number of cells obtained is limited. Here, we compared the MSC-like cell populations, obtained from alternative sources for MSC: adipose tissue and skin, with the standard phenotype of human bone marrow MSC (BM-MSCs). MSC from human adipose tissue (human adipose stromal cells (hATSCs)) and h
View details →Laura A. Pratt, Debra J. Brody, Qiuping Gu · 2011 · PubMed
In 2005–2008, 11% of Americans aged 12 and over took antidepressant medication. There were significant differences in antidepressant medication usage rates between groups. Females were 2½ times as likely as males to take antidepressants.…
View details →Joseph Kan, Taichiro Morimoto, Kitichai Rungcharassaeng et al. · 2010 · PubMed
This study evaluated the reliability of assessing visually the facial gingival biotype of maxillary anterior teeth with and without the use of a periodontal probe in comparison with direct measurements. Forty-eight patients (20 men, 28…
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