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Browse the failure-mode index

11,421 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of Routine Intraoperative Lithotripsy on Surgical Strategy and Outcomes in Laparoscopic Bile Duct Exploration: A Single-Centre Cohort Study.

Elsamalouty I, Gupta A, Whitmore M et al. · 2026 · Cureus

Background Laparoscopic bile duct exploration (LBDE) enables single-stage management of common bile duct (CBD) stones. However, large or impacted stones often necessitate choledochotomy, which is associated with increased morbidity and…

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Negative / Null Result ReportMedicine

Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.

Dobrzycka M, Wołoszyn P, Prud M et al. · 2026 · Journal of clinical medicine

Background : Frailty is associated with adverse postoperative outcomes and functional decline in older adults undergoing colorectal cancer (CRC) surgery. The long-term course of frailty and functional outcomes among patients undergoing…

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Negative / Null Result ReportMedicine

Acute effects of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic function and blood pressure in sedentary older adults: A pilot randomized controlled trial.

Ladriñán-Maestro A, Sánchez-Sierra A, Elfoukahi O et al. · 2026 · PloS one

The aim of this study was to evaluate the acute effects of a single session of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic regulation, blood pressure, and arterial oxygen saturation in sedentary older adults. A…

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Negative / Null Result ReportMedicine

Effectiveness of gaseous ozone in reducing microbial contamination: evaluation of environmental disinfection in healthcare settings.

Mastrantonio R, Romantini A, Lombardo C et al. · 2026 · Infection control and hospital epidemiology

Objective Environmental contamination is a significant factor in the transmission of healthcare-associated infections. This study evaluated the effectiveness of gaseous ozone in reducing microbial contamination within hospital settings,…

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Negative / Null Result ReportMedicine

Colonoscopic and oral microbiota transplant therapy yield similar stool and neoterminal ileal engraftment profiles in a single-blind pilot randomized trial.

Moutsoglou D, Staley C, Kabage AJ et al. · 2026 · Inflammatory bowel diseases

Background The intestinal microbiota play a key role in Crohn's disease (CD) and postoperative recurrence following ileocecal resection. Microbiota transplant therapy (MTT) could impact postoperative CD recurrence. This study aimed to…

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Negative / Null Result ReportOpen accessMedicine

A randomized controlled pilot trial comparing peri-implant tissue health beneath CAD/CAM-milled PEEK versus cobalt-chromium telescopic crowns for mandibular overdentures.

El Asfahani IA, Khalifa A, Tawfik D et al. · 2026 · International journal of implant dentistry

Purpose This pilot randomized clinical trial compared peri-implant tissue health around milled cobalt-chromium (CoCr) versus polyether ether ketone (PEEK) secondary telescopic crowns in implant-retained mandibular overdentures over 12…

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Negative / Null Result ReportOpen accessMedicine

<i>Pseudomonas aeruginosa</i> gene expression changes during established biofilm infection in a cystic fibrosis lung model.

Harrington NE, Allen F, Garcia Maset R et al. · 2026 · Microbiology (Reading, England)

The opportunistic pathogen Pseudomonas aeruginosa forms biofilm infections in the lungs of people with the genetic condition cystic fibrosis (CF) that can persist for decades. There are numerous P. aeruginosa lifestyle changes associated…

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Negative / Null Result ReportOpen accessMedicine

Early Weight Loss After Sleeve Gastrectomy Selectively Improves Intermetatarsal Angle Without Affecting Hallux Valgus Angle.

Türkoğlu F, Sarı S, Gencer EN et al. · 2026 · Journal of clinical medicine

Background/Objectives : While bariatric surgery is known to improve plantar pressure distribution and reduce foot-related symptoms, its impact on radiographic forefoot alignment parameters, such as the intermetatarsal angle (IMA) and…

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Negative / Null Result ReportMedicine

Temporal change in patients with mitral annular calcification after successful aortic valve intervention.

Abdul-Kafi O, Chedid M, Ansani T et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background Patients with severe aortic valve stenosis and concomitant mild to moderate mitral stenosis (MS) or mitral regurgitation (MR) from mitral annular calcification (MAC) often undergo aortic valve replacement (AVR) while sparing the…

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Negative / Null Result ReportMedicine

Early impact of Japan's 2024 physician work hour reform on cardiovascular revascularization: a multi-center interrupted time series analysis using a National-Level DPC database.

Morishita T, Takada D, Itoshima H et al. · 2026 · Cardiovascular intervention and therapeutics

Japan introduced nationwide physician work-hour limits in April 2024. Because cardiovascular emergencies require continuous in-hospital availability, concerns existed that restricting duty hours could reduce access to revascularization or…

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Negative / Null Result ReportOpen accessMedicine

The Frontal QRS-T Angle Remains Unchanged in Patients Without Structural Heart Disease Receiving Flecainide Therapy.

Kucukosmanoglu M, Ardıc ML, Koca F et al. · 2026 · Journal of cardiovascular development and disease

Introduction: Prolongation of the QT interval and QRS duration, which are markers of ventricular repolarization and depolarization, has been reported in patients receiving flecainide therapy. However, the effects of flecainide on the QRS-T…

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Negative / Null Result ReportOpen accessMedicine

Imidacloprid induces hepatorenal toxicity in male albino rats via oxidative, immune inflammatory, and proliferative effects: a 90-day study.

Khwanes SA, Mohamed RA, Abd El-Rahman HA et al. · 2026 · Scientific reports

Imidacloprid (IM), a systemic neonicotinoid pesticide, is widely used globally due to its high effectiveness against a broad range of insects at minimal application rates. The current study aimed to examine how this insecticide can induce…

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Negative / Null Result ReportMedicine

An Evaluation of the Influence of Natural Clay and Natural Clay/TiO<sub>2</sub> Nanocomposites on the Color Stability of Heat-Polymerized Maxillofacial Silicone After Disinfection.

Abdalqadir M, Raouf L, Mohammed K et al. · 2026 · Polymers

This study aimed to investigate the effect of time and different disinfecting agents on nanocomposite filler composed of natural clay nanoparticles (modified and non-modified) added to maxillofacial silicone elastomers and readymade…

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Negative / Null Result ReportMedicine

Pelvic Floor Health Knowledge With Enhanced Education During Pregnancy.

Nicola-Ducey L, Ward L, Holland A et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Prior to delivery, there are postpartum pelvic floor recovery topics to provide education on; however, because of a variety of factors, the majority of these are commonly unaddressed, leaving a patient unknowledgeable and…

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Negative / Null Result ReportMedicine

Enhancing Intercultural Sensitivity Through Collaborative Online International Learning Among Three Countries: A Mixed-Method Study.

Ying Z, Kondo A, De D et al. · 2026 · Journal of transcultural nursing : official journal of the Transcultural Nursing Society

Introduction We evaluated a Collaborative Online International Learning (COIL) programme in enhancing nursing students' intercultural sensitivity and understanding of cultural safety. Methods From April to May 2024, nursing students in…

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Negative / Null Result ReportMedicine

Curcumin nanoparticles combined with narlumosbart regulate wingless-type MMTV integration site (wnt)/β-catenin signaling pathway in osteoblast-like cells.

Zhang H, Zhao Y · 2026 · Pakistan journal of pharmaceutical sciences

Background Narlumosbart is a key agent for modulating bone cell function. Given the potential of curcumin nanoparticles to inhibit cell growth when applied alone. Objectives This study aims to investigate the role of their combination with…

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Negative / Null Result ReportMedicine

Ocular Effects of Topical 1% Cyclopentolate in New Zealand White Rabbits: A Controlled Evaluation of Intraocular Pressure, Pupil Size, and Tear Production.

Arfaee F, Shariati S, Armin A · 2026 · Veterinary ophthalmology

Objective Mydriatic and cycloplegic agents are widely used in veterinary ophthalmology to enable posterior segment examination. This study evaluated the effects of topical 1% cyclopentolate on intraocular pressure (IOP), horizontal pupil…

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