11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Koca SB, Kırkgöz T, Kara L et al. · 2026 · BMC endocrine disorders
BACKGROUND: Spexin has an inhibitory effect on the hypothalamus (GnRH expression), pituitary (LH and FSH expression) and ovary (estradiol expression). However, Phoenixin potentiate GnRH-stimulated GnRH receptor expression. Our aim is to…
View details →Altun MNŞ, Yıldız İ · 2026 · Journal of pediatric nursing
Purpose This study aimed to determine the levels of e-health literacy and quality of life in adolescents with Congenital Heart Disease (CHD), to examine associated factors, and to explore the relationship between e-health literacy and…
View details →Sun X, Zhou Q, Qian W et al. · 2026 · BMC medical education
Background Teaching postoperative follow-up for renal cell carcinoma (RCC) is challenging during brief urology rotations. We evaluated a structured module based on a simplified risk model (IMDB: venous invasion, tumor size ≥ 7 cm, systemic…
View details →Mitsea A, Christoloukas N, Rontogianni A et al. · 2026 · Journal of imaging
AI methods (machine learning and deep learning methods) presented promising results concerning the accuracy of dental age estimation and sex determination. Therefore, this pilot study aims to evaluate the efficacy of an artificial…
View details →Ulas O, Yuceer RO, Hasbek Z et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Neuroendocrine neoplasms are heterogeneous tumours arising from endocrine gland cells and the neuroendocrine system. Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) constitute two-thirds of this tumour…
View details →Silva VBC, Lucina SB, Wolf M et al. · 2026 · American journal of veterinary research
Objective To assess right ventricular (RV) systolic function using conventional echocardiography and advanced techniques, including strain and tissue motion annular displacement (TMAD), in dogs with and without pulmonary hypertension (PH).…
View details →Çerçer Z, Biçer Şahin F, Kanarya T · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association
Background and aim It is important to include fathers in the evaluation of the breastfeeding process. This study aimed to assess fathers' breastfeeding attitudes and participation. Methods The cross-sectional study data were collected…
View details →Igarashi A, Rekate A, Fujiwara K et al. · 2026 · Acta ophthalmologica
Purpose To evaluate whether early postoperative corneal thickness is associated with 12-month endothelial cell and visual outcomes after Descemet membrane endothelial keratoplasty (DMEK). Methods This retrospective multicentre study…
View details →Pillet P, Tremblay-Mercier J, Picard C et al. · 2026 · Neurobiology of aging
Preclinical studies consistently associate body temperature with tau phosphorylation in the brain. This study examined the relationship between body temperature taken at lumbar puncture (LP) and CSF pTau181 levels in 142 cognitively…
View details →Hamama I, Katodia V, Landry NM et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM
Objectives Hypoglycemia is a common metabolic problem in newborns, often asymptomatic but can lead to cognitive impairment and neuromotor delays. This study assesses the practicality and accuracy of whole blood capillary bedside glucose…
View details →Bakaç E, Bayburt KA, Diker N et al. · 2026 · Cranio : the journal of craniomandibular practice
Objective To assess early temporomandibular joint (TMJ) adaptation by evaluating angular and volumetric changes of the mandibular condyle relative to the cranial base in skeletal Class III patients following orthognathic surgery using…
View details →Elyasi B · 2026 · Veterinary medicine and science
Background The main goal of this study was to identify various brightness, motion and Doppler echocardiographic variables in small-breed dogs with myxomatous mitral valve disease. Animals Sixty client-owned small-breed dogs with mitral…
View details →Aydemir M, Sarkılar G, Atay T et al. · 2026 · Turk gogus kalp damar cerrahisi dergisi
Background Hypotension during anesthesia induction is a clinically significant event linked to perioperative complications. This study aimed to assess if arterial stiffness and stiffness index, measured by Doppler ultrasonography (USG),…
View details →Kook PH · 2026 · Journal of feline medicine and surgery
ObjectivesIt remains unclear whether pancreatic lipase immunoreactivity (PLI) and lipase activity similarly reflect clinical status and disease severity in cats with suspected pancreatitis. This retrospective cohort study aimed to directly…
View details →Sakai M, Miyati T, Ohno N et al. · 2026 · Magnetic resonance imaging
Purpose To apply dynamical network biomarker (DNB) theory to diffusion MRI and develop the diffusion MRI-derived DNB (dMRI-DNB) index for evaluating neurofluid fluctuation in idiopathic normal pressure hydrocephalus (iNPH). Methods…
View details →Zhang C, Xie C, Zhang Z et al. · 2026 · Pathogens (Basel, Switzerland)
Background Sepsis, a life-threatening organ dysfunction caused by dysregulated host responses to infection, frequently involves impaired macrophage efferocytosis that leads to apoptotic cell accumulation, secondary necrosis, and persistent…
View details →Ito K, Hiranaka T, Basaqr AA et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Background Kinematic alignment (KA) aims to restore the distal and posterior joint surfaces by matching the resected bone to the implant thickness. However, whether KA also accurately reproduces the anterior femoral anatomy, including the…
View details →Barman Kakil Ş, Sarı SA, Hazar L · 2026 · Current eye research
Purpose To evaluate retinal and optic nerve head microcirculation in children with dyslexia using optical coherence tomography angiography (OCTA) and to explore whether retinal microvascular parameters differ between dyslexic and typically…
View details →Jiang C, Cheng P, Liu Y et al. · 2025 · Journal of pediatric orthopedics
Introduction Imaging-based measurement indices of patellar height are essential for diagnosing patella alta in children and adolescents. The Patellotrochlear Index (PTI) measures the cartilaginous anatomy which is crucial for identifying…
View details →Gül O, Ayazoglu MA, Yazıcı A et al. · 2026 · Journal of shoulder and elbow surgery
Background Perianchor fluid collection may differ according to anchor material following arthroscopic rotator cuff repair (ARCR), but its relationship with tendon healing remains unclear. This study aimed to compare perianchor fluid…
View details →Kocak OF, Alpayci M, Demir CY et al. · 2025 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Objective To determine the frequency and severity of joint hypermobility (JH) in rhinoplasty patients and to assess rhinoplasty satisfaction in rhinoplasty cases with JH. Study design Comparative cross-sectional study. Place and Duration…
View details →Alsayegh MMA, Sallom BA, Fadel EA et al. · 2026 · Scientific reports
Prenatal exposure to trace metal elements remains a significant public health concern, particularly because these elements can cross the placental barrier and accumulate in fetal tissues. Meconium and neonatal hair are commonly used as…
View details →Metrouh O, Bulman J, DeBacker SS et al. · 2026 · Academic radiology
Rationale and objectives This study aimed to evaluate the correlation between Interventional Radiology (IR) trainees' clinical performance during residency and their final National Residency Matching Program (NRMP) rank order list (ROL)…
View details →Zakariaei Z, Hosseini SH, Alizadeh-Navaei R et al. · 2026 · BMC infectious diseases
Background The infectious hypothesis of obsessive-compulsive disorder (OCD) has gained traction, with Toxoplasma gondii (T. gondii) proposed as a potential risk factor due to its neurotropic properties and ability to alter neurotransmitter…
View details →Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology
Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…
View details →Afsar E, Sadeghi-Bazargani H, Salehpour F et al. · 2026 · Scientific reports
Traumatic brain injury (TBI) continues to be one of the world's top causes of mortality and long-term disability. It is a severe and frequently fatal disorder. Patients with traumatic brain injury (TBI) not only sustain neurological…
View details →Ruffin JC, Stem CT, Pletzer S et al. · 2026 · Pediatric emergency care
Objective Pediatric heart failure is a rare condition with significant morbidity that requires timely diagnosis and treatment. Mitral valve E-point septal separation (EPSS) may be used as an estimate of systolic function in this…
View details →Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)
In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…
View details →Öztürk G, Orhon F, Bayrakoğlu D et al. · 2026 · International archives of allergy and immunology
The severity and incidence of invasive pneumococcal infections increase in inborn errors of immunities. However, there are limited number of studies in the literature evaluating pneumococcal antibody levels in patients with a prediagnosis…
View details →Abdelaziz AW, Alkherkhisy MM, El-Sheikh HR et al. · 2026 · BMC psychiatry
Background Lipid metabolism and its regulatory molecules, especially adipokines, have gained significant attention in recent pathogenesis research of autism spectrum disorder (ASD). Aims To evaluate serum fatty acid-binding protein 4…
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