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Browse the failure-mode index

11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Relationship between hamstring flexibility (askling H-test) and isokinetic strength ratios in elite soccer players with prior hamstring strain injury: A cross-sectional study.

Takla MKN, Rageh MRM, Aboalata MAM et al. · 2026 · Journal of back and musculoskeletal rehabilitation

BackgroundRecurrent hamstring strain injuries are associated with deficits in eccentric strength and altered muscle-tendon extensibility, which may persist and contribute to reinjury risk.ObjectiveTo examine the relationship between…

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Negative / Null Result ReportOpen accessMedicine

Correlation Between Baseline Serum Testosterone Levels and Cognitive Gain Following Combined Oral Contraceptive Treatment in Patients With Polycystic Ovary Syndrome.

Kumari S, Marwah S, Manna S et al. · 2026 · Cureus

Background Combined oral contraceptives (COCs) are the cornerstone therapy for polycystic ovary syndrome (PCOS). While COCs have been shown to improve cognitive performance, the relationship between these gains and hormonal profiles,…

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Negative / Null Result ReportMedicine

A Comparative Analysis of Differences in Salivary hBD-2 Levels and Their Correlation with Dental Caries and Unstimulated Saliva pH in Children with Primary and Permanent Dentition.

Stojković B, Igić M, Jevtović Stoimenov T et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This exploratory study aimed to investigate potential differences and associations between salivary hBD-2 levels and dental caries, as well as between unstimulated salivary pH and salivary hBD-2 levels, in children…

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Negative / Null Result ReportOpen accessMedicine

FeNO as a Non-Invasive Biomarker of Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps: Correlation with Serum IgE and Eosinophils.

Fereydouni S, Jabbari-Azad F, Bakhshaee M et al. · 2026 · Iranian journal of otorhinolaryngology

Introduction Chronic rhinosinusitis with nasal polyps is a heterogeneous inflammatory disorder often driven by type 2 inflammation. Identification of non-invasive biomarkers, such as fractional exhaled nitric oxide (FeNO), may support the…

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Negative / Null Result ReportMedicine

Associations Between Dynamic Quantitative Sensory Testing and Physical Therapy Outcomes in Chronic Low Back Pain: An Exploratory, Prospective Longitudinal Cohort Study.

Petrey K, Golden A, Durbin J et al. · 2026 · European journal of pain (London, England)

Background The primary objective of this study was to determine whether baseline conditioned pain modulation (CPM) is associated with pain and disability outcomes following a 6-week course of physical therapy intervention. Secondary…

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Negative / Null Result ReportMedicine

Different effect of aldosterone on corrected HCO<sub>3</sub><sup>-</sup> across primary aldosteronism subtypes.

Yasuda H, Yokota K, Katabami T et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Primary aldosteronism (PA) causes biochemical abnormalities such as hypokalemia and metabolic alkalosis. This study aimed to compare the effects of aldosterone on serum potassium and corrected bicarbonate (cHCO 3 - , defined as Na - Cl -…

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Negative / Null Result ReportMedicine

Axial length, anterior chamber parameters, and white-to-white corneal diameter: Their inter-correlations with intraocular pressure among young Saudis.

Alotaibi W, Alrasheed S · 2026 · JPMA. The Journal of the Pakistan Medical Association

Objective To evaluate axial length, anterior chamber angle, anterior chamber depth, refractive errors and white-to-white corneal diameter, and to assess their inter-correlations with intraocular pressure among young individuals. Methods…

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Negative / Null Result ReportMedicine

Correlation between blood biomarkers and patient-reported outcomes (PROs) of depression and mental health scores in individuals with multiple sclerosis (iwMS).

Baharnoori M, Glanz B, Polgar-Turcsanyi M et al. · 2026 · Journal of the neurological sciences

Background Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising biomarkers for Multiple Sclerosis (MS) disease activity. There is less known about their association with the symptomatic…

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Negative / Null Result ReportOpen accessMedicine

Positive correlation between IL-6 levels and lumbar bone mineral density in menopausal women diagnosed with osteoporosis in comparison to menopausal women without osteoporosis.

Alhosseini R, Aghaie M, Ghorbani S et al. · 2026 · BMC research notes

BACKGROUND: Osteoporosis is a common bone disorder characterized by decreased bone density. Interleukin-6 (IL-6), plays a crucial role in bone homeostasis. This study aimed to evaluate the relationship between serum levels of IL-6 and…

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Negative / Null Result ReportMedicine

Multiple sclerosis and related disorders multiple sclerosis across Isfahan Province, Iran: Urban-rural disparities and no association with air quality measures.

Etemadifar M, Bagheri S, Dehghani A et al. · 2026 · Multiple sclerosis and related disorders

Background Multiple sclerosis (MS) prevalence varies worldwide and appears to be rising in Iran. Environmental factors like air pollution have been hypothesized to contribute to MS risk. This study aimed to map MS prevalence across Isfahan…

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Negative / Null Result ReportMedicine

Association of Triglyceride-glucose Index and Obesity Metrics with Cardiovascular Disease Among U.S. Adults with Hyperlipidemia: Findings from the NHANES 2007-2016.

Lan P, Lan T · 2026 · Metabolic syndrome and related disorders

Background Hyperlipidemia constitutes a systemic metabolic disorder. The correlation of cardiovascular disease [CVD] with the triglyceride-glucose index [TyG] in individuals with hyperlipidemia remains unclear. The current study examined…

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Negative / Null Result ReportMedicine

Does Remodeling of Distal Femoral Extension Osteotomy Cause Recurrence of Knee Flexion Deformity in Children With Cerebral Palsy?

Gahukamble A, Arikrishnan AM, Thuppale VE et al. · 2026 · Journal of pediatric orthopedics

Background Distal femoral extension osteotomy (DFEO) is an established surgical option for correcting knee flexion deformity (KFD) in children with cerebral palsy. However, the extension deformity created at the distal femur may remodel…

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Negative / Null Result ReportMedicine

Phthalate esters and microplastics in sediments of Haomeiliao Wetland, Southwestern Taiwan: Occurrence, spatial distribution, and management implications.

Bandola AM, Wang MH, Guo BF et al. · 2026 · Marine pollution bulletin

Phthalate esters (PAEs) and microplastics (MPs) are emerging contaminants in aquatic environments. However, their co-occurrence in wetland sediments remains poorly understood. This study aimed to quantify PAE concentrations and MP…

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Negative / Null Result ReportMedicine

Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics.

Yokoyama S, Shimada M, Nakagawa J et al. · 2026 · European journal of drug metabolism and pharmacokinetics

Background and objective Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is transported into hepatocytes via OATP1B1, which is encoded by the SLCO1B1 gene. Although interindividual variability in vadadustat…

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