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Browse the failure-mode index

11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of a 3.5 mm Tibial Plateau Leveling Osteotomy Locking Compression Plate on Serial Postoperative Tibial Plateau Angle Maintenance, Short-Term Osteotomy Healing, and Complication Rates in 45 to 70 kg Dogs.

Acuña J, Barnhart MD, Kennedy SC et al. · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T

To evaluate the effect of a 3.5 mm tibial plateau leveling osteotomy (TPLO) locking compression plate on serial postoperative tibial plateau angle (TPA) maintenance, short-term osteotomy healing, and complication rates in dogs weighing 45…

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Negative / Null Result ReportMedicine

Investigation of Metabolites and Mineral Content in Blood Serum of Dairy Cows of the Simmental Breed in Samsun Province During the Transition Period.

Ormancı N, Bölükbaş B, Waqas M et al. · 2026 · Biological trace element research

This study evaluated the metabolic and mineral profiles in the blood serum of Simmental dairy cows during the transition period to assess their energy, protein, and mineral status. A total of 78 cows from 10 farms in Samsun Province were…

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Negative / Null Result ReportMedicine

How does organizational sacralization affect healthcare professionals' work engagement and turnover intentions through perceived organizational support?

Şengüllendi MF · 2026 · Journal of health organization and management

Purpose In recent years, the migration of healthcare professionals from developing countries to developed countries has accelerated. Türkiye is one of the countries negatively affected by the migration of healthcare professionals. This…

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Negative / Null Result ReportMedicine

Seems Like a Touch? Comparing Emotional Experience and Illusion of Touch of Visual and Haptic Presentations of Mediated Social Touch in VR.

Tietenberg J, Furtges T, Masuch M · 2026 · IEEE transactions on visualization and computer graphics

Social virtual reality (VR) applications enable users to experience highly immersive mediated interactions and social experiences. Especially embodied nonverbal communication, like mediated social touch, is mostly unique to social VR and…

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Negative / Null Result ReportMedicine

Exploring the impact of sleep apnea on renal transplant outcomes.

Satuluru S, Brower D, Mehta V et al. · 2026 · The American journal of the medical sciences

Background Sleep apnea (SA), a common diagnosis, has been shown to exhibit increased prevalence in patients with end-stage renal disease (ESRD). There is no clear consensus on the impact of SA on renal transplant outcomes. Methods We…

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Negative / Null Result ReportMedicine

Prewarming and thermal manipulation of long stored eggs: effect on embryonic development, hatching traits, body weight, rectal temperature, carcass, and organ traits at 3 days of age in broiler chickens.

Abdallah N, Baylan M, Kursun K et al. · 2026 · Journal of thermal biology

This study investigated the effect of prewarming (PD) and thermal manipulation (TM) of long-stored eggs on embryonic development, hatching traits, body weight (BW), rectal temperature (RT), carcass, and organ traits in broilers at 3 days…

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Negative / Null Result ReportOpen accessMedicine

Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells.

Marinello WP, Zylka MJ · 2026 · Frontiers in toxicology

Introduction Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA), are persistent environmental contaminants known for bioaccumulation and adverse health effects, including neurodevelopmental toxicity.…

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Negative / Null Result ReportMedicine

Distinct Pause Patterns in Autism: Effects of Sex and Conversational Context in French-Speaking (Pre)adolescents.

Belenger M, Dumont C, Geelhand P et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose We investigated sex differences in the production of pauses in autistic (pre-)adolescents in two conversational contexts: a monologue and an interactive discussion. Method This study included 107 French-speaking participants ( M…

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Negative / Null Result ReportMedicine

Efficacy analysis of CAR-T cells against CD123-positive malignant tumors and exploration of the feasibility of combination therapy with venetoclax.

Zhang M, Chai X, Zhang X et al. · 2026 · Annals of hematology

Chimeric antigen receptor T cells (CAR-T cells) have been widely applied in hematologic malignancies. It has shown limited efficacy in the treatment of myeloid neoplasms. We retrospectively analyzed the safety and efficacy of CD123 CAR-T…

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Negative / Null Result ReportMedicine

Impact of an Individualized Dietary Intervention on Body Composition and Clinical Outcomes in Patients with Neovascular Age-Related Macular Degeneration: A Pilot Study.

Szulim D, Kucharska E, Machalińska A et al. · 2026 · Nutrients

Background/Objectives : Age-related macular degeneration (AMD) is a leading cause of permanent deterioration of central vision in elderly people. While anti-VEGF therapy remains the standard of care for neovascular AMD, disease progression…

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Negative / Null Result ReportMedicine

The Impact of a Unique Military Treatment Facility-Based Sports Medicine Model on Readiness in the Army: A Prospective Longitudinal Analysis Comparing 2 Military Health System Entry Portal Pathways on the Duration of Healthcare Management and the Incidence of Recurrence Within 24 Months.

Suttles S, Boeth RR, Frazier M et al. · 2026 · Military medicine

Objective Describe an innovative Sports Medicine clinic design implemented in an outpatient Physical Therapy (PT) clinic within a Military Treatment Facility (MTF) for both referral and direct access (DA) entry portal pathways, and to…

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Negative / Null Result ReportMedicine

Effect of hydrogen peroxide disinfectant on the flexural strength of different custom impression tray materials fabricated using conventional and digital methods.

Lengerli Efe A, Özen Sütüven E, Uçar Y et al. · 2026 · International journal of computerized dentistry

Aim The aim was to evaluate the effect of hydrogen peroxide disinfectant exposure for 60 minutes -representing the longest exposure time recommended for achieving the widest antimicrobial spectrum- on the flexural strength (FS) of…

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Negative / Null Result ReportOpen accessMedicine

Haptic perception of 2.5D surface feature height.

Hwang I, Yun S, Park J · 2026 · Scientific reports

The present study investigates the human haptic perception of 2.5D dome-shaped surface features in terms of difference and absolute thresholds. We conducted two experiments to measure the thresholds, analyzing the effect of sample base…

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Negative / Null Result ReportOpen accessMedicine

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension.

Yaman İ, Korkmaz H, Akağaç AE et al. · 2026 · Journal of cardiovascular development and disease

Background Pulmonary arterial hypertension (PAH) is a rare and progressive disorder characterized by increased pulmonary vascular resistance and vascular remodeling. Genetic polymorphisms, epigenetic modifications, and ion channel…

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