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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Prognostic Value of Combined Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index in Advanced Ovarian Cancer Treated With Neoadjuvant Chemotherapy.

Ishida H, Egashira H, Asano N et al. · 2026 · Cureus

Background Inflammation- and nutrition-related biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) have been reported as prognostic factors for ovarian cancer. However, their clinical…

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Negative / Null Result ReportMedicine

Effect of remazolam combined with hydromorphone postoperative analgesia on cognitive function in elderly patients undergoing hip replacement.

Zheng X, Fu X, Shao Y et al. · 2026 · American journal of translational research

Objective To investigate the effect of remazolam combined with hydromorphone on postoperative cognitive function in elderly patients undergoing hip replacement. Methods 184 elderly patients who underwent hip replacement in Sir Run Run Shaw…

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Negative / Null Result ReportOpen accessMedicine

Effects of ultrasound-assisted tumbling on physicochemical properties, myofibrillar protein structure, and protein oxidation during beef curing.

Jin L, Zhang J, Zhang R et al. · 2026 · Ultrasonics sonochemistry

The aim of this study was to investigate the effects of ultrasound-assisted tumbling (100, 300, 500, and 700 W) with different treatment times (30, 60, 90, 120, 150, and 180 min) on the quality, myofibrillar protein structure, and protein…

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Negative / Null Result ReportMedicine

<i>Invitro</i> Hepatic like Differentiation of Umbilical Cord-Derived Mesenchymal Stem Cells through FGF and IGF Factor Preconditioning.

Zahid Habib Q, Tahir M, Bakhtawar F et al. · 2026 · Journal of stem cells & regenerative medicine

Introduction Liver diseases remain a major global health burden, with limited treatment options for advanced hepatic dysfunction. Current treatment options are limited and mainly supportive, with liver transplantation being the only…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the Advantages of Silicone Stent in Revision Endoscopic Dacryocystorhinostomy in a Tertiary Care Hospital.

Sonawane C, Raval RR, Bajaj A et al. · 2026 · International archives of otorhinolaryngology

Introduction Silicone stents are often employed in dacryocystorhinostomy (DCR) procedures to maintain the patency of the newly created tear drainage passage during the healing stage. These stents are flexible, biocompatible, and generally…

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Negative / Null Result ReportOpen accessMedicine

The effect of timing on rehabilitation results in tumor-related spinal cord injuries.

Yorulmaz E, Geler-Kulcu D, Ramazanoglu AF et al. · 2026 · Turkish journal of physical medicine and rehabilitation

Objectives This study aims to investigate the impact of early initiated rehabilitation on outcomes in patients with spinal cord injuries related to tumors. Patients and methods In this retrospective cohort study conducted between January…

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Negative / Null Result ReportOpen accessMedicine

Acute Effect of Percussive Massage on Cross-Section Area, Muscle Strength, and Late Muscle Pain of the Quadriceps Muscle Following a Fatigue Protocol in Physically Active Men: Randomized Clinical Trial.

da Rosa Castilho A, Aguiar AF, Ribeiro AS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy

Background and purpose The massage gun is widely used to alleviate delayed-onset muscle soreness (DOMS); however, empirical evidence regarding its physiological effects remains limited. Objectives This study aimed to evaluate the acute…

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Negative / Null Result ReportMedicine

Less Is More! An Analysis of Postoperative Outcomes Comparing Low-Dose E. Coli-Derived rhBMP-2 and Mammalian rhBMP-2 in Lateral Lumbar Spinal Fusion Surgery.

Chiu ST, Seah SJ, Zeng GJ et al. · 2026 · Clinical spine surgery

Study design Retrospective clinical study. Objective Investigating the fusion effect and side effect profile between low-dose E.BMP-2 and mammalian rhBMP-2. Summary of background data Recombinant human bone morphogenetic protein-2…

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Negative / Null Result ReportOpen accessMedicine

Clinical outcomes of implants in atrophic ridges augmented with collagenated xenogeneic or autogenous bone: 4-year follow-up of a randomized clinical trial.

Romito GA, Soares HH, Nishyama R et al. · 2026 · Brazilian oral research

This study aimed to evaluate the long-term outcomes of dental implants placed in alveolar ridges augmented with collagenated xenogeneic bone blocks (CXBB) or autogenous bone blocks (ABB). In this non-interventional study, 20 patients…

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Negative / Null Result ReportOpen accessMedicine

Taurine supplementation in fish meal-free diet improved growth, alleviated hypoxic-induced gill injury associating with Ca<sup>2+</sup> homeostasis and endoplasmic reticulum stress in sub-adult grass carp (<i>Ctenopharyngodon idella</i>).

Yan J, Feng L, Wu P et al. · 2026 · Animal nutrition (Zhongguo xu mu shou yi xue hui)

Taurine is a multifunctional feed additive that is abundant in fish meal but scarce in plant protein sources. The aim of this study was to investigate the effects of taurine supplementation in fish meal-free diet on sub-adult grass carp (…

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Negative / Null Result ReportOpen accessMedicine

Impact of Continuous Nursing Intervention Delivered via Internet+ Platform on Inflammatory Responses in Ulcerative Colitis Patients.

Zhu J, Ren X, Wang Q et al. · 2026 · Patient preference and adherence

Objective To explore the application effect of continuity nursing intervention based on the "Internet +" platform in patients with ulcerative colitis (UC) and analyze its impact on patients' inflammatory responses. Methods A retrospective…

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Negative / Null Result ReportMedicine

The effectiveness of virtual reality in reducing preoperative anxiety among oral surgery patients under general anesthesia: a salivary stress biomarker and questionnaire-based study.

Yuza AT, Nurwiadh A, Hadikhrisna I et al. · 2026 · BMC oral health

Background Preoperative anxiety is a common psychological response to surgical operations affecting the emotional, cognitive and physiological state of the patient. It can be measured by both objective and subjective methods. While the…

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Negative / Null Result ReportMedicine

Craniofacial Growth and Hypodontia in Individuals Born with Van der Woude Syndrome.

Vesterbacka M, Parikakis K, Ganzer N et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo study craniofacial growth and hypodontia in individuals born with Van der Woude syndrome (VWS) and compare with matched controls with and without a cleft.DesignA multicenter retrospective case-control study.SettingIndividuals…

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Negative / Null Result ReportOpen accessMedicine

Optical coherence tomography angiography evaluation of retinal and choriocapillaris changes after pars plana vitrectomy for macula-off rhegmatogenous retinal detachment: perfluoropropane versus silicone oil tamponade.

Karatepe MS, Erol YÖ · 2026 · BMC ophthalmology

BACKGROUND: Rhegmatogenous retinal detachment (RRD) with macular involvement may lead to persistent visual impairment despite successful anatomical repair. Different intravitreal tamponade agents used during pars plana vitrectomy (PPV) may…

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Negative / Null Result ReportOpen accessMedicine

Correlation of Scaphotrapezoid Contact Pressures With Degree of Trapezoid Resection: Does Eliminating Contact Matter?

Anz H, Roylance J, Ismaily S et al. · 2026 · Journal of hand surgery global online

Purpose Scaphotrapeziotrapezoid (STT) arthritis is the third most common hand arthritis in the United States. In the setting of thumb carpometacarpal arthroplasty, varying degrees of partial excision of the proximal trapezoid have been…

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Negative / Null Result ReportOpen accessMedicine

Differential spatiotemporal dynamics of cell wall-degrading enzymes underlie pathogenicity variation in two <i>Alternaria</i> species causing kiwifruit soft rot.

Ling LZ, Tai SH, Teng H et al. · 2026 · PeerJ

Kiwifruit soft rot caused by fungal pathogens can result in substantial postharvest losses. While Alternaria alternata and A. tenuissima have been implicated in this disease, their pathogenic mechanisms remain poorly characterized. This…

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Negative / Null Result ReportOpen accessMedicine

Instability of Oculomotor Control in Parkinson's Disease Without Freezing of Gait: Evidence From Reflexive and Voluntary Saccade Variability.

Daeinejad FS, Foumani MS, Behzadipour S et al. · 2026 · The European journal of neuroscience

Parkinson's disease (PD) is associated with alterations in both voluntary and reflexive eye movements; however, the characteristics of oculomotor variability across task contexts remain incompletely understood. This study investigated…

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Negative / Null Result ReportOpen accessMedicine

Osteogenic Differentiation Induced by Dental Pulp Stem Cells Secretome: A Dose-Dependent Comparative Study.

Kadkhodazadeh M, Amid R, Kheiri A et al. · 2026 · Clinical and experimental dental research

Objectives To investigate the effects of dental pulp stem cell-derived conditioned medium (DPSC-CM) on the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Primary goals were to (i)…

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Negative / Null Result ReportMedicine

Comparison of Myringoplasty Outcomes Among External Auditory Canal Packing, Blood on the Graft Surface, or No External Auditory Canal Packing for Chronic Tympanic Membrane Perforation: A Randomized Study.

Lou Z, Yang H · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective The objective of this study was to compare graft outcomes and complications of myringoplasty among external auditory canal packing (EAC) with Nasopore, blood on the graft surface, and no EAC packing. Materials and methods…

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