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11,291 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Adjuvant doxorubicin vs metronomic cyclophosphamide and meloxicam vs surgery alone for cats with mammary carcinomas: A retrospective study of 137 cases

Gonçalo N. Petrucci, Joaquim Henriques, Luís Lobo et al. · 2020 · Veterinary and Comparative Oncology

This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical…

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Negative / Null Result ReportOpen accessMedicine

Adjuvant Radiotherapy After Radical Cystectomy for Patients with High-risk Muscle-invasive Bladder Cancer: Results of a Multicentric Phase II Trial

Valérie Fonteyne, Piet Dirix, Charles Van Praet et al. · 2021 · European Urology Focus

BACKGROUND: High-risk muscle-invasive bladder cancer (MIBC) has a poor prognosis. Old trials showed that external beam radiotherapy (EBRT) after radical cystectomy (RC) decreases the incidence of local recurrences but induces severe…

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Negative / Null Result ReportOpen accessMedicine

ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells

Arjan Kol, Anton Terwisscha van Scheltinga, Martin Pool et al. · 2017 · Oncotarget

// Arjan Kol 1 , Anton Terwisscha van Scheltinga 2 , Martin Pool 1 , Christian Gerdes 3 , Elisabeth de Vries 1 , Steven de Jong 1 1 Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 3 Roche Pharma Research & Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland Correspondence to: Steven de Jong, email: s.de.jong@umcg.nl Keywords: non-small cell lung cancer,

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Negative / Null Result ReportOpen accessMedicine

Prophylaxis with Sirolimus and Tacrolimus ± Antithymocyte Globulin Reduces the Risk of Acute Graft-versus-Host Disease without an Overall Survival Benefit Following Allogeneic Stem Cell Transplantation

Lindsay Rosenbeck, Patrick J. Kiel, Iftekhar Kalsekar et al. · 2010 · Biology of Blood and Marrow Transplantation

Methotrexate (MTX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared…

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Negative / Null Result ReportMedicine

Moderate Running and Plyometric Training During Off-Season Did Not Show a Significant Difference on Soccer-Related High-Intensity Performances Compared with No-Training Controls

Daisuke Nakamura, Tomohiro Suzuki, Mikinobu Yasumatsu et al. · 2011 · The Journal of Strength and Conditioning Research

Several investigators have reported the effects of reduced training and interrupted training on athletic performance, but few reports are available for soccer players. The purpose of this study was to examine, using the Yo-Yo intermittent…

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Negative / Null Result ReportOpen accessMedicine

Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population

Jawed Alam, Sankar Maiti, Prachetash Ghosh et al. · 2012 · Journal of Medical Microbiology

A novel virulence factor, duodenal ulcer-promoting gene A (dupA), in Helicobacter pylori has been found to be associated with disease in certain populations but not in others. This study analysed a South-east Indian population as part of…

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Negative / Null Result ReportMedicine

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel

Mikko T. Holmberg, Aleksi Tornio, Maria Paile‐Hyvärinen et al. · 2018 · Clinical Pharmacology & Therapeutics

CYP3A enzymes participate in the elimination of ticagrelor and the bioactivation of clopidogrel and prasugrel. We studied the effects of functional CYP3A genetic variants (CYP3A4*22; rs35599367 and CYP3A5*3; rs776746) on the…

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Negative / Null Result ReportMedicine

Randomized clinical trial of extensive intraoperative peritoneal lavage versus standard treatment for resectable advanced gastric cancer (CCOG 1102 trial)

Kazunari Misawa, Yoshinari Mochizuki, Munetoshi Sakai et al. · 2019 · British journal of surgery

BACKGROUND: A survival benefit of extensive intraoperative peritoneal lavage (EIPL) has been reported in patients with gastric cancer with positive peritoneal cytology. The hypothesis of this study was that EIPL may reduce peritoneal…

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Negative / Null Result ReportOpen accessMedicine

Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo

Federica Albanese, Daniela Mercatelli, Luca Finetti et al. · 2021 · Neurobiology of Disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since…

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Negative / Null Result ReportOpen accessMedicine

Continuous neuromuscular blockade infusion for out-of-hospital cardiac arrest patients treated with targeted temperature management: A multicenter randomized controlled trial

Byung Kook Lee, In Soo Cho, Joo Suk Oh et al. · 2018 · PLoS ONE

INTRODUCTION: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM). METHODS: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM. The primary outcome was serum lactate levels at 24 hours after drug infusion. The secondary ou

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Negative / Null Result ReportOpen accessMedicine

Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters

Tasneem Zaihra, Christopher J. Walsh, Sara Ahmed et al. · 2016 · BMC Pulmonary Medicine

BACKGROUND: Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability of phenotypes based on a combination of physiological, clinical and biomarker data are currently lacking. Our objective was to assess the longitudinal stability of clusters derived from repeated measures of airway and physiological data over a 1-year period in moderate and severe asthmatics. METHODS: A total of 125 subjects, 48 with moderate asthma (MA) and 77 with severe asth

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Negative / Null Result ReportOpen accessMedicine

Peak Width of Skeletonized Water Diffusion MRI in the Neonatal Brain

Manuel Blesa, Paola Galdi, Gemma Sullivan et al. · 2020 · Frontiers in Neurology

Preterm birth is closely associated with cognitive impairment and generalized dysconnectivity of neural networks inferred from water diffusion MRI (dMRI) metrics. Peak width of skeletonized mean diffusivity (PSMD) is a metric derived from histogram analysis of mean diffusivity across the white matter skeleton, and it is a useful biomarker of generalized dysconnectivity and cognition in adulthood. We calculated PSMD and five other histogram based metrics derived from diffusion tensor imaging (DTI) and neurite orientation and dispersion imaging (NODDI) in the newborn, and evaluated their accurac

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Negative / Null Result ReportOpen accessMedicine

Effect of postoperative radiotherapy on survival for surgically managed pT3N0 and pT4aN0 laryngeal cancer: Analysis of the National Cancer Data Base

Evan M. Graboyes, Kevin Y. Zhan, Elizabeth Garrett‐Mayer et al. · 2017 · Cancer

BACKGROUND: The current study was conducted to determine the effect of postoperative radiotherapy (PORT) on overall survival in patients with surgically managed pT3-T4aN0 laryngeal squamous cell carcinoma (SCC). METHODS: A review of the…

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Negative / Null Result ReportOpen accessMedicine

Randomized multicentre feasibility trial of intermediate care versus standard ward care after emergency abdominal surgery (InCare trial)

Morten Vester‐Andersen, Tina Waldau, Jørn Wetterslev et al. · 2015 · British journal of surgery

BACKGROUND: Emergency abdominal surgery carries a considerable risk of death and postoperative complications. Early detection and timely management of complications may reduce mortality. The aim was to evaluate the effect and feasibility…

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Negative / Null Result ReportOpen accessMedicine

Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial

Pierre‐Édouard Bollaert, Alexandra Monnier, Francis Schneider et al. · 2023 · Critical Care

BACKGROUND: In critically ill patients, positive fluid balance is associated with excessive mortality. The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ill patients. METHODS: POINCARE-2 was a stepped wedge cluster open-label randomized controlled trial. We recruited critically ill patients in twelve volunteering intensive care units from nine French hospitals. Eligible patients were ≥ 18 years old, under mechanical ventilation, admitted to one of the 12 recruiting units for > 48 and ≤ 72 h, and had an expected length of stay

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Negative / Null Result ReportOpen accessMedicine

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

Ngan T.K. Tran, Stella Aslibekyan, Hemant K. Tiwari et al. · 2015 · Frontiers in Genetics

Proprotein convertase subtilisin/kexin type 9 (encoded by PCSK9) plays a well-known role in the regulation of low-density lipoprotein (LDL) receptors, and an inhibitor of this enzyme is a promising new therapeutic for hyperlipidemia. Recently, animal and human studies also implicate PCSK9 genetic variation in the regulation of blood pressure. The goal of this study was to examine if common and rare polymorphisms in PCSK9 are associated with blood pressure in an African-American population at high risk for cardiovascular disease. Using genomic data assayed on the Affymetrix 6.0 array (n = 1199)

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Negative / Null Result ReportOpen accessMedicine

Associations Between Medical History, Cognition, and Behavior in Youth With Down Syndrome: A Report From the Down Syndrome Cognition Project

Tracie C. Rosser, Jamie O. Edgin, George T. Capone et al. · 2018 · American Journal on Intellectual and Developmental Disabilities

The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and…

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Negative / Null Result ReportMedicine

No significant association between vitamin D and COVID-19: A retrospective study from a northern Italian hospital

Davide Ferrari, Massimo Locatelli · 2020 · International Journal for Vitamin and Nutrition Research

Abstract. The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies…

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Negative / Null Result ReportOpen accessMedicine

Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

Raquel Ajub Moysés, Rossana Veronica Mendoza López, Patrı́cia Maluf Cury et al. · 2013 · Clinics

OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: T

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Negative / Null Result ReportOpen accessMedicine

Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci

Yolandi Swart, Caitlin Uren, Paul D. van Helden et al. · 2021 · Frontiers in Genetics

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis , is a complex disease. The risk of developing active TB is in part determined by host genetic factors. Most genetic studies investigating TB susceptibility fail to replicate association signals particularly across diverse populations. South African populations arose because of multi-wave genetic admixture from the indigenous KhoeSan, Bantu-speaking Africans, Europeans, Southeast Asian-and East Asian populations. This has led to complex genetic admixture with heterogenous patterns of linkage disequilibrium and associated traits.

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Negative / Null Result ReportOpen accessMedicine

Common intensive care scoring systems do not outperform age and glasgow coma scale score in predicting mid-term mortality in patients with spontaneous intracerebral hemorrhage treated in the intensive care unit

Marika Fallenius, Markus B. Skrifvars, Matti Reinikainen et al. · 2017 · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine

BACKGROUND: Intensive care scoring systems are widely used in intensive care units (ICU) around the world for case-mix adjustment in research and benchmarking. The aim of our study was to investigate the usefulness of common intensive care scoring systems in predicting mid-term mortality in patients with spontaneous intracerebral hemorrhage (ICH) treated in intensive care units (ICU). METHODS: We performed a retrospective observational study including adult patients with spontaneous ICH treated in Finnish ICUs during 2003-2012. We used six-month mortality as the primary outcome of interest. We

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Negative / Null Result ReportOpen accessMedicine

Advances and challenges in immunotherapy in head and neck cancer

Hazem Aboaid, Taimur Khalid, Abbas Hussain et al. · 2025 · Frontiers in Immunology

Head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with suboptimal survival outcomes despite advances in surgery, radiotherapy, and chemotherapy. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1), has transformed treatment paradigms, yet its full potential in HNSCC is still being explored. This review evaluates the current landscape of immunotherapy in both locally advanced (LA) and recurrent/metastatic (R/M) HNSCC, discussing key clinical trials, emerging biomarker

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Negative / Null Result ReportOpen accessMedicine

Exercise training effects on natural killer cells: a preliminary proteomics and systems biology approach

Francisco Llavero, Adrián Castillo‐García, Carmen Fiuza‐Luces et al. · 2026 · PubMed

BACKGROUND: Regular exercise, particularly moderate-intensity continuous training (MICT), can improve immune function. Natural killer (NK) cells, a subset of lymphocytes that react to infections, are the most responsive innate immune cells…

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