11,419 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Frick, Whyte-Fagundes, Baraban · 2026 · Pharmacology research & perspectives
Syntaxin-binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 (STXBP1) C.…
View details →Lofters, Wilks, Lee et al. · 2026 · medRxiv : the preprint server for health sciences
Fetal hemoglobin (HbF) prevents the polymerization of sickle hemoglobin (HbS). HbF, measured usually as a percent of total hemoglobin (%HbF), is inversely associated with the severity of sickle cell disease (SCD) but fails to capture the…
View details →Rachidi, Amanallah, Benzakour et al. · 2026 · Cureus
Alcohol-induced hypoglycemia is an uncommon but potentially life-threatening metabolic complication, particularly in the setting of prolonged fasting and chronic alcohol use. We report the case of a 63-year-old man with a history of…
View details →Jumah, Brooks, Siddiq et al. · 2026 · Missouri medicine
Chronic carotid occlusion (CCO) carries a significant risk of ischemic stroke, particularly in patients with impaired cerebrovascular reserve. Extracranial-intracranial (EC-IC) bypass emerged as a popular treatment strategy with high…
View details →Wu, Wang, Liu et al. · 2026 · Phytomedicine : international journal of phytotherapy and phytopharmacology
Peripheral nerve injury frequently causes refractory neuropathic pain and muscle atrophy. While clinical care focuses on analgesia, effective therapies for muscle wasting are lacking. Angelica dahurica (BZ) is known for its analgesic…
View details →Ma, Wei, Cai et al. · 2026 · IEEE transactions on image processing : a publication of the IEEE Signal Processing Society
Virtual try-on (VTON) aims to synthesize specific fashion images dressed in given garments, which possesses great potential in real-world scenarios. Existing methods generally stand on the shoulder of the single-view VTON to train a…
View details →Gyurina, Radványi, Sasi-Szabó et al. · 2026 · Cells
Catecholamines are crucial signaling molecules that initiate thermogenesis in adipocytes through beta-adrenergic receptors (ADRBs). Adipocyte catecholamine resistance is a common feature of pediatric obesity, often impeding weight loss and…
View details →Hsiao, Lai, Chen et al. · 2026 · The journal of headache and pain
Objective and interpretable brain signatures for migraine diagnosis and phenotyping remain limited. Edge-centric connectivity treats interregional connections as primary analytical units and captures higher-order, frequency-resolved…
View details →Kang, Kim, Kim et al. · 2026 · Experimental & molecular medicine
Inducible T cell costimulator (ICOS) signalling is essential for follicular helper T (Tfh) cell activation and has emerged as a therapeutic target in B cell-dependent autoimmune diseases such as systemic lupus erythematosus (SLE). However,…
View details →Li, Zhang, Leng et al. · 2026 · IEEE journal of biomedical and health informatics
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that requires early and efficient diagnosis. Functional magnetic resonance imaging (fMRI), with high temporal and spatial resolution, is a powerful tool for…
View details →Lindell, Sayed, Campos Duran et al. · 2026 · The Journal of clinical investigation
Sepsis is a leading cause of morbidity and mortality in critically ill children, yet heterogeneous immune responses complicate the development of targeted therapies and the host immune factors driving sepsis pathobiology remain unclear. We…
View details →Nagaraj, Prasad, Bhat et al. · 2026 · Annals of Indian Academy of Neurology
Olfactory dysfunction is a common nonmotor symptom and prodromal marker of Parkinson's disease (PD). Despite its early occurrence, hyposmia is frequently underrecognized, emphasizing the need for objective, culturally appropriate tools.…
View details →Gezer, Demir · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
Traumatic posterior meniscal root tears disrupt normal load transmission, resulting in meniscal extrusion and accelerated osteoarthritis. Although transtibial pull-out repair is widely used, creation of a 4.5-mm tibial tunnel at the joint…
View details →Ito, Spellman, Khan et al. · 2026 · Paediatric anaesthesia
In pediatric-aged patients, distributive (vasoplegic) shock is commonly caused by sepsis, anaphylaxis, or the humoral/immunologic response following cardiopulmonary bypass. In general, the first-line vasoactive agent for children is…
View details →Mohamed, Alharbi, Alanazi et al. · 2026 · Cureus
Internuclear ophthalmoplegia (INO) is a distinct ocular motility disorder localizing to the medial longitudinal fasciculus (MLF). Because the MLF is a microscopic, highly myelinated tract, small inflammatory lesions can cause significant…
View details →Mohamed, Farah, Elhamaky et al. · 2026 · Radiology case reports
Inferior vena cava (IVC) filter penetration is an increasingly recognized complication, particularly after prolonged dwell time or failed retrieval. Although often asymptomatic, multidirectional penetration into adjacent structures may…
View details →Niu, Liu, Sun et al. · 2026 · Journal of nanobiotechnology
Urethral reconstruction often fails due to the foreign body reaction (FBR) triggered by the graft, leading to chronic inflammation, fibrosis, and lumen obstruction. To address this challenge, we developed an innovative strategy: a…
View details →Ciani Berlingeri, Phillips, Mejia Bibriesca et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor behaviors is difficult because most…
View details →Chen, Yang, Liu et al. · 2026 · Journal of hazardous materials
Assessing water quality comprehensively is crucial for predicting environmental risks. However, existing toxicity assessments are limited to specific physiological processes or reference organisms, failing to capture holistic hazards. Here…
View details →Fujikata, Muramatsu, Mizoguchi · 2026 · The Journal of chemical physics
X-ray absorption near-edge structure (XANES) provides element-specific insights into local electronic and structural environments, but quantitative interpretation of molecular XANES under periodic boundary conditions (PBC) remains…
View details →Pizza, Perelli, Grassi et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
To investigate whether posterior tibial slope (PTS) is associated with failure after posterior cruciate ligament reconstruction (PCLR) in a cohort of patients undergoing isolated PCLR and PCL-based multiligament knee injuries (MLKI)…
View details →Vivanco-Aravena, Leiva, Hidalgo · 2026 · The journal of spinal cord medicine
Ventilator dependence is a major cause of morbidity and mortality in patients with high cervical spinal cord injury (CSCI), largely due to diaphragmatic dysfunction. Conventional assessment of inspiratory muscle strength, such as maximal…
View details →Hu, Yang, Li et al. · 2026 · Frontiers in pediatrics
Catch-up growth (CUG) before two years of age in small-for-gestational-age (SGA) infants is a key predictor of adult short stature. We aimed to establish and temporally validate a prediction nomogram for faltering CUG (FCUG) in full-term…
View details →Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international
Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…
View details →Su, Huang, Wang · 2026 · SLAS technology
The accumulation of pathological bronchial secretions compromises ventilation and oxygenation in critically ill patients and may lead to atelectasis or secondary infection in severe cases, making timely identification and removal of…
View details →Alomar-Dominguez, Bauer, Fries et al. · 2026 · Thrombosis research
Massive blood loss during surgery or trauma leads to dilutional coagulopathy. While fibrinogen is typically the first factor to reach critical levels, factor XIII (FXIII) also decreases proportionally, further impairing clot stability.…
View details →Haider, Kamran · 2026 · Cureus
Penile intraepithelial neoplasia (PeIN) is a premalignant lesion with clinical features that often overlap with benign inflammatory dermatoses. Although biopsy remains the diagnostic gold standard, topical acetic acid application producing…
View details →Liao, Xiang, Chen et al. · 2026 · PloS one
The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…
View details →Ippoliti, Gori, Coscarella et al. · 2026 · Skin health and disease
Abrocitinib, a selective Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy in moderate-to-severe atopic dermatitis (AD), although data in patients whose AD is resistant to multiple systemic therapies remain limited. We report the…
View details →Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics
Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…
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