Defective inducible T cell costimulator signalling drives neuropilin-1 hi CD4 + T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model.
Kang; Kim; Kim; O; Yoon; Joo; Hong; Kim · 2026 · Experimental & molecular medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Inducible T cell costimulator (ICOS) signalling is essential for follicular helper T (Tfh) cell activation and has emerged as a therapeutic target in B cell-dependent autoimmune diseases such as systemic lupus erythematosus (SLE). However,…
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Metadata source: PubMed · DOI 10.1038/s12276-026-01756-6