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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Longitudinal five-year follow-up by muscle MRI and high-resolution nerve ultrasound in hereditary neuropathies.

Vockert KL, Winter N, Kirschmann FS et al. · 2026 · Neurological research and practice

Background and aims Hereditary polyneuropathies are rare heterogeneous neurological disorders that cause progressive muscle weakness and disability. As new therapies emerge, sensitive imaging biomarkers to monitor disease progression are…

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Negative / Null Result ReportMedicine

Liquid Chromatography-High-Resolution Mass Spectrometric Determination of Nitrite Ion Concentration in the Natural Water Resources.

Ganji SK, Talari K, Maloth RK et al. · 2026 · Rapid communications in mass spectrometry : RCM

Rationale Nitrite anion is among the highly reactive anions and converts the secondary amines to their corresponding carcinogenic N-nitroso metabolites in the human body. Nitrite ion is highly abundant in natural waters and enters the body…

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Negative / Null Result ReportMedicine

Exploratory comparative analysis of automated morphologic and perfusion features derived from one-stop computed tomography angiography and computed tomography perfusion in large unruptured intracranial aneurysms.

Niu J, Huang W, Zou J · 2026 · Clinical neurology and neurosurgery

Purpose To compare rupture-related signals captured by automatically extracted computed tomography angiography (CTA) morphologic features and threshold-based computed tomography perfusion (CTP) metrics in large unruptured intracranial…

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Negative / Null Result ReportMedicine

Cinnamon-loaded PVA/gelatin/starch electrospun fibers as novel sustainable nanocomposites for active food packaging.

Vencato AA, Juchem ALM, Clerici NJ et al. · 2026 · International journal of biological macromolecules

This study produced six formulations using polyvinyl alcohol (PVA) blended with gelatin or gelatin-starch, incorporating cinnamon powder (CP) or cinnamon essential oil (CEO). Homogeneous nanofibers with diameters ranging from 367 to 532 nm…

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Negative / Null Result ReportOpen accessMedicine

Identification and multi-layered validation of seven diagnostic biomarkers for dilated cardiomyopathy via integrative machine learning, single-cell transcriptomics, and Mendelian randomization.

Li J, Song Z, Wang G et al. · 2026 · Frontiers in cell and developmental biology

Background Dilated cardiomyopathy (DCM) is the most common non-ischemic cardiomyopathy and a major cause of heart failure, but disease-specific molecular biomarkers remain limited. This study aimed to identify and prioritize tissue-level,…

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Negative / Null Result ReportOpen accessMedicine

Non-Essential Element-Based Nanoparticles in Rice: Unraveling the Impacts of Yttrium Oxide and Zirconium Oxide Nanoparticles on Root Accumulation and Antioxidant Responses.

Xie B, Rui Y · 2026 · Plants (Basel, Switzerland)

Nanotechnology has attracted increasing attention in agricultural and environmental research, but the biological effects and potential risks of nanoparticles based on non-essential elements remain insufficiently understood. This study…

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Negative / Null Result ReportMedicine

Current comorbid psychiatric symptoms in the statistical indirect association between childhood attention-deficit/hyperactivity disorder symptoms and functional impairment among university students.

Koyuncu Z, Evcil FY, Kilimci ÖS et al. · 2026 · BMC psychiatry

Objective This study investigated whether current comorbid psychiatric symptoms were involved in statistical indirect associations between childhood attention-deficit/hyperactivity disorder (ADHD) symptoms (CAS) and functional impairment…

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Negative / Null Result ReportMedicine

Influence of inhalation exposure to biogenic volatile organic compounds from Syringa oblata flowers on behavior, spatial working memory, and hematological parameters in mice.

Tuo Y, Yang S, Dai X et al. · 2026 · Journal of ethnopharmacology

Ethnopharmacological relevance Syringa oblata Lindl. emits a variety of biogenic volatile organic compounds (BVOCs) during full bloom, which forms the key chemical basis for its characteristic floral scent. Species of the genus Syringa…

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Negative / Null Result ReportMedicine

Exploring Emotional Abuse, Physical Abuse and Mobile Phone Dependence in Left- and Non-Left-Behind Adolescents: Roles of Self-Esteem, Social Anxiety, and Loneliness.

Zhen B, Yang X, Yao B · 2026 · Scandinavian journal of psychology

Child abuse has been significantly associated with children's mobile phone dependence (MPD), particularly in left-behind children (LBC). However, whether distinct forms of child abuse (physical and emotional) are associated with MPD in LBC…

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Negative / Null Result ReportMedicine

Plasma protein biomarkers for early risk prediction of colorectal cancer.

Chen W, Ge X, Hu C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Prospective studies are necessary to determine the association between circulating proteins and colorectal cancer (CRC) risk, offering non-invasive biomarkers for early CRC risk prediction and interventions. The Olink Explore-3072 platform…

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