286 real negative results, null findings, and replication failures in Medicine · Replication Failure. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jason Smith, Rebecca Cardigan, Emily Sanderson et al. · 2026 · New England Journal of Medicine
BACKGROUND: Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. METHODS: We conducted a pragmatic,…
View details →Noor Wortelboer, Annemiek van Ommen-Nijhof, Inge R. Konings et al. · 2026 · JAMA Oncology
Importance: Cyclin-dependent kinase (CDK) 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy are widely used in hormone receptor (HR)-positive, ERBB2-negative advanced breast cancer (ABC). The SONIA trial evaluates the optimal…
View details →Mihir A Kelshiker, Patrik Bächtiger, Camille F Petri et al. · 2026 · The Lancet
BACKGROUND: Early detection of cardiovascular disease is a global public health priority. Artificial intelligence (AI)-enabled stethoscopes offer robust performance characteristics in point-of-care detection of heart failure, atrial fibrillation, and valvular heart disease (VHD). We conducted a pragmatic, cluster-randomised controlled implementation trial to determine the real-world effect and implementation challenges of AI-stethoscopes. METHODS: UK primary care practices were cluster randomised 1:1 to intervention (training and implementation in use of AI-stethoscopes in routine care) or con
View details →Yang L, Zhuang H, Yang Z et al. · 2026 · Medical ultrasonography
Aims To evaluate the applicability of transluminal dual-plane shear wave elastography (SWE) for measuring the anal sphincter in healthy adult women. Material and methods This prospective study recruited 140 healthy women between January…
View details →Silva SJ, Romero F, Magder LS et al. · 2026 · Academic medicine : journal of the Association of American Medical Colleges
Purpose Interest in research careers among medical graduates is decreasing, and fewer physicians report research as their primary work activity. This study examines the implementation of a required scholarly research course at the…
View details →Van Brussel L, Geurden T · 2026 · Ticks and tick-borne diseases
Background Rapid and high efficacy against ticks after attachment has the potential to aid in the prevention of tick-borne pathogen transmission. The objective of the study was to assess the speed-of-kill of Simparica Trio® against Ixodes…
View details →Dong B, Xian Z · 2026 · Journal of visualized experiments : JoVE
Adolescent bipolar disorder is a severe psychiatric condition frequently complicated by school refusal behavior, a debilitating functional impairment that often persists even after the pharmacological stabilization of mood symptoms. While…
View details →Özdemir HE, Albayrak MT, Koçluk Y · 2026 · Journal of clinical medicine
Purpose : To investigate whether the season in which photorefractive keratectomy (PRK) with mitomycin C (MMC) is performed influences postoperative corneal transparency considering seasonal variations in ultraviolet (UV) exposure. Methods…
View details →Minkhorst K, Munn A, MacDermid J et al. · 2025 · Archives of physical medicine and rehabilitation
Objective To evaluate whether the addition of an orthosis improved the efficacy of cortisone injection for the nonoperative management of trigger finger. Design Block randomized controlled trial. Setting Outpatient hand clinic.…
View details →Sadeghpour M, Laughter M, Rizzo SI et al. · 2026 · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Background Despite evidence supporting efficacy of low-fluence Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) 1,064-nm lasers, treatment protocols are not standardized and limited to mostly retrospective, observational,…
View details →Arenas Hoyos J, Dalela D, Schlomer BJ et al. · 2026 · Journal of pediatric urology
Background There is insufficient evidence to support the effectiveness of preoperative antibiotic prophylaxis in reducing surgical site infections (SSI) during urgent testicular torsion (TT) surgeries. Objective The primary objective was…
View details →Wang J, Du L, Wang Y et al. · 2026 · Cellular oncology (Dordrecht, Netherlands)
Purpose Combinations of anti-PD-1/PD-L1 immunotherapy (IO) and anti-VEGF tyrosine kinase inhibitor (TKI) are recommended as first-line therapy for metastatic renal cell carcinoma (RCC). We aimed to evaluate the predictive value of tissue…
View details →Lin MC, Jiang X, Qiu ZC et al. · 2026 · Head & neck
Background Management of the clinically node-negative (cN0) neck in intermediate-grade mucoepidermoid carcinoma (MEC) of the head and neck remains controversial. Methods We retrospectively reviewed patients with cN0 intermediate-grade MEC…
View details →Baxi SM, Igbinosa II, Main EK et al. · 2026 · AJOG global reports
Background Postpartum hemorrhage (PPH) is the leading global cause of maternal morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent that has been shown to reduce hemorrhage-related mortality in trauma, is used…
View details →Wang C, Li S, Lu H et al. · 2026 · BMC gastroenterology
Background While routine use of abdominal drainage in cases of perforated appendicitis is not generally recommended, there exists a paucity of evidence regarding the detailed stratification of its necessity based on varying degrees of…
View details →Vukšić J, Kustić D · 2026 · Rheumatology international
To examine whether salivary gland ultrasonography (SGUS) and scintigraphy (SGS) reflect systemic disease activity (ESSDAI) and patient-reported index (ESSPRI) in primary Sjögren's disease (PSD). We retrospectively enrolled 118 patients…
View details →Can V, Polat F, Kaya AF et al. · 2026 · Journal of cardiovascular pharmacology
Abstract Mechanical heart valve replacement necessitates long-term warfarin anticoagulation to prevent thromboembolic complications, yet achieving adequate anticoagulation control remains challenging. This study evaluated whether mean…
View details →Liu Y, Zhong S, Zhong K et al. · 2026 · Frontiers in endocrinology
Aim To investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive disorders of pregnancy in subsequent pregnancy (s-HDP). Methods A retrospective cohort of 5, 928 women with two…
View details →Amuji DN, Iweala EEJ · 2026 · BMC cancer
BACKGROUND: Breast cancer (BC) is a major cause of cancer-related mortality among women worldwide. Genetic polymorphisms, such as those in the Mesenchymal Epithelial Transition factor (MET) proto-oncogene, may influence cancer risk and…
View details →Cheng WJ, Kao CL, Hung IY · 2026 · Frontiers in nutrition
Background Hearing impairment is associated with an elevated risk of depression, yet modifiable risk factors in this population remain poorly characterized. Although vitamin D deficiency (VDD) has been linked to depression in general…
View details →Sheng YC, Chen X, Zhang YF et al. · 2026 · Huan jing ke xue= Huanjing kexue
Achieving ecological protection and high-quality development is the fundamental goal of sustainable development in the Yellow River Basin， and it is also an inevitable choice for the practice of the concept of Chinese-style modernization.…
View details →Bhatia A, Chen Z, Zhang Y et al. · 2026 · Cancer
Background Ataxia telangiectasia Rad3-related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors…
View details →Hata Y, Iida O, Torii S et al. · 2026 · European heart journal. Case reports
Background The long-term vascular response to paclitaxel-eluting stents (PESs) in infrapopliteal (IP) lesions remains histologically uncharacterized. Case summary A 78-year-old woman with chronic limb-threatening ischaemia underwent…
View details →Webster E, Ng L, Prendergast K et al. · 2026 · Journal of insect physiology
Climate change and urbanisation are major drivers of global insect pollinator decline. However, the combined effects of these stressors remain poorly understood, particularly in relation to pollinator behaviour. Understanding how these…
View details →Gkantidis N, Tsikouriadou E, Halazonetis D et al. · 2026 · Scientific reports
The present study investigated the association between facial shape and self-perceived personality and psychosocial traits. The study population consisted of 613 young adults (399 females and 214 males) aged 21-35 years, with similar…
View details →Bi X, Yu Y, Zhou S et al. · 2024 · Nephron
Introduction The renoprotective benefits of adding immunosuppressant therapy to corticosteroid (CS) treatment for immunoglobulin A nephropathy (IgAN) patients with less than 25% crescent formation (C1) remain uncertain, warranting further…
View details →Döhner H, Späth D, Saadati M et al. · 2026 · Blood
Abstract Core-binding factor acute myeloid leukemia (CBF-AML) is associated with KIT mutations and deregulated expression of KIT. We report results from the randomized, open-label, phase 3 trial of intensive chemotherapy with or without…
View details →Pyzer AR, Dillon LW, Sharon E et al. · 2025 · Blood advances
Abstract We conducted a multicenter, open-label, randomized phase 2 study to assess the efficacy of nivolumab (Nivo) as maintenance therapy for patients with acute myeloid leukemia (AML) in first complete remission (CR) or CR with…
View details →Eroğlu AS, Demirtaş OK · 2026 · Acta neurochirurgica
Objectives This study aims to retrospectively analyze the factors affecting implant failure in patients who underwent anterior cervical plating (ACP) following anterior cervical discectomy and fusion (ACDF). Methods Data from 332 patients…
View details →Yano K, Ishida T, Yokosuka K et al. · 2026 · Internal medicine (Tokyo, Japan)
Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for…
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