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Browse the failure-mode index

270 real negative results, null findings, and replication failures in Medicine · Replication Failure. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Replication FailureOpen accessMedicine

Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study.

Liu Y, Zhong S, Zhong K et al. · 2026 · Frontiers in endocrinology

Aim To investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive disorders of pregnancy in subsequent pregnancy (s-HDP). Methods A retrospective cohort of 5, 928 women with two…

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Replication FailureOpen accessMedicine

A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950).

Bhatia A, Chen Z, Zhang Y et al. · 2026 · Cancer

Background Ataxia telangiectasia Rad3-related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors…

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Replication FailureMedicine

Facial shape and self-perceived personality traits in young adults.

Gkantidis N, Tsikouriadou E, Halazonetis D et al. · 2026 · Scientific reports

The present study investigated the association between facial shape and self-perceived personality and psychosocial traits. The study population consisted of 613 young adults (399 females and 214 males) aged 21-35 years, with similar…

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Replication FailureOpen accessMedicine

Time To Inject Some Contrast into the Nephrotoxicity Debate.

Florens N, Demiselle J · 2026 · Kidney360

Iodinated contrast media have long been feared for causing contrast-induced AKI (CI-AKI), a concern rooted in early reports with high-osmolar agents. Experimental data suggest potential nephrotoxic mechanisms, yet clinical evidence from…

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Replication FailureOpen accessMedicine

Evaluation of the quality of life of children and adolescents with type 1 diabetes mellitus before and after an intervention with a remote multiprofessional educational program.

Fritz CK, de Leão AAP, Sbalqueiro FVF et al. · 2026 · Jornal de pediatria

Objective This study aims to evaluate the quality of life (QoL) and glycemic control of children and adolescents living with type 1 diabetes mellitus (T1D) before and after an intervention with a multidisciplinary educational program.…

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Replication FailureMedicine

Lymph node metastasis, dissection efficacy, and prognostic differences between direct and incidental gallbladder carcinoma: A retrospective study.

Xu K, Zhang R, Yuan Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Aims Gallbladder carcinoma (GBC) has a poor prognosis, with lymph node metastasis (LNM) being a key prognostic factor. Controversies remain regarding lymph node dissection (LND) utility and prognostic differences of direct (DGBC) vs.…

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Replication FailureOpen accessMedicine

When anticoagulant therapy is not enough: recurrent stroke.

Stazi F · 2026 · European heart journal supplements : journal of the European Society of Cardiology

Despite the use of oral anticoagulants, the residual risk of recurrent ischaemic stroke in patients with atrial fibrillation (AF) is ∼4% per year; however, in patients who experience a stroke despite oral anticoagulant therapy (OAT), this…

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Replication FailureOpen accessMedicine

Radiotherapy Offered Limited Additional Benefits on Cancer-specific Survival for Patients with Resectable Subcutaneous Malignant Peripheral Nerve Sheath Tumors: A Population-based Retrospective Cohort Analysis.

Xiao Y, Li Z, Hu B et al. · 2025 · Neurologia medico-chirurgica

For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant…

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Replication FailureOpen accessMedicine

At 75 Years, Is Lithium the Gold Standard in Bipolar Disorder?

Belmaker RH · 2025 · Pharmaceuticals (Basel, Switzerland)

Lithium was the first discovered mood stabilizer for bipolar disorder. However, several antiepileptics such as valproate and carbamazepine have also proven to be mood stabilizers in all phases of bipolar disorder with profiles barely…

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Replication FailureOpen accessMedicine

Awake targeted memory reactivation doesn't work.

Hoffman LJ, Foley JM, Tanrıverdi B et al. · 2025 · Memory & cognition

Memories are pliable and can be biased by post-encoding information. In targeted memory reactivation (TMR) studies, participants encode information then sleep, during which time sounds or scents that were previously associated with the…

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Replication FailureOpen accessMedicine

Vitamin D supplementation on prediabetic adults with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial

Md Habibul Ghani, Md. Shahed Morshed, Tahniyah Haq et al. · 2023 · Bangabandhu Sheikh Mujib Medical University Journal

Hypovitaminosis D (<20 ng/mL) is thought to increase insulin resistance and meta-inflammation contributing to the pathogenesis of diabetes mellitus (DM). Correcting vitamin D deficiency in people with prediabetes might halt its progression to DM. The aim of this study was to examine the effect of vitamin D supplementation on insulin resistance, glycemic status, and inflammation in prediabetic adults with vitamin D deficiency. This doubleblind randomized placebo-controlled trial was done among 27 newly detected prediabetic adults with hypovitaminosis D randomly assigned to 60,000 IU of vitamin

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Replication FailureMedicine

Spinal Cord Stimulation Failed to Improve Parkinson's Disease Symptoms in Randomized Crossover Double-Blinded Evaluation.

Carra RB, Garcia LÁL, Menezes JR et al. · 2025 · Movement disorders : official journal of the Movement Disorder Society

Background Epidural electrical spinal cord stimulation has been studied for more than a decade for Parkinson's disease symptoms, but compelling evidence for its effectiveness is still lacking. Objective The aim of this study was to…

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Replication FailureMedicine

Targeted Temperature Management After Pediatric Cardiac Arrest: A Quality Improvement Program With Multidisciplinary Implementation in the PICU.

McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…

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Replication FailureOpen accessMedicine

Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Small Cell Lung Cancer: A Dramatic Recovery after Chemotherapy.

Yano K, Ishida T, Yokosuka K et al. · 2026 · Internal medicine (Tokyo, Japan)

Tumor management is the cornerstone of treatment for anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that is refractory to immunosuppressive therapy. However, little is known about the effectiveness of chemotherapy for…

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Replication FailureOpen accessMedicine

Pulmonary expansion manoeuvres compared to usual care on ventilatory mechanics, oxygenation, length of mechanical ventilation and hospital stay, extubation, atelectasis, and mortality of patients in mechanical ventilation: A randomized clinical trial.

Karina da Silva, Cristino Carneiro Oliveira, Leandro Ferracini Cabral et al. · 2023 · PLoS ONE

Pulmonary expansion manoeuvres are therapeutic techniques used to prevent and reverse atelectasis; however, no randomized controlled trials have provided evidence supporting the use of this intervention among individuals on mechanical ventilation. Objective To evaluate the effects of chest compression-decompression and chest block manoeuvres compared to usual care among patients on mechanical ventilation. Methods The current study was a randomized clinical trial of adult subjects on mechanical ventilation for 12 to 48 hours. The control group received usual care (passive or active mobilization

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Replication FailureMedicine

No evidence in favor of the existence of "intentional" binding.

Kong G, Aberkane C, Desoche C et al. · 2024 · Journal of experimental psychology. Human perception and performance

Intentional binding refers to the subjective temporal compression between a voluntary action and its subsequent sensory outcome. Despite some studies challenging the link between temporal compression and intentional action, intentional…

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