11,283 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Sabine L. Vriezinga, Renata Auricchio, E. Bravi et al. · 2014 · New England Journal of Medicine
BACKGROUND: A window of opportunity has been suggested for reducing the risk of celiac disease by introducing gluten to infants at 4 to 6 months of age. METHODS: We performed a multicenter, randomized, double-blind, placebo-controlled…
View details →Daniel F. McAuley, John G. Laffey, Cecilia O’Kane et al. · 2014 · New England Journal of Medicine
BACKGROUND: Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that treatment with…
View details →Stan B. Kaye, Jan Lubiński, Ursula A. Matulonis et al. · 2011 · Journal of Clinical Oncology
PURPOSE: Olaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in BRCA1- or BRCA2-deficient cells, has shown promising clinical efficacy in nonrandomized phase II trials in patients…
View details →Nazlı Dizman, Luís Meza, Paulo Gustavo Bergerot et al. · 2022 · Nature Medicine
Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation of the gut microbiome. In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/or sarcomatoid histology and intermediate- or poor-risk disease were randomized 2:1 to receive nivolumab and ipilimumab with or without daily oral CBM588, respectively. Stool metagenomic s
View details →A. A. de Graaff, Thomas D’Hooghe, G.A.J. Dunselman et al. · 2013 · Human Reproduction
STUDY QUESTION: To what extent do the management of endometriosis and the symptoms that remain after treatment affect the quality of life in women with the disease? SUMMARY ANSWER: Many women with endometriosis had impaired quality of life…
View details →Christiane Maria Prado Jerônimo, Maria Eduarda Leão de Farias, Fernando Val et al. · 2020 · Clinical Infectious Diseases
BACKGROUND: Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2…
View details →Janine Giese‐Davis, Kate Collie, Kate M. Rancourt et al. · 2010 · Journal of Clinical Oncology
PURPOSE: Numerous studies have examined the comorbidity of depression with cancer, and some have indicated that depression may be associated with cancer progression or survival. However, few studies have assessed whether changes in…
View details →Alan Pollack, Gail Walker, Eric M. Horwitz et al. · 2013 · Journal of Clinical Oncology
PURPOSE: To determine if escalated radiation dose using hypofractionation significantly reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for prostate cancer. PATIENTS AND METHODS: Between June 2002 and…
View details →Mary E. Tinetti, Ling Han, David S. H. Lee et al. · 2014 · JAMA Internal Medicine
IMPORTANCE The effect of serious injuries, such as hip fracture and head injury, on mortality and function is comparable to that of cardiovascular events. Concerns have been raised about the risk of fall injuries in older adults taking…
View details →MVE Veenendaal, R.C. Painter, Susanne R. de Rooij et al. · 2013 · BJOG An International Journal of Obstetrics & Gynaecology
OBJECTIVE: We previously showed that maternal under-nutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. Also, we found increased neonatal adiposity among the grandchildren of women…
View details →Natalie Hofmann, Felista Mwingira, Seif Shekalaghe et al. · 2015 · PLoS Medicine
BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission to mosquitoes. The sensitivity of molecular detection by PCR is limited by the abundance of the target sequence in a DNA sample; thus, detection becomes imperfect at low densities. We aimed to increase PCR diagnostic sensitivity by targeting multi-copy genomic sequences for reliable det
View details →Amir Englund, Paul D. Morrison, Judith Nottage et al. · 2012 · Journal of Psychopharmacology
Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue…
View details →Bradley C. Leibovich, Christine M. Lohse, Paul L. Crispen et al. · 2010 · The Journal of Urology
PURPOSE: There are significant differences in clinicopathological features among renal cell carcinoma histological subtypes but controversy exists regarding the independent impact of histological subtype on patient outcome after…
View details →Silvana Galderisi, Alessandro Rossi, Paola Rocca et al. · 2014 · World Psychiatry
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital…
View details →Dan Frampton, Tommy Rampling, Aidan Cross et al. · 2021 · The Lancet Infectious Diseases
BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of…
View details →Nitin Shivappa, James R. Hébert, Ernst Rietzschel et al. · 2015 · British Journal Of Nutrition
Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, and inflammatory markers. In the present study, we examined the ability of…
View details →Sarah R. Preis, Joseph M. Massaro, Udo Hoffmann et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
BACKGROUND: Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat. METHODS AND RESULTS: Participants with neck circumference measures who…
View details →Sèverine Sabia, Aline Dugravot, Jean‐François Dartigues et al. · 2017 · BMJ
This study found no evidence of a neuroprotective effect of physical activity. Previous findings showing a lower risk of dementia in physically active people may be attributable to reverse causation-that is, due to a decline in physical activity levels in the preclinical phase of dementia.
View details →Almudena Marí Sáez, Sabrina Weiß, Kathrin Nowak et al. · 2014 · EMBO Molecular Medicine
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2-year-old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free-tailed bats (Mops condylurus). Bats in this family have previously been dis
View details →Thomas J. Lynch, Taral Patel, Luke Dreisbach et al. · 2010 · Journal of Clinical Oncology
PURPOSE To evaluate the efficacy of cetuximab plus taxane/carboplatin (TC) as first-line treatment of advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS This multicenter, open-label, phase III study enrolled 676…
View details →Claus Z. Simonsen, Albert J. Yoo, Leif H. Sørensen et al. · 2018 · JAMA Neurology
Importance: Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but there is uncertainty regarding the optimal anesthetic approach during…
View details →Charles E. Geyer, Judy E. Garber, Richard D. Gelber et al. · 2022 · Annals of Oncology
BACKGROUND: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewe
View details →André Lamy, P.J. Devereaux, Dorairaj Prabhakaran et al. · 2013 · New England Journal of Medicine
BACKGROUND: Previously, we reported that there was no significant difference at 30 days in the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal failure requiring dialysis between patients who…
View details →Ming Yang, Shuo Chen, Bo Huang et al. · 2020 · European Urology Focus
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), involves multiple organs. Testicular involvement is largely unknown. OBJECTIVE: To determine the pathological changes…
View details →Bojing Liu, Fang Fang, Nancy L. Pedersen et al. · 2017 · Neurology
OBJECTIVE: To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS: Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978…
View details →Steffen Boettcher, Peter G. Miller, Rohan Sharma et al. · 2019 · Science
p53—still hazy after all these years? The gene encoding the p53 tumor suppressor protein is the most frequently mutated gene in human cancer. Yet decades after the gene's discovery, the biology of cancer-associated missense mutations in…
View details →Melissa L. Johnson, Byoung Chul Cho, Alexander Luft et al. · 2022 · Journal of Clinical Oncology
PURPOSE The open-label, phase III POSEIDON study evaluated tremelimumab plus durvalumab and chemotherapy (T + D + CT) and durvalumab plus chemotherapy (D + CT) versus chemotherapy alone (CT) in first-line metastatic non–small-cell lung…
View details →Yann Malato, Syed Naqvi, Nina Schürmann et al. · 2011 · Journal of Clinical Investigation
Recent evidence has contradicted the prevailing view that homeostasis and regeneration of the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary epithelial cells. These new data suggest that liver…
View details →Matthew M. Grabowski, Pablo F. Recinos, Amy S. Nowacki et al. · 2014 · Journal of neurosurgery
OBJECT: The impact of extent of resection (EOR) on survival for patients with glioblastoma (GBM) continues to be a point of debate despite multiple studies demonstrating that increasing EOR likely extends survival for these patients. In…
View details →Jean‐Pierre Gérard, D. Azria, S. Gourgou-Bourgade et al. · 2012 · Journal of Clinical Oncology
PURPOSE: The ACCORD 12 trial investigated the value of two different preoperative chemoradiotherapy (CT-RT) regimens in T3-4 Nx M0 resectable rectal cancer. Clinical results are reported after follow-up of 3 years. PATIENTS AND METHODS:…
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