Negative / Null Result ReportOpen accessMedicine
Raffaele Di Fenza, Naman S. Shetty, Stefano Gianni et al. · 2023 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives The primary outcome was the change in arterial oxygenation (PaO2/Fi O2) at 48…
View details →Negative / Null Result ReportMedicine
Douglas K. Rex, Indira Bhavsar-Burke, Daniel Buckles et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Real-time prediction of histologic features of small colorectal polyps may prevent resection and/or pathologic evaluation and therefore decrease colonoscopy costs. Previous studies showed that computer-aided diagnosis (CADx)…
View details →Negative / Null Result ReportMedicine
Robert A. Comley, Simon Červenka, Sven Pålhagen et al. · 2010 · Journal of Neuroimaging
BACKGROUND: Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls,…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaoyan Zhang, Sufang Shi, Yan Ouyang et al. · 2018 · Journal of Translational Medicine
BACKGROUND: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated in independent cohorts before it can be widely applied to clinical practice. METHODS: Biopsy-proven IgAN patients were continuously recruited from two large renal centers in China from 1989 to 2014. All patients were followed for more than 1 year unless end stage renal disease (ESRD) occurred within 12 months. Crescents were defined as focal cellular or fibrocellular crescent format
View details →Negative / Null Result ReportOpen accessMedicine
Shuang-Jie Cao, Yue Zhang, Yuxiu Zhang et al. · 2023 · British Journal of Anaesthesia
BACKGROUND: Experimental evidence indicates that i.v. anaesthesia might reduce cancer recurrence compared with volatile anaesthesia, but clinical information is observational only. We therefore tested the primary hypothesis that…
View details →Negative / Null Result ReportOpen accessMedicine
Ilaria Salvato, Antonio Marchini · 2024 · Cancers
Despite decades of research and the best up-to-date treatments, grade 4 Glioblastoma (GBM) remains uniformly fatal with a patient median overall survival of less than 2 years. Recent advances in immunotherapy have reignited interest in utilizing immunological approaches to fight cancer. However, current immunotherapies have so far not met the anticipated expectations, achieving modest results in their journey from bench to bedside for the treatment of GBM. Understanding the intrinsic features of GBM is of crucial importance for the development of effective antitumoral strategies to improve pat
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Shigeki Nanjo, Tadaaki Yamada, Hiroshi Nishihara et al. · 2013 · PLoS ONE
PURPOSE: Although EGF receptor tyrosine kinase inhibitors (EGFR-TKI) have shown dramatic effects against EGFR mutant lung cancer, patients ultimately develop resistance by multiple mechanisms. We therefore assessed the ability of combined treatment with the Met inhibitor crizotinib and new generation EGFR-TKIs to overcome resistance to first-generation EGFR-TKIs. EXPERIMENTAL DESIGN: Lung cancer cell lines made resistant to EGFR-TKIs by the gatekeeper EGFR-T790M mutation, Met amplification, and HGF overexpression and mice with tumors induced by these cells were treated with crizotinib and a ne
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Joshua T. Kantrowitz, Christoph U. Correll, Rakesh Jain et al. · 2023 · The International Journal of Neuropsychopharmacology
BACKGROUND: Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective for negative and cognitive symptoms and are associated with a range of troublesome side effects. A significant unmet medical need for more effective and better-tolerated therapies remains. METHODS: A roundtable consisting of 4 experts in the treatment of patients with schizophrenia convened to discuss the current treatment landscape, unmet needs from patient and societal
View details →Negative / Null Result ReportOpen accessMedicine
Yasuhiro Koh, Manabu Aoki, Matthew Danish et al. · 2011 · Journal of Virology
Dimerization of HIV protease is essential for the acquisition of protease's proteolytic activity. We previously identified a group of HIV protease dimerization inhibitors, including darunavir (DRV). In the present work, we examine whether…
View details →Negative / Null Result ReportOpen accessMedicine
Daniel V.T. Catenacci, Agnes Ang, Wei‐Li Liao et al. · 2016 · Cancer
BACKGROUND: MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC),…
View details →Negative / Null Result ReportOpen accessMedicine
Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken et al. · 2025 · Frontiers in Public Health
Background: Artificial Intelligence (AI) is rapidly transforming the nursing profession, presenting significant opportunities and challenges. Despite its promising potential in enhancing nursing education, clinical practice, and operational efficiency, critical barriers related to ethics, workforce adaptation, and humanistic care persist. Aim: This integrative review systematically evaluates the integration of AI in nursing practice, with a specific focus on nursing education, clinical care, workload management, and professional perceptions. Methods: Guided by PRISMA 2020 and the SPIDER framew
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Brian W. Timmons · 2026 · PubMed
Considerable advances have been made in exercise immunology over the last two decades, and it is becoming evident that many of the health benefits of regular physical activity may be directly related to activation of the immune system. The…
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Andrew M. Bean, Rebecca Payne, Guy Parsons et al. · 2026 · Nature Medicine
Global healthcare providers are exploring the use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly perfect scores on medical licensing exams, but this does not necessarily translate to accurate performance in real-world settings. We tested whether LLMs can assist members of the public in identifying underlying conditions and choosing a course of action (disposition) in ten medical scenarios in a controlled study with 1,298 participants. Participants were randomly assigned to receive assistance from an LLM (GPT-4o, Llama 3, Command R+) or a source
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Ricardo Parreira, Shelley Cook, Ângela Celis de Almeida Lopes et al. · 2012 · Virus Research
We describe the full genetic characterization of an insect-specific flavivirus (ISF) from Culex theileri (Theobald) mosquitoes collected in Portugal. This represents the first isolation and full characterization of an ISF from Portuguese mosquitoes. The virus, designated CTFV, for Culex theileri flavivirus, was isolated in the C6/36 Stegomyia albopicta (=Aedes albopictus) cell line, and failed to replicate in vertebrate (Vero) cells in common with other ISFs. The CTFV genome encodes a single polyprotein with 3357 residues showing all the features expected for those of flaviviruses. Phylogeneti
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Grazia Crescimanno, Oreste Marrone, Andrea Vianello · 2011 · Respirology
BACKGROUND AND OBJECTIVE: Although non-invasive ventilation is widely used for the management of patients with neuromuscular disease, it remains unclear which ventilatory mode is associated with optimal patient-ventilator interaction and…
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Miles Piper, Benjamin Van Court, Adam Mueller et al. · 2021 · Clinical Cancer Research
PURPOSE: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular…
View details →Negative / Null Result ReportMedicine
Ian R. Nelson, Jason Chen, Rebecca Love et al. · 2016 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Anterior cruciate ligament reconstructions (ACLRs) in skeletally immature patients are increasing. The purpose of this study is to describe the demographics, graft usage, revision, and re-operation rates in skeletally immature…
View details →Negative / Null Result ReportOpen accessMedicine
Khurum Khan, David Cunningham, Clare Peckitt et al. · 2016 · Oncotarget
// Khurum Khan 1 , David Cunningham 1 , Clare Peckitt 1 , Sarah Barton 1 , Diana Tait 1 , Maria Hawkins 1,2 , David Watkins 1 , Naureen Starling 1 , Sheela Rao 1 , Ruwaida Begum 1 , Janet Thomas 1 , Jacqui Oates 1 , Vincenza Guzzardo 3 , Matteo Fassan 3 , Chiara Braconi 1,4 and Ian Chau 1 1 Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK 2 CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK 3 Department of Medicine, University of Padua, Padua, IT 4 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutt
View details →Negative / Null Result ReportOpen accessMedicine
Hye Jun Lee, Jae Eun Lee, Seung‐Yup Ku et al. · 2013 · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
OBJECTIVE: To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS: We retrospectively studied 43 infertile women with…
View details →Negative / Null Result ReportOpen accessMedicine
Catarina Dinis Fernandes, Cuong V. Dinh, Iris Walraven et al. · 2018 · Physics and Imaging in Radiation Oncology
BACKGROUND AND PURPOSE: High-risk prostate cancer patients are frequently treated with external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15-35% will experience biochemical recurrence (BCR) within five years. Magnetic…
View details →Negative / Null Result ReportOpen accessMedicine
Ziad S. Saad, Derrek P. Hibar, Maggie Fedgchin et al. · 2020 · The International Journal of Neuropsychopharmacology
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has…
View details →Negative / Null Result ReportOpen accessMedicine
Anouk Wouters, Gerda Croiset, Nienke R. Schripsema et al. · 2017 · Advances in Health Sciences Education
Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct admission based on top pre-university grade point averages (≥8 out of 10; top-pu-GPA). We also considered whether students had participated in selection, prior to being admitted through weighted lottery. Year-1 (pre-clinical) and Year-4 (clinical) stude
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Gonçalo N. Petrucci, Joaquim Henriques, Hugo Gregório et al. · 2020 · Journal of Feline Medicine and Surgery
Objectives Although feline mammary carcinomas (FMCs) are highly metastatic, the literature and treatment options pertaining to advanced tumours are scarce. This study aimed to investigate the clinical outcome of metastatic FMC with or…
View details →Negative / Null Result ReportOpen accessMedicine
Bengt Sorbe, CHRISTIAN JURESTA, Cecilia Ahlin · 2014 · Oncology Letters
The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma…
View details →Negative / Null Result ReportOpen accessMedicine
Anna C. Navis, Sanne A. M. van Lith, Sander M. J. van Duijnhoven et al. · 2015 · Acta Neuropathologica
MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors are in clinical trials. We here describe a novel variant of MET that is expressed in 6% of high-grade gliomas. Characterization of this mutation in a glioma cell line revealed that it consists of an intronic deletion, resulting in a splice event connecting an intact splice donor site in exon 6 with
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Fulya Akpinar, Andrea C. Timm, John Yin · 2015 · Journal of Virology
UNLABELLED: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth. In coinfections with helper virus, the diversion of viral proteins to the replication and packaging of DIP genomes can interfere…
View details →Negative / Null Result ReportMedicine
John T. Kanegaye, Jennifer M. Jacob, Denise Malicki · 2014 · PEDIATRICS
OBJECTIVE: The performance of automated flow cytometric urinalysis is not well described in pediatric urinary tract infection. We sought to determine the diagnostic performance of automated cell counts and emergency department…
View details →Negative / Null Result ReportOpen accessMedicine
Ivo M.B. Francischetti, Emile B. Gordon, Bruna Bizzarro et al. · 2014 · PLoS ONE
BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopo
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Reina Yamaji, Shinya Yamada, Mai Quynh Le et al. · 2015 · Journal of Virology
UNLABELLED: Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among…
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Sarah Cockayne, Caroline Fairhurst, Joy Adamson et al. · 2017 · Trials
BACKGROUND: Randomised controlled trials are generally regarded as the 'gold standard' experimental design to determine the effectiveness of an intervention. Unfortunately, many trials either fail to recruit sufficient numbers of participants, or recruitment takes longer than anticipated. The current embedded trial evaluates the effectiveness of optimised patient information sheets on recruitment of participants in a falls prevention trial. METHODS: A three-arm, embedded randomised methodology trial was conducted within the National Institute for Health Research-funded REducing Falls with ORth
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