Negative / Null Result ReportOpen accessMedicine
Yasuhiro Koh, Manabu Aoki, Matthew Danish et al. · 2011 · Journal of Virology
Dimerization of HIV protease is essential for the acquisition of protease's proteolytic activity. We previously identified a group of HIV protease dimerization inhibitors, including darunavir (DRV). In the present work, we examine whether…
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Daniel V.T. Catenacci, Agnes Ang, Wei‐Li Liao et al. · 2016 · Cancer
BACKGROUND: MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC),…
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Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken et al. · 2025 · Frontiers in Public Health
Background: Artificial Intelligence (AI) is rapidly transforming the nursing profession, presenting significant opportunities and challenges. Despite its promising potential in enhancing nursing education, clinical practice, and operational efficiency, critical barriers related to ethics, workforce adaptation, and humanistic care persist. Aim: This integrative review systematically evaluates the integration of AI in nursing practice, with a specific focus on nursing education, clinical care, workload management, and professional perceptions. Methods: Guided by PRISMA 2020 and the SPIDER framew
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Ricardo Parreira, Shelley Cook, Ângela Celis de Almeida Lopes et al. · 2012 · Virus Research
We describe the full genetic characterization of an insect-specific flavivirus (ISF) from Culex theileri (Theobald) mosquitoes collected in Portugal. This represents the first isolation and full characterization of an ISF from Portuguese mosquitoes. The virus, designated CTFV, for Culex theileri flavivirus, was isolated in the C6/36 Stegomyia albopicta (=Aedes albopictus) cell line, and failed to replicate in vertebrate (Vero) cells in common with other ISFs. The CTFV genome encodes a single polyprotein with 3357 residues showing all the features expected for those of flaviviruses. Phylogeneti
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Andrew M. Bean, Rebecca Payne, Guy Parsons et al. · 2026 · Nature Medicine
Global healthcare providers are exploring the use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly perfect scores on medical licensing exams, but this does not necessarily translate to accurate performance in real-world settings. We tested whether LLMs can assist members of the public in identifying underlying conditions and choosing a course of action (disposition) in ten medical scenarios in a controlled study with 1,298 participants. Participants were randomly assigned to receive assistance from an LLM (GPT-4o, Llama 3, Command R+) or a source
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Grazia Crescimanno, Oreste Marrone, Andrea Vianello · 2011 · Respirology
BACKGROUND AND OBJECTIVE: Although non-invasive ventilation is widely used for the management of patients with neuromuscular disease, it remains unclear which ventilatory mode is associated with optimal patient-ventilator interaction and…
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Miles Piper, Benjamin Van Court, Adam Mueller et al. · 2021 · Clinical Cancer Research
PURPOSE: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular…
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Ian R. Nelson, Jason Chen, Rebecca Love et al. · 2016 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Anterior cruciate ligament reconstructions (ACLRs) in skeletally immature patients are increasing. The purpose of this study is to describe the demographics, graft usage, revision, and re-operation rates in skeletally immature…
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Khurum Khan, David Cunningham, Clare Peckitt et al. · 2016 · Oncotarget
// Khurum Khan 1 , David Cunningham 1 , Clare Peckitt 1 , Sarah Barton 1 , Diana Tait 1 , Maria Hawkins 1,2 , David Watkins 1 , Naureen Starling 1 , Sheela Rao 1 , Ruwaida Begum 1 , Janet Thomas 1 , Jacqui Oates 1 , Vincenza Guzzardo 3 , Matteo Fassan 3 , Chiara Braconi 1,4 and Ian Chau 1 1 Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK 2 CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK 3 Department of Medicine, University of Padua, Padua, IT 4 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutt
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Hye Jun Lee, Jae Eun Lee, Seung‐Yup Ku et al. · 2013 · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
OBJECTIVE: To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS: We retrospectively studied 43 infertile women with…
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Catarina Dinis Fernandes, Cuong V. Dinh, Iris Walraven et al. · 2018 · Physics and Imaging in Radiation Oncology
BACKGROUND AND PURPOSE: High-risk prostate cancer patients are frequently treated with external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15-35% will experience biochemical recurrence (BCR) within five years. Magnetic…
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Ziad S. Saad, Derrek P. Hibar, Maggie Fedgchin et al. · 2020 · The International Journal of Neuropsychopharmacology
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has…
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Anouk Wouters, Gerda Croiset, Nienke R. Schripsema et al. · 2017 · Advances in Health Sciences Education
Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct admission based on top pre-university grade point averages (≥8 out of 10; top-pu-GPA). We also considered whether students had participated in selection, prior to being admitted through weighted lottery. Year-1 (pre-clinical) and Year-4 (clinical) stude
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Gonçalo N. Petrucci, Joaquim Henriques, Hugo Gregório et al. · 2020 · Journal of Feline Medicine and Surgery
Objectives Although feline mammary carcinomas (FMCs) are highly metastatic, the literature and treatment options pertaining to advanced tumours are scarce. This study aimed to investigate the clinical outcome of metastatic FMC with or…
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Bengt Sorbe, CHRISTIAN JURESTA, Cecilia Ahlin · 2014 · Oncology Letters
The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma…
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Anna C. Navis, Sanne A. M. van Lith, Sander M. J. van Duijnhoven et al. · 2015 · Acta Neuropathologica
MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors are in clinical trials. We here describe a novel variant of MET that is expressed in 6% of high-grade gliomas. Characterization of this mutation in a glioma cell line revealed that it consists of an intronic deletion, resulting in a splice event connecting an intact splice donor site in exon 6 with
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Fulya Akpinar, Andrea C. Timm, John Yin · 2015 · Journal of Virology
UNLABELLED: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth. In coinfections with helper virus, the diversion of viral proteins to the replication and packaging of DIP genomes can interfere…
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John T. Kanegaye, Jennifer M. Jacob, Denise Malicki · 2014 · PEDIATRICS
OBJECTIVE: The performance of automated flow cytometric urinalysis is not well described in pediatric urinary tract infection. We sought to determine the diagnostic performance of automated cell counts and emergency department…
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Ivo M.B. Francischetti, Emile B. Gordon, Bruna Bizzarro et al. · 2014 · PLoS ONE
BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopo
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Reina Yamaji, Shinya Yamada, Mai Quynh Le et al. · 2015 · Journal of Virology
UNLABELLED: Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among…
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Sarah Cockayne, Caroline Fairhurst, Joy Adamson et al. · 2017 · Trials
BACKGROUND: Randomised controlled trials are generally regarded as the 'gold standard' experimental design to determine the effectiveness of an intervention. Unfortunately, many trials either fail to recruit sufficient numbers of participants, or recruitment takes longer than anticipated. The current embedded trial evaluates the effectiveness of optimised patient information sheets on recruitment of participants in a falls prevention trial. METHODS: A three-arm, embedded randomised methodology trial was conducted within the National Institute for Health Research-funded REducing Falls with ORth
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Jing Wang, Ting Xu, Lirong Wu et al. · 2022 · JTO Clinical and Research Reports
IntroductionDurvalumab after concurrent chemoradiation (CCRT) for NSCLC improves survival, but only in a subset of patients. We investigated the effect of severe radiation-induced lymphopenia (sRIL) on survival in these…
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Anwaar Saeed, Robin Park, Harsh B. Pathak et al. · 2024 · Nature Communications
CAMILLA is a basket trial (NCT03539822) evaluating cabozantinib plus the ICI durvalumab in chemorefractory gastrointestinal cancer. Herein, are the phase II colorectal cohort results. 29 patients were evaluable. 100% had confirmed pMMR/MSS tumors. Primary endpoint was met with ORR of 27.6% (95% CI 12.7-47.2%). Secondary endpoints of 4-month PFS rate was 44.83% (95% CI 26.5-64.3%); and median OS was 9.1 months (95% CI 5.8-20.2). Grade≥3 TRAE occurred in 39%. In post-hoc analysis of patients with RAS wild type tumors, ORR was 50% and median PFS and OS were 6.3 and 21.5 months respectively. Explo
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Susanne R. Youngren-Ortiz, David B. Hill, Peter Hoffmann et al. · 2017 · Journal of Aerosol Medicine and Pulmonary Drug Delivery
BACKGROUND: Aerosol delivery of chemotherapeutic nanocarriers represents a promising alternative for lung cancer therapy. This study optimized gemcitabine (Gem)-loaded gelatin nanocarriers (GNCs) cross-linked with genipin (Gem-GNCs) to…
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Joji Suzuki, Jeffrey DeVido, Inder Kalra et al. · 2015 · American Journal on Addictions
BACKGROUND AND OBJECTIVES: Opioid dependent patients are hospitalized frequently. We aimed to determine if initiation of buprenorphine treatment during hospitalization facilitates entry into treatment following discharge. METHODS:…
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Koji Matsuo, Muneaki Shimada, Harushige Yokota et al. · 2017 · Oncotarget
// Koji Matsuo 1, 2, * , Muneaki Shimada 3, 4, * , Harushige Yokota 5 , Toyomi Satoh 6 , Hidetaka Katabuchi 7 , Shoji Kodama 8, 9 , Hiroshi Sasaki 10, 11 , Noriomi Matsumura 12, 13 , Mikio Mikami 14 and Toru Sugiyama 15 1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA 2 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA 3 Department of Obstetrics and Gynecology, Tottori University, Tottori, Japan 4 Current affiliation: Department of Obstetrics and Gynecology, Tohoku Univ
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Ji‐Feng Feng, Liang Wang, Xun Yang et al. · 2019 · Cancer Management and Research
Background: We firstly identified a combination of lactate dehydrogenase (LDH) along with albumin (ALB), which was defined as LAR (LDH/ALB ratio). The purpose of our study here was initially to explore the prognostic role of LAR in…
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Hasan Akın, Aysun Ölçmen, Özgür İşgörücü et al. · 2011 · The Thoracic and Cardiovascular Surgeon
Mediastinal lymph node dissection, an important part of surgery for non-small cell lung cancer, is associated with a risk of chylothorax. Although mortality has significantly decreased in recent years, it still worries thoracic surgeons.…
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Bertrand Sauneuf, Benoît Champigneulle, Alexis Soummer et al. · 2013 · Critical Care
INTRODUCTION: The overall outcome of septic shock has been recently improved. We sought to determine whether this survival gain extends to the high-risk subgroup of patients with cirrhosis. METHODS: Cirrhotic patients with septic shock admitted to a medical intensive care unit (ICU) during two consecutive periods (1997-2004 and 2005-2010) were retrospectively studied. RESULTS: Forty-seven and 42 cirrhotic patients presented with septic shock in 1997-2004 and 2005-2010, respectively. The recent period differed from the previous one by implementation of adjuvant treatments of septic shock includ
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Juliane Jaitner, Tanja Morath, Robert A. Byrne et al. · 2012 · Circulation Cardiovascular Interventions
BACKGROUND: The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T,…
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