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Browse the failure-mode index

11,324 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis.

Carr JF, Basurto De Santiago C, Bhut SA et al. · 2026 · mBio

In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane…

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Negative / Null Result ReportMedicine

Dynamic inflation prevents and standardized lung recruitment reverts volume loss associated with percutaneous tracheostomy during volume control ventilation: results from a Neuro-ICU population.

Bastia L, Garberi R, Querci L et al. · 2024 · Journal of clinical monitoring and computing

To determine how percutaneous tracheostomy (PT) impacts on respiratory system compliance (C rs ) and end-expiratory lung volume (EELV) during volume control ventilation and to test whether a recruitment maneuver (RM) at the end of PT may…

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Negative / Null Result ReportMedicine

Effects of mindfulness-based stress reduction on levels of depression, anxiety, stress, and hopelessness in parents of children with autism: A randomized controlled trial.

Yurttutan S, Geçkil E · 2026 · Journal of pediatric nursing

Aim This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on depression, anxiety, stress, and hopelessness among parents of children with autism (Autism Spectrum Disorder [ASD]). Method A…

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Negative / Null Result ReportOpen accessMedicine

Computer-Assisted Intramedullary Nailing of Intertrochanteric Fractures Did Not Prevent Tip-Apex Distance Outliers.

Hansen RH, Rölfing JD, Nielsen CL et al. · 2023 · Journal of clinical medicine

Intertrochanteric femoral fractures are commonly treated with intramedullary nails (IMNs). A tip-apex distance (TAD) of more than 20-25 mm is associated with an increased risk of cut-out. The Stryker Adaptive Positioning System (ADAPT) is…

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Negative / Null Result ReportMedicine

Pre-Post Evaluation of Documentation Burden, Time Perception, and Cognitive Workload of Ambient AI Scribe Tools.

Arko L, Nguyen TH, Stoffel M et al. · 2026 · AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Documentation burden and cognitive load contribute to clinician burnout, and ambient AI scribes offer a promising solution, though real-world evaluations remain limited. This study evaluated the impact of an ambient AI scribe on…

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Negative / Null Result ReportOpen accessMedicine

The launch and diffusion of new patented medicines by therapeutic value.

Zhang W, Guh DP, Tam ACT et al. · 2026 · Health affairs scholar

Introduction Evidence on the launch and diffusion of therapeutically important new medicines is limited. We examined the launch and diffusion of new patented medicines in 14 countries by therapeutic value. Methods We analyzed IQVIA MIDAS®…

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Negative / Null Result ReportMedicine

Effects of a game-based learning ıntervention on self-reported learning strategies and professional attitudes in kinesiophobia management education: a parallel-group randomized controlled trial.

Yılmaz NA, Caner İ · 2026 · BMC medical education

Innovative educational strategies are increasingly needed in physiotherapy education to support students' learning and professional development. Game-based learning (GBL) is an interactive, student-centered approach that may enhance…

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Negative / Null Result ReportMedicine

Engineering a Fungal Non-Reducing Polyketide Synthase with an Apparently Inactive Product-Template Domain Reveals Insights into the Catalytic Reprogramming.

Yin R, Qin Y, Liang X et al. · 2026 · International journal of molecular sciences

Fungal iterative non-reducing polyketide synthases (NR-PKS) contain a unique product template (PT) domain for aromatic cyclization. Among them, some NR-PKSs, such as the sorbicillin NR-PKS (SorB), have an apparently inactive PT. It is…

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Negative / Null Result ReportMedicine

Changing the narrative: stories reduce biases against anomalous faces.

Bilici N, Paruzel-Czachura M, Workman CI et al. · 2026 · BMC psychology

Facial anomalies, such as scars, are often linked to an "anomalous-is-bad" stereotype, in which people with visible differences are seen as less warm or less moral. We developed the "Normalizing Anomalies with Mobile Exposure" (NAME)…

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Negative / Null Result ReportMedicine

Randomized controlled trial of Understanding Social Situations versus problem-solving training in improving social function in people with psychosis.

Fiszdon JM, Wang K, Fulford D et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objectives Poor social function in people with psychosis has been linked to impairments in social cognition and neurocognition, which in turn have been identified as promising treatment targets. We developed a novel social cognitive…

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Negative / Null Result ReportMedicine

Changes in corneal astigmatism, axial length and anterior chamber depth after vitrectomy and phacovitrectomy in rhegmatogenous retinal detachment.

Liu N, Zhao J, Wu B et al. · 2026 · International ophthalmology

Purpose To evaluate the changes in corneal astigmatism, axial length and anterior chamber depth following vitrectomy versus phacovitrectomy in patients with rhegmatogenous retinal detachment (RRD) under more detail group.To discuss how to…

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Negative / Null Result ReportMedicine

A Virtual Tai Chi Intervention for Older Adults with Mobility Disabilities: Results from a Single-Arm Clinical Trial with the TechSAge Tele Tai Chi Program.

Mitzner TL, Remillard ET, Mumma KT et al. · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives : Telewellness programs can expand access to exercise and social opportunities for older adults, especially those with mobility disabilities. The TechSAge Tele Tai Chi clinical trial assessed whether the Tai Chi for…

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