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Browse the failure-mode index

11,418 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Basket study of oral progesterone antagonist onapristone extended-release in combination with anastrozole in progesterone receptor-positive recurrent adult-type granulosa cell tumor of the ovary.

Finch L, Andres S, Iasonos A et al. · 2025 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective We sought to determine the safety and efficacy of the oral progesterone antagonist onapristone in combination with anastrozole in patients with recurrent progesterone receptor-positive adult-type granulosa cell tumor of the…

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Negative / Null Result ReportOpen accessMedicine

ADP101 multifood oral immunotherapy for food-allergic patients: Harmony phase 1/2 randomized clinical trial.

Kim EH, Carr WW, Assa'ad AH et al. · 2025 · The journal of allergy and clinical immunology. Global

Background Oral immunotherapy is an established approach to desensitize the immune system in the context of allergic disease; however, the only currently approved product is for peanut allergy. ADP101 is a novel, pharmaceutical-grade,…

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Negative / Null Result ReportMedicine

Combination of metronomic oral pazopanib and topotecan for recurrent glioblastoma with and without previous bevacizumab: Results from a phase 2 clinical trial.

Ozer BH, Cohen AL, Colman H et al. · 2026 · Neuro-oncology advances

Background Glioblastoma (GBM) has limited effective salvage therapy options. The combination of the Type 1B topoisomerase/HIF1α inhibitor topotecan and the tyrosine kinase inhibitor pazopanib has shown promise in solid tumors and may be…

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Negative / Null Result ReportOpen accessMedicine

Persistent Hyperparathyroidism in Vitamin D-Dependent Rickets Type 2A Does Not Prevent Normalization of Hypophosphatemia or Healing of the Rickets.

Lodefalk M, Nilsson O · 2025 · Hormone research in paediatrics

Introduction Vitamin D-dependent rickets type 2A (VDDR2A) is a rare, autosomal recessive disorder caused by pathogenic variants of the VDR gene encoding the vitamin D receptor. It has been proposed to be a form of parathyroid hormone…

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Negative / Null Result ReportOpen accessMedicine

A Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor-Hair Serum for the Prevention of Chemotherapy-Induced Alopecia.

Mann K, Potluri P, Paul EE et al. · 2026 · Journal of cosmetic dermatology

Introduction Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for…

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Negative / Null Result ReportOpen accessMedicine

Germination control by a hard seed coat: insights from a tropical legume.

Pereira GF, Sanches MC, De-Paula OC et al. · 2025 · Scientific reports

Classifying seed dormancy is an essential task for plant propagation; however, several plant species lack information about the kind of dormancy the seeds have or inaccurate reports are passed on without an in-depth investigation. We…

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Negative / Null Result ReportOpen accessMedicine

Effect of N-Acetylcysteine, Ascorbic Acid, and a Vitamin E Analog on Oxidative and Storage Lesions in Canine Packed Red Blood Cells.

Roque-Torres JL, Woolcock AD, Santos A et al. · 2025 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To describe storage and oxidative lesions in canine packed red blood cells (pRBCs) during routine storage with additives, including saline, N-acetylcysteine (NAC), ascorbic acid (AA), and vitamin E analog (VE). Design…

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Negative / Null Result ReportOpen accessMedicine

Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy.

Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Pharmaceuticals (Basel, Switzerland)

Background/Objectives : Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…

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Negative / Null Result ReportMedicine

Electrical Muscle Stimulation With or Without Blood Flow Restriction Does Not Prevent the Impairment in Glycemic Control After 1 Week of Physical Inactivity.

Pignanelli C, Robertson AA, Handy RM et al. · 2025 · Scandinavian journal of medicine & science in sports

Physical inactivity depresses glycemic control, an impairment that can be prevented with exercise. We investigated whether electrical muscle stimulation (EMS) with blood flow restriction (BFR) could similarly prevent the impairments in…

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Negative / Null Result ReportOpen accessMedicine

Effects of Ovariectomy and Sex Steroids on Prolactin Synthesis.

Cairang Z, Kanasaki H, Tumurbaatar T et al. · 2025 · International journal of endocrinology

Prolactin (PRL) plays a variety of roles to maintain female reproductive functions. In female rats, Prl mRNA expression in the anterior pituitary was significantly suppressed by OVX. The OVX-induced inhibition of PRL expression was…

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Negative / Null Result ReportMedicine

Association of the addition of a multicomponent additive to the human milk provided to preterm newborns with outcomes: A prospective cohort.

Mendes TGM, Nunes ACP, Dantas de Carvalho AV et al. · 2025 · Clinical nutrition ESPEN

Background The nutritional needs of preterm newborns (PTNB) are increased and enhancing nutritional management is essential to meet them. The addition of multicomponent additive (MA) to human milk (HM) is used as a treatment strategy. The…

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Negative / Null Result ReportMedicine

Arrhythmic Risk and Clinical Features in Catecholaminergic Polymorphic Ventricular Tachycardia: Results From a Multicenter Study in Korea.

Cho MJ, Song MK, Jun SY et al. · 2025 · The American journal of cardiology

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but life-threatening inherited arrhythmia in children, often associated with sudden cardiac death (SCD). Risk stratification remains challenging. This study aimed to…

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Negative / Null Result ReportOpen accessMedicine

Diverticular perforation with exclusive local invasion in cytomegalovirus infection during ganciclovir treatment: an autopsy case report.

Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…

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Negative / Null Result ReportMedicine

Peripherally administered TNF inhibitor is not protective against α-synuclein-induced dopaminergic neuronal death in rats.

Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2025 · Neurobiology of disease

The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important…

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Negative / Null Result ReportOpen accessMedicine

Occupational Transmission of Measles Despite COVID-19 Precautions.

De Carli G, Giombini E, Colosi A et al. · 2025 · Pathogens (Basel, Switzerland)

To determine whether patient-to-doctor transmission of measles occurred in an emergency department (ED) despite isolation precautions and full personal protective equipment (PPE) during the COVID-19 pandemic, an epidemiological and…

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Negative / Null Result ReportOpen accessMedicine

GalNAc Carbohydrate Prevents the Formation of Neutrophil Extracellular Traps and Increase Myeloperoxidase Enzyme Activity in Interactions of Neutrophils and Entamoeba histolytica Preincubated With GalNAc.

Levaro-Loquio D, Cruz-Baquero A, Higuera-Martínez G et al. · 2026 · BioMed research international

During amoebic infection, neutrophils are the first cells of the immune system to interact with trophozoites of Entamoeba histolytica, initiating amoebicidal activity. Different lectins and carbohydrates can participate in the mechanism of…

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Negative / Null Result ReportOpen accessMedicine

Impact of age on the reliability of GE Entropy™ module indices for guidance of maintenance of anaesthesia in adult patients: a single-centre retrospective analysis.

Ebensperger M, Kreuzer M, Kratzer S et al. · 2025 · British journal of anaesthesia

Background The GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or…

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