11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kahveci ME, Yigit AA, Kabakci R · 2026 · Reproduction in domestic animals = Zuchthygiene
Linuron, chloridazon and metribuzin are herbicides thought to have potential endocrine disruption (ED) effects. This study investigated the effects of linuron, chloridazon and metribuzin on bovine granulosa cell viability and oestrogen…
View details →Kashiri M, Berk B, Yemenicioğlu A · 2026 · International journal of biological macromolecules
This study aimed at utilizing soy protein-based emulsion gel as a fat substitute in spirulina enriched plant-based spreadable cheese (PBC). For this purpose, spirulina enriched vegetable oil-in-water emulsions prepared using soy protein as…
View details →Jaafar LS, Sous NS, Shehadi HH et al. · 2026 · The Journal of nutrition
Background Emerging evidence suggests that each Branched-chain amino acids (BCAA; leucine, valine, and isoleucine) exert distinct physiological effects. Moreover, leucine and valine, but not isoleucine, are structural components of…
View details →Rebeis LM, Baruselli PS, Harden H et al. · 2026 · Journal of dairy science
The aim of this study was to evaluate the effects of administering 325 mg of recombinant bovine somatotropin (rbST) at the initiation of the synchronization protocol (SYNCd) and/or on the day of embryo transfer (ETd) using a 2 × 2…
View details →Roubalová R, Luthar J, Procházková P et al. · 2026 · NPJ biofilms and microbiomes
Anorexia nervosa (AN) is a severe eating disorder that profoundly affects quality of life. Despite increasing understanding of the neurobiological basis of the disease, many patients develop a chronic course of illness accompanied by a…
View details →Schade AC, Vilella KD, Neves ETB et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Objective To assess the impact of parental psychosocial profile on the effectiveness of educational interventions aiming to improve oral hygiene among preschool children living in a rural area. Methods A controlled randomised trial…
View details →Persons AL, Napier TC · 2026 · Drug and alcohol dependence reports
Background The addiction profile of opioids reflects imbalances in downstream transmitters, including dopamine and serotonin (5-HT). The atypical antidepressant mirtazapine has multiple sites of action, including antagonism at 5-HT 2A…
View details →Lu S, Paengkoum S, Chen S et al. · 2025 · Animal Nutrition
This experiment aimed to investigate the potential impact of supplementing different levels of black soldier fly (BSF) on growth performance, serum antioxidants, and ruminal microbiota of goats. Twenty-four native Anglo-Thai male goats…
View details →Schommer S, Drost L, Finke J et al. · 2026 · Biological psychology
Human learning and memory are considered 'embodied', but it is unclear which body signals affect which memory facet. We investigated whether ascending cardiac signals affect memory encoding and consolidation. Due to its relevance for…
View details →Padoin Y, de Pellegrin SF, Castillo DC et al. · 2026 · European journal of oral sciences
This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into…
View details →Zimmermann V, Fourré N, Senn L et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose Duration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18…
View details →Crook G, Lamberth E, Lockhart SP et al. · 2026 · Open forum infectious diseases
This phase 3 trial compared immunogenicity and safety of 2-dose versus 3-dose PF-06425090 Clostridioides difficile vaccine regimens in ≥50-year-olds (N = 1994) at increased C difficile infection risk. Because C difficile toxin-A but not C…
View details →Palmi S, Arponen O, Murto M et al. · 2026 · JAMA network open
Importance Statin use has been associated with improved survival in patients with breast cancer, but there are no data on the association between statin use and survival in different intrinsic breast cancer subtypes. Objective To assess…
View details →Gunun N, Kaewpila C, Kesorn P et al. · 2026 · Animal bioscience
Objective The aim of this study was to evaluate the effect of the inclusion of tomato pomace silage (TPS) on feed intake, nutrient digestibility, blood parameters, immune response, milk yield, and milk nutritional composition in dairy…
View details →Sunada S, Kuroishi T · 2026 · Journal of oral biosciences
Immunoglobulin A (IgA)-producing cells in the three major murine salivary glands (SGs) were analyzed using flow cytometry. Sublingual glands (SLGs) had significantly higher frequencies of IgA + cells than other SGs. IgA + cells expressed…
View details →Wang M, Wang X, Zeng Y et al. · 2026 · Journal of animal science
This study evaluated the effects of replacing dietary glucose with fructose on intestinal development in weaned pigs and assessed epithelial growth using a small intestinal organoid model. A total of 26 weaned pigs ([Yorkshire × Landrace]…
View details →Shchulkin AV, Chernykh IV, Abalenikhina YV et al. · 2026 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Objective To compare the effects of Mexidol, Cerebrolysin, and Cortexin on the levels of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF α ), and apoptosis markers in the rat brain following middle cerebral…
View details →Vicente ACS, Salas-Solis GK, Johnson ML et al. · 2026 · Journal of dairy science
Peas (Pisum sativum L.) have 24% CP and could have the potential to partially replace soybean meal (SBM), which is the most used protein source in dairy diets in the USA. Sprouting can improve nutrient availability via enzymatic and…
View details →Wallbom N, Khansari AR, Sandblom E et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
The trade-off between growth and immunity in fish has been assumed to relate to energetic costs associated with immune functions. Here, we hypothesized that immunization with a bivalent mineral oil-adjuvanted vaccine elevates standard…
View details →Rout M, Blackett P, Sanghera DK · 2026 · Nutrients
Background: Vitamin D (25(OH)D) deficiency affects over one billion people globally and is associated with type 2 diabetes (T2D) and cardiometabolic diseases. However, causal relationships remain unclear, as vitamin D supplementation has…
View details →İren AY, Yiğit E · 2026 · BMC oral health
BACKGROUND: The aim of this in-vitro study was to evaluate the effect of preheating on the flexural strength, flexural modulus and microhardness of several commercially available single-shade universal resin composites (SSURCs). METHODS:…
View details →Kim SJ, Park K, Daher R et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study aimed to evaluate the impact of storage temperature and duration on the dimensional stability and mechanical properties of 3D-printed surgical guides. Materials and methods Sixty surgical guides were designed using two…
View details →Lazado CC, Brenne H, Olaisen D et al. · 2026 · Scientific reports
The diplomonad parasite Spironucleus salmonicida causes spironucleosis, a systemic infection characterised by internal haemorrhaging, splenomegaly, and granulomatous lesions in multiple organs. Prevention is the primary control strategy,…
View details →Zhang S, Zheng T, Zhou M et al. · 2026 · Journal of phycology
This study investigates the chemical and morphological responses of two domoic acid (DA)-producing diatoms, Pseudo-nitzschia multiseries and P. fukuyoi, to conspecific chemical cues released from mechanically damaged cells. Cell homogenate…
View details →Setiawan AS, Caesarini M, Musnamirwan IA et al. · 2026 · BMC public health
Background Stunting, a form of chronic malnutrition, is associated with impaired growth and potential changes in salivary function that may increase susceptibility to early childhood caries (ECC). These oral conditions may further…
View details →Yang H, Dai T, Wolf RM · 2026 · NPJ digital medicine
Artificial intelligence (AI) is increasingly used for diagnostic screening. In diabetic retinopathy screening, autonomous AI systems can identify disease without a specialist. However, patient trust in AI remains a challenge, and it…
View details →Roy C, Ouellet DR, Pellerin D et al. · 2026 · Journal of dairy science
The current experiment studied 2 situations proposed to lead to decreased milk protein yield (MPY). First, NRC (2001) predicts that substitution of soybean meal (SBM) by canola meal (CM) decreases MP supply, thereby negatively affecting…
View details →Jing S, Wang J, Cheng S et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
Voltage-gated sodium channels (VGSCs) are emerging therapeutic targets for cancers including neural tumors such as neuroblastomas and gliomas. BmK IT2, a neurotoxic polypeptide from the scorpion Buthus martensii Karsch, is a known…
View details →Onu CJ, Adu M, Jabbar D et al. · 2026 · Biochimica et biophysica acta. Molecular and cell biology of lipids
Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from…
View details →Tiburcio MA, Cali MP, Pereira LMB et al. · 2026 · Dalton transactions (Cambridge, England : 2003)
Amyloid deposits of amyloid-β (Aβ) and hyperphosphorylated tau are pathological hallmarks of Alzheimer's disease (AD), which accounts for most dementia cases worldwide. This study investigates the effect of the complex [Ru(phen) 2 (pNDIp)]…
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