11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Lin M, Tapuc A, Matyjek M et al. · 2026 · Comprehensive psychiatry
Autistic traits are associated with atypical social behaviors, particularly in approach-avoidance tendencies. However, the differential impact of these traits on responses to social versus non-social stimuli, and the variation of these…
View details →Geng F, Guo R, Shao Y · 2026 · Journal of psychiatric research
Background The jumping-to-conclusions (JTC) bias, which involves making hasty decisions based on limited evidence, has been extensively studied in schizophrenia spectrum disorders but remains under-explored in affective disorders,…
View details →Khan H, Ghafoor T, Khattak TA et al. · 2026 · Transplantation and cellular therapy
Infantile Osteopetrosis is a rare inherited bone disorder characterized by a reduced or complete lack of osteoclast function, leading to defective bone resorption and increased bone density. The defective osteoclast differentiation or…
View details →Incerti Parenti S, Evangelisti E, Maglioni A et al. · 2026 · Cranio : the journal of craniomandibular practice
Objective To investigate whether fixed orthodontic treatment affects sleep and awake bruxism activities, temporomandibular disorder (TMD) prevalence, and pressure pain thresholds (PPTs) of masticatory muscles in healthy adults. Methods In…
View details →Jacob G, Lourenço PR, Diniz FMM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study evaluated the effect of calcium hydroxide-based intracanal medication protocols on the sealer-dentin interface, considering bond strength, adhesive interface adaptation, failure pattern, and dentin gelatinolytic…
View details →Jian PT, Lin YW · 2026 · Contact dermatitis
Background Hairdressers often reuse disposable gloves, yet the effect of repeated washing on protection against oxidative hair-dye sensitizers is unclear. Objectives To determine how reuse and wash type influence the permeation of…
View details →Soares EADS, Crisp AH, Fernandes PT et al. · 2026 · Scandinavian journal of psychology
Premenstrual syndrome (PMS) is a set of symptoms related to hormonal changes occurring during the premenstrual period. Effective coping strategies for managing PMS have not been clearly established, and it remains unclear whether these…
View details →Mies F, Olchowik-Grabarek E, Crutzen R et al. · 2026 · Biochemical and biophysical research communications
In this report we demonstrate that iodogallic acid (IGA) and iodoferulic acid (IFA) do not acutely affect transepithelial cation transport, however, prolonged basolateral application of IFA induced a delayed decrease in open-circuit…
View details →Bodilsen TS, Andreasen TH, Olsen MH et al. · 2026 · Acta neurochirurgica
Background Invasive multimodal neuromonitoring (MMNM) is standard of care in many neuro-intensive care units for patients with severe acute brain injury. MMNM is used for monitoring of early signs of secondary brain injury. Still, the…
View details →Lindhard K, Hansen HP, Gliese K et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN
Introduction In patients on hemodialysis, the risk of arteriovenous fistula (AVF) failure is unacceptably high. Up to 67% of AVFs need an intervention within one year after placement. There are no effective treatments to prolong AVF…
View details →Goto K, Ishizuka S, Nakamura-Takahashi A et al. · 2026 · Journal of oral biosciences
Objectives Hypophosphatasia (HPP) is a congenital disease caused by mutations in the tissue non-specific alkaline phosphatase gene. HPP is characterized by impaired hard tissue mineralization and premature tooth loss. Mild-type HPP…
View details →Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics
Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…
View details →Zeni NG, Perricone V, Tognoli C et al. · 2026 · Poultry science
The poultry sector faces increasing sustainability challenges related to feed-food competition, volatility in the cereal markets and the environmental impact of poultry production. In this context, the use of products from the bakery and…
View details →Flämig L, Felix Zhu W, Hoffmann K et al. · 2026 · Organic & biomolecular chemistry
Agonists of the κ-opioid receptor are useful drugs for the treatment of severe pain, itching skin diseases and inflammatory and immunological diseases. Herein, novel κ agonists with the κ-pharmacophoric ethylenediamine system embedded in a…
View details →Chiang YW, Chang JY, Yeh KL et al. · 2026 · Investigative ophthalmology & visual science
Purpose To investigate whether exposure to artificial lighting with different correlated color temperatures (CCTs) affects ocular structure and myopia-related molecular signaling pathways before axial elongation in a murine model. Methods…
View details →Yamakawa R, Sakaue Y, Okada S et al. · 2026 · Gait & posture
Background Hip osteoarthritis (HOA) often leads to compensatory movements such as trunk lateral bending during gait due to pain and restricted range of motion. Because multiple joints coordinate to control the center of mass (CoM) during…
View details →Swainson A, Cerminara NL, Apps R et al. · 2026 · Psychology and aging
Studies over the past 3 decades have shown decreased motor adaptation with age. The most widely supported theory for this change proposes that older adults fail to successfully implement cognitive strategies to facilitate performance.…
View details →Ma Y, Lai A, Deng X et al. · 2026 · Food chemistry
β-glucan could regulate starch retrogradation and digestion; however, its combined role with starch fine molecular structures remains unknown. Therefore, nine starches were selected, and their retrogradation and digestion properties were…
View details →Sharma P, Sivaramakrishnan P, Dahal S et al. · 2026 · Respiratory medicine
In malignant pleural effusion (MPE), malignant cells may settle in a gravity-dependent gradient due to the weight of cells. We aimed to compare diagnostic yield of cytology between aspirates from lower, upper and 5th intercostal spaces in…
View details →Nijssen KMR, Adam TC, Mensink RP et al. · 2026 · Metabolism: clinical and experimental
Introduction Nutritional ketosis may prevent age-related cognitive decline, but underlying mechanisms remain unclear. This study investigated acute ketone monoester (KME) supplementation on brain insulin responsiveness and cognitive…
View details →Bonifácio DB, da Silva A, Estrada YMF et al. · 2026 · Nutrition, metabolism, and cardiovascular diseases : NMCD
Background and aims The effect of consuming a mix of Brazilian nuts on energy metabolism has not been explored. Thus, the present study aimed to evaluate the effects of acute and chronic consumption of mixed nuts on markers of energy…
View details →Fan Y, Gao G, Jiang X et al. · 2026 · Veterinary sciences
The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…
View details →Lelis ALJ, da Silva LAF, Casali DM et al. · 2026 · Scientific reports
This study evaluated the effects of rumen-protected metabolizable methionine (RPM) supplementation on performance, carcass traits, ruminal morphometry, cecal histology, and meat quality of crossbred heifers finished on Urochloa brizantha…
View details →Flora C, Engdahl S, Pettit RS · 2026 · Pediatric pulmonology
Background Many people with cystic fibrosis (PwCF) are colonized with Pseudomonas aeruginosa. Some studies have found that PwCF who use both tobramycin (TOB) and azithromycin during PEx treatment, have worse clinical outcomes, including a…
View details →Akkan Aydogmus FS, Gursoy T, Ozdemir O et al. · 2026 · BMC ophthalmology
Background To evaluate the outcome of treat and extend (T&E) for neovascular age related macular degeneration (nAMD) at 12, 18 and 24 months and the impact of clinical characteristics on treatment success defined as extension of treatment…
View details →Lines JB, Cungi PJ, Da Silva C et al. · 2026 · BMJ military health
Introduction Non-surgical management of non-neurological thoracic or lumbar spine (TL) fractures seems to provide good results in the civilian population, leading to return to work in most cases. However, data on the military population…
View details →García-García A, Goyoaga M, Nuño F et al. · 2026 · Carbohydrate Polymers.
Despite the increasing interest on self-healing hydrogels in the fabrication of customized scaffolds for tissue engineering applications, their optimal printability is still a challenge due to the weak mechanical stability of dynamic…
View details →Shimoyama M, Nakada-Tsukui K, Nozaki T · 2026 · Journal of cell science
Rho guanine nucleotide-exchange factors (RhoGEFs) activate Rho and Rac small GTPases, orchestrating cellular processes, such as actin remodeling, endocytosis and migration. In the protozoan parasite Entamoeba histolytica, the causative…
View details →Vera-Escalona I, Peralta-Prato J, Jorquera E et al. · 2026 · Gene
Over the decades, the Cytochrome Oxidase I (COI) gene has been widely used as a low-cost standardized identification method for phylogenetic and phylogeographic studies. However, the literature of the COI gene amplification, cloning, and…
View details →Pu Y, Gampa A, Simon C et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Atrial arrhythmias (AA), including atrial fibrillation (AF) and atrial flutter, are a significant clinical problem in oncological patients. The effect of AA on clinical outcome of patients with non-small cell lung cancer (NSCLC) is not…
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