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Browse the failure-mode index

11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of providing access to a cycling exergaming platform on cardiorespiratory fitness and cardiometabolic health in adolescents: a randomised, controlled trial.

Berg J, Wang AI, Madssen E et al. · 2026 · Scientific reports

Insufficient physical activity (PA) among adolescents has deleterious consequences for their health. Exergaming, which combines exercise with gaming, is enjoyable, but the long-term effects of exergaming on adolescent health remain poorly…

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Negative / Null Result ReportMedicine

The Association Between Sitting Delivery During the Second Stage of Labor and Pelvic Floor Function in Primiparas: A Prospective Cohort Study.

Gong J, Xie B, Wei Y et al. · 2026 · Healthcare (Basel, Switzerland)

Background/objectives Pregnancy and childbirth are independent risk factors for pelvic floor injury. The choice of delivery position, as an interventionable factor during labor, has received much attention. This study aimed to assess the…

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Negative / Null Result ReportMedicine

Nationwide questionnaire survey on collaboration for the management of chronic kidney disease from the perspective of referrals in Japan.

Hatta T, Kobayashi K, Tatematsu S et al. · 2026 · Clinical and experimental nephrology

Background Preventing end-stage renal failure progression of patients with chronic kidney disease (CKD) requires collaboration between nephrologists and general practitioners. Following the 2013 and 2019 surveys in Japan, a nationwide…

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Negative / Null Result ReportMedicine

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows.

Park K, Kim J, Hu H et al. · 2026 · Journal of dairy science

Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies…

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Negative / Null Result ReportMedicine

Are gaps in the time of submissions and approvals of new drugs between Health Canada and the Food and Drug Administration related to therapeutic value? A cross-sectional study.

Lexchin J · 2026 · Health policy (Amsterdam, Netherlands)

Background Health Canada is proposing to use decisions by foreign regulators in approving new drugs to speed up their marketing. Objectives To investigate the length of gaps in submissions to and approvals by Health Canada compared to the…

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Negative / Null Result ReportMedicine

Do potentially traumatic events experienced by people in one's social circle affect one's own mental health and emotional support? Findings from a prospective population-based study.

van der Velden PG, Contino C, Kempe S et al. · 2026 · Acta psychologica

Background Adults may have individuals in their social circle who were recently exposed to potentially traumatic events (PTEs). The present study aims to examine if these adults are at increased risk for mental health problems and reduced…

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Negative / Null Result ReportMedicine

Optimizing Necrotizing Otitis Externa Management: The Role of PET-CT in Antibiotic Stewardship.

Zammit M, Davies T, Youssef A · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To optimize antibiotic regimens in necrotizing otitis externa (NOE) and skull base osteomyelitis (SBO) and evaluate the role of positron emission tomography-computed tomography (PET-CT) in disease monitoring. Study design A…

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Negative / Null Result ReportMedicine

Folded-flap palatoplasty performed with a needle-tip monopolar cautery: retrospective cohort of 66 brachycephalic dogs.

Miloro R, Mala B, Ceplecha V et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To evaluate short- and long-term patient outcomes retrospectively, investigate anesthetic and surgical times, and assess clinically relevant surgical wound complications associated with the use of needle-tip monopolar…

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Negative / Null Result ReportMedicine

Midazolam versus midazolam-promethazine combination for oral sedation in third molar surgery: A randomized split-mouth trial.

Castanha D, Lessa TC, Martins-de-Araújo ES et al. · 2026 · Medicina oral, patologia oral y cirugia bucal

Background Oral sedation is widely utilized in dental surgical practice for anxiety management during third molar extractions. Midazolam is one of the most frequently employed drugs; however, the clinical benefits of its association with…

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Negative / Null Result ReportMedicine

Comparison of prehospital tidal volume delivery performance between automated transport ventilators and bag-valve devices in out-of-hospital cardiac arrest patients: does the pressure limit matter?

Chen CH, Yu PH, Fan CY et al. · 2026 · Frontiers in medicine

Background Automatic transport ventilators (ATVs) are a potential option for ventilating patients experiencing out-of-hospital cardiac arrest (OHCA); however, their tidal volume delivery performance at different pressure limits compared…

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Negative / Null Result ReportMedicine

Effects of a home-based exercise and physical activity intervention after inpatient rehabilitation on real-world mobility in older adults with cognitive impairment: a secondary analysis of a randomised controlled trial.

Werner C, Ullrich P, Degli Angeli L et al. · 2026 · Age and ageing

Persistent mobility limitations after inpatient rehabilitation are common in older adults with cognitive impairment (CI). Home-based exercise interventions can improve locomotor capacity during this vulnerable period; however, evidence…

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Negative / Null Result ReportMedicine

Tolerability and effectiveness of definitive chemoradiotherapy in locally advanced lung cancer patients with combined pulmonary fibrosis and emphysema.

Fujimoto K, Kogo M, Kobayashi H et al. · 2026 · Cancer treatment and research communications

Background This study evaluated the efficacy and safety of definitive chemoradiotherapy (CRT) for lung cancer in patients with combined pulmonary fibrosis and emphysema (CPFE), focusing on radiation pneumonitis (RP). Materials and methods…

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Negative / Null Result ReportMedicine

DNAemia Thresholds to Discontinue Antivirals in Preemptive Management for Cytomegalovirus Seropositive Recipients After Kidney Transplantation.

Miehrig AH, Foresto RD, Tedesco-Silva H et al. · 2026 · Transplantation

Background Treatment of cytomegalovirus (CMV) after kidney transplantation aims to achieve cessation of viral replication; however, the use of highly sensitive DNA assays creates uncertainty regarding the optimal DNAemia threshold for…

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Negative / Null Result ReportMedicine

Patient factors outweigh procedure extent in infection risk after cervical disc arthroplasty.

Mastrokostas PG, Said M, Mastrokostas LE et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To determine the 90-day incidence of surgical site infection (SSI) after cervical disc arthroplasty (CDA), compare single versus multilevel procedures, and identify independent predictors of SSI. Methods We identified adult…

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Negative / Null Result ReportMedicine

Adrenocorticotropin hormone regulates sphingosine-1-phosphate synthesis via cortisol in bovine adrenocortical cells.

Medina-Moctezuma ZB, Guzmán-Sánchez A, González-Aretia D et al. · 2026 · Biochemical and biophysical research communications

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) stimulate the synthesis of sphingosine-1 phosphate (S1P) in Gs-coupled receptors dependent manner, enabling S1P to mediate specific bioactivities of FSH and LH. Because…

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Negative / Null Result ReportMedicine

Do congenital heart diseases or chromosomal anomalies influence the surgical outcomes of esophagocoloplasty in esophageal atresia patients?

Tannuri ACA, Abe Takahasi BN, de Almeida Estrambk G et al. · 2026 · Journal of pediatric surgery

Background Esophageal atresia (EA) is frequently associated with congenital heart disease (CHD) and chromosomal anomalies, mainly Down syndrome (DS). While these conditions affect outcomes following primary repair, their specific impact on…

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Negative / Null Result ReportMedicine

Application of quinoa oil emulsions in fresh goat cheese: effects on lipid profile, technological properties and microstructure.

Muñoz-Tebar N, Lucas-González R, Muñoz-Bas C et al. · 2026 · Food chemistry

This study investigates the use of quinoa oil emulsion as a novel plant-based ingredient to improve the nutritional quality of fresh goat cheese. Quinoa oil emulsions (3 and 6 g/L) were characterized and incorporated in fresh cheese. The…

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Negative / Null Result ReportMedicine

GnRH Administration Increases Synchronisation of Ovulation in Mares.

Cui B, Liu Y, Wu X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The objective of this study was to evaluate the effects of exogenous GnRH administration at the beginning of estrus synchronisation in mares during the spring transitional period. Estrus was synchronised using a progesterone releasing…

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Negative / Null Result ReportMedicine

Physiologic, Psychological, Nutritional, and Rest-Activity Observations During 120 Days of Low-Tech Off-Grid Living in the Baja California Desert: A 2-Participant Field Case Study.

Mauvieux B, Montardy Q, Remilly M et al. · 2026 · Wilderness & environmental medicine

Off-grid low-tech living is increasingly proposed for arid environments, yet longitudinal field data documenting health, nutrition, and rest-activity organization under real-world conditions remain scarce. Our objective was to describe…

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