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Browse the failure-mode index

11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Hematopoietic progenitor cells (HPCs) mobilization following high-intensity interval exercise in cancer patients undergoing bone marrow transplantation: preliminary results from a randomized controlled trial.

Zarekar T, Ahmadizad S, Hajifathali A et al. · 2026 · Stem cell research & therapy

Background and objective Hematopoietic progenitor cells (HPCs) mobilization is essential for successful bone marrow transplantation but may be impaired in cancer patients due to prior treatments. High-intensity interval exercise (HIIE) has…

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Negative / Null Result ReportMedicine

Amplicon sequencing reveals impact of imidacloprid residues on diversity profile of grape fructosphere microbiota.

Deore P, Upadhyay A, Thekkumpurath AS et al. · 2026 · World journal of microbiology & biotechnology

In grape, fructosphere microbiota play an important role in nutrient cycling, pathogen suppression, berry quality, and fermentation processes. Insecticide imidacloprid (IM) is used to manage several insect pests of grape. However, the…

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Negative / Null Result ReportMedicine

Clinical Outcome of EMG-Based Pelvic Floor Biofeedback in Patients With Constipation-Impact of Prior Anorectal Manometry/Balloon Expulsion Test for Patient Selection. A Retrospective Study.

Kochhar S, Channapragada T, Shenoy V et al. · 2026 · Neurogastroenterology and motility

Introduction Pelvic floor biofeedback therapy (BFT) is the mainstay treatment for dyssynergic defecation, a condition defined by the Rome criteria. This retrospective study compares outcomes between patients referred for EMG-based BFT…

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Negative / Null Result ReportMedicine

Comparison of Urodynamic Outcomes of Surgery Using the Photoselective Vaporization 180 W XPS System and Transurethral Resection of the Prostate: A Propensity Score-Matched Analysis in Real-World Clinical Practice.

Saito Y, Kyoda Y, Nofuji S et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Objectives No previous studies have directly compared pre- and postoperative pressure flow study (PFS) outcomes between transurethral resection of the prostate (TURP) and photoselective vaporization of the prostate using the GreenLight XPS…

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Negative / Null Result ReportMedicine

Rose danio (Danio roseus): A native Mekong basin alternative to zebrafish for acute, developmental, and neurobehavioral toxicity testing.

Seetapan K, Nobsathian S, Bullangpoti V et al. · 2026 · Environmental toxicology and chemistry

The fish embryo toxicity test is widely used as an alternative to conventional acute fish toxicity assays, but its ecological relevance may be limited when the model species is nonnative to the region of interest. Here, we evaluated rose…

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Negative / Null Result ReportMedicine

Advancements in Breast Lipofilling: A 12-Year Retrospective Comparative Analysis of Patient Satisfaction and Complication Rates across Fat Preparation Methods.

Loucas R, Loucas M, Müller R et al. · 2026 · Plastic and reconstructive surgery

Background Breast lipofilling is a commonly utilized method in plastic surgery for breast reconstruction and augmentation. However, the procedure is often limited by the unpredictable survival of fat grafts, leading to dissatisfied…

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Negative / Null Result ReportMedicine

Balancing relief and reflux: A prospective comparative study on gastric myotomy length and post-operative outcomes in laparoscopic Heller's myotomy for achalasia.

Yadav S, Kiran SP, Gurjar SK et al. · 2026 · Journal of minimal access surgery

Introduction Laparoscopic Heller's myotomy (LHM) with a partial fundoplication is the standard surgical therapy for achalasia cardia. However, the ideal gastric extension of the myotomy remains controversial, as it may influence both…

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Negative / Null Result ReportMedicine

Association Between Epicardial Adipose Tissue Thickness and Early Arrhythmia Recurrence After Electrical Cardioversion for Atrial Fibrillation and Atrial Flutter in Patients With and Without Heart Failure-An Observational Study.

Kadum F, Benko K, Batičić L et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Atrial fibrillation (AF) and atrial flutter are associated with significant morbidity. While electrical cardioversion (ECV) is a standard treatment for sinus rhythm restoration, early arrhythmia recurrence is…

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Negative / Null Result ReportMedicine

Short Versus Extended Duration of Triple Antithrombotic Therapy After Percutaneous Coronary Intervention in Patients Requiring Oral Anticoagulation: A Retrospective Single-Center Study.

Kurpad KP, Vorla M, Bin-Farooq T et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background Balancing ischemic and bleeding risks in patients undergoing percutaneous coronary intervention (PCI) who require anticoagulation remains a clinical challenge. While dual antithrombotic therapy (DAT) with a P2Y12 inhibitor and…

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Negative / Null Result ReportMedicine

Pediatric Robotic Cochlear Implantation: Hearing Outcomes.

Marie A, Leclere JC, Fleming Y et al. · 2026 · Audiology & neuro-otology

Introduction Cochlear implantation is the standard of care for children with severe-to-profound sensorineural hearing loss, offering substantial improvements in speech intelligibility, tonal audiometry perception, language acquisition, and…

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Negative / Null Result ReportMedicine

Generativity in Physician Assistants: Insights Amid a Preceptor Shortage.

Chung K · 2026 · The journal of physician assistant education : the official journal of the Physician Assistant Education Association

Introduction Amid a preceptor shortage, this pilot study examined the relationship between generativity, a psychosocial construct reflecting concern for guiding the next generation, and demographic characteristics among physician…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of dexmedetomidine versus fentanyl on postoperative pain and recovery after pediatric tonsillectomy: A retrospective cohort study.

Jallad M, AlAnazi B, Aloqbawi A et al. · 2026 · Saudi journal of anaesthesia

Background Pediatric tonsillectomy is commonly associated with significant postoperative pain. Opioids remain a mainstay for perioperative analgesia but carry risks of respiratory depression and prolonged recovery, especially in patients…

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Negative / Null Result ReportMedicine

The interplay of APOE genotype, plasma levels, and cognitive functions in middle-aged adults with a parental history of Alzheimer's disease.

Mattar YA, Refaat O, El-Makawi S et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Background Family history and APOE ε4 carriage represent the strongest non-modifiable Alzheimer's disease (AD) risk factors after advancing age. Early identification of cognitive markers in individuals at risk is essential for effective…

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Negative / Null Result ReportMedicine

Axial Force Transmission Through Orthosis Straps in a Neonatal Hip Flexion-Abduction Orthosis: An Exploratory In Vivo Study in Infants with Developmental Dysplasia of the Hip.

Schwanitz von Keitz P, Liebau KH, Mittelmeier W et al. · 2026 · Children (Basel, Switzerland)

Background: Developmental dysplasia of the hip (DDH) is the most common congenital musculoskeletal disorder in newborns. Flexion-abduction orthoses are widely used in early treatment; however, in vivo data on their biomechanical load…

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Negative / Null Result ReportMedicine

A randomized controlled trial to evaluate the efficacy and safety of a double-walled incubator compared to a radiant warmer in the care of extremely low-birth-weight infants.

Kabra NS, Umate SS, Halder P et al. · 2026 · Journal of tropical pediatrics

This study compared the safety and efficacy of double-walled incubators versus radiant warmers in extremely low-birth weight (ELBW: birth weight < 1000 g) preterm infants, hypothesizing that incubator care would reduce the time to regain…

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Negative / Null Result ReportMedicine

Macromolecular crowding and ionic strength diminish the energetic severity of the Arrhenius break point of thermolysin: Implications for biological significance.

Miller JJ, Duggal M, Bahnson BJ · 2026 · Protein science : a publication of the Protein Society

A growing number of enzymes demonstrate deviations from typical linear kinetic temperature dependencies as modeled by the Arrhenius and Eyring equations. These deviations may manifest as biphasic temperature dependencies consisting of two…

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Negative / Null Result ReportMedicine

Perioperative Outcomes of Robot-Assisted Partial Nephrectomy Using Hinotori Compared With da Vinci Xi: A Propensity Score-matched Analysis.

Kanehira M, Nozaki Y, Ogasawara K et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS

Introduction Robot-assisted partial nephrectomy (RAPN) using the da Vinci Surgical System (DVSS) is broadly performed globally. In Japan, the Hinotori Surgical Robot System (HSRS) has recently been developed. However, few studies have…

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