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Browse the failure-mode index

11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Performance, non-carcass components, serum biochemistry panel and intestinal morphology of Texel lambs fed with bioactive peptides.

Nascimento GO, Otávio KS, Ferreira J et al. · 2026 · Tropical animal health and production

Bioactive peptides (BP) have been investigated as potential functional feed additives due to their reported immunomodulatory and metabolic properties. This study evaluated the effects of dietary BP supplementation on growth performance,…

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Negative / Null Result ReportMedicine

Endogenous Theta as a Function of Task Load and Working Memory Capacity: Revisiting the Role of Slower Frequencies in Theta-Gamma Coupling.

Tortajada M, Rodríguez-Larios J, Martínez-Pérez V et al. · 2026 · Journal of cognitive neuroscience

Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in working memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…

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Negative / Null Result ReportMedicine

Real-World Data on Treatment Compliance and Visual Outcomes Between Patients With Diabetic Macular Edema or Retinal Vein Occlusion Receiving Antivascular Endothelial Growth Factor Injections or Intravitreal Corticosteroid Implants.

Kim SB, Lopez A, Gu X et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To evaluate real-world differences in treatment frequency, appointment compliance, and visual outcomes among patients with DME or RVO whose eyes either remained on antivascular endothelial growth factor (anti-VEGF) therapy or were…

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Negative / Null Result ReportMedicine

Testing the efficacy of a defocusing intervention to improve affective forecasting accuracy in younger and older adults.

Sobel Misieczko M, Barber SJ · 2026 · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

Affective forecasting, the process of predicting future feelings, is key for decision-making, but prone to errors. Prior research suggests that age differences in forecasting accuracy vary by event valence such that older adults tend to be…

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Negative / Null Result ReportMedicine

Effects of Dry-Land Versus In-Water Resistance Priming Exercise on Performance Parameters of Young Female Water Polo Players.

Brisola GMP, da Cruz AL, Belorio LGDS et al. · 2026 · Journal of strength and conditioning research

Abstract Brisola, GMP, da Cruz, AL, Belorio, LGdS, Grossi, JP, De Poli, RAB, Zagatto, AM, Esco, MR, and Mendes, OdC. Effects of dry-land versus in-water resistance priming exercise on performance parameters of young female water polo…

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Negative / Null Result ReportMedicine

A single autoregressive integrated moving average with exogenous variable outperforms ensembles of autoregressive models for forecasting influenza hospitalizations in the contiguous United States.

Arraes Rocha Felix V, Rohani P, Drake JM · 2026 · Journal of the Royal Society, Interface

Infectious disease forecasting is important to public health decision-making, particularly for mitigating the burden of seasonal influenza. We propose and evaluate comprehensive autoregressive modelling approaches (autoregressive…

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Negative / Null Result ReportMedicine

Mycorrhizal inoculation and crop rotation as soil sustainable management strategies to reduce fertilizer use and water consumption in horticultural crops

Vargas Ribera PR, Nogales A, Calvet C et al. · 2026 · Applied Soil Ecology.

Crop rotation enhances agroecosystem sustainability by reducing nutrient loss, improving soil fertility, and decreasing crop evapotranspiration. Arbuscular mycorrhizal fungi (AMF) inoculation further supports enhanced nutrient and water…

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Negative / Null Result ReportMedicine

A Phase 2b Multicenter Study to Evaluate Basmisanil as an Adjunctive Treatment in Patients With Cognitive Impairment Associated With Schizophrenia.

Umbricht D, Abt M, Derks M et al. · 2026 · The Journal of clinical psychiatry

Objective: Cognitive impairment associated with schizophrenia (CIAS) is a key driver of functional deficits in patients with this disorder. CIAS may involve deficient NMDA receptor-dependent neurotransmission. Negative allosteric…

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Negative / Null Result ReportMedicine

Delivery of nano-formulated drugs to solid tumours is selectively increased by co-application of the vascular disrupting agent CA4P.

Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology

Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…

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Negative / Null Result ReportMedicine

Clinical efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy for limited-stage small cell lung cancer (including induction ± consolidation ± second-line immunotherapy): A propensity score matching study based on real-world data.

Zhao A, Chen W, Liang Y et al. · 2026 · Cancer treatment and research communications

Objective To compare and analyze the efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC)-including induction immunotherapy plus…

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Negative / Null Result ReportMedicine

Exercise preconditioning attenuates ischemic neurological deficits without modulating motor learning in a rodent model of focal cortical ischemia.

Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research

Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…

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Negative / Null Result ReportMedicine

Does air abrasion improve the retention of restorations in non-carious cervical lesions? An 18-month split-mouth randomized controlled trial.

Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry

Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…

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Negative / Null Result ReportMedicine

Efficacy of a short multimodal workshop including stress management and communication skills training on objective structured clinical examination performance and exam-related anxiety in French medical students: a randomized controlled study.

Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions

Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…

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