Negative / Null Result ReportOpen accessMedicine
Vladimir Lazarević, A-S Hörstedt, Bertil Johansson et al. · 2014 · Blood Cancer Journal
The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively…
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Anna Elisabet Olafsdottir, Daniel D. Reidpath, Subhash Pokhrel et al. · 2011 · BMC Public Health
BACKGROUND: The literature on health systems focuses largely on the performance of healthcare systems operationalised around indicators such as hospital beds, maternity care and immunisation coverage. A broader definition of health systems however, needs to include the wider determinants of health including, possibly, governance and its relationship to health and health equity. The aim of this study was to examine the relationship between health systems outcomes and equity, and governance as a part of a process to extend the range of indicators used to assess health systems performance. METHOD
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Nienke M. Siebelink, Susan M. Bögels, Anne Speckens et al. · 2021 · Journal of Child Psychology and Psychiatry
BACKGROUND: Family mindfulness-based intervention (MBI) for child attention-deficit/hyperactivity disorder (ADHD) targets child self-control, parenting and parental mental health, but its effectiveness is still unclear. METHODS: MindChamp…
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Timothy P. LaBranche, Alison M. Bendele, Brian C Omura et al. · 2016 · Annals of the Rheumatic Diseases
OBJECTIVE: To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. METHODS:…
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David Casadevall, Javier Gimeno, Sergi Clavé et al. · 2015 · Oncotarget
// David Casadevall 1, 6, * , Javier Gimeno 2, * , Sergi Clavé 3, 4, * , Álvaro Taus 1 , Lara Pijuan 2 , Miriam Arumí 1 , Marta Lorenzo 4 , Silvia Menéndez 4 , Israel Cañadas 4 , Joan Albanell 1, 4, 5 , Sergio Serrano 2 , Blanca Espinet 3, 4 , Marta Salido 3, 4 , Edurne Arriola 1, 4, # 1 Servei d’Oncologia Mèdica, Hospital del Mar, Barcelona, Spain 2 Servei de Patologia, Hospital del Mar, Barcelona, Spain 3 Laboratori de Citogenètica Molecular, Servei de Patologia, Hospital del Mar, Barcelona, Spain 4 Cancer Research Program, IMIM (Hospita
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Karin Welén, Ebba Rosendal, Magnus Gisslén et al. · 2021 · European Urology
BACKGROUND: Men are more severely affected by COVID-19. Testosterone may influence SARS-CoV-2 infection and the immune response. OBJECTIVE: To clinically, epidemiologically, and experimentally evaluate the effect of antiandrogens on…
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Levent Dizdar, Georg Fluegen, Guus van Dalum et al. · 2019 · Molecular Oncology
The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system in M0 and M1 colorectal cancer (CRC) patients. A total of 80 patients (31 M0, 49 M1) with CRC were enrolled. CTCs were simultaneously measured in the peripheral blood using CS and the CC, and the results of both assays were correlated to clinicopathological variables and overall su
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Josep Tabernero, Paulo M. Hoff, Lin Shen et al. · 2022 · Gastric Cancer
BACKGROUND: Dual-targeted anti-HER2 therapy significantly improves outcomes in HER2-positive breast cancer and could be beneficial in other HER2-positive cancers. JACOB's end-of study analyses aimed to evaluate the long-term efficacy and safety of pertuzumab plus trastuzumab and chemotherapy for previously untreated HER2-positive metastatic gastric or gastroesophageal junction cancer. METHODS: Eligible patients were randomized 1:1 to pertuzumab/placebo plus trastuzumab and chemotherapy every 3 weeks. PRIMARY ENDPOINT: overall survival (OS). Secondary endpoints included progression-free surviva
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Christoph Röllig, Hubert Serve, Richard Noppeney et al. · 2021 · Leukemia
Early results of the randomized placebo-controlled SORAML trial showed that, in patients with newly diagnosed acute myeloid leukaemia (AML), sorafenib led to a significant improvement in event-free (EFS) and relapse-free survival (RFS). In order to describe second-line treatments and their implications on overall survival (OS), we performed a study after a median follow-up time of 78 months. Newly diagnosed fit AML patients aged ≤60 years received sorafenib (n = 134) or placebo (n = 133) in addition to standard chemotherapy and as maintenance treatment. The 5-year EFS was 41 versus 27% (HR 0.6
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Clark DuMontier, Hajime Uno, Tammy T. Hshieh et al. · 2021 · Haematologica
We conducted a randomized controlled trial in older adults with hematologic malignancies to determine the impact of geriatrician consultation embedded in our oncology clinic alongside standard care. From February 2015 to May 2018,…
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Chia‐Hsuin Chang, Jou‐Wei Lin, Fu‐Chun Chiu et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: This study examined the effect of radiofrequency catheter ablation (RFA) on reducing morbidity and mortality among patients with atrial fibrillation (AF). METHODS AND RESULTS: A retrospective cohort of patients with AF without…
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Alice Monzani, Anna Rapa, P Fonio et al. · 2011 · Journal of Pediatric Gastroenterology and Nutrition
OBJECTIVE: The aim of this study was to evaluate performance of serum antibodies against deamidated gliadin peptides (a-DGPs) in detecting compliance with gluten-free diet (GFD) in children with celiac disease (CD). PATIENTS AND METHODS:…
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M. J. Ryan, Holly Morgan, Amedeo Chiribiri et al. · 2021 · European Heart Journal
Patients with ischaemic left ventricular dysfunction frequently undergo myocardial viability testing. The historical model presumes that those who have extensive areas of dysfunctional-yet-viable myocardium derive particular benefit from…
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Charles Honoré, V. Atallah, Olivier Mir et al. · 2017 · PLoS ONE
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, Fren
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Manish R. Patel, Gerald S. Falchook, K Hamada et al. · 2021 · Cancer Medicine
Abstract Background Microsatellite‐stable (MSS) colorectal cancer (CRC) tends to be poorly immunogenic, with limited treatment options. In MSS CRC xenograft models, trifluridine/tipiracil (FTD/TPI) plus programed death 1 inhibitors resulted in synergistic antitumor activity and increased tumor immunogenicity. This phase 2 study evaluated FTD/TPI plus nivolumab in patients with MSS metastatic CRC. Methods This single‐arm, safety lead‐in study used a Simon's two‐stage design (enrolling 6 patients in the safety lead‐in, proceeding to stage 2 if ≥2 of the first 15 patients achieved a partial or co
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Sriram Balusu, Bart De Strooper · 2024 · Acta Neuropathologica
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal loss observed in AD brains. Recent evidence shows that necroptosis is abundant in AD, that necroptosis is closely linked to the appearance of Tau pathology, and that necroptosis markers accumulate in granulovacuolar neurodegeneration vesicles (GVD). We review here the neuron-specific activation of the granulovacuolar mediated neuronal-necroptosis pathway, the potential AD-relevant triggers upstream of this pathway, and the interaction of the necrosome with the endo-lysosomal p
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Tomris Özben · 2014 · Current Topics in Medicinal Chemistry
Radiation and some chemotherapeutic agents used in conventional cancer treatment generate reactive oxygen species (ROS), and a high ROS level diminishes cellular antioxidant capacity and leads to apoptosis and cancer cell death.…
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Mira Johri, Valéry Ridde, Rolf Heinmüller et al. · 2014 · Bulletin of the World Health Organization
OBJECTIVE: To estimate the impact on maternal and child mortality after eliminating user fees for pregnant women and for children less than five years of age in Burkina Faso. METHODS: Two health districts in the Sahel region eliminated user fees for facility deliveries and curative consultations for children in September 2008. To compare health-care coverage before and after this change, we used interrupted time series, propensity scores and three independent data sources. Coverage changes were assessed for four variables: women giving birth at a health facility, and children aged 1 to 59 mont
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Brit Mollenhauer, Frederick DuBois Bowman, Daniel Drake et al. · 2018 · Journal of Neurochemistry
Abstract α‐Synuclein is the major component of Lewy bodies and a candidate biomarker for neurodegenerative diseases in which Lewy bodies are common, including Parkinson's disease and dementia with Lewy bodies. A large body of literature suggests that these disorders are characterized by reduced concentrations of α‐synuclein in cerebrospinal fluid (CSF), with overlapping concentrations compared to healthy controls and variability across studies. Several reasons can account for this variability, including technical ones, such as inter‐assay and inter‐laboratory variation (reproducibility). We co
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Jolien Schildermans, Greet De Vlieger · 2020 · Frontiers in Medicine
Cytomegalovirus (CMV) is one of the most pathogenic viruses in human. After a primary infection, CMV resides in the host for life as a latent infection. When immunity is reduced, CMV can escape the suppressive effects of the immune system and lead to viremia and antigenemia. This reactivation, first seen in transplant patients, has also been documented in non-immunocompromised CMV-seropositive critically ill patients and is associated with higher morbidity and mortality. In the latter, it is not clear whether CMV reactivation is an innocent bystander or the cause of this observed worse outcome
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Yonghui Zhang, Feng Cheng, Xueting Du et al. · 2016 · Oncotarget
// Yong-Hui Zhang 1 , Feng Cheng 1 , Xue-Ting Du 1 , Jin-Lai Gao 1 , Xiao-Lin Xiao 1 , Na Li 1 , Shan-Liang Li 1 and De-Li Dong 1 1 Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, P.R.China Correspondence to: De-Li Dong, email: // Keywords : bone morphogenetic protein 11, growth differentiation factor 11, smad2/3, smad1/5/8,
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Y Yamamura, Chisa Nakashima, Atsushi Otsuka · 2024 · Frontiers in Medicine
The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three main factors: dysregulation of the immune response, barrier dysfunction, and pruritus. In the lesional skin of AD, various innate immune cells, including Th2 cells, type 2 innate lymphoid cells (ILC2s), and basophils, produce Th2 cytokines [interleukin (IL)-4, IL-5, IL-13, IL-31]. Alarmins such as TSLP, IL-25, and IL-33 are also produced by epidermal keratinocytes, amplifying type 2 inflammation. In the chronic phase, not only Th2 cells but also Th22 and Th17 cells increase in number, leading to suppre
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Wei‐Cheng Lin, Yi‐Fang Ding, Han‐Lin Hsu et al. · 2017 · Cancer
BACKGROUND: Few large, prospective, randomized studies have investigated the value and optimal application of neoadjuvant chemoradiotherapy followed by surgery (trimodality therapy) or definitive concurrent chemoradiotherapy (CCRT) for patients with thoracic esophageal squamous cell carcinoma (TESCC). METHODS: The authors analyzed data from patients with TESCC in the Taiwan Cancer Registry database. To compare their outcomes, patients with TESCC were enrolled and categorized into the following groups according to treatment modality: group 1, those who underwent surgery alone; group 2, those wh
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Carla Wunderle, Franziska Stumpf, Philipp Schüetz · 2024 · Journal of Parenteral and Enteral Nutrition
The complex interplay between nutrition and inflammation has become a major focus of research in recent years across different clinical settings and patient populations. Inflammation has been identified as a key driver for disease-related…
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Katja Werlenius, Sara Kinhult, Tora S. Solheim et al. · 2023 · JAMA Network Open
Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized phase II/III clinical trial with parallel group design. Patients were recruited at 7 study sites in Sweden and 2 sites in Norway between January 2017 and November 2020. Eligible patients were 18 years
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Salah Uddin Khan, Henrik Salje, Abu Sayeed Md. Abdul Hannan et al. · 2014 · PLoS neglected tropical diseases
BACKGROUND: Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment. The objectives of this study were to describe the transmission dynamics of JEV among pigs in northwestern Bangladesh and estimate the potential impact of vaccination to reduce incidence among pigs. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a comprehe
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Sumit K. Subudhi, Bilal A. Siddiqui, Ana M. Aparicio et al. · 2021 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint therapy (ICT) has low response rates in patients with metastatic castration-resistant prostate cancer (mCRPC), in part due to few T cells in the tumor microenvironment (TME). Anti-cytotoxic T…
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Gil Awada, Laïla Ben Salama, Jennifer Cremer et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: No treatment demonstrated to improve survival in patients with recurrent glioblastoma (rGB) in a randomized trial. Combining axitinib with the programmed cell death ligand 1 blocking monoclonal antibody avelumab may result in…
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Emily N. C. Manoogian, Michael J. Wilkinson, Monica A. O'Neal et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits. OBJECTIVE: To determine the effects of TRE as a lifestyle…
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Yoshimasa Miyagawa, Kazuhiro Araki, Ayako Bun et al. · 2018 · Clinical Breast Cancer
INTRODUCTION: Although eribulin and nab-paclitaxel are chemotherapy agents widely used for locally advanced or metastatic breast cancer (MBC), their predictive factors remain unknown. Because the absolute neutrophil-to-lymphocyte ratio…
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