11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Domsic RT, Gao S, Laffoon M et al. · 2021 · Rheumatology (Oxford, England)
Objectives Clinical trials in early diffuse cutaneous systemic sclerosis (SSc) using the modified Rodnan skin score (mRSS) as the primary outcome measure have most often been negative. We wanted to assess how the definition of disease…
View details →Kremer L, Bus JD, Webb LE et al. · 2021 · Scientific reports
Affective states can be inferred from responses to ambiguous and threatening stimuli, using Judgement Bias Tasks (JBTs) and Attention Bias Tasks (ABTs). We investigated the separate and interactive effects of personality and housing…
View details →Mason MG, Richardson EJ, Giarrusso C et al. · 2025 · Journal of the experimental analysis of behavior
This experiment explored a rodent model of functional class formation by assessing the transfer of a novel discriminative function across class members. Following simple successive discrimination reversal training and consistently strong…
View details →Chamberlain DB, Chamberlain JM · 2017 · Annals of emergency medicine
Study objective We demonstrate the application of a Bayesian approach to a recent negative clinical trial result. A Bayesian analysis of such a trial can provide a more useful interpretation of results and can incorporate previous…
View details →Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
View details →Puvvada SD, Guillén-Rodríguez JM, Rivera XI et al. · 2017 · Oncology
Objective Aggressive lymphomas (aNHL) including diffuse large B-cell lymphoma (DLBCL) have poor outcomes in relapsed refractory patients. Prior studies have demonstrated that loss of major histocompatibility complex class II (MHCII)…
View details →Regel A, Sepriano A, Baraliakos X et al. · 2017 · RMD open
To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society (ASAS)/European League Against Rheumatism…
View details →Abdelrahman KM, Hackshaw KV · 2021 · Biomedicines
Neuropathic pain affects 7-10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake…
View details →Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
View details →Kitchin SS, Lakshmanan S, Kinninger A et al. · 2023 · The British journal of cardiology
Atrial fibrillation (AF) is a common arrhythmia associated with poor outcomes. N-3 fatty acids have been shown to provide significant cardiovascular risk reduction, but they may exacerbate the risk of AF. The pathway by which N-3 fatty…
View details →Konishi K · 2024 · Entropy (Basel, Switzerland)
We comment on the so-called negative result experiments (also known as null measurements, interaction-free measurements, and so on) in quantum mechanics (QM), in the light of the new general understanding of the quantum-measurement…
View details →Yarnall S, Saben JL, Sun N et al. · 2025 · Journal of genetic counseling
This observational study aimed to capture patients' experiences after reviewing carrier screening (CS) and/or noninvasive prenatal cell-free DNA testing (NIPT) results with Natera's Educational Virtual Assistant (NEVA). Patients, partners…
View details →Van Der Pol B, Ippolito J, Gao R et al. · 2026 · Sexually transmitted diseases
Background Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the…
View details →Ding JJ, Chiu CF, Su YT et al. · 2025 · Pediatric research
Background Maternal hypercalcemia is a rare but potentially serious cause of late-onset neonatal hypocalcemia. Data on the clinical characteristics and outcomes of mother-baby couplets with maternal hypercalcemia and subsequent neonatal…
View details →Džafić F, Ahmetović A, Čoloman N et al. · 2026 · International archives of allergy and immunology
Introduction Allergic rhinitis (AR) is a prevalent health concern. In Europe, 20-40% of the population is affected. Diagnostic methods include skin tests, measurement of serum immunoglobulin E (IgE), nasal smear for eosinophils, and…
View details →Kohan R, Gil-Campesino H, García Rodríguez IO et al. · 2026 · Emerging infectious diseases
We report 2 cases of donor-derived Strongyloides stercoralis infection in renal transplant recipients. Despite initial negative serologic testing in donor samples, retrospective testing confirmed transmission. This report underscores the…
View details →Le Duc W, Butler CR, Argyropoulos GPD et al. · 2025 · PLoS biology
Rodent and human data implicate the hippocampus in the arbitration of approach-avoidance conflict (AAC), which arises when an organism is confronted with a stimulus associated simultaneously with reward and punishment. Yet, the precise…
View details →Kim CK, Lee YR, Ong L et al. · 2022 · Journal of Alzheimer's disease : JAD
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic…
View details →Li W, Bunch CM, Zackariya S et al. · 2025 · Scientific reports
Disordered hemostasis associated with life-threatening hemorrhage commonly afflicts patients in the emergency department, critical care unit, and perioperative settings. Rapid and sensitive hemostasis phenotyping is needed to guide…
View details →Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
View details →Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers
Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…
View details →Howland RH · 2015 · Journal of psychosocial nursing and mental health services
Seven topics previously described in this column are revisited. The use of quantitative electroencephalography has been shown in a prospective study to be effective for predicting antidepressant treatment response. A novel antidepressant…
View details →Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open
Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…
View details →Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
View details →Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
View details →Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
View details →Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
View details →Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
View details →Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe
Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…
View details →Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease
Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…
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