11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Harding JF, Walzer J, Piatt R et al. · 2025 · Contraception
Objectives It is important to identify programs that can work in multiple contexts to support adolescent parents in achieving their reproductive health goals. A randomized controlled trial in Ohio in 2012 found that the Teen Options to…
View details →Guest H, Plack CJ, Munro KJ et al. · 2026 · International journal of audiology
Objective Adult auditory brainstem response (ABR) amplitudes are employed by both researchers and clinicians, but exhibit substantial between-subject variability, reducing their sensitivity as measures of underlying auditory health. One…
View details →Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology
This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…
View details →Zhu J, Yi Y, Ma L et al. · 2026 · Italian journal of pediatrics
BACKGROUND: Observational epidemiology studies suggested a relationship between single-carbon metabolism and vitamin levels with autism spectrum disorder (ASD) risk. We aimed to explore the causal relationship between them at the genetic…
View details →Rosales MR, Pulido JC, Sideris J et al. · 2026 · PloS one
Introduction Motor impairments have been reported in infants at elevated likelihood of autism and those later diagnosed with autism. However, empirical studies comparing higher to lower likelihood infants are lacking, limiting our…
View details →Gusmão B, Zürn MK, Topolinski S · 2026 · Cognition & emotion
Individuals attribute a higher truth value to repeated compared to novel information, the well-known truth effect. Also, information that contradicts what we have heard earlier is considered falser than both repeated and completely new…
View details →Nieves-Méndez C · 2025 · Frontiers in human neuroscience
This perspective article explores the transformative potential of brain-Computer Interfaces (BCI) in undergraduate systems engineering programs, a domain characterized by high attrition and a widening gap between rapid technological…
View details →Alotaibi AM, Alosaimi MH, Orfali RS et al. · 2025 · Brain research bulletin
Hallucinations are often associated with alterations in brain activation, particularly in language-related and sensory processing areas. Existing models suggest different frameworks for understanding the relationship between brain…
View details →Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research
Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…
View details →Okunoye G, George Samuel C, Abdullahi H et al. · 2026 · Cureus
Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant maternal and neonatal risks, and its prevalence is particularly high in Qatar. Myo-inositol has been proposed as an insulin-sensitizing supplement that…
View details →Verhelst H, Gerrits R, Karlsson EM · 2025 · Neurobiology of language (Cambridge, Mass.)
Developmental dyslexia is a common learning disability marked by reading and spelling difficulties. While previous imaging studies aiming to elucidate the neurobiological mechanisms of this disorder have reported white matter alterations,…
View details →Andersson PF, Testori M, Lo Iacono S · 2026 · PloS one
The willingness to engage in costly punishment of free riders (prosocial punishment) is crucial to foster group cooperation and understand public goods provision. While prosocial punishment is common across societies, its motivations…
View details →Aguado J, Gutierrez L, Forns J et al. · 2025 · American journal of epidemiology
Studying the effect of duration of treatment on prognostic outcomes using real-world data is challenging because only people who survive for a long time can receive a treatment for a long time. Specifying a target trial helps overcome such…
View details →McLone SG, Coleman CM, Matzke HJ et al. · 2026 · American journal of epidemiology
Firearm violence is a public health crisis in the United States and negatively impacts individuals and communities. We used data from The Healthy Chicago Survey, a citywide survey of 8754 respondents from 2020 to 2021, and police-reported…
View details →Garcia Campos LS, Lempert KM · 2025 · Frontiers in psychology
Introduction Uncertain decisions can be risky (with known probabilities) or ambiguous (with unknown probabilities). Previous studies have found that negative affect can increase risk aversion and ambiguity aversion, but it is unknown if…
View details →Suberry A, Okun S, Ayalon L · 2026 · The Gerontologist
Background and objectives Ageism often emerges in childhood, yet rigorously evaluated school-based interventions-especially in multicultural settings-are scarce. The study evaluated the efficacy of a 90-min educational intervention to…
View details →Merz LM, von Hohenberg BC, Bergmann NT et al. · 2025 · Science advances
Expanding gray wolf ( Canis lupus ) populations in Europe and North America contribute to increased risks of livestock predation, which can threaten human livelihoods and lead government agencies to target wolves for lethal removal. Public…
View details →Seizer L, Kratzer L, Löchner J et al. · 2026 · Clinical psychology & psychotherapy
Psychotherapy process research increasingly uses intensive longitudinal monitoring to capture dynamic patterns of change in patients. In this study, 283 psychiatric inpatients diagnosed with depression (n = 70), PTSD (n = 148),…
View details →Hauser I · 2022 · The Journal of the Acoustical Society of America
This paper reconsiders a classic claim about phonetic variability-that speech sounds in larger phonemic inventories should exhibit less within-category variability in production. Although this hypothesis is intuitive, existing literature…
View details →Gonzalez-Nahm S, Griffith E, Maguire RL et al. · 2026 · Childhood obesity (Print)
Objective To assess the longitudinal associations between maternal diet during pregnancy and child adiposity between ages 2 and 12 years. Methods Repeated measures linear regression models with autoregressive covariance were used to assess…
View details →Wei C, Ng VWS, Wei Y et al. · 2025 · BMC psychiatry
AIMS: Preclinical studies have suggested potential anticancer effects of valproate, but clinical evidence is limited and inconclusive. This study aims to reexamine the relationship between valproate use and cancer incidence, using lithium…
View details →Winkelman JW, Levine MJ · 2026 · AACE endocrinology and diabetes
Type 2 diabetes mellitus is a highly prevalent metabolic disorder and a well-established risk factor for colorectal cancer (CRC), mediated by hyperglycemia, hyperinsulinemia, chronic inflammation, and obesity-related metabolic dysfunction.…
View details →Acierno J, Tedaldi E, Ginn J et al. · 2026 · Communications psychology
Social norms have a reliable and oftentimes strong influence on individual attitudes and behaviors across environmental and other domains. This influence has been theorized to differ by cultural tightness-the extent to which people adhere…
View details →D'Agostini M, Vanden Bossche L, Burger AM et al. · 2025 · Psychophysiology
Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a strategy to facilitate fear extinction learning based on the hypothesis that taVNS increases central noradrenergic activity. Four studies out of six found taVNS…
View details →· 2025 · Nature
Neutrinos are the most abundant fundamental matter particles in the Universe and play a crucial part in particle physics and cosmology. Neutrino oscillation, discovered about 25 years ago, shows that the three known species mix with each…
View details →Xiang Y, Xu L, Sun Y et al. · 2025 · Medicine
Mobile phone use has become ubiquitous in modern life, raising public concern over its potential effects on male reproductive health. While several observational studies have reported associations between prolonged phone use and decreased…
View details →He J, Sabroso-Lasa S, Coscia C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background Observational studies consistently report reduced pancreatic ductal adenocarcinoma (PDAC) risk among individuals with atopic conditions (asthma and rhinitis); however, the underlying biological mechanism remains unclear. This…
View details →Schleimer JP, Rencken CA, Wagenaar BH et al. · 2026 · JAMA network open
Importance Background checks aim to prevent illegal firearm transfers. Existing research has shown little evidence for the effect of point-of-sale comprehensive background check (CBC) policies on firearm-related violence at the state…
View details →Walda SAE, van Weerdenburg M, Bosman AMT · 2024 · Research in developmental disabilities
Background Poor decoding and spelling (literacy) skills have been associated with weak working memory. Aims The aim of this study was to elucidate the contribution of working memory to literacy progress in students with dyslexia. It has…
View details →Bertoldi AD, Flores TR, Silveira MPT et al. · 2026 · Ciencia & saude coletiva
This study aimed to investigate the association between the use of antimicrobials during pregnancy and excess weight in children at ages three, 12, 24 and 48 months. Data of participants from the 2015 Pelotas (Brazil) Birth Cohort study…
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