11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Paulich KN, Place C, Giordano G et al. · 2025 · Frontiers in psychology
Introduction Cannabis, which contains cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), has become the third-most-commonly used psychoactive substance in the United States. The legal market has grown alongside the…
View details →Rock A, Neth MR, Newgard CD et al. · 2026 · Resuscitation plus
Study objective Our objective was to determine the association between anterior-posterior (AP) and anterior-lateral (AL) pad placement and outcomes for patients with out-of-hospital cardiac arrest (OHCA) with an initial non-shockable…
View details →Picerni E, Piras F, Laricchiuta D et al. · 2026 · Brain sciences
Background: Hypnotizability is a psychophysiological trait measured by standardized scales whose scores indicate the proneness to modify perception, memory, and behavior according to specific suggestions, and to experience the hypnotic…
View details →Haskaraca FN, Proft M, Liszkowski U et al. · 2023 · Frontiers in psychology
It has been long assumed that meta-representational theory of mind (ToM) -our ability to ascribe mental states to ourselves and other people- emerges around age four as indicated in performance on explicit verbal false belief tasks. In…
View details →Wang J, Moriguchi Y · 2023 · Heliyon
Media exposure, such as viewing fantastical content, can have negative, immediate, and long-term effects on children's executive function. A recent study showed that watching fantastical content on a tablet can impair children's inhibitory…
View details →Quddus DY, Aydin S, Waheed AA et al. · 2026 · Frontiers in nutrition
Background Traumatic brain injury (TBI) affects 69 million individuals annually and represents a major global health burden. Ketogenic interventions have emerged as a potential therapy to address deficits following TBI. This scoping review…
View details →Liu F, Wang Q, Han S et al. · 2026 · Frontiers in cardiovascular medicine
Introduction Heart failure with preserved ejection fraction (HFpEF) is associated with substantial functional limitation and recurrent hospitalization, while effective pharmacological options remain limited. Exercise-based cardiac…
View details →Mizuho T, Narumi T, Kuzuoka H · 2023 · IEEE transactions on visualization and computer graphics
Advances in virtual reality technology have enabled the creation of virtual environments (VEs) with significantly high visual fidelity when compared to real environments (REs). In this study, we use a high-fidelity VE to examine two…
View details →Luchetti M, Terracciano A, Karakose S et al. · 2026 · Journal of the International Neuropsychological Society : JINS
Objective This study examines how multiple dimensions of socio-emotional well-being relate to cognitive functioning in older adults, and whether the associations vary by cognitive status, depression, and socio-demographic factors. Methods…
View details →Roth TS, Samara I, Perea-Garcia JO et al. · 2024 · Scientific reports
Primate faces provide information about a range of variant and invariant traits, including some that are relevant for mate choice. For example, faces of males may convey information about their health or genetic quality through symmetry or…
View details →Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging
Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…
View details →Hu L, Gao Z, Gao Q et al. · 2024 · Scientific reports
Holding and processing actions in visual working memory (VWM) is crucial for daily functioning, but it is capacity-limited. The vestibular system, which is activated by both vestibular signals and visual gravitational motion, may be…
View details →Meyer JH, Wang Z, Santhirakumar A et al. · 2024 · EClinicalMedicine
Background Postpartum blues (PPB) is a frequent syndrome of sad mood, crying spells, anxiety, restlessness, reduced appetite, and irritability, typically peaking day 5 postpartum. When severe, it greatly increases risk for later postpartum…
View details →Ruiz Hispán E, Pedregal M, Cristobal I et al. · 2021 · Journal of clinical medicine
Peritoneal metastases from gastric cancer play a key role in the fatal prognosis of the disease. The lack of efficacy of actual therapeutic approaches together with the outcomes achieved with checkpoint inhibitors in gastric cancer compel…
View details →Rabbia M, Guridi Ormazabal M, Staunton H et al. · 2024 · Journal of neuromuscular diseases
Background Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne…
View details →Chase DM, Huang HQ, Deng W et al. · 2025 · Gynecologic oncology
Objective To prospectively evaluate the impact of adjuvant chemoradiation (RT + CIS) versus radiation (RT) on quality of life (QOL) and patient-reported outcomes (PROs) among patients with intermediate-risk, stage I-IIA cervical cancer…
View details →Floreani ED, Orlandi S, Chau T · 2022 · Frontiers in human neuroscience
Brain-computer interfaces (BCIs) are being investigated as an access pathway to communication for individuals with physical disabilities, as the technology obviates the need for voluntary motor control. However, to date, minimal research…
View details →Corpening B, Bürgler A, Tamási B et al. · 2025 · Environmental epidemiology (Philadelphia, Pa.)
Background Prior research suggests pollen allergies may be associated with cognitive function, although the effect sizes and specific cognitive outcomes varied across studies. With pollen seasons starting earlier and intensifying due to…
View details →Shkreli L, Woud ML, Bergunde L et al. · 2025 · European journal of psychotraumatology
Background: Steroid hormone dysregulations have frequently been implicated in posttraumatic stress disorder (PTSD) pathogenesis. However, the translation into naturalistic clinical settings as markers of symptomatology and treatment…
View details →Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas
Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…
View details →Willems YE, Raffington L, Ligthart L et al. · 2024 · Frontiers in psychiatry
Background Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding,…
View details →Madrigano J, Yan D, Liu T et al. · 2024 · GeoHealth
Indonesia faces significant air quality issues due to multiple emissions sources, including rapid urbanization and peatland fires associated with agricultural land management. Limited prior research has estimated the episodic shock of…
View details →Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council
Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…
View details →Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…
View details →Abdul Jafar NK, Tham EKH, Fok D et al. · 2026 · Nutrients
Background: Maternal chronotype, maternal sleep, and breastfeeding practices are separately associated with maternal mood. However, it is not known if maternal mood mediates the associations between maternal chronotype or maternal sleep…
View details →Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science
Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…
View details →Torkan A, Zoghi M, Foroughimehr N et al. · 2025 · Brain sciences
Background Research on the impact of 5G mobile phone electromagnetic exposure on corticospinal excitability and intracortical mechanisms is still poorly understood. Objective This randomized controlled pilot study explored the effects of…
View details →Galang CM, Obhi SS · 2023 · Experimental brain research
Previous research has shown that empathic pain observation can lead to motor facilitation in the form of faster reaction times. However, it is unclear whether participants are focusing on the others' pain or simply focusing on their own…
View details →Rosenheck R, Kurtz SG, Anand ST et al. · 2023 · Psychiatry research
Multi-site randomized effectiveness trials evaluate treatments under real-world conditions. Whether results change practice is under-studied. A 6-month 26-site Veterans Health Administration (VHA) cooperative study published in 2011…
View details →Das S, Freedland SJ · 2023 · Cancer prevention research (Philadelphia, Pa.)
Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have…
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